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  1. Article ; Online: Does anesthesia duration or number of cases per patient predict safety events?

    Berens, R J / Greene, C C / Frahm, C E / McCormick, M E / Hoffman, G M

    Paediatric anaesthesia

    2024  Volume 34, Issue 6, Page(s) 568–574

    Abstract: Background: The need for dental rehabilitation under general anesthesia is increasing, with varying needs between patients. Mortality has been found to be a rare event in these patients; however other perioperative events can and do occur. Previous ... ...

    Abstract Background: The need for dental rehabilitation under general anesthesia is increasing, with varying needs between patients. Mortality has been found to be a rare event in these patients; however other perioperative events can and do occur. Previous studies have established increased incidence of perioperative events with younger, sicker children, and longer anesthetics, however, no studies to date have evaluated if the incidence of perioperative events is more closely associated with one long anesthetic or multiple anesthetics per patient.
    Aims: To evaluate the association of perioperative events related to single anesthetic duration or number of anesthetics per patient for dental rehabilitation.
    Methods: After Children's Wisconsin Human Research Protection Program determined this quality activity did not meet the definition of human subjects research, we performed an epidemiologic observational evaluation by extracting all dental related cases (dental alone or with oral surgeon vs. dental with other specialties) with an associated general anesthesia encounter from Children's Wisconsin electronic data warehouse from June 1, 2015 to December 31, 2021. These cases occurred at a free-standing children's hospital or associated pediatric-only ambulatory surgery center. The risk of perioperative safety events was analyzed for previously identified risk groups such as American Society of Anesthesiologists Physical Status (ASA-PS), patient age, anesthesia case time with the addition of number of dental cases per patient.
    Results: In this study, 8468 procedures were performed on 8082 patients. Of this cohort, 7765 patients underwent one procedure for dental care while 317 patients underwent a total of 703 dental-related procedures, ranging from two to five procedures per patient. Multivariable logistic regression identified increased risk of perioperative events in patients with ASA-PS 3 (n = 1459, rate 1.78%, p value .001, OR 5.7, CI 2.1-15.5) and ASA-PS 4 (n = 86, rate 5.8%, p < .001, OR 17.2, CI 4.4-67.3), anesthesia duration (p < .001, OR 1.46, CI 1.21-1.76), but no increased risk with number of anesthetics per patient (p value .54, OR 0.81, CI 0.4-1.61).
    Conclusions: Limiting dental care under general anesthesia to multiple short cases may decrease the risk of perioperative events when compared to completing all treatment in one long operative session.
    MeSH term(s) Humans ; Child ; Female ; Male ; Child, Preschool ; Anesthesia, General/methods ; Anesthesia, General/adverse effects ; Adolescent ; Patient Safety ; Wisconsin/epidemiology ; Infant ; Time Factors
    Language English
    Publishing date 2024-02-21
    Publishing country France
    Document type Journal Article ; Observational Study
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An enduring role for hippocampal pattern completion in addition to an emergent non-hippocampal contribution to holistic episodic retrieval after a 24-hour delay.

    Joensen, Bárður H / Ashton, Jennifer E / Berens, Sam C / Gaskell, M Gareth / Horner, Aidan J

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  

    Abstract: ... events' that were composed of multiple overlapping pairs of event elements (e.g., person-location, object ...

    Abstract Episodic memory retrieval is associated with the holistic neocortical reinstatement of all event information; an effect driven by hippocampal pattern completion. However, whether holistic reinstatement occurs, and whether hippocampal pattern completion continues to drive reinstatement, after a period of consolidation is unclear. Theories of systems consolidation predict either a time-variant or -invariant role of the hippocampus in the holistic retrieval of episodic events. Here, we assessed whether episodic events continue to be reinstated holistically and whether hippocampal pattern completion continues to facilitate holistic reinstatement following a period of consolidation. Female and male human participants learnt 'events' that were composed of multiple overlapping pairs of event elements (e.g., person-location, object-location, location-person). Importantly, encoding occurred either immediately before or 24-hours before retrieval. Using fMRI during the retrieval of events, we show evidence for holistic reinstatement, as well as a correlation between reinstatement and hippocampal pattern completion, regardless of whether retrieval occurred immediately or 24-hours after encoding. Thus, hippocampal pattern completion continues to contribute to holistic reinstatement after a delay. However, our results also revealed that some holistic reinstatement can occur without evidence for a corresponding signature of hippocampal pattern completion after a delay (but not immediately after encoding). We therefore show that hippocampal pattern completion, in addition to a non-hippocampal process, has a role in holistic reinstatement following a period of consolidation. Our results point to a consolidation process where the hippocampus and neocortex may work in an additive, rather than compensatory, manner to support episodic memory retrieval.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1740-23.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Authors' Reply: SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM.

    Fonkem, Ekokobe / Peng, Sen / Berens, Michael / Mukherjee, Sanjib

    Journal of neuropathology and experimental neurology

    2021  Volume 80, Issue 3, Page(s) 290–291

    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Glioblastoma/diagnostic imaging ; Glioblastoma/genetics ; Humans ; Mutation/genetics ; SMARCB1 Protein/genetics
    Chemical Substances SMARCB1 Protein ; SMARCB1 protein, human
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlaa105.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of two sequential SARS-CoV-2 outbreaks on a haematology-oncology ward and the role of infection prevention.

    van der Zwet, W C / Klomp-Berens, E A / Demandt, A M P / Dingemans, J / van der Veer, B M J W / van Alphen, L B / Dirks, J A M C / Savelkoul, P H M

    Infection prevention in practice

    2024  Volume 6, Issue 1, Page(s) 100335

    Abstract: Two SARS-CoV-2 nosocomial outbreaks occurred on the haematology ward of our hospital. Patients on the ward were at high risk for severe infection because of their immunocompromised status. Whole Genome Sequencing proved transmission of a particular SARS- ... ...

    Abstract Two SARS-CoV-2 nosocomial outbreaks occurred on the haematology ward of our hospital. Patients on the ward were at high risk for severe infection because of their immunocompromised status. Whole Genome Sequencing proved transmission of a particular SARS-CoV-2 variant in each outbreak. The first outbreak (20 patients/31 healthcare workers (HCW)) occurred in November 2020 and was caused by a variant belonging to lineage B.1.221. At that time, there were still uncertainties on mode of transmission of SARS-CoV-2, and vaccines nor therapy were available. Despite HCW wearing II-R masks in all patient contacts and FFP-2 masks during aerosol generating procedures (AGP), the outbreak continued. Therefore, extra measures were introduced. Firstly, regular PCR-screening of asymptomatic patients and HCW; positive patients were isolated and positive HCW were excluded from work as a rule and they were only allowed to resume their work if a follow-up PCR CT-value was ≥30 and were asymptomatic or having only mild symptoms. Secondly, the use of FFP-2 masks was expanded to some long-lasting, close-contact, non-AGPs. After implementing these measures, the incidence of new cases declined gradually. Thirty-seven percent of patients died due to COVID-19. The second outbreak (10 patients/2 HCW) was caused by the highly transmissible omicron BA.1 variant and occurred in February 2022, where transmission occurred on shared rooms despite the extra infection control measures. It was controlled much faster, and the clinical impact was low as the majority of patients was vaccinated; no patients died and symptoms were relatively mild in both patients and HCW.
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hippocampal and medial prefrontal cortices encode structural task representations following progressive and interleaved training schedules.

    Sam C Berens / Chris M Bird

    PLoS Computational Biology, Vol 18, Iss 10, p e

    2022  Volume 1010566

    Abstract: Memory generalisations may be underpinned by either encoding- or retrieval-based generalisation mechanisms and different training schedules may bias some learners to favour one of these mechanisms over the other. We used a transitive inference task to ... ...

    Abstract Memory generalisations may be underpinned by either encoding- or retrieval-based generalisation mechanisms and different training schedules may bias some learners to favour one of these mechanisms over the other. We used a transitive inference task to investigate whether generalisation is influenced by progressive vs randomly interleaved training, and overnight consolidation. On consecutive days, participants learnt pairwise discriminations from two transitive hierarchies before being tested during fMRI. Inference performance was consistently better following progressive training, and for pairs further apart in the transitive hierarchy. BOLD pattern similarity correlated with hierarchical distances in the left hippocampus (HIP) and medial prefrontal cortex (MPFC) following both training schedules. These results are consistent with the use of structural representations that directly encode hierarchical relationships between task features. However, such effects were only observed in the MPFC for recently learnt relationships. Furthermore, the MPFC appeared to maintain structural representations in participants who performed at chance on the inference task. We conclude that humans preferentially employ encoding-based mechanisms to store map-like relational codes that can be used for memory generalisation. These codes are expressed in the HIP and MPFC following both progressive and interleaved training but are not sufficient for accurate inference.
    Keywords Biology (General) ; QH301-705.5
    Subject code 006
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.

    Metcalf, Kevin James / Hayward, Mary-Kate / Berens, Eric / Ironside, Alastair J / Stashko, Connor / Hwang, E Shelley / Weaver, Valerie M

    Matrix biology plus

    2022  Volume 14, Page(s) 100105

    Abstract: Tumors feature elevated sialoglycoprotein content. Sialoglycoproteins promote tumor progression and are linked to immune suppression via the sialic acid-Siglec axis. Understanding factors that increase sialoglycoprotein biosynthesis in tumors could ... ...

    Abstract Tumors feature elevated sialoglycoprotein content. Sialoglycoproteins promote tumor progression and are linked to immune suppression via the sialic acid-Siglec axis. Understanding factors that increase sialoglycoprotein biosynthesis in tumors could identify approaches to improve patient response to immunotherapy. We quantified higher levels of sialoglycoproteins in the fibrotic regions within human breast tumor tissues. Human breast tumor subtypes, which are more fibrotic, similarly featured increased sialoglycoprotein content. Further analysis revealed the breast cancer cells as the primary cell type synthesizing and secreting the tumor tissue sialoglycoproteins and confirmed that the more aggressive, fibrotic breast cancer subtypes expressed the highest levels of sialoglycoprotein biosynthetic genes. The more aggressive breast cancer subtypes also featured greater infiltration of immunosuppressive
    Language English
    Publishing date 2022-03-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-0285
    ISSN (online) 2590-0285
    DOI 10.1016/j.mbplus.2022.100105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Myths and Legends of Ancient Greece and Rome

    Berens, E. M

    2014  

    Abstract: ... The author sets before the reader a lifelike picture of the deities of classical times as they were conceived and worshipped by the ancients themselves, and thereby to awaken in the minds of young students a desire to become more intimately ... ...

    Abstract The author sets before the reader a lifelike picture of the deities of classical times as they were conceived and worshipped by the ancients themselves, and thereby to awaken in the minds of young students a desire to become more intimately acquainted with the noble productions of classical antiquity. The aim was to render the legends, which form the second portion of this work, a picture of old Greek life; its customs, superstitions, and princely hospitalities, for which reason they are given at somewhat greater length than is usual in works of this kind
    Language English
    Size Online-Ressource (462 p)
    Publisher Start Classics
    Publishing place Lanham
    Document type Book ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Conference proceedings: Gesundheitskompetenz bei Menschen mit türkischem und ex-sowjetischem Migrationshintergrund in Deutschland – Ergebnisse der HLS-MIG Studie 2020

    Mensing, M / Berens, E-M / Klinger, J / Schaeffer, D / Carol, S

    Das Gesundheitswesen

    2021  Volume 83, Issue 08/09

    Event/congress Das Soziale in Medizin und Gesellschaft - Aktuelle Megatrends fordern uns heraus 56. Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP), Leipzig, digital, 2021-09-22
    Language German
    Publishing date 2021-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0041-1732156
    Database Thieme publisher's database

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  9. Article ; Online: Cancer Cell Invasion and Metastasis in Zebrafish Models (Danio rerio).

    Roth, Sarah Martinez / Berens, Eric B / Sharif, Ghada M / Glasgow, Eric / Wellstein, Anton

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2294, Page(s) 3–16

    Abstract: Cancer cell vascular invasion and extravasation at metastatic sites are hallmarks of malignant progression of cancer and associated with poor disease outcome. Here we describe an in vivo approach to study the invasive ability of cancer cells into the ... ...

    Abstract Cancer cell vascular invasion and extravasation at metastatic sites are hallmarks of malignant progression of cancer and associated with poor disease outcome. Here we describe an in vivo approach to study the invasive ability of cancer cells into the vasculature and their hematogenous metastatic seeding in zebrafish (Danio rerio). In one approach, extravasation of fluorescently labeled cancer cells is monitored in zebrafish embryos whose vasculature is marked by a contrasting fluorescent reporter. After injection into the precardiac sinus of 2-day-old embryos, cancer cells can extravasate from the vasculature into tissues over the next few days. Extravasated cancer cells are identified and counted in live embryos via fluorescence microscopy. In a second approach, intravasation of cancer cells can be evaluated by changing their injection site to the yolk sac of zebrafish embryos. In addition to monitoring the impact of drivers of malignant progression, candidate inhibitors can be studied in this in vivo model system for their efficacy as well as their toxicity for the host.
    MeSH term(s) Animals ; Disease Models, Animal ; Neoplasm Invasiveness/pathology ; Transendothelial and Transepithelial Migration ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays/methods ; Zebrafish
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1350-4_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany

    González Santamarina, Belén / Weber, Michael / Menge, Christian / Berens, Christian

    2022  

    Abstract: ... gene was blaCTX-M-1 (16/39). One strain was classified as enteropathogenic E. coli. The positive ...

    Abstract South American camelids (SAC) are increasingly kept in Europe in close contact with humans and other livestock species and can potentially contribute to transmission chains of epizootic, zoonotic and antimicrobial-resistant (AMR) agents from and to livestock and humans. Consequently, SAC were included as livestock species in the new European Animal Health Law. However, the knowledge on bacteria exhibiting AMR in SAC is too scarce to draft appropriate monitoring and preventive programs. During a survey of SAC holdings in central Germany, 39 Escherichia coli strains were isolated from composite fecal samples by selecting for cephalosporin or fluoroquinolone resistance and were here subjected to whole-genome sequencing. The data were bioinformatically analyzed for strain phylogeny, detection of pathovars, AMR genes and plasmids. Most (33/39) strains belonged to phylogroups A and B1. Still, the isolates were highly diverse, as evidenced by 28 multi-locus sequence types. More than half of the isolates (23/39) were genotypically classified as multidrug resistant. Genes mediating resistance to trimethoprim/sulfonamides (22/39), aminoglycosides (20/39) and tetracyclines (18/39) were frequent. The most common extended-spectrum-β-lactamase gene was blaCTX-M-1 (16/39). One strain was classified as enteropathogenic E. coli. The positive results indicate the need to include AMR bacteria in yet-to-be-established animal disease surveillance protocols for SAC.
    Keywords Text ; ddc:570 ; South American camelids -- antimicrobial resistance -- virulence factor -- pathovar -- genome analysis -- E. coli -- Germany
    Subject code 630
    Language English
    Publishing date 2022-08-25
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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