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  1. Article ; Online: Increased Risk of Acute Pancreatitis with Codeine Use in Patients with a History of Cholecystectomy.

    Kim, Juhyeun / Tabner, Andrew John / Johnson, Graham David / Brumback, Babette A / Hartzema, Abraham

    Digestive diseases and sciences

    2019  Volume 65, Issue 1, Page(s) 292–300

    Abstract: Background: Codeine has a spasmodic effect on sphincter of Oddi and is suspected to cause acute pancreatitis in patients with a history of cholecystectomy.: Aims: To assess the association between codeine use and acute pancreatitis in patients with a ...

    Abstract Background: Codeine has a spasmodic effect on sphincter of Oddi and is suspected to cause acute pancreatitis in patients with a history of cholecystectomy.
    Aims: To assess the association between codeine use and acute pancreatitis in patients with a previous cholecystectomy.
    Methods: We conducted a retrospective nested case-control study using the 2005-2015 MarketScan
    Results: Of the 664,083 patients included in the cohort, 1707 patients were hospitalized for acute pancreatitis (incidence 1.1 per 1000 person-years) and were matched to 17,063 controls. Compared with non-use of codeine, use of codeine was associated with an increased risk of acute pancreatitis (OR 2.67; 95% CI 1.63, 4.36), particularly elevated in the first 15 days of codeine use (OR 5.37; 95% CI 2.70, 10.68). Compared with use of NSAIDs, use of codeine was also associated with an increased risk of acute pancreatitis (OR 2.64; 95% CI 1.54, 4.52).
    Conclusion: Codeine is associated with an increased risk of acute pancreatitis in patients who have previously undergone cholecystectomy; greater clinician awareness of this association is needed.
    MeSH term(s) Acute Disease ; Administrative Claims, Healthcare ; Adolescent ; Adult ; Analgesics, Opioid/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Cholecystectomy/adverse effects ; Codeine/adverse effects ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis/chemically induced ; Pancreatitis/diagnosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Young Adult
    Chemical Substances Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal ; Codeine (Q830PW7520)
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05803-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: β-Adrenoreceptor agonists in the management of pain associated with renal colic: a systematic review.

    Tabner, Andrew John / Johnson, Graham David / Fakis, Apostolos / Surtees, Jane / Lennon, Robert Iain

    BMJ open

    2016  Volume 6, Issue 6, Page(s) e011315

    Abstract: Objectives: To determine whether β-adrenoreceptor agonists are effective analgesics for patients with renal colic through a systematic review of the literature.: Setting: Adult emergency departments or acute assessment units.: Participants: Human ... ...

    Abstract Objectives: To determine whether β-adrenoreceptor agonists are effective analgesics for patients with renal colic through a systematic review of the literature.
    Setting: Adult emergency departments or acute assessment units.
    Participants: Human participants with proven or suspected renal colic.
    Interventions: β-adrenoreceptor agonists.
    Outcome measures: Primary: level of pain at 30 min following administration of the β-agonist. Secondary: level of pain at various time points following β-agonist administration; length of hospital stay; analgesic requirement; stone presence, size and position; degree of hydronephrosis.
    Results: 256 records were screened and 4 identified for full-text review. No articles met the inclusion criteria.
    Conclusions and implications: There is no evidence to support or refute the proposed use of β-agonists for analgesia in patients with renal colic. Given the biological plausibility and existing literature base, clinical trials investigating the use of β-adrenoreceptor agonists in the acute setting for treatment of the pain associated with renal colic are recommended.
    Trial registration number: CRD42015016266.
    MeSH term(s) Adrenergic beta-Agonists/therapeutic use ; Analgesics/therapeutic use ; Emergency Medical Services ; Humans ; Pain/etiology ; Pain Management ; Renal Colic/drug therapy ; Time Factors
    Chemical Substances Adrenergic beta-Agonists ; Analgesics
    Language English
    Publishing date 2016-06-20
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2016-011315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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