Article ; Online: Temporal Kinetics of RNAemia and Associated Systemic Cytokines in Hospitalized COVID-19 Patients.
mSphere
2021 Volume 6, Issue 3, Page(s) e0031121
Abstract: ... kinetics of viral RNA in serum (RNAemia) and the associated inflammatory cytokines and chemokines during ... the course of COVID-19 in hospitalized patients. We show that RNAemia can be detected in 90% of the patients ... in hospitalized patients, with the highest frequency and duration in patients who develop critical disease ...
| Abstract | COVID-19 is associated with a wide range of extrarespiratory complications, of which the pathogenesis is currently not fully understood. However, both systemic spread and systemic inflammatory responses are thought to contribute to the systemic pathogenesis. In this study, we determined the temporal kinetics of viral RNA in serum (RNAemia) and the associated inflammatory cytokines and chemokines during the course of COVID-19 in hospitalized patients. We show that RNAemia can be detected in 90% of the patients who develop critical disease, compared to 50% of the patients who develop moderate or severe disease. Furthermore, RNAemia lasts longer in patients who develop critical disease. Elevated levels of interleukin-10 (IL-10) and MCP-1-but not IL-6-are associated with viral load in serum, whereas higher levels of IL-6 in serum were associated with the development of critical disease. In conclusion, RNAemia is common in hospitalized patients, with the highest frequency and duration in patients who develop critical disease. The fact that several cytokines or chemokines are directly associated with the presence of viral RNA in the circulation suggests that the development of RNAemia is an important factor in the systemic pathogenesis of COVID-19. |
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| MeSH term(s) | COVID-19/etiology ; COVID-19/immunology ; COVID-19/virology ; Cytokines/blood ; Hospitalization ; Humans ; Kinetics ; RNA, Viral/blood ; SARS-CoV-2/genetics ; Severity of Illness Index |
| Chemical Substances | Cytokines ; RNA, Viral |
| Language | English |
| Publishing date | 2021-05-28 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2379-5042 |
| ISSN (online) | 2379-5042 |
| DOI | 10.1128/mSphere.00311-21 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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