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  1. Article: B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors: Which One Is the Best Performer?

    de Falco, Renato / Vargas, Maria / Palma, Daniela / Savoia, Marcella / Miscioscia, Anna / Pinchera, Biagio / Vano, Martina / Servillo, Giuseppe / Gentile, Ivan / Fortunato, Giuliana

    Journal of clinical medicine

    2021  Volume 10, Issue 12

    Abstract: ... natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been ... useful predictor of fatal outcome in COVID-19 patients. One hundred and seventy-four patients affected ... with COVID-19 were recruited, and markers of cardiac disease and the clinical history of the patients were ...

    Abstract Increased concentrations of B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been reported. The aim of this study is to evaluate which of these common markers of cardiac disease is the most useful predictor of fatal outcome in COVID-19 patients. One hundred and seventy-four patients affected with COVID-19 were recruited, and markers of cardiac disease and the clinical history of the patients were collected at admission in the infectious disease unit or intensive care unit. NT-proBNP, BNP and HsTnI values were higher in in-hospital non-surviving patients. Receiver operating characteristic (ROC) curve analysis of NT-proBNP, BNP and HsTnI was performed, with NT-proBNP (AUC = 0.951) and HsTnI (AUC = 0.947) being better performers (
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors

    Renato de Falco / Maria Vargas / Daniela Palma / Marcella Savoia / Anna Miscioscia / Biagio Pinchera / Martina Vano / Giuseppe Servillo / Ivan Gentile / Giuliana Fortunato

    Journal of Clinical Medicine, Vol 10, Iss 2726, p

    Which One Is the Best Performer?

    2021  Volume 2726

    Abstract: ... natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been ... useful predictor of fatal outcome in COVID-19 patients. One hundred and seventy-four patients affected ... with COVID-19 were recruited, and markers of cardiac disease and the clinical history of the patients were ...

    Abstract Increased concentrations of B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been reported. The aim of this study is to evaluate which of these common markers of cardiac disease is the most useful predictor of fatal outcome in COVID-19 patients. One hundred and seventy-four patients affected with COVID-19 were recruited, and markers of cardiac disease and the clinical history of the patients were collected at admission in the infectious disease unit or intensive care unit. NT-proBNP, BNP and HsTnI values were higher in in-hospital non-surviving patients. Receiver operating characteristic (ROC) curve analysis of NT-proBNP, BNP and HsTnI was performed, with NT-proBNP (AUC = 0.951) and HsTnI (AUC = 0.947) being better performers ( p = 0.01) than BNP (AUC = 0.777). Logistic regression was performed assessing the relation of HsTnI and NT-proBNP to fatal outcome adjusting for age and gender, with only NT-proBNP being significant. The population was then divided into two groups, one with higher NT-proBNP values at admission than the cut-off resulted from the ROC curve (511 ng/L) and a second one with lower values. The Kaplan–Meier analysis showed an absence of fatal outcome in the group of patients with NT-proBNP values lower than the cut-off ( p < 0.001). NT-proBNP proved to be the best prognostic tool for fatal outcome among markers of cardiac disease in COVID-19 patients.
    Keywords COVID-19 ; BNP ; NT-proBNP ; troponin ; prognostic markers ; fatal outcome ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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