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  1. Article: Parvovirus B19 infection and idiopathic thrombocytopenic purpura.

    van Elsacker-Niele, A M / Weiland, H T / Kroes, A C / Kappers-Klunne, M C

    Annals of hematology

    1996  Volume 72, Issue 3, Page(s) 141–144

    Abstract: ... and for parvovirus B19 DNA. In only one patient (1.7%) was evidence of recent B19 infection found ... retrospectively analyzed. Stored serum samples were tested for parvovirus B19-specific IgG and IgM anti-bodies ... Parvovirus B19 is not a frequent cause of adult ITP and should be tested for only when there are ...

    Abstract The potential association of human parvovirus B19 infection with idiopathic thrombocytopenic purpura (ITP) was studied. All 60 adult patients presenting with ITP at the University Hospital Rotterdam - Dijkzigt during a 12-year period (41 with acute ITP, 19 with chronic ITP) were included. Patient files were retrospectively analyzed. Stored serum samples were tested for parvovirus B19-specific IgG and IgM anti-bodies, and for parvovirus B19 DNA. In only one patient (1.7%) was evidence of recent B19 infection found. Parvovirus B19 is not a frequent cause of adult ITP and should be tested for only when there are other indications of possible parvovirus B19 involvement.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Aged ; Antibodies, Viral/analysis ; Chronic Disease ; DNA, Viral/analysis ; Erythema Infectiosum ; Female ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Male ; Middle Aged ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/immunology ; Purpura, Thrombocytopenic/immunology ; Purpura, Thrombocytopenic/virology ; Retrospective Studies
    Chemical Substances Antibodies, Viral ; DNA, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 1996-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s002770050152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Association of human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura: a meta analysis of Chinese literatures].

    Zhang, Yao-Dong / Hu, Qun / Liu, Shuang-You / Liu, Ai-Guo / Wang, Guan-Ling / Xiong, Hao / Sun, Yan

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2009  Volume 11, Issue 12, Page(s) 999–1001

    Abstract: Objective: To study the relationship between human parvovirus B19 infection and childhood ... between human parvovirus B19 infection and childhood ITP published between 1994 and 2008 were retrieved ... CI=7.07-26.59, Z=7.75, p<0.01).: Conclusions: Human parvovirus B19 infection is closely associated ...

    Abstract Objective: To study the relationship between human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura (ITP) by the principle of evidence based medicine.
    Methods: Papers related to the relationship between human parvovirus B19 infection and childhood ITP published between 1994 and 2008 were retrieved electronically from the Chinese Journals Full-text Database and the Wanfang Data. These relevant papers on case-control trials were statistically studied by meta analysis.
    Results: Eight papers that met the inclusion criteria were included for this meta analysis. Five hundred and sixteen cases of childhood ITP and 246 healthy controls were enrolled. The meta analysis showed that the incidence of human parvovirus B19 infection in the ITP group was significantly higher than that in the control group (OR=13.71, 95% CI=7.07-26.59, Z=7.75, p<0.01).
    Conclusions: Human parvovirus B19 infection is closely associated with childhood ITP.
    MeSH term(s) Child ; Erythema Infectiosum/complications ; Female ; Humans ; Male ; Purpura, Thrombocytopenic, Idiopathic/etiology
    Language Chinese
    Publishing date 2009-12
    Publishing country China
    Document type English Abstract ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 1008-8830
    ISSN 1008-8830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Kronik idiopatik trombositopenik purpura olgularinda parvovirus B19 seroprevalansi.

    Uslu, Hakan / Kiki, Ilhami / Ozbek, Ahmet / Erdem, Fuat / Ayyildiz, Ahmet

    Mikrobiyoloji bulteni

    2007  Volume 41, Issue 4, Page(s) 597–602

    Abstract: Although there are several studies indicating the relationship between parvovirus B19 (PV-B19) and ... acute idiopathic thrombocytopenic purpura (ITP) which is a form seen frequently in children, the data ... etiological agents and factors other than PV-B19 were eliminated on the basis of clinical and laboratory ...

    Title translation Seroprevalence of parvovirus B19 in patients with chronic idiopathic thrombocytopenic purpura.
    Abstract Although there are several studies indicating the relationship between parvovirus B19 (PV-B19) and acute idiopathic thrombocytopenic purpura (ITP) which is a form seen frequently in children, the data are not enough in terms of chronic ITP, which is a more insidious form frequently seen in adults. The aim of this study was to investigate PV-B19 seroprevalence in adult chronic ITP cases diagnosed at the haematology clinics of Atatürk University Research Hospital in Erzurum (located in eastern Anatolia, Turkey). A total of 61 patients (38 female, 23 male; mean age: 34.4 +/- 11.2 years) and 60 healthy control subjects (30 female, 30 male; mean age: 35.6 +/- 9.6 years) were included to the study. All possible etiological agents and factors other than PV-B19 were eliminated on the basis of clinical and laboratory findings. PV-B19 antibodies were screened by ELISA method, and 73.7% (45/61) of the patients were found IgG, whereas 3.2% (2/61) were found IgM seropositive. In the control group, these rates were detected as 38.3% (23/60) and 1.6% (1/60), respectively. IgG antibodies were negative in the two patients and one control who were positive for IgM. The presence of PV-B19 DNA was investigated in all of the three IgM positive subjects, and was found positive in only one patient by real-time polymerase chain reaction (PCR). The difference between patient and control groups with regard to IgG seropositivity was found statistically significant (p < 0.01), however statistical evaluation could not be performed for IgM seropositivity because of the low number of cases. As a result although the rate of IgG positivity was found statistically higher in the ITP patients in our study, this data is inefficient for the evaluation of relationship between PV-B19 and chronic ITP, indicating the need for further studies.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; Case-Control Studies ; Chronic Disease ; DNA, Viral/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Parvoviridae Infections/complications ; Parvoviridae Infections/epidemiology ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/immunology ; Parvovirus B19, Human/isolation & purification ; Polymerase Chain Reaction ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/virology ; Seroepidemiologic Studies ; Turkey/epidemiology
    Chemical Substances Antibodies, Viral ; DNA, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language Turkish
    Publishing date 2007-10
    Publishing country Turkey
    Document type English Abstract ; Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3943: Show issues Location:
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  4. Article: Parvovirus: the expanding spectrum of disease.

    Heegaard, E D / Hornsleth, A

    Acta paediatrica (Oslo, Norway : 1992)

    1995  Volume 84, Issue 2, Page(s) 109–117

    Abstract: ... idiopathic thrombocytopenic purpura, transient erythroblastopenia of childhood, Diamond-Blackfan anemia) and, finally, (3 ... states. The discovery of the human parvovirus B19 in 1975 and subsequent studies of its effects in humans ... a heterogeneous group of diseases, in which the etiologic role of parvovirus is less clear and sometimes putative ...

    Abstract Treatment of parvovirus infections among immunocompromised hosts using immunoglobulin has provided the clinician with a useful therapeutic tool but has also highlighted the problems concerning chronic disease states. The discovery of the human parvovirus B19 in 1975 and subsequent studies of its effects in humans have identified this virus as the causative agent of a broad spectrum of diseases. Recent improvements regarding the development of sensitive PCR techniques and methods for cultivation have provided new insight into its pathogenic role, its virology and immunology, and the varied clinical manifestations. The current state of knowledge concerning parvovirus enabled us to divide the long list of diseases caused by this virus into three main categories: (1) disease found among normal hosts (asymptomatic disease, erythema infectiosum, arthropathy, hydrops fetalis), (2) hematologic diseases (aplastic crisis, chronic anemia, idiopathic thrombocytopenic purpura, transient erythroblastopenia of childhood, Diamond-Blackfan anemia) and, finally, (3) a heterogeneous group of diseases, in which the etiologic role of parvovirus is less clear and sometimes putative (neurologic disease, rheumatologic disease, vasculitic and myocarditic syndromes). In particular, arthropathy, hydrops fetalis and the hematologic disorders may be of pediatric concern. Consequently, it is of paramount importance that in all of these cases the clinician includes parvovirus as a differential diagnosis.
    MeSH term(s) Erythema Infectiosum/diagnosis ; Erythema Infectiosum/epidemiology ; Erythema Infectiosum/therapy ; Erythema Infectiosum/virology ; Hematologic Diseases/virology ; Humans ; Parvovirus B19, Human ; Polymerase Chain Reaction ; Rheumatic Diseases/virology
    Language English
    Publishing date 1995-02
    Publishing country Norway
    Document type Journal Article ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0803-5253 ; 0365-1436
    ISSN (online) 1651-2227
    ISSN 0803-5253 ; 0365-1436
    DOI 10.1111/j.1651-2227.1995.tb13591.x
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  5. Article: Parvovirus B19 infection in Taiwanese patients with hematological disorders.

