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  1. Article ; Online: Synovitis in psoriatic arthritis: immunohistochemistry, comparisons with rheumatoid arthritis, and effects of therapy.

    van Kuijk, Arno W R / Tak, Paul P

    Current rheumatology reports

    2011  Volume 13, Issue 4, Page(s) 353–359

    Abstract: ... from the available studies comparing synovial tissue of PsA and rheumatoid arthritis patients are discussed ... Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis ... that affects the peripheral joints, spine, and entheses. Most patients with PsA present with peripheral ...

    Abstract Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis that affects the peripheral joints, spine, and entheses. Most patients with PsA present with peripheral synovitis of the oligoarticular or polyarticular subtype. As one of the targets of this disease, studies on the synovium may provide insight into the mechanisms involved in this condition. Key findings from the available studies comparing synovial tissue of PsA and rheumatoid arthritis patients are discussed in this review. Also, changes in the synovial infiltrate, expression of proinflammatory cytokines and adhesion molecules, and vascularity in synovial tissue after treatment with various medications are addressed. Finally, a model for proof-of-principle study design using serial synovial biopsies is described, which could be used to predict clinical (in)efficacy in early clinical trial design in PsA.
    MeSH term(s) Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/metabolism ; Arthritis, Psoriatic/pathology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Biomarkers/metabolism ; Cell Adhesion Molecules/metabolism ; Cytokines/metabolism ; Humans ; Research Design ; Synovial Membrane/blood supply ; Synovial Membrane/metabolism ; Synovial Membrane/pathology ; Synovitis/drug therapy ; Synovitis/metabolism ; Synovitis/pathology
    Chemical Substances Biomarkers ; Cell Adhesion Molecules ; Cytokines
    Language English
    Publishing date 2011-04-16
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-011-0181-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Paradoxical arthritis occurring during anti-TNF in patients with inflammatory bowel disease: histological and immunological features of a complex synovitis.

    Alivernini, Stefano / Pugliese, Daniela / Tolusso, Barbara / Bui, Laura / Petricca, Luca / Guidi, Luisa / Mirone, Luisa / Rapaccini, Gian Ludovico / Federico, Francesco / Ferraccioli, Gianfranco / Armuzzi, Alessandro / Gremese, Elisa

    RMD open

    2018  Volume 4, Issue 1, Page(s) e000667

    Abstract: ... immunoglobulin (Ig)M/IgA rheumatoid factor (RF)) were collected. Psoriatic arthritis (PsA) and ACPA/IgM-RF/IgA-RF ... negative rheumatoid arthritis (RA) were enrolled as comparison.: Results: 10 patients with IBD (age 46 ... ST and CM paired samples were stained through immunohistochemistry (IHC) for CD68, CD21, CD20, CD3 ...

    Abstract Objective: Paradoxical arthritis under tumour necrosis factor inhibitor (TNF-i) for inflammatory bowel disease (IBD) has been described. This study aims to evaluate the histological features of paired synovial tissue (ST) and colonic mucosa (CM) tissue in patients with IBD developing paradoxical arthritis under TNF-i.
    Methods: Patients with IBD without history of coexisting joint involvement who developed arthritis under TNF-i were enrolled. Each patient underwent ST biopsy and ileocolonoscopy with CM biopsies. ST and CM paired samples were stained through immunohistochemistry (IHC) for CD68, CD21, CD20, CD3 and CD117. Clinical and immunological parameters (anticitrullinated peptides antibodies (ACPA)-immunoglobulin (Ig)M/IgA rheumatoid factor (RF)) were collected. Psoriatic arthritis (PsA) and ACPA/IgM-RF/IgA-RF negative rheumatoid arthritis (RA) were enrolled as comparison.
    Results: 10 patients with IBD (age 46.0±9.7 years, 13.2±9.9 years of disease duration, 2.5±1.6 years of TNF-i exposure, six with Crohn's disease and four with ulcerative colitis, respectively) were studied. At ST level, IHC revealed that patients with IBD with paradoxical arthritis showed more similar histological findings in terms of synovial CD68
    Conclusion: Patients with IBD may develop histologically proven synovitis during TNF-i, comparable to PsA. The inhibition of inflammatory pathways alternative to TNF (IL12/1L23) may be an effective therapeutic option for severe paradoxical articular manifestations.
    Language English
    Publishing date 2018-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2018-000667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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