Article: Chlamydia trachomatis-associated tubal factor subfertility: Immunogenetic aspects and serological screening.
2006 Volume 12, Issue 6, Page(s) 719–730
Abstract: ... trachomatis infections, which may ascend to the upper genital tract and increase the risk of tubal factor ... Chlamydia (C.) trachomatis female genital tract infections usually remain asymptomatic and ... subfertility. Pattern recognition receptors (PRRs) of the toll-like receptor (TLR) and nucleotide-binding ...
| Abstract | Chlamydia (C.) trachomatis female genital tract infections usually remain asymptomatic and untreated. Therefore, an adequate immune response, rather than antibiotic treatment, is essential to clear the pathogen. Most women will effectively clear C. trachomatis infections, but some will have persistent C. trachomatis infections, which may ascend to the upper genital tract and increase the risk of tubal factor subfertility. Pattern recognition receptors (PRRs) of the toll-like receptor (TLR) and nucleotide-binding oligomerization domain (NOD) families recognize C. trachomatis and initiate the immune response. Host immune factors are determinants of the course of C. trachomatis infections. Genetic variations in TLR and NOD genes may affect receptor function, leading to inadequate recognition of C. trachomatis, an inadequate immune response, and consequently an increased risk of persistence and late sequelae. For the risk assessment of tubal pathology in subfertile women, C. trachomatis immunoglobulin (Ig) G antibody testing (CAT) in serum is widely used. A positive CAT is indicative of a previous infection but not of a persistent infection. Measuring serological markers of persistence, of which C-reactive protein (CRP) seems promising, in CAT-positive women may identify a subgroup of subfertile women with persistent C. trachomatis infections and the highest risk of tubal pathology. |
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| MeSH term(s) | C-Reactive Protein/analysis ; Chlamydia Infections/complications ; Chlamydia Infections/diagnosis ; Chlamydia Infections/immunology ; Chlamydia trachomatis/immunology ; Chlamydia trachomatis/pathogenicity ; Fallopian Tube Diseases/complications ; Fallopian Tube Diseases/microbiology ; Female ; Humans ; Infertility, Female/diagnosis ; Infertility, Female/immunology ; Infertility, Female/microbiology ; Serologic Tests/methods ; Virulence Factors/metabolism | |||||
| Chemical Substances | Virulence Factors ; C-Reactive Protein (9007-41-4) | |||||
| Language | English | |||||
| Publishing date | 2006-11 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1286738-x | |||||
| ISSN | 1460-2369 ; 1355-4786 | |||||
| ISSN (online) | 1460-2369 | |||||
| ISSN | 1355-4786 | |||||
| DOI | 10.1093/humupd/dml030 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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