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Article ; Online: Management of non-ST elevation acute myocardial infarction in frail older adults: revascularization or not?

Bellini, Beatrice / Di Marco, Maurizio / Tonelli, Francesca / Torres, Alessandra / Zoncapè, Mirko

2024 Volume 19, Issue 2, Page(s) 561–563

MeSH term(s)	Humans ; Aged ; Frail Elderly ; Myocardial Infarction/therapy ; Coronary Artery Disease ; Non-ST Elevated Myocardial Infarction ; ST Elevation Myocardial Infarction ; Treatment Outcome ; Percutaneous Coronary Intervention ; Myocardial Revascularization
Language	English
Publishing date	2024-01-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03497-0
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Article ; Online: Comparative structural and functional analysis of the glycine-rich regions of Class A and B J-domain protein cochaperones of Hsp70.

Ciesielski, Szymon J / Schilke, Brenda A / Stolarska, Milena / Tonelli, Marco / Tomiczek, Bartlomiej / Craig, Elizabeth A

FEBS letters

2024

Abstract: J-domain proteins are critical Hsp70 co-chaperones. A and B types have a poorly understood glycine-rich region ( ... ...

Abstract	J-domain proteins are critical Hsp70 co-chaperones. A and B types have a poorly understood glycine-rich region (G
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14857
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Article ; Online: Ancient human colonization explains dung beetle species richness in the Mediterranean and Macaronesian islands

Tonelli, Mattia / Dellacasa, Marco / Lobo, Jorge M.

Journal of Biogeography. 2023 Dec., v. 50, no. 12 p.2095-2108

2023

Abstract: AIM: Different hypothesis have been proposed to explain differences in species richness among islands. However, few studies have attempted to compare the explanatory power of multiple hypotheses using a large data set. Here, we analyse how different ... ...

Abstract	AIM: Different hypothesis have been proposed to explain differences in species richness among islands. However, few studies have attempted to compare the explanatory power of multiple hypotheses using a large data set. Here, we analyse how different types of predictors (energetic/climatic, environmental heterogeneity, island biogeography and anthropogenic) affect variation in dung beetle species richness on Mediterranean and Macaronesian islands. LOCATION: Mediterranean and Macaronesian islands. TAXON: Dung beetles. METHODS: Using a large data set of islands (n = 147), we extracted the species richness of dung beetles on each island using 362 bibliographic reference sources. We performed GLMs to analyse the relationship between the species richness of dung beetles and 11 explanatory variables (temperature, evapotranspiration, aridity, area, maximum elevation, connection to continent during LGM, geological origin, distance from continent, nearest continent, years since first human colonization and human density) representing four types of causal hypotheses. We also included as a covariate the number of published papers studying dung beetles as a surrogate of the survey/study effort carried out in each island. RESULTS: GLMs suggest that the years since first human colonization, the number of published papers and island area were the predictors with a higher explanatory capacity. The volcanic character of the islands and the distance from the mainland had some relevance in the case of Scarabaeinae and Geotrupinae, and maximum elevation appeared relevant in the species richness of Scarabaeinae and Aphodiidae. The anthropogenic and island biogeography hypotheses on the variation in species richness were the ones that have the strongest explanatory capacity, regardless of the inclusion of the surrogate of survey effort as a covariate in the models. MAIN CONCLUSIONS: The long history of human movements and agricultural activities has facilitated the colonization of dung beetles and provided trophic resources for their persistence, leading to increased species richness. Thus, the importance of anthropogenic factors in shaping the biodiversity patterns of island biogeography cannot be ignored. These human‐induced influences may play a fundamental role in altering the biogeographic patterns of islands, even overriding the importance of other variables. Consequently, our findings underline the profound impact of historical human actions on islands biodiversity.
Keywords	Scarabaeidae ; biogeography ; data collection ; dry environmental conditions ; dung beetles ; evapotranspiration ; feces ; geographical distribution ; humans ; species richness ; surveys ; temperature
Language	English
Dates of publication	2023-12
Size	p. 2095-2108.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	188963-1
ISSN	0305-0270
ISSN	0305-0270
DOI	10.1111/jbi.14715
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Article ; Online: Smart contracts software metrics: A first study.

Tonelli, Roberto / Pierro, Giuseppe Antonio / Ortu, Marco / Destefanis, Giuseppe

PloS one

2023 Volume 18, Issue 4, Page(s) e0281043

Abstract: Smart contracts (SC) are software programs that reside and run over a blockchain. The code can be written in different languages with the common purpose of implementing various kinds of transactions onto the hosting blockchain. They are ruled by the ... ...

Abstract	Smart contracts (SC) are software programs that reside and run over a blockchain. The code can be written in different languages with the common purpose of implementing various kinds of transactions onto the hosting blockchain. They are ruled by the blockchain infrastructure with the intent to automatically implement the typical conditions of traditional contracts. Programs must satisfy context-dependent constraints which are quite different from traditional software code. In particular, since the bytecode is uploaded in the hosting blockchain, the size, computational resources, interaction between different parts of the program are all limited. This is true even if the specific programming languages implement more or less the same constructs as that of traditional languages: there is not the same freedom as in normal software development. The working hypothesis used in this article is that Smart Contract specific constraints should be captured by specific software metrics (that may differ from traditional software metrics). We tested this hypothesis on 85K Smart Contracts written in Solidity and uploaded on the Ethereum blockchain. We analyzed Smart Contracts from two repositories "Etherscan" and "Smart Corpus" and we computed the statistics of a set of software metrics related to Smart Contracts and compared them to the metrics extracted from more traditional software projects. Our results show that generally, Smart Contract metrics have more restricted ranges than the corresponding metrics in traditional software systems. Some of the stylized facts, like power law in the tail of the distribution of some metrics, are only approximate but the lines of code follow a log-normal distribution which reminds us of the same behaviour already found in traditional software systems.
MeSH term(s)	Blockchain ; Software ; Programming Languages
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281043
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis.

Francesconi, Valeria / Rizzo, Marco / Schenone, Silvia / Carbone, Anna / Tonelli, Michele

Current medicinal chemistry

2023 Volume 31, Issue 15, Page(s) 1955–1982

Abstract: Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, ...

Abstract	Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route of administration, and cost, reflecting their low priority in global health management. Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This scenario claims the need of addressing more adequate therapies. Among the diverse strategies implemented, the medicinal chemistry efforts have also focused their attention on the benzimidazole nucleus as a promising pharmacophore for the generation of new drug candidates. Hence, the present review provides a global insight into recent progress in benzimidazole-based derivatives drug discovery against important protozoan diseases, such as malaria, leishmaniasis and trypanosomiasis. The more relevant chemical features and structure-activity relationship studies of these molecules are discussed for the purpose of paving the way towards the development of more viable drugs for the treatment of these parasitic infections.
MeSH term(s)	Humans ; Antiparasitic Agents/therapeutic use ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Antiprotozoal Agents/chemistry ; Malaria/drug therapy ; Trypanosomiasis/drug therapy ; Leishmaniasis/drug therapy ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use
Chemical Substances	Antiparasitic Agents ; Antiprotozoal Agents ; Benzimidazoles
Language	English
Publishing date	2023-09-16
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230915093928
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Article ; Online: Full opening of helix bundle crossing does not lead to NaK channel activation.

Kurauskas, Vilius / Tonelli, Marco / Henzler-Wildman, Katherine

The Journal of general physiology

2022 Volume 154, Issue 12

Abstract: A critical part of ion channel function is the ability to open and close in response to stimuli and thus conduct ions in a regulated fashion. While x-ray diffraction studies of ion channels suggested a general steric gating mechanism located at the helix ...

Abstract	A critical part of ion channel function is the ability to open and close in response to stimuli and thus conduct ions in a regulated fashion. While x-ray diffraction studies of ion channels suggested a general steric gating mechanism located at the helix bundle crossing (HBC), recent functional studies on several channels indicate that the helix bundle crossing is wide-open even in functionally nonconductive channels. Two NaK channel variants were crystallized in very different open and closed conformations, which served as important models of the HBC gating hypothesis. However, neither of these NaK variants is conductive in liposomes unless phenylalanine 92 is mutated to alanine (F92A). Here, we use NMR to probe distances at near-atomic resolution of the two NaK variants in lipid bicelles. We demonstrate that in contrast to the crystal structures, both NaK variants are in a fully open conformation, akin to Ca2+-bound MthK channel structure where the HBC is widely open. While we were not able to determine what a conductive NaK structure is like, our further inquiry into the gating mechanism suggests that the selectivity filter and pore helix are coupled to the M2 helix below and undergo changes in the structure when F92 is mutated. Overall, our data show that NaK exhibits coupling between the selectivity filter and HBC, similar to K+ channels, and has a more complex gating mechanism than previously thought, where the full opening of HBC does not lead to channel activation.
MeSH term(s)	Ion Channel Gating/physiology ; Ion Channels/chemistry ; Ions ; Protein Conformation
Chemical Substances	Ion Channels ; Ions
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202213196
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Article ; Online: Backbone and side chain chemical shift assignment of diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris, an organophosphorus-degrading enzyme.

Chen, Julian C-H / Tonelli, Marco / Anderson, Penelope / Michalczyk, Ryszard / Blum, Marc-Michael / Williams, Robert F

Biomolecular NMR assignments

2023 Volume 17, Issue 1, Page(s) 55–60

Abstract: NMR chemical shift assignments are reported for backbone ( ...

Abstract	NMR chemical shift assignments are reported for backbone (
MeSH term(s)	Animals ; Loligo/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Phosphoric Triester Hydrolases/chemistry ; Phosphoric Triester Hydrolases/metabolism ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/metabolism
Chemical Substances	diisopropyl-fluorophosphatase (EC 3.1.8.2) ; Phosphoric Triester Hydrolases (EC 3.1.8.-) ; Organophosphorus Compounds
Language	English
Publishing date	2023-02-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2388861-1
ISSN	1874-270X ; 1874-2718
ISSN (online)	1874-270X
ISSN	1874-2718
DOI	10.1007/s12104-023-10120-y
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Article ; Online: Smart contracts software metrics

Roberto Tonelli / Giuseppe Antonio Pierro / Marco Ortu / Giuseppe Destefanis

PLoS ONE, Vol 18, Iss 4, p e

A first study.

2023 Volume 0281043

Abstract	Smart contracts (SC) are software programs that reside and run over a blockchain. The code can be written in different languages with the common purpose of implementing various kinds of transactions onto the hosting blockchain. They are ruled by the blockchain infrastructure with the intent to automatically implement the typical conditions of traditional contracts. Programs must satisfy context-dependent constraints which are quite different from traditional software code. In particular, since the bytecode is uploaded in the hosting blockchain, the size, computational resources, interaction between different parts of the program are all limited. This is true even if the specific programming languages implement more or less the same constructs as that of traditional languages: there is not the same freedom as in normal software development. The working hypothesis used in this article is that Smart Contract specific constraints should be captured by specific software metrics (that may differ from traditional software metrics). We tested this hypothesis on 85K Smart Contracts written in Solidity and uploaded on the Ethereum blockchain. We analyzed Smart Contracts from two repositories "Etherscan" and "Smart Corpus" and we computed the statistics of a set of software metrics related to Smart Contracts and compared them to the metrics extracted from more traditional software projects. Our results show that generally, Smart Contract metrics have more restricted ranges than the corresponding metrics in traditional software systems. Some of the stylized facts, like power law in the tail of the distribution of some metrics, are only approximate but the lines of code follow a log-normal distribution which reminds us of the same behaviour already found in traditional software systems.
Keywords	Medicine ; R ; Science ; Q
Subject code	005
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Magnetic-Field Dependence of LC-Photo-CIDNP in the Presence of Target Molecules Carrying a Quasi-Isolated Spin Pair.

Li, Siyu / Yang, Hanming / Hofstetter, Heike / Tonelli, Marco / Cavagnero, Silvia

Applied magnetic resonance

2022 Volume 54, Issue 1, Page(s) 59–75

Abstract: NMR spectroscopy is well known for its superb resolution, especially at high applied magnetic field. However, the sensitivity of this technique is very low. Liquid-state low-concentration photo-chemically-induced dynamic nuclear polarization (LC-photo- ... ...

Abstract	NMR spectroscopy is well known for its superb resolution, especially at high applied magnetic field. However, the sensitivity of this technique is very low. Liquid-state low-concentration photo-chemically-induced dynamic nuclear polarization (LC-photo-CIDNP) is a promising emerging methodology capable of enhancing NMR sensitivity in solution. LC-photo-CIDNP works well on solvent-exposed Trp and Tyr residues, either in isolation or within proteins. This study explores the magnetic-field dependence of the LC-photo-CIDNP experienced by two tryptophan isotopologs in solution upon
Language	English
Publishing date	2022-10-15
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1480644-7
ISSN	1613-7507 ; 0937-9347
ISSN (online)	1613-7507
ISSN	0937-9347
DOI	10.1007/s00723-022-01506-7
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Article ; Online: The transition to electric vehicles and a net zero economy: A model based on circular economy, stakeholder theory, and system thinking approach

Demartini, Melissa / Ferrari, Marco / Govindan, Kannan / Tonelli, Flavio

Journal of Cleaner Production. 2023 Apr. 14, p.137031-

2023 , Page(s) 137031–

Abstract: Greenhouse gas emissions and air pollution are major contributors to climate change, causing harm to both the planet and people. Since transportation is a significant source of these emissions, several European countries have implemented plans to switch ... ...

Abstract	Greenhouse gas emissions and air pollution are major contributors to climate change, causing harm to both the planet and people. Since transportation is a significant source of these emissions, several European countries have implemented plans to switch to electric cars and decrease emissions by 2050. However, this transition presents many challenges, including issues with redesigning supply chains, scarcity of raw materials, and impacts on employment, technology, mobility behaviour, and infrastructure. The aim of this study is to develop a model based on system dynamics and agent-based approaches to evaluate effects of the electric and net zero economy transitions on the automotive supply chains and relevant stakeholders. The study incorporates principles of circular economy, stakeholder theory, and system thinking approach. The research considers various stakeholders such as automotive manufacturers, suppliers, and workers, and it explores several operations such as production, de-manufacturing, and end-of-life activities for three types of vehicles: fuel, hybrid, and electric. The results of the model show that a transition towards electric vehicles and a net zero economy is only possible through the implementation of circular economy, which can generate new business opportunities, reductions in raw material consumption, and a resulting increase in competitiveness; however, at the same time, this transition can have several implications for job. Indeed, the EV transition will significantly reduce the number of manufacturing jobs available in the automotive industry due to an increase in automation, fewer moving parts, and simpler engines. Therefore, it is fundamental that companies and policy makers use the results of this study to reduce the negative effects on employment and plan specific programs and policies to support the developing of new skills for workers and favour their relocation in the supply chain (i.e., end of life activities).
Keywords	air pollution ; automation ; circular economy ; climate change ; employment ; fuels ; greenhouse gases ; industry ; infrastructure ; issues and policy ; raw materials ; stakeholders ; supply chain ; transportation ; Electric vehicle ; Net zero economy ; de-manufacturing ; Stakeholder theory ; System thinking ; System dynamics ; Agent based
Language	English
Dates of publication	2023-0414
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	0959-6526
DOI	10.1016/j.jclepro.2023.137031
Database	NAL-Catalogue (AGRICOLA)

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