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  1. Article: Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis.

    de Saint Basile, Geneviève / Sepulveda, Fernando E / Maschalidi, Sophia / Fischer, Alain

    F1000Research

    2015  Volume 4, Issue F1000 Faculty Rev, Page(s) 930

    Abstract: The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively ... on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules ... about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led ...

    Abstract The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively emerged as an important effector pathway not only for host defence but also for immune regulation. The analysis of an early-onset, severe, primary immune dysregulatory syndrome known as hemophagocytic lymphohistiocytosis (HLH) has been decisive in highlighting this latter role and identifying key effectors on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules. Studies of cytotoxicity-deficient murine counterparts have helped to define primary HLH as a syndrome in which uncontrolled T-cell activation in response to lymphocytic choriomeningitis virus infection results in excessive macrophage activation and inflammation-associated cytopenia. Recent recognition of late-onset HLH, which occurs in a variety of settings, in association with hypomorphic, monoallelic mutations in genes encoding components of the granule-dependent cytotoxic pathway or even in the absence of such mutations has broadened our view about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led to the development of a model in which disease occurs when a threshold is reached through the accumulation of genetic and environmental risk factors. Nevertheless, validation of this model will require further investigations.
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.6754.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis [version 1; referees

    Geneviève de Saint Basile / Fernando E. Sepulveda / Sophia Maschalidi / Alain Fischer

    F1000Research, Vol

    2 approved]

    2015  Volume 4

    Abstract: The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively ... on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules ... about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led ...

    Abstract The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively emerged as an important effector pathway not only for host defence but also for immune regulation. The analysis of an early-onset, severe, primary immune dysregulatory syndrome known as hemophagocytic lymphohistiocytosis (HLH) has been decisive in highlighting this latter role and identifying key effectors on the basis of gene mutation analyses and mediators in the maturation and secretion of cytotoxic granules. Studies of cytotoxicity-deficient murine counterparts have helped to define primary HLH as a syndrome in which uncontrolled T-cell activation in response to lymphocytic choriomeningitis virus infection results in excessive macrophage activation and inflammation-associated cytopenia. Recent recognition of late-onset HLH, which occurs in a variety of settings, in association with hypomorphic, monoallelic mutations in genes encoding components of the granule-dependent cytotoxic pathway or even in the absence of such mutations has broadened our view about the mechanisms that underlie the perturbation of immune homeostasis. These findings have led to the development of a model in which disease occurs when a threshold is reached through the accumulation of genetic and environmental risk factors. Nevertheless, validation of this model will require further investigations.
    Keywords Antigen Processing & Recognition ; Cytoskeleton ; Genetics of the Immune System ; Immune Response ; Immunity to Infections ; Innate Immunity ; Leukemia & Proliferative Disorders of Hematic Cells ; Leukocyte Activation ; Leukocyte Signaling & Gene Expression ; Medical Genetics ; Membranes & Sorting ; Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases

    Bryceson, Yenan / Krzewski, Konrad

    2015  

    Abstract: Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune ... lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been ... secretion, they can influence other cells of the immune system. Through these processes, cytotoxic ...

    Abstract Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity
    Keywords Immunologic diseases. Allergy ; Medicine (General)
    Size 1 electronic resource (163 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090202
    ISBN 9782889192793 ; 2889192792
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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