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  1. Article: Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients.

    van Lier, Dirk / Kox, Matthijs / Santos, Karine / van der Hoeven, Hans / Pillay, Janesh / Pickkers, Peter

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Critically ill #COVID19 patients display markedly increased alternative angiotensin pathway ... activity compared to healthy controls, reflected by increased blood ACE2 levels as well as decreased ... angiotensin-II and enhanced angiotensin-1-7 formation ...

    Abstract Critically ill #COVID19 patients display markedly increased alternative angiotensin pathway activity compared to healthy controls, reflected by increased blood ACE2 levels as well as decreased angiotensin-II and enhanced angiotensin-1-7 formation
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00848-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients

    Dirk van Lier / Matthijs Kox / Karine Santos / Hans van der Hoeven / Janesh Pillay / Peter Pickkers

    ERJ Open Research, Vol 7, Iss

    2021  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: High rate of increased level of plasma Angiotensin II and its gender difference in COVID-19: an analysis of 55 hospitalized patients with COVID-19 in a single hospital, WuHan, China

    Liu, N. / Hong, Y. / Chen, R.-G. / Zhu, H.-M.

    Abstract: ... Novel coronavirus disease(COVID-19), Angiotensin-converting enzyme 2 (ACE2), Angiotensin II(AngII ... patients. Patients with elevated AngII level were more likely to be critically ill with COVID-19 ... Of the 55 patients with COVID-19, 34(61.8%) had an increased level of AngII. The severity of COVID-19 and ...

    Abstract Background: 2019 Novel coronavirus disease (COVID-19) is turning into a pandemic globally lately. Angiotensin-converting enzyme 2 (ACE2) is identified as an important functional receptor for SARS-Cov-2. ACE2 and ACE are homologues with inverse functions in the renin-angiotensin system. ACE converts angiotensin I into a vital vasoactive peptide called angiotensin II(AngII), whereas ACE2 hydrolyzes AngII into a series of vasodilators. There were few reports illustrated the expression of AngII in COVID-19. This study aimed to demonstrate the expression of angiotensin II in COVID-19 and how it correlated to the disease. Methods: We enrolled 55 patients with COVID-19 admitted to renmin Hospital of Wuhan University from January 21st to February 21st, 2020. Demographic data were collected upon admission. COVID-19 nuclear acid, plasma AngII, Renin and aldosterone in the lying position without sodium restriction, and other laboratory indicators were together measured by the laboratory department of our hospital. Findings: Of the 55 patients with COVID-19, 34(61.8%) had an increased level of AngII. The severity of COVID-19 and male is positively related with the level of AngII. The level of blood lymphocyte, PCT, ALT, and AST were remarkably severe with those of normal level of AngII (P < 0.05). CD4/CD8 cells ratio was significantly higher whereas CD3+CD8+ cells amount, CD3+CD8+ cells proportion, CD56+CD16+CD3- cells amount and CD19+CD3- cells amount were considerably lower than those of normal level of AngII (P < 0.05). Abnormal rates of blood lymphocyte and PCT were significantly higher in Patients with elevated AngII level. The results of binary logistic regression analysis showed that the severity of COVID-19 (OR=4.123) and CD4/CD8 ratio(OR=4.050) were the co-directional impact factor while female(OR=0.146) was inverse impact factor of elevated AngII level. Interpretation: High rate of increased level of AngII was detected in COVID-19 patients. Patients with elevated AngII level were more likely to be critically ill with COVID-19. Considering the gender differences in ACE2 expression and no gender differences in angiotensin expression, the gender differences in AngII level might indicate less loss of ACE2 in female patients. Elevated AngII level was correlated with CD4/CD8 ratio, suggesting it might involve in immune disorder. Keywords: 2019 Novel coronavirus disease(COVID-19), Angiotensin-converting enzyme 2 (ACE2), Angiotensin II(AngII), gender differences
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.04.27.20080432
    Database COVID19

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  4. Article ; Online: High rate of increased level of plasma Angiotensin II and its gender difference in COVID-19: an analysis of 55 hospitalized patients with COVID-19 in a single hospital, WuHan, China

    Liu, Na / Hong, Yan / Chen, Ren-Gui / Zhu, Heng-Mei

    medRxiv

    Abstract: ... Angiotensin-converting enzyme 2 (ACE2) is identified as an important functional receptor for SARS−Cov−2. ACE2 ... Novel coronavirus disease(COVID−19), Angiotensin-converting enzyme 2 (ACE2), Angiotensin II(AngII ... patients. Patients with elevated AngII level were more likely to be critically ill with COVID−19 ...

    Abstract Background: 2019 Novel coronavirus disease (COVID−19) is turning into a pandemic globally lately. Angiotensin-converting enzyme 2 (ACE2) is identified as an important functional receptor for SARS−Cov−2. ACE2 and ACE are homologues with inverse functions in the renin−angiotensin system. ACE converts angiotensin I into a vital vasoactive peptide called angiotensin II(AngII), whereas ACE2 hydrolyzes AngII into a series of vasodilators. There were few reports illustrated the expression of AngII in COVID−19. This study aimed to demonstrate the expression of angiotensin II in COVID−19 and how it correlated to the disease. Methods: We enrolled 55 patients with COVID−19 admitted to renmin Hospital of Wuhan University from January 21st to February 21st, 2020. Demographic data were collected upon admission. COVID−19 nuclear acid, plasma AngII, Renin and aldosterone in the lying position without sodium restriction, and other laboratory indicators were together measured by the laboratory department of our hospital. Findings: Of the 55 patients with COVID−19, 34(61.8%) had an increased level of AngII. The severity of COVID−19 and male is positively related with the level of AngII. The level of blood lymphocyte, PCT, ALT, and AST were remarkably severe with those of normal level of AngII (P < 0.05). CD4/CD8 cells ratio was significantly higher whereas CD3+CD8+ cells amount, CD3+CD8+ cells proportion, CD56+CD16+CD3- cells amount and CD19+CD3- cells amount were considerably lower than those of normal level of AngII (P < 0.05). Abnormal rates of blood lymphocyte and PCT were significantly higher in Patients with elevated AngII level. The results of binary logistic regression analysis showed that the severity of COVID−19 (OR=4.123) and CD4/CD8 ratio(OR=4.050) were the co-directional impact factor while female(OR=0.146) was inverse impact factor of elevated AngII level. Interpretation: High rate of increased level of AngII was detected in COVID−19 patients. Patients with elevated AngII level were more likely to be critically ill with COVID−19. Considering the gender differences in ACE2 expression and no gender differences in angiotensin expression, the gender differences in AngII level might indicate less loss of ACE2 in female patients. Elevated AngII level was correlated with CD4/CD8 ratio, suggesting it might involve in immune disorder. Keywords: 2019 Novel coronavirus disease(COVID−19), Angiotensin-converting enzyme 2 (ACE2), Angiotensin II(AngII), gender differences
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.27.20080432
    Database COVID19

    Full text online

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    Inter-library loan at ZB MED

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