LIVIVO - Search results -

Search results

Result 1 - 10 of total 48

Article ; Online: PANDAS

Jornal de Pediatria, Vol 83, Iss 3, Pp 201-

uma nova doença? PANDAS: a new disease?

2007 Volume 208

Abstract: ... over the actual existence of this new pediatric disease. The name of this new disease, supposedly ... a etiopatogenia, tratamento e profilaxia de PANDAS. FONTES DOS DADOS: Revisão de literatura científica através do ... MEDLINE no período de 1989 a 2006. SÍNTESE DOS DADOS: Os critérios diagnósticos para PANDAS foram ...

Abstract	OBJETIVO: Apresentar as bases diagnósticas e analisar as evidências que têm sido apontadas para a etiopatogenia, tratamento e profilaxia de PANDAS. FONTES DOS DADOS: Revisão de literatura científica através do MEDLINE no período de 1989 a 2006. SÍNTESE DOS DADOS: Os critérios diagnósticos para PANDAS foram estabelecidos há quase 10 anos, mas ainda há muita controvérsia sobre a real existência desta nova doença pediátrica. A escolha deste nome para uma nova doença, supostamente de origem pós-estreptocócica, baseia-se no acrônimo de P (pediátrico, porque ocorre em crianças), A (auto-imune), N (neuropsiquiátrico), D (doença), A (associada) e S (Streptococcus). Os tiques e os sintomas obsessivo-compulsivos são as principais manifestações clínicas da doença e surgem após infecções estreptocócicas, provavelmente por mecanismos auto-imunes. Apesar de estes sintomas neuropsiquiátricos serem comuns na coréia reumática, também de etiologia pós-estreptocócica, em PANDAS faltam os movimentos clássicos da coréia e as outras manifestações de febre reumática. As possibilidades de terapia antimicrobiana e imunológica estão sendo pesquisadas e demonstram viabilidade de uso em alguns casos. CONCLUSÕES: Pesquisas ainda são necessárias para responder à pergunta-título. Enquanto isso não ocorre, a identificação de casos de tiques e transtorno obsessivo-compulsivo em crianças deve considerar a possibilidade de PANDAS, buscando a evidência de infecção estreptocócica precedendo os episódios. OBJECTIVE: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. SOURCES: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. SUMMARY OF THE FINDINGS: The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new pediatric disease. The name of this new disease, supposedly of poststreptococcal etiology, derives from an acronym that stands for pediatric autoimmune neuropsychiatric disease associated with streptococcal infection. Tics and obsessive-compulsive symptoms are the major clinical signs of the disease, which develop after streptococcal infections, probably through autoimmune mechanisms. Even though these neuropsychiatric symptoms are common in rheumatic chorea, whose etiology is also poststreptococcal, the classic choreiform movements and other symptoms of rheumatic fevers are absent in PANDAS. The use of antimicrobial and immunologic therapy has been investigated and considered feasible in some cases. CONCLUSIONS: Further research is still necessary in order to answer the question posed in the title of this article. In the meantime, the identification of tic disorders and obsessive-compulsive disorders in children should include the possibility of PANDAS, seeking to provide evidence of previous streptococcal infection.
Keywords	PANDAS ; estreptococos ; coréia ; febre reumática ; tiques ; transtorno obsessivo-compulsivo ; streptococci ; chorea ; rheumatic fever ; tics ; obsessive-compulsive disorder ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	Sociedade Brasileira de Pediatria
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A new canine distemper virus lineage identified from red pandas in China.

Wang, Ruichen / Wang, Xiaohu / Zhai, Junqiong / Zhang, Pian / Irwin, David M / Shen, Xuejuan / Chen, Wu / Shen, Yongyi

Transboundary and emerging diseases

2021 Volume 69, Issue 4, Page(s) e944–e952

Abstract: ... suggest that the analyzed strains belong to a new CDV lineage, which we designate as Asia-6. Our finding ... the genomes of CDV isolated from the lungs of two dead red pandas in China. Histopathological and ... to fatal diseases in a wide range of carnivore species. Based on the sequences of the haemagglutinin (H ...

Abstract	Canine distemper virus (CDV) is a highly contagious virus that causes multi-systemic, sub-clinical to fatal diseases in a wide range of carnivore species. Based on the sequences of the haemagglutinin (H) gene, CDV strains have been classified into 18 major genetic lineages. In this study, we characterized the genomes of CDV isolated from the lungs of two dead red pandas in China. Histopathological and immunohistochemical analyses revealed damage due to viral infection in these lungs. The two strains showed a deep genetic distance from the other 18 recognized lineages (>4.6% at nucleotide level and >5.0% at amino acid level). The maximum clade credibility tree of the H- gene sequences showed that they belonged to an independent clade and had diverged a relatively long time ago from the Asia-4 lineage (since 1884). These results suggest that the analyzed strains belong to a new CDV lineage, which we designate as Asia-6. Our finding indicates that CDV infections in wildlife in China are complex and are a threat to endangered carnivores.
MeSH term(s)	Animals ; Carnivora ; China/epidemiology ; Distemper/epidemiology ; Distemper Virus, Canine/genetics ; Dog Diseases ; Dogs ; Hemagglutinins, Viral/genetics ; Phylogeny
Chemical Substances	Hemagglutinins, Viral
Language	English
Publishing date	2021-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14370
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article ; Online: Identification of a novel circovirus in blood sample of giant pandas (Ailuropoda melanoleuca).

Dai, Ziyuan / Wang, Hao / Feng, Zhanghao / Ma, Li / Yang, Shixing / Shen, Quan / Wang, Xiaochun / Zhou, Tianji / Zhang, Wen

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2021 Volume 95, Page(s) 105077

Abstract: ... GPCV was a putative new species within genus Circovirus based on the species demarcation criteria ... nucleic acid in the blood sample from giant pandas. According to these methods, the complete genome sequence ... giant pandas was identified. The GPCV genome is 2090 bp in size and reveals two putative ambisense ...

Abstract	The members of the family Circoviridae are considered to be one of the smallest autonomously replicating viruses that are classified into two genera, Circovirus and Cyclovirus. Circoviruses have been found in a variety of vertebrates, but whether they infect endangered protected animals has not been studied in much detail. Here, viral metagenomics and PCR methods were used to detect and verify viral nucleic acid in the blood sample from giant pandas. According to these methods, the complete genome sequence of a novel circovirus, the giant panda associated circovirus (GPCV) from the blood sample of three giant pandas was identified. The GPCV genome is 2090 bp in size and reveals two putative ambisense open-reading frames, encoding the major structural capsid protein and the replication associated protein, respectively, the latter having two predicted introns. Pairwise sequence comparison and phylogenetic analyses indicated GPCV was a putative new species within genus Circovirus based on the species demarcation criteria of the International Committee on the Taxonomy of Viruses. It is the first time that circovirus has been identified from blood sample of giant pandas. These efforts will contribute to future analyses to illuminate the evolutionary relationships between classified and newly identified members of the family Circoviridae.
MeSH term(s)	Animals ; Circoviridae Infections/blood ; Circoviridae Infections/veterinary ; Circoviridae Infections/virology ; Circovirus/classification ; Circovirus/genetics ; Female ; Genome, Viral ; Male ; Ursidae
Language	English
Publishing date	2021-09-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2021.105077
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: PANDAS: a new disease?

de Oliveira, Sheila Knupp Feitosa

Jornal de pediatria

2007 Volume 83, Issue 3, Page(s) 201–208

Abstract: ... existence of this new pediatric disease. The name of this new disease, supposedly of poststreptococcal ... Objective: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence ... for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual ...

Abstract	Objective: To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. Sources: Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. Summary of the findings: The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists over the actual existence of this new pediatric disease. The name of this new disease, supposedly of poststreptococcal etiology, derives from an acronym that stands for pediatric autoimmune neuropsychiatric disease associated with streptococcal infection. Tics and obsessive-compulsive symptoms are the major clinical signs of the disease, which develop after streptococcal infections, probably through autoimmune mechanisms. Even though these neuropsychiatric symptoms are common in rheumatic chorea, whose etiology is also poststreptococcal, the classic choreiform movements and other symptoms of rheumatic fevers are absent in PANDAS. The use of antimicrobial and immunologic therapy has been investigated and considered feasible in some cases. Conclusions: Further research is still necessary in order to answer the question posed in the title of this article. In the meantime, the identification of tic disorders and obsessive-compulsive disorders in children should include the possibility of PANDAS, seeking to provide evidence of previous streptococcal infection.
MeSH term(s)	Abbreviations as Topic ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/microbiology ; Autoimmune Diseases/prevention & control ; Child ; Child, Preschool ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/microbiology ; Obsessive-Compulsive Disorder/prevention & control ; Streptococcal Infections/drug therapy ; Streptococcal Infections/prevention & control ; Streptococcal Infections/psychology ; Tics/drug therapy ; Tics/microbiology ; Tics/prevention & control
Language	English
Publishing date	2007-05-04
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.2223/JPED.1615
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1265: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A new canine distemper virus lineage identified from red pandas in China

Wang, Ruichen / Wang, Xiaohu / Zhai, Junqiong / Zhang, Pian / Irwin, David M. / Shen, Xuejuan / Chen, Wu / Shen, Yongyi

Transboundary and emerging diseases. 2022 July, v. 69, no. 4

2022

Abstract: ... suggest that the analyzed strains belong to a new CDV lineage, which we designate as Asia‐6. Our finding ... the genomes of CDV isolated from the lungs of two dead red pandas in China. Histopathological and ... to fatal diseases in a wide range of carnivore species. Based on the sequences of the haemagglutinin (H ...

Abstract	Canine distemper virus (CDV) is a highly contagious virus that causes multi‐systemic, sub‐clinical to fatal diseases in a wide range of carnivore species. Based on the sequences of the haemagglutinin (H) gene, CDV strains have been classified into 18 major genetic lineages. In this study, we characterized the genomes of CDV isolated from the lungs of two dead red pandas in China. Histopathological and immunohistochemical analyses revealed damage due to viral infection in these lungs. The two strains showed a deep genetic distance from the other 18 recognized lineages (>4.6% at nucleotide level and >5.0% at amino acid level). The maximum clade credibility tree of the H‐ gene sequences showed that they belonged to an independent clade and had diverged a relatively long time ago from the Asia‐4 lineage (since 1884). These results suggest that the analyzed strains belong to a new CDV lineage, which we designate as Asia‐6. Our finding indicates that CDV infections in wildlife in China are complex and are a threat to endangered carnivores.
Keywords	Canine morbillivirus ; amino acids ; carnivores ; genes ; genetic distance ; hemagglutinins ; histopathology ; immunohistochemistry ; viruses ; wildlife ; China
Language	English
Dates of publication	2022-07
Size	p. e944-e952.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14370
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: The COVID-19 pandemic and children with PANS/PANDAS: an evaluation of symptom severity, telehealth, and vaccination hesitancy.

O'Dor, Sarah L / Zagaroli, J S / Belisle, R M / Hamel, M A / Downer, O M / Homayoun, S / Williams, K A

Child psychiatry and human development

2022 Volume 55, Issue 2, Page(s) 327–335

Abstract: ... diagnosed COVID-19 experienced new or worsened psychiatric symptoms, particularly mood lability, OCD, and ... The current study assessed the impact of the COVID-19 pandemic on children with PANS/PANDAS ... of minors with PANS/PANDAS. Caregivers answered questions regarding PANS/PANDAS symptoms, telehealth care ...

