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Article ; Online: Biogas from microalgae: an overview emphasizing pretreatment methods and their energy return on investment (EROI).

Marques, Aline de Luna / Araújo, Ofélia de Queiroz Fernandes / Cammarota, Magali Christe

2018 Volume 41, Issue 2, Page(s) 193–201

Abstract: Studies have reported enhancements in methane yield from pretreatment methods that benefit the anaerobic digestion (AD) of microalgae. However, energy return on investment (EROI), i.e., methane production enhancement achieved over energy input, may be ... ...

Abstract	Studies have reported enhancements in methane yield from pretreatment methods that benefit the anaerobic digestion (AD) of microalgae. However, energy return on investment (EROI), i.e., methane production enhancement achieved over energy input, may be unfavorable. Aiming to quantify EROI of AD microalgae pretreatment, about 180 experiments applied to 30 microalgae biomasses were compiled through an extensive literature survey, classified into 4 pretreatments (physical, enzymatic, chemical, and hybrid), and analyzed. Most of these pretreatments enhanced methane yield, especially the enzymatic alternative. EROI was evaluated for the most efficient pretreatments. Only in one thermal pretreatment the energy resulting from the increase in methane production exceeded the energy demanded by the biomass pretreatment (EROI 6.8) and other two thermal pretreatments presented EROI 1. The other pretreatments presented EROI < 1, concluding that none of the evaluated methods was energy-efficient. Feasibility of pretreatment requires advancements in low energy-demanding strategies and outstanding biomass densification.
MeSH term(s)	Anaerobiosis ; Biofuels/microbiology ; Hot Temperature ; Methane/metabolism ; Microalgae/growth & development ; Microalgae/metabolism
Chemical Substances	Biofuels ; Methane (OP0UW79H66)
Language	English
Publishing date	2018-12-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-018-2629-x
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Article ; Online: 1

de Luna Marques, Aline / Caruso, Icaro Putinhon / Santana-Silva, Marcos Caique / Bezerra, Peter Reis / Araujo, Gabriela Rocha / Almeida, Fabio Ceneviva Lacerda / Amorim, Gisele Cardoso

Biomolecular NMR assignments

2021 Volume 15, Issue 1, Page(s) 153–157

Abstract: Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. ... ...

Abstract	Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. During viral replication, a discontinuous transcription of the genome takes place, producing the subgenomic messenger RNAs. The nucleocapsid protein (N) plays a pivotal role in the regulation of this process, acting as an RNA chaperone and participating in the nucleocapsid assembly. The isolated N-terminal domain of protein N (N-NTD) specifically binds to the transcriptional regulatory sequences and control the melting of the double-stranded RNA. Here, we report the resonance assignments of the N-NTD of HKU1-CoV.
MeSH term(s)	Betacoronavirus/chemistry ; Carbon Isotopes ; Coronavirus Nucleocapsid Proteins/chemistry ; Escherichia coli/metabolism ; Hydrogen ; Magnetic Resonance Spectroscopy ; Nitrogen Isotopes ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; Software
Chemical Substances	Carbon Isotopes ; Coronavirus Nucleocapsid Proteins ; Nitrogen Isotopes ; Nitrogen-15 ; Hydrogen (7YNJ3PO35Z) ; Carbon-13 (FDJ0A8596D)
Language	English
Publishing date	2021-01-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2388861-1
ISSN	1874-270X ; 1874-2718
ISSN (online)	1874-270X
ISSN	1874-2718
DOI	10.1007/s12104-020-09998-9
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Diversitas Journal, Vol 6, Iss 1, Pp 1680-

analyzeof the depalatalization of the palatal lateral

2021 Volume 1698

Abstract: The present work goalto investigate the depalatalization of the palatal lateral /λ/, as in words like ‘filho’, ‘julho’ and ‘mulher’ etc. in the Agreste, Sertão and Litoral of Alagoas. The exchange of a palatal phoneme by an alveolar is investigated as a ... ...

Abstract	The present work goalto investigate the depalatalization of the palatal lateral /λ/, as in words like ‘filho’, ‘julho’ and ‘mulher’ etc. in the Agreste, Sertão and Litoral of Alagoas. The exchange of a palatal phoneme by an alveolar is investigated as a result of not supporting the tip of the tongue correctly on the hard palate when producing the phoneme. In this research, the theoretical contribution of Variationist Sociolinguistics (LABOV, 2008 [1972]; WEINREICH, LABOV, HERZOG, 2006 and others) is used, which provides that each variational element within the language suffers from a social valuation that directs its realization. The research has 128interviews of spontaneous speech of informants stratified in sex, age, education and region. The analysis process is done with the aid of the following computer programs: Praat (acoustic analysis),R and Rstudio (statistical analysis). The linguistic variables (context/previous vowel, context/next vowel, number of syllables, grammatical class and tonicity) are correlated to social variables. The results indicate that the depalatalized variant apparently suffers ethnographic pressures and is proportionally favored by the proximity of the Litoral, while the Sertão inhibits it. This variant clearly carries negative social values, being avoided by women and more educated people. Linguistically, the depalatalized variant is conditioned by the previous context, the following context, tonicity and grammatical class.
Keywords	variationist sociolinguistics ; phonetics and phonology ; alagoas ; Education ; L ; Science ; Q ; Social Sciences ; H
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Universidade Estadual de Alagoas
Document type	Article ; Online
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Article ; Online: Leishmanicidal activity of Morita-Baylis-Hillman adducts.

Vieira, Ana Carolina Santana / da Silva Santos, Mariana / Leite, Anderson Brandão / da Silva, Amanda Evelyn / Cavalcante-Silva, Luiz Henrique Agra / de Souza Augusto Pereira, Gabrielle / Marques, Sany Delany Gomes / de Oliveira Santos, Barbara Viviana / Duarte, Alysson Wagner Fernandes / de Queiroz, Aline Cavalcante / de Luna-Freire, Kristerson Reinaldo / Alexandre-Moreira, Magna Suzana

Parasitology research

2022 Volume 121, Issue 2, Page(s) 751–762

Abstract: Leishmaniasis is a neglected disease that affects millions of people, mostly in developing countries. Although this disease has a high impact on public health, there are few drug options to treat the different leishmaniasis forms. Additionally, these ... ...

Abstract	Leishmaniasis is a neglected disease that affects millions of people, mostly in developing countries. Although this disease has a high impact on public health, there are few drug options to treat the different leishmaniasis forms. Additionally, these current therapies have various adverse effects, including gastrointestinal disturbances, headache, pancreatitis, and hepatotoxicity. Thus, it is essential to develop new drug prototypes to treat leishmaniasis. Accordingly, the present study aimed to evaluate the leishmanicidal activity of Morita-Baylis-Hillman adducts and their O-acetylates, carboxylic acid derivatives, and acid and ester derivatives of 2-methyl-phenylpropanoids against Leishmania chagasi. Initially, we evaluated the cytotoxicity of 16 derivatives (1-16G) against J774A.1 macrophages. Eight derivatives (2G, 4G, 5G, 7G, 9G, 10G, 13G, and 15G) showed no cytotoxicity at up to the maximum concentration tested (100 μM). When evaluated for antileishmanial effect against promastigote forms, 1G, 6G, 8G, 10G, 11G, 13G, 14G, 15G, and 16G displayed significant toxicity compared to the control (0.1% DMSO). Additionally, the compounds 1G, 5G, 7G, 9G, 11G, 13G, 14G, and 16G reduced macrophage infection by amastigotes. Thus, we conclude that these derivatives have antileishmanial effects, particularly 1G, which showed activity against promastigotes and amastigotes, and low toxicity against macrophages.
MeSH term(s)	Antiprotozoal Agents/toxicity ; Humans ; Leishmaniasis/drug therapy ; Macrophages ; Organic Chemicals
Chemical Substances	Antiprotozoal Agents ; Organic Chemicals
Language	English
Publishing date	2022-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-021-07421-3
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Article: Leishmanicidal activity of Morita-Baylis–Hillman adducts

Parasitology research. 2022 Feb., v. 121, no. 2

2022

Abstract	Leishmaniasis is a neglected disease that affects millions of people, mostly in developing countries. Although this disease has a high impact on public health, there are few drug options to treat the different leishmaniasis forms. Additionally, these current therapies have various adverse effects, including gastrointestinal disturbances, headache, pancreatitis, and hepatotoxicity. Thus, it is essential to develop new drug prototypes to treat leishmaniasis. Accordingly, the present study aimed to evaluate the leishmanicidal activity of Morita-Baylis–Hillman adducts and their O-acetylates, carboxylic acid derivatives, and acid and ester derivatives of 2-methyl-phenylpropanoids against Leishmania chagasi. Initially, we evaluated the cytotoxicity of 16 derivatives (1-16G) against J774A.1 macrophages. Eight derivatives (2G, 4G, 5G, 7G, 9G, 10G, 13G, and 15G) showed no cytotoxicity at up to the maximum concentration tested (100 μM). When evaluated for antileishmanial effect against promastigote forms, 1G, 6G, 8G, 10G, 11G, 13G, 14G, 15G, and 16G displayed significant toxicity compared to the control (0.1% DMSO). Additionally, the compounds 1G, 5G, 7G, 9G, 11G, 13G, 14G, and 16G reduced macrophage infection by amastigotes. Thus, we conclude that these derivatives have antileishmanial effects, particularly 1G, which showed activity against promastigotes and amastigotes, and low toxicity against macrophages.
Keywords	Leishmania donovani ; amastigotes ; antileishmanial properties ; carboxylic acids ; cytotoxicity ; drugs ; gastrointestinal system ; headache ; hepatotoxicity ; leishmaniasis ; macrophages ; pancreatitis ; parasitology ; promastigotes ; public health
Language	English
Dates of publication	2022-02
Size	p. 751-762.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-021-07421-3
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Article ; Online: Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids.

Caruso, Icaro Putinhon / Dos Santos Almeida, Vitor / do Amaral, Mariana Juliani / de Andrade, Guilherme Caldas / de Araújo, Gabriela Rocha / de Araújo, Talita Stelling / de Azevedo, Jéssica Moreira / Barbosa, Glauce Moreno / Bartkevihi, Leonardo / Bezerra, Peter Reis / Dos Santos Cabral, Katia Maria / de Lourenço, Isabella Otênio / Malizia-Motta, Clara L F / de Luna Marques, Aline / Mebus-Antunes, Nathane Cunha / Neves-Martins, Thais Cristtina / de Sá, Jéssica Maróstica / Sanches, Karoline / Santana-Silva, Marcos Caique /

Vasconcelos, Ariana Azevedo / da Silva Almeida, Marcius / de Amorim, Gisele Cardoso / Anobom, Cristiane Dinis / Da Poian, Andrea T / Gomes-Neto, Francisco / Pinheiro, Anderson S / Almeida, Fabio C L

International journal of biological macromolecules

2022 Volume 203, Page(s) 466–480

Abstract: The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding protein, which plays a major role in nucleocapsid assembly and discontinuous RNA transcription, facilitating the template switch of transcriptional regulatory ... ...

Abstract	The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding protein, which plays a major role in nucleocapsid assembly and discontinuous RNA transcription, facilitating the template switch of transcriptional regulatory sequences (TRS). Here, we dissect the structural features of the N protein N-terminal domain (N-NTD) and N-NTD plus the SR-rich motif (N-NTD-SR) upon binding to single and double-stranded TRS DNA, as well as their activities for dsTRS melting and TRS-induced liquid-liquid phase separation (LLPS). Our study gives insights on the specificity for N-NTD(-SR) interaction with TRS. We observed an approximation of the triple-thymidine (TTT) motif of the TRS to β-sheet II, giving rise to an orientation difference of ~25° between dsTRS and non-specific sequence (dsNS). It led to a local unfavorable energetic contribution that might trigger the melting activity. The thermodynamic parameters of binding of ssTRSs and dsTRS suggested that the duplex dissociation of the dsTRS in the binding cleft is entropically favorable. We showed a preference for TRS in the formation of liquid condensates when compared to NS. Moreover, our results on DNA binding may serve as a starting point for the design of inhibitors, including aptamers, against N, a possible therapeutic target essential for the virus infectivity.
MeSH term(s)	Binding Sites ; COVID-19/virology ; DNA/chemistry ; DNA/metabolism ; Gene Expression Regulation, Viral ; Host-Pathogen Interactions ; Humans ; Hydrogen Bonding ; Models, Molecular ; Nucleic Acids/chemistry ; Nucleic Acids/metabolