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  1. AU=Omelchenko Tatiana
  2. AU=DuBois James M.
  3. AU=Holloway Lewis
  4. AU="Alina L. A. OANCEA"
  5. AU="Ioachimescu, Octavian C"
  6. AU="Ramani, Kritika"
  7. AU="Méndez-Albiñana, Pablo"
  8. AU="Xie, Hongming"
  9. AU="Attila Toth"
  10. AU="Rocío Martínez dePablos"
  11. AU="Hou, Ting-Jun"
  12. AU="María Gracia de Garnica García"
  13. AU="Zirbes, Christian"

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  1. Artikel ; Online: Cellular protrusions in 3D: Orchestrating early mouse embryogenesis.

    Omelchenko, Tatiana

    Seminars in cell & developmental biology

    2022  Band 129, Seite(n) 63–74

    Abstract: Cellular protrusions generated by the actin cytoskeleton are central to the process of building the body of the embryo. Problems with cellular protrusions underlie human diseases and syndromes, including implantation defects and pregnancy loss, ... ...

    Abstract Cellular protrusions generated by the actin cytoskeleton are central to the process of building the body of the embryo. Problems with cellular protrusions underlie human diseases and syndromes, including implantation defects and pregnancy loss, congenital birth defects, and cancer. Cells use protrusive activity together with actin-myosin contractility to create an ordered body shape of the embryo. Here, I review how actin-rich protrusions are used by two major morphological cell types, epithelial and mesenchymal cells, during collective cell migration to sculpt the mouse embryo body. Pre-gastrulation epithelial collective migration of the anterior visceral endoderm is essential for establishing the anterior-posterior body axis. Gastrulation mesenchymal collective migration of the mesoderm wings is crucial for body elongation, and somite and heart formation. Analysis of mouse mutants with disrupted cellular protrusions revealed the key role of protrusions in embryonic morphogenesis and embryo survival. Recent technical approaches have allowed examination of the mechanisms that control cell and tissue movements in vivo in the complex 3D microenvironment of living mouse embryos. Advancing our understanding of protrusion-driven morphogenesis should provide novel insights into human developmental disorders and cancer metastasis.
    Mesh-Begriff(e) Actins/metabolism ; Animals ; Cell Movement ; Cell Surface Extensions/metabolism ; Embryonic Development ; Endoderm ; Female ; Gastrulation ; Humans ; Mesoderm ; Mice ; Pregnancy
    Chemische Substanzen Actins
    Sprache Englisch
    Erscheinungsdatum 2022-05-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2022.05.005
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  2. Artikel ; Online: Cutting forces when grinding parts from martensite aging steels with highporous abrasive, borazon and diamond wheels

    Vladimir Lebedev / Alla Bespalova / Tatiana Chumachenko / Yevhen Omelchenko / Tatiana Nikolaieva

    ScienceRise, Iss 4, Pp 11-

    2021  Band 16

    Abstract: Object of research. The article investigates the cutting forces when grinding martensitic-aging steels with highly porous grinding wheels. The problem to be solved is the regularities of the change in the magnitude of the cutting forces when grinding ... ...

    Abstract Object of research. The article investigates the cutting forces when grinding martensitic-aging steels with highly porous grinding wheels. The problem to be solved is the regularities of the change in the magnitude of the cutting forces when grinding maraging steels with highly porous CBN wheels. Main scientific results. The studies were performed on martensiticaging steel H8K18M14. As a result of the experiments, it was found that when grinding wheels made of materials such as electrocorundum, CBN (borazon) and diamond, a significant role is played by the values of the cutting force, which increase during processing. During the experiment it was found out: the cutting forces Py and Pz in the width of the allowable modes, which are most often used in circular and flat grinding, can reach the following values: with the structure of the wheel 26 come to values from 2.714N to 30.721 and with the structure of the wheel 40 come to values from 2.49N to 28.185N. Reducing the grain size of the wheel, let’s obtain the effect of increasing the energy costs of the grinding process, by increasing the magnitude of the cutting forces. If to compare the cutting forces that occur when grinding different wheels, it is possible to note the following: in comparison with electrocorundum wheels when using wheels with KNB cutting forces are reduced by 20-25 %, and when grinding with diamond wheels, the effect of cutting forces is reduced by 25 - 30 %. When grinding with highly porous wheels, the cutting force is 15-20 % higher than when grinding with wheels of normal porosity. The area of practical use of research results-grinding technology for maraging steels. Innovative technological product – relationship between processing modes and the magnitude of cutting forces when grinding maraging steels. Scope of application of an innovative technological product-mechanical engineering technology
    Schlagwörter grinding ; martensitic-aging steels ; cutting forces ; strength ; density ; electrocorundum ; borazon ; diamond ; Science (General) ; Q1-390
    Thema/Rubrik (Code) 670
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag PC Technology Center
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Regulation of collective cell migration by RhoGAP myosin IXA.

    Omelchenko, Tatiana

    Small GTPases

    2012  Band 3, Heft 4, Seite(n) 213–218

    Abstract: Collective cell migration is a key process during epithelial morphogenesis, tissue regeneration and tumor dissemination. During collective epithelial migration, anterior-posterior polarity, apical-basal polarity and cell-cell junctions must be ... ...

    Abstract Collective cell migration is a key process during epithelial morphogenesis, tissue regeneration and tumor dissemination. During collective epithelial migration, anterior-posterior polarity, apical-basal polarity and cell-cell junctions must be dynamically coordinated, but the underlying molecular mechanisms controlling this complex behavior are unclear. Rho GTPases regulate the actin cytoskeleton, in particular protrusive and contractile activities at cell-cell contacts. Recently, a number of regulators - nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) - have been identified and suggested to provide spatio-temporal control of Rho GTPases at cell-cell contacts. One of these is myosin IXA, a member of class IX, single-headed actin motors having a conserved RhoGAP domain. Using its actin-binding and motor activities, myosin IX interacts with actin filaments and moves toward filament plus ends. At the plasma membrane, myosin IX's RhoGAP activity negatively regulates Rho to facilitate localized reorganization of the actin cytoskeleton. Here, I discuss how myosin IXA regulates Rho and the actin cytoskeleton during the assembly of nascent cell-cell contacts and how this might contribute to collective epithelial migration.
    Mesh-Begriff(e) Actins/physiology ; Animals ; Cell Movement/physiology ; Epithelial Cells/physiology ; GTPase-Activating Proteins/physiology ; Humans ; Myosins/physiology ; rho GTP-Binding Proteins/physiology
    Chemische Substanzen Actins ; GTPase-Activating Proteins ; MYO9A protein, human ; rho GTPase-activating protein ; Myosins (EC 3.6.4.1) ; rho GTP-Binding Proteins (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2012-06-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2682247-7
    ISSN 2154-1256 ; 2154-1248
    ISSN (online) 2154-1256
    ISSN 2154-1248
    DOI 10.4161/sgtp.20495
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo.

    Omelchenko, Tatiana / Hall, Alan / Anderson, Kathryn V

    Nature communications

    2020  Band 11, Heft 1, Seite(n) 6066

    Abstract: Coordinated directional migration of cells in the mesoderm layer of the early embryo is essential for organization of the body plan. Here we show that mesoderm organization in mouse embryos depends on β-Pix (Arhgef7), a guanine nucleotide exchange factor ...

    Abstract Coordinated directional migration of cells in the mesoderm layer of the early embryo is essential for organization of the body plan. Here we show that mesoderm organization in mouse embryos depends on β-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42. As early as E7.5, β-Pix mutants have an abnormally thick mesoderm layer; later, paraxial mesoderm fails to organize into somites. To define the mechanism of action of β-Pix in vivo, we optimize single-cell live-embryo imaging, cell tracking, and volumetric analysis of individual and groups of mesoderm cells. Use of these methods shows that wild-type cells move in the same direction as their neighbors, whereas adjacent β-Pix mutant cells move in random directions. Wild-type mesoderm cells have long polarized filopodia-like protrusions, which are absent in β-Pix mutants. The data indicate that β-Pix-dependent cellular protrusions drive and coordinate collective migration of the mesoderm in vivo.
    Mesh-Begriff(e) Animals ; Cell Movement ; Cell Polarity ; Cell Surface Extensions/metabolism ; Embryo, Mammalian/cytology ; Epithelium/embryology ; Female ; Gastrulation ; Green Fluorescent Proteins/metabolism ; Imaging, Three-Dimensional ; Male ; Mesoderm/cytology ; Mesoderm/embryology ; Mice, Inbred C57BL ; Morphogenesis ; Mutation/genetics ; Phenotype ; Primitive Streak/cytology ; Rheology ; Rho Guanine Nucleotide Exchange Factors/metabolism
    Chemische Substanzen Rho Guanine Nucleotide Exchange Factors ; Green Fluorescent Proteins (147336-22-9)
    Sprache Englisch
    Erscheinungsdatum 2020-11-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-19889-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

    Tatiana Omelchenko / Alan Hall / Kathryn V. Anderson

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 13

    Abstract: Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, ...

    Abstract Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cells due to defective cell protrusions.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: CHRONIC PAIN AND PHYSICAL THERAPY IN CHILDREN WITH PARALYTIC SYNDROMES: ARE THERE ANY CHANGES DURING LOCKDOWN?

    Orlova, Natalia / Riga, Olena / Ishchenko, Tatiana / Onikiienko, Оlexander / Omelchenko, Olena / Urivaeva, Marina / Alenina, Inna

    Wiadomosci lekarskie (Warsaw, Poland : 1960)

    2022  Band 75, Heft 9 pt 2, Seite(n) 2262–2269

    Abstract: Objective: The aim: To evaluate an influence of physical therapy on chronic pain in children with paralytic's syndrome and to maternal emotional status on lockdown time during the COVID-19 pandemic.: Patients and methods: Materials and methods: Data ... ...

    Abstract Objective: The aim: To evaluate an influence of physical therapy on chronic pain in children with paralytic's syndrome and to maternal emotional status on lockdown time during the COVID-19 pandemic.
    Patients and methods: Materials and methods: Data from 96 children and their mothers (96 persons) were included in the study. On-site services of physical therapists before the pandemic (2018- 2019) were received by 64 children and by 32 children during quarantine measures due to COVID-19 pandemic (2020). The age of the children ranged from 1 to 6 years, the median age was 3 years and 3 months.
    Results: Results: We note that there were more boys with paralytic syndromes. Among the leading paralytic syndromes, the most common was spastic tetraparesis. The frequency of children with level III-V motor disorders prevailed.
    Conclusion: Conclusions: The authors consider that physical rehabilitation in children with paralytic syndromes reduces the incidence of moderate chronic pain and improves the emotional state of parents. But, these changes do not occur during the pandemic.
    Mesh-Begriff(e) Child ; Male ; Female ; Humans ; Child, Preschool ; Infant ; Pandemics ; COVID-19/epidemiology ; Chronic Pain ; Communicable Disease Control ; Physical Therapy Modalities
    Sprache Englisch
    Erscheinungsdatum 2022-11-15
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 414731-5
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
    DOI 10.36740/WLek202209215
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  7. Artikel ; Online: Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets.

    Reva, Boris A / Omelchenko, Tatiana / Nair, Sujit S / Tewari, Ashutosh K

    The Urologic clinics of North America

    2020  Band 47, Heft 4S, Seite(n) e9–e16

    Abstract: Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated ... ...

    Abstract Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.
    Mesh-Begriff(e) Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/immunology ; Tumor Escape/drug effects ; Tumor Escape/immunology
    Chemische Substanzen Immune Checkpoint Inhibitors ; Interferon-gamma (82115-62-6)
    Sprache Englisch
    Erscheinungsdatum 2020-12-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 192293-2
    ISSN 1558-318X ; 0094-0143
    ISSN (online) 1558-318X
    ISSN 0094-0143
    DOI 10.1016/j.ucl.2020.10.004
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  8. Artikel: The most likely but largely ignored triggering factor for breast (or all) cancer invasion.

    Man, Yan-Gao / Mannion, Ciaran / Stojadinovic, Alexander / Peoples, George E / Cho, William Cs / Fu, Sidney W / Tan, Xiaohui / Hsiao, Yi-Hsuan / Liu, Aijun / Semczuk, Andrzej / Zarogoulidis, Paul / Gapeev, Andrei B / Deng, Xiyun / Peng, Xiaoning / Reva, Boris A / Omelchenko, Tatiana / Wang, Jialian / Song, Guohong / Chen, Tingtao

    Journal of Cancer

    2023  Band 14, Heft 4, Seite(n) 573–590

    Abstract: Breast cancer development and progression are believed to be a sequential process, from normal to hyperplastic, ... ...

    Abstract Breast cancer development and progression are believed to be a sequential process, from normal to hyperplastic, to
    Sprache Englisch
    Erscheinungsdatum 2023-02-27
    Erscheinungsland Australia
    Dokumenttyp Editorial
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.82291
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  9. Artikel ; Online: Environmental management and the poverty monitoring in the subjects of the Russian Federation

    Omelchenko Irina / Dozortzev Oleg / Danilina Marina / Vas’kov Alexander / Selivanova Olga / Vartanyanz Tatiana

    E3S Web of Conferences, Vol 217, p

    2020  Band 07011

    Abstract: The degradation of the natural world undermines efforts to eradicate poverty, scientists warn and note that the only chance for global prosperity for all countries is to recognize the fight against poverty as an environmental challenge. The most ... ...

    Abstract The degradation of the natural world undermines efforts to eradicate poverty, scientists warn and note that the only chance for global prosperity for all countries is to recognize the fight against poverty as an environmental challenge. The most important driver for achieving environmental sustainability is the fight against poverty. It is generally accepted that poverty is a consequence of environmental degradation. On the basis of the materials from 77 constituent entities of the Russian Federation the authors determined that the provided regional action plans to achieve the national goal of halving the poverty level is not sufficient and propose the additional list of measures to achieve this goal. The authors propose the methods for calculating the target value of the poverty level indicator (the level of the population with incomes below the subsistence level and the distribution of target persons across the constituent entity of the Russian Federation.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Mri and ultrasound criteria for the diagnosis of a sports hernia in football players.

    Ioffe, Oleksandr Yu / Negria, Natalia M / Omelchenko, Anastasiia V / Stetsenko, Oleksandr P / Dibrova, Yuri A / Kryvopustov, Mykola S / Tsiura, Yuri P / Tarasiuk, Tatiana V

    Wiadomosci lekarskie (Warsaw, Poland : 1960)

    2020  Band 73, Heft 4, Seite(n) 755–760

    Abstract: Objective: The aim of the study is to specify diagnostic MRI and ultrasound criteria for a sports hernia in order to verify its diagnosis in football players.: Patients and methods: Materials and methods: The study included 50 professional and ... ...

    Abstract Objective: The aim of the study is to specify diagnostic MRI and ultrasound criteria for a sports hernia in order to verify its diagnosis in football players.
    Patients and methods: Materials and methods: The study included 50 professional and amateur football players aged 15 to 34 from 2016 to 2019. The criteria for inclusion in the study were: the presence of groin pain in football players, which prevented them from continuing to actively participate in sports activities.
    Results: Results: The findings of the study revealed that during MRI the two factors, which had the strongest influence, were "increased MR signal intensity on PDfs observed from the structures of the inguinal canal" and "increased MR signal intensity on PDfs observed from bone marrow of superior ramus of the pubic bone". During ultrasound of the inguinal area, the main criterion for a sports hernia diagnosis was "increased size of the inguinal canal". The verification of the diagnosis was carried out on the basis of the presence of a protrusion in the posterior wall of the inguinal canal. For a sports hernia diagnosis the MRI sensitivity is 91.67% (95% CI 77.5 - 98.2), specificity -78.57% (95% CI 49.2 - 95.3) and the sensitivity of ultrasound is 88.89% (95% CI 73.9 - 96.9), the specificity - 50% (95% CI 23.0 - 77).
    Conclusion: Conclusions: The combination of MRI and ultrasound makes it possible to accurately detect the presence of a sports hernia in the football player. Based on the findings of our study, we formulated MRI and ultrasound criteria for a sports hernia diagnosis.
    Mesh-Begriff(e) Adolescent ; Adult ; Football ; Groin ; Hernia ; Hernia, Inguinal ; Humans ; Magnetic Resonance Imaging ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-07-28
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 414731-5
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
    ISSN 0043-5147 ; 1895-0485 ; 0860-8865
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