Abstract	The current study assessed the impact of the COVID-19 pandemic on children with PANS/PANDAS, a condition characterized by sudden-onset obsessive-compulsive, tic, or restrictive eating symptoms following infection. We conducted an anonymous survey between February and June 2021 of 254 self-reported caregivers of minors with PANS/PANDAS. Caregivers answered questions regarding PANS/PANDAS symptoms, telehealth care, and intention to vaccinate their child against COVID-19. PANS/PANDAS symptoms during COVID-19 infections were assessed when applicable. Children's OCD symptoms and coercive behaviors towards caregivers, along with the caregivers' mental health, relationship satisfaction, and burden, were assessed using standardized questionnaires. A majority of respondents endorsed a negative impact on their child's friendships, relationships with extended family, hobbies, and academic skills due to the pandemic. Children with suspected or diagnosed COVID-19 experienced new or worsened psychiatric symptoms, particularly mood lability, OCD, and anxiety. Telehealth care was the preferred treatment modality if the child had mild symptoms of PANS/PANDAS. A majority of caregivers reported high levels of relationship dissatisfaction and caregiver burden. As expected, these data suggest an overall negative impact of the COVID-19 pandemic on children with PANS/PANDAS and their caregivers.
MeSH term(s)	Child ; Humans ; Pandemics ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Streptococcal Infections/diagnosis ; Streptococcal Infections/epidemiology ; Vaccination Hesitancy ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/epidemiology ; Obsessive-Compulsive Disorder/psychology ; COVID-19/prevention & control ; Telemedicine
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-022-01401-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 772: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A novel missense mutation in the HSF4 gene of giant pandas with senile congenital cataracts.

You, Yuyan / Bai, Chao / Liu, Xuefeng / Xia, Maohua / Yin, Yanqiang / Chen, Yucun / Wang, Wei / Jia, Ting / Lu, Yan / Pu, Tianchun / Zhang, Chenglin / Li, Xiaoguang / Wang, Liqin / Xiu, Yunfang / Niu, Lili / Zhou, Jun / Du, Yang / Liu, Yanhui / Xu, Suhui

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5411

Abstract: ... a potential new genetic determinant that could help to predict the risk of cataracts in giant pandas. ... are increasingly prevalent among aging populations of captive giant pandas (Ailuropoda melanoleuca ... of cataract development in order to distinguish between congenital and age-related disease. Here we screened ...

Abstract	Cataracts are a common cause of visual impairment and blindness in mammals. They are usually associated with aging, but approximately one third of cases have a significant genetic component. Cataracts are increasingly prevalent among aging populations of captive giant pandas (Ailuropoda melanoleuca) and it is therefore important to identify genetic determinants that influence the likelihood of cataract development in order to distinguish between congenital and age-related disease. Here we screened for cataract-related genetic effects using a functional candidate gene approach combined with bioinformatics to identify the underlying genetic defect in a giant panda with congenital cataracts. We identified a missense mutation in exon 10 of the HSF4 gene encoding heat shock transcription factor 4. The mutation causes the amino acid substitution R377W in a highly conserved segment of the protein between the isoform-specific and downstream hydrophobic regions. Predictive modeling revealed that the substitution is likely to increase the hydrophobicity of the protein and disrupt interactions with spatially adjacent amino acid side chains. The mutation was not found in 13 unaffected unrelated animals but was found in an unrelated animal also diagnosed with senile congenital cataract. The novel missense mutation in the HSF4 gene therefore provides a potential new genetic determinant that could help to predict the risk of cataracts in giant pandas.
MeSH term(s)	Animals ; Cataract/congenital ; Cataract/veterinary ; Mutation, Missense ; Transcription Factors/genetics ; Ursidae/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84741-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Severe Psychotic Symptoms in Youth with PANS/PANDAS: Case-Series.

Pavone, Piero / Parano, Enrico / Battaglia, Chiara / Marino, Silvia / Trifiletti, Rosario Rich / Marino, Simona D / Falsaperla, Raffaele

Journal of child and adolescent psychopharmacology

2020 Volume 30, Issue 9, Page(s) 567–571

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adolescent ; Autoimmune Diseases/complications ; Child ; Female ; Humans ; Italy ; Male ; New Jersey ; Obsessive-Compulsive Disorder/complications ; Psychotic Disorders/therapy ; Quality of Life/psychology ; Streptococcal Infections/complications ; Surveys and Questionnaires ; Tics/etiology
Language	English
Publishing date	2020-07-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1055410-5
ISSN	1557-8992 ; 1044-5463
ISSN (online)	1557-8992
ISSN	1044-5463
DOI	10.1089/cap.2020.0050
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3091: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: PANDAS/PANS in childhood: Controversies and evidence.

Wilbur, Colin / Bitnun, Ari / Kronenberg, Sefi / Laxer, Ronald M / Levy, Deborah M / Logan, William J / Shouldice, Michelle / Yeh, E Ann

Paediatrics & child health

2018 Volume 24, Issue 2, Page(s) 85–91

Abstract: ... with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of this entity, and ... with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS ... of the autoimmune hypothesis of PANDAS is lacking, given the heightened attention to this entity and apparent rise ...

Abstract	Since first defined in 1998, paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS), have garnered significant attention and controversy. The role of streptococcal infection in children with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of this entity, and the role of symptomatic and disease-modifying therapies, including antibiotics, immunotherapy, and psychoactive drugs, are all issues that have yet to be definitively addressed. While definitive proof of the autoimmune hypothesis of PANDAS is lacking, given the heightened attention to this entity and apparent rise in use of this diagnostic category, addressing questions around diagnosis, treatment, and etiology is imperative. In this paper, we review current working definitions of PANDAS/PANS, discuss published evidence for interventions related to this entity, and propose a clinical approach to children presenting with acute symptoms satisfying criteria for PANDAS/PANS.
Language	English
Publishing date	2018-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2106767-3
ISSN	1918-1485 ; 1205-7088
ISSN (online)	1918-1485
ISSN	1205-7088
DOI	10.1093/pch/pxy145
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5774: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS.

Frick, Luciana / Pittenger, Christopher

Journal of immunology research

2016 Volume 2016, Page(s) 8606057

Abstract: ... Tourette syndrome, and PANDAS. We also explore new hypotheses as to the potential contributions of microglial ... animal model work are creating new opportunities to elucidate these issues. ... with Streptococcal Infections (PANDAS). The mechanistic details of this pathophysiology, however, remain unclear. Here we focus ...

Abstract	There is accumulating evidence that immune dysregulation contributes to the pathophysiology of obsessive-compulsive disorder (OCD), Tourette syndrome, and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The mechanistic details of this pathophysiology, however, remain unclear. Here we focus on one particular component of the immune system: microglia, the brain's resident immune cells. The role of microglia in neurodegenerative diseases has been understood in terms of classic, inflammatory activation, which may be both a consequence and a cause of neuronal damage. In OCD and Tourette syndrome, which are not characterized by frank neural degeneration, the potential role of microglial dysregulation is much less clear. Here we review the evidence for a neuroinflammatory etiology and microglial dysregulation in OCD, Tourette syndrome, and PANDAS. We also explore new hypotheses as to the potential contributions of microglial abnormalities to pathophysiology, beyond neuroinflammation, including failures in neuroprotection, lack of support for neuronal survival, and abnormalities in synaptic pruning. Recent advances in neuroimaging and animal model work are creating new opportunities to elucidate these issues.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Child ; Disease Models, Animal ; Humans ; Mice ; Microglia/immunology ; Microglia/physiology ; Obsessive-Compulsive Disorder/etiology ; Obsessive-Compulsive Disorder/immunology ; Obsessive-Compulsive Disorder/physiopathology ; Streptococcal Infections/immunology ; Streptococcal Infections/physiopathology ; Tourette Syndrome/immunology ; Tourette Syndrome/physiopathology
Language	English
Publishing date	2016
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2016/8606057
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito