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  1. TI=Asymptomatic Cases and Limited Transmission of SARS CoV 2 in Residents and Healthcare Workers in Three Dutch Nursing Homes
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  1. Article: Asymptomatic Cases and Limited Transmission of SARS-CoV-2 in Residents and Healthcare Workers in Three Dutch Nursing Homes.

    van Buul, Laura W / van den Besselaar, Judith H / Koene, Fleur M H P H / Buurman, Bianca M / Hertogh, Cees M P M

    Gerontology & geriatric medicine

    2020  Volume 6, Page(s) 2333721420982800

    Abstract: ... residents and 542 healthcare workers of three Dutch nursing homes (NHs) with recent SARS-CoV-2 introduction ... in transmission of SARS-CoV-2 in nursing homes. We conducted two serial point-prevalence surveys, including ... SARS-CoV-2 positive and both remained asymptomatic. Although a limited number of SARS-CoV-2 positive ...

    Abstract We aimed to assess the contribution of a- and presymptomatic residents and healthcare workers in transmission of SARS-CoV-2 in nursing homes. We conducted two serial point-prevalence surveys, including standardized symptom assessment and nasopharyngeal and oropharyngeal testing for SARS-CoV-2, among 297 residents and 542 healthcare workers of three Dutch nursing homes (NHs) with recent SARS-CoV-2 introduction. At the first point-prevalence survey, 15 residents tested positive of which one was presymptomatic and three remained asymptomatic. At the second point-prevalence survey one resident and one healthcare worker tested SARS-CoV-2 positive and both remained asymptomatic. Although a limited number of SARS-CoV-2 positive cases were identified, this study confirms a- and presymptomatic occurrence of Covid-19. We additionally describe factors that may contribute to the prevention of transmission. Taken together, our study complements the discussion on effective SARS-CoV-2 screening in NHs.
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844974-5
    ISSN 2333-7214 ; 2333-7214
    ISSN (online) 2333-7214
    ISSN 2333-7214
    DOI 10.1177/2333721420982800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Asymptomatic cases and limited transmission of SARS-CoV-2 in residents and healthcare workers in three Dutch nursing homes

    van Buul, Laura W / van den Besselaar, Judith Henriette / Koene, Fleur M.H.P.H. / Buurman, Bianca M. / Hertogh, Cees M.P.M.

    medRxiv

    Abstract: ... and healthcare workers in transmission of SARS-CoV-2 in three nursing homes. Methods Two serial point ... prevalence surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes ... residents and 542 healthcare workers participated in the study. At the first point-prevalence survey, 15 ...

    Abstract Purpose Many nursing homes worldwide have been hit by outbreaks of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to assess the contribution of a- and presymptomatic residents and healthcare workers in transmission of SARS-CoV-2 in three nursing homes. Methods Two serial point-prevalence surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes with recent SARS-CoV-2 introduction. Nasopharyngeal and oropharyngeal testing for SARS-CoV-2, including reverse-transcriptase polymerase chain reaction (rRT-PCR) was conducted with reporting of cycle threshold (Ct). Participants were categorized as symptomatic, presymptomatic or asymptomatic with standardized symptom assessment. Results In total, 297 residents and 542 healthcare workers participated in the study. At the first point-prevalence survey, 15 residents tested positive of which one was presymptomatic (Ct value>35) and three remained asymptomatic (Ct value of 23, 30 and 32). At the second point-prevalence survey one resident and one healthcare worker tested SARS-CoV-2 positive (Ct value >35 and 24, respectively) and both remained asymptomatic. Conclusion This study confirms a- and presymptomatic occurrence of Covid-19 among residents and health care workers. Ct values below 25 suggested that these cases have the potential to contribute to viral spread. However, very limited transmission impeded the ability to answer the research question. We describe factors that may contribute to the prevention of transmission and argue that the necessity of large-scale preemptive testing in nursing homes may be dependent of the local situation regarding prevalence of cases in the surrounding community and infection control opportunities.
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.08.31.20185033
    Database COVID19

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  3. Article ; Online: Asymptomatic cases and limited transmission of SARS-CoV-2 in residents and healthcare workers in three Dutch nursing homes

    Buul, Laura W van / Besselaar, Judith Henriette van den / Koene, Fleur M.H.P.H. / Buurman, Bianca M. / Hertogh, Cees M.P.M.

    Abstract: ... and healthcare workers in transmission of SARS-CoV-2 in three nursing homes. Methods Two serial point ... prevalence surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes ... residents and 542 healthcare workers participated in the study. At the first point-prevalence survey, 15 ...

    Abstract Purpose Many nursing homes worldwide have been hit by outbreaks of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to assess the contribution of a- and presymptomatic residents and healthcare workers in transmission of SARS-CoV-2 in three nursing homes. Methods Two serial point-prevalence surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes with recent SARS-CoV-2 introduction. Nasopharyngeal and oropharyngeal testing for SARS-CoV-2, including reverse-transcriptase polymerase chain reaction (rRT-PCR) was conducted with reporting of cycle threshold (Ct). Participants were categorized as symptomatic, presymptomatic or asymptomatic with standardized symptom assessment. Results In total, 297 residents and 542 healthcare workers participated in the study. At the first point-prevalence survey, 15 residents tested positive of which one was presymptomatic (Ct value>35) and three remained asymptomatic (Ct value of 23, 30 and 32). At the second point-prevalence survey one resident and one healthcare worker tested SARS-CoV-2 positive (Ct value >35 and 24, respectively) and both remained asymptomatic. Conclusion This study confirms a- and presymptomatic occurrence of Covid-19 among residents and health care workers. Ct values below 25 suggested that these cases have the potential to contribute to viral spread. However, very limited transmission impeded the ability to answer the research question. We describe factors that may contribute to the prevention of transmission and argue that the necessity of large-scale preemptive testing in nursing homes may be dependent of the local situation regarding prevalence of cases in the surrounding community and infection control opportunities.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20185033
    DOI 10.1101/2020.08.31.20185033
    Database COVID19

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