    Lee, Yuan-Ming / Tsai, Wen-Hui / You, Jie-Yu / Ing-Tiau Kuo, Benjamin / Liao, Pen-Tung / Ho, Chi-Kuan / Hsu, Hui-Chi

    Journal of medical virology

    2003  Volume 71, Issue 4, Page(s) 605–609

    Abstract: ... diagnosed as having idiopathic thrombocytopenic purpura (ITP). Viremia of B19 virus could be detected ... Human parvovirus B19 has a strong tissue tropism for erythroid progenitor cells and is a causative ... higher seropositive rates for B19 than occur in normal controls and that study of occult parvovirus B19 ...

    Abstract Human parvovirus B19 has a strong tissue tropism for erythroid progenitor cells and is a causative agent for anemia. However, it remains unclear whether patients with hematological disorders are at a higher risk of B19 infection. In the present study, we evaluated the prevalence of B19 infection in 278 patients with hematological disorders by indirect antibody capture enzyme-linked immunosorbent assay. Virus inoculation into cell culture (of TF-6, WRL-68, and HL-60) was carried out using serum from patients with positive IgM anti-B19 and was then examined by nested polymerase chain reaction, dot-blot analysis, and sequence analysis. Our data demonstrated that the total seropositive rates of either IgG or IgM were 71.9%. The seropositive rates increase significantly with age (P < 0.001). After adjustment for age, the seropositive rate was significantly higher in our patients than in the general population with standardized rate ratio of 1.56 (95% CI = 1.43-1.68). No significant difference was found among different disease subgroups (P = 0.311). Nine patients (3.2%) had active B19 infection with positive IgM antibody, with four diagnosed as having idiopathic thrombocytopenic purpura (ITP). Viremia of B19 virus could be detected in eight of nine patients, including three patients in serum only, three patients in bone marrow only, and two patients in both serum and bone marrow. We conclude that patients with hematological disease have higher seropositive rates for B19 than occur in normal controls and that study of occult parvovirus B19 infection is recommended in patients with hematological disease.
    MeSH term(s) Adult ; Aged ; Antibodies, Viral/blood ; Base Sequence ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Female ; Hematologic Diseases/complications ; Humans ; Male ; Middle Aged ; Parvoviridae Infections/complications ; Parvoviridae Infections/immunology ; Parvoviridae Infections/virology ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/immunology ; Parvovirus B19, Human/pathogenicity ; Taiwan
    Chemical Substances Antibodies, Viral ; DNA, Viral
    Language English
    Publishing date 2003-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.10517
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  6. Article: [Genetic diversity of human Parvovirus B19 VP1 unique region].

    Qian, Xin-hong / Zhang, Guo-cheng / Jiao, Xi-ying / Zhang, Ping / Sun, Xin / Cao, Yu-hong / Xu, Dong-liang / Fei, Lin-lin / Huang, Wen-jin

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2003  Volume 41, Issue 2, Page(s) 128–130

    Abstract: ... such as erythema infectious, transient aplastic crisis, aplastic anemia, idiopathic thrombocytopenic purpura and ... with idiopathic thrombocytopenic purpura by PCR. The purified PCR product was cloned into pGEM-T easy vector and transfected into the host ... structural proteins VP1 and VP2. Most neutralizing linear epitopes of HPV B19 cluster in the VP1 unique and VP1-VP2 ...

    Abstract Objective: Human Parvovirus B19 (HPV B19) is a small (23 nm), non-enveloped DNA virus found in 1974. It has been proved that HPV B19 is associated with a variety of childhood diseases, such as erythema infectious, transient aplastic crisis, aplastic anemia, idiopathic thrombocytopenic purpura and arthropathy, etc. There have been no any effective vaccines to prevent HPV B19 infection so far. The HPV B19 genome is composed of 5.6 kb single strand DNA. This genome encodes a nonstructural protein NS1, two structural proteins VP1 and VP2. Most neutralizing linear epitopes of HPV B19 cluster in the VP1 unique and VP1-VP2 junction regions. Only proteins encoded by genes of the VP1 unique and VP1-VP2 junction regions can stimulate bodies to produce protective antibodies. Aim of the present study was to get the VP1 unique region gene of HPV B19 and to analyze the genetic diversity so as to further study its function and application.
    Methods: The VP1 unique region gene of HPV B19 was amplified from the serum of a child with idiopathic thrombocytopenic purpura by PCR. The purified PCR product was cloned into pGEM-T easy vector and transfected into the host strain E. coli (DH5 alpha). Positive clones were chosen and then the target gene was sequenced.
    Results: The target gene sequence of HPV B19 VP1 unique region was amplified and cloned successfully. It had 705 nucleotides. Compared with the relevant sequences published in Genbank, the sequencing results were revealed with two nucleotides changes in the HPV B19 VP1 unique region, but their coding amino acid were not changed.
    Conclusion: It is suggested that genetic diversity exists in the VP1 unique region of HPV B19. Construction of the recombinant plasmid of HPV B19 VP1 unique region gene might benefit to further study.
    MeSH term(s) Capsid Proteins/genetics ; Child ; DNA, Viral/chemistry ; DNA, Viral/genetics ; Genetic Variation ; Humans ; Mutation ; Parvovirus B19, Human/genetics ; Polymerase Chain Reaction ; Sequence Analysis, DNA
    Chemical Substances Capsid Proteins ; DNA, Viral ; capsid protein VP1, parvovirus B19
    Language Chinese
    Publishing date 2003-02
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
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  7. Article: Diverse hematologic effects of parvovirus B19 infection.

    Mustafa, M M / McClain, K L

    Pediatric clinics of North America

    1996  Volume 43, Issue 3, Page(s) 809–821

    Abstract: Human parvovirus B19 is linked with a broadening spectrum of hematologic disorders, including ... aplastic crises in the context of hemolytic anemias, neutropenia, thrombocytopenia, and ... hemophagocytic syndromes. Children with any of these cytopenias should be screened for the presence of B19 ...

    Abstract Human parvovirus B19 is linked with a broadening spectrum of hematologic disorders, including aplastic crises in the context of hemolytic anemias, neutropenia, thrombocytopenia, and hemophagocytic syndromes. Children with any of these cytopenias should be screened for the presence of B19 because treatment with intravenous gamma globulin may provide resolution of abnormal blood counts if other therapeutic options, such as transfusion, are not adequate or desired.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Adolescent ; Adult ; Child ; Child, Preschool ; DNA, Viral ; Female ; Humans ; Infant ; Male ; Parvoviridae Infections/complications ; Parvoviridae Infections/etiology ; Parvoviridae Infections/virology ; Parvovirus B19, Human/pathogenicity ; Polymerase Chain Reaction ; Purpura, Thrombocytopenic, Idiopathic/complications
    Chemical Substances DNA, Viral
    Language English
    Publishing date 1996-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/s0031-3955(05)70434-x
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  8. Article: Role of parvovirus B19 infection in childhood idiopathic thrombocytopenic purpura.

    Heegaard, E D / Rosthøj, S / Petersen, B L / Nielsen, S / Karup Pedersen, F / Hornsleth, A

    Acta paediatrica (Oslo, Norway : 1992)

    1999  Volume 88, Issue 6, Page(s) 614–617

    Abstract: ... for idiopathic thrombocytopenic purpura (ITP), we examined the role of parvovirus B19 in 47 children with newly diagnosed ITP. Specific ... to anaemia, several case reports indicate that parvovirus B19 infection may also cause the development ... viral DNA indicating a current or recent parvovirus B19 infection was demonstrated in 6 of 47 patients ...

    Abstract Although parvovirus B19 exhibits a strong tissue-tropism for erythroid progenitor cells leading to anaemia, several case reports indicate that parvovirus B19 infection may also cause the development of thrombocytopenia. Despite recent studies, the frequency and clinical relevance of this association have remained questionable. Consequently, and in view of the paucity of evidence regarding a viral aetiology for idiopathic thrombocytopenic purpura (ITP), we examined the role of parvovirus B19 in 47 children with newly diagnosed ITP. Specific viral DNA indicating a current or recent parvovirus B19 infection was demonstrated in 6 of 47 patients (13%) employing the polymerase chain reaction technique. Our study suggests that children with ITP and associated parvovirus B19 infection are characterized by acute onset of profound thrombocytopenia. Among the parvovirus B19 positive children, duration of disease was brief in three children treated with immunoglobulin but chronic in the remaining three patients given high-dose steroids. Prospective studies are needed to confirm these initial observations. This virus should be considered as a possible aetiologic agent in some children with ITP.
    MeSH term(s) Acute Disease ; Anti-Inflammatory Agents/therapeutic use ; Antigens, Viral/genetics ; Bone Marrow/physiology ; Child ; Chronic Disease ; DNA, Viral/genetics ; Female ; Follow-Up Studies ; Globins/genetics ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunohistochemistry ; Male ; Methylprednisolone/therapeutic use ; Parvoviridae Infections/complications ; Parvoviridae Infections/genetics ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/isolation & purification ; Polymerase Chain Reaction/methods ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/virology ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Anti-Inflammatory Agents ; Antigens, Viral ; DNA, Viral ; Immunoglobulins, Intravenous ; Globins (9004-22-2) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 1999-06
    Publishing country Norway
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0803-5253 ; 0365-1436
    ISSN (online) 1651-2227
    ISSN 0803-5253 ; 0365-1436
    DOI 10.1080/08035259950169251
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  9. Article ; Online: Parvovirus B19 Infection Presenting as Pre-B-Cell Acute Lymphoblastic Leukemia: A Transient and Progressive Course in Two Children.

    Yetgin, Sevgi / Çetin, Mualla / Aslan, Deniz / Öyürek, Emel / Anlar, Banu / Uçkan, Duygu

    Journal of pediatric hematology/oncology

    2004  Volume 26, Issue 10, Page(s) 689–692

    Abstract: ... idiopathic thrombocytopenic purpura. In addition, parvovirus B19 infection may precede or be associated ... with acute lymphoblastic leukemia (ALL). The authors present two cases of parvovirus B19 infection and bone marrow infiltration ... Parvovirus B19 is the causative agent of various forms of hematologic diseases such as aplastic ...

    Abstract Parvovirus B19 is the causative agent of various forms of hematologic diseases such as aplastic crisis in patients with hemolytic anemia, aplastic anemia, hypoplastic anemia, and idiopathic thrombocytopenic purpura. In addition, parvovirus B19 infection may precede or be associated with acute lymphoblastic leukemia (ALL). The authors present two cases of parvovirus B19 infection and bone marrow infiltration with pre-B-cell lymphoblasts; one patients was diagnosed as having ALL, and the other patient, with neurologic findings, showed total resolution of the blastic morphology and phenotype.
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/01.mph.0000136454.01329.38
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  10. Article: Parvovirus B19 infection presenting as pre-B-cell acute lymphoblastic leukemia: a transient and progressive course in two children.

    Yetgin, Sevgi / Cetin, Mualla / Aslan, Deniz / Ozyurek, Emel / Oyürek, Emel / Anlar, Banu / Uçkan, Duygu

    Journal of pediatric hematology/oncology

    2004  Volume 26, Issue 10, Page(s) 689–692

    Abstract: ... idiopathic thrombocytopenic purpura. In addition, parvovirus B19 infection may precede or be associated ... with acute lymphoblastic leukemia (ALL). The authors present two cases of parvovirus B19 infection and bone marrow infiltration ... Parvovirus B19 is the causative agent of various forms of hematologic diseases such as aplastic ...

    Abstract Parvovirus B19 is the causative agent of various forms of hematologic diseases such as aplastic crisis in patients with hemolytic anemia, aplastic anemia, hypoplastic anemia, and idiopathic thrombocytopenic purpura. In addition, parvovirus B19 infection may precede or be associated with acute lymphoblastic leukemia (ALL). The authors present two cases of parvovirus B19 infection and bone marrow infiltration with pre-B-cell lymphoblasts; one patients was diagnosed as having ALL, and the other patient, with neurologic findings, showed total resolution of the blastic morphology and phenotype.
    MeSH term(s) Antibodies, Viral/blood ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Ataxia/etiology ; Bone Marrow/pathology ; Child, Preschool ; Female ; Fever of Unknown Origin/etiology ; Gastroenteritis/complications ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Nystagmus, Pathologic/etiology ; Parvoviridae Infections/diagnosis ; Parvovirus B19, Human/immunology ; Parvovirus B19, Human/isolation & purification ; Parvovirus B19, Human/pathogenicity ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/virology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/virology ; Remission Induction ; Remission, Spontaneous
    Chemical Substances Antibodies, Viral ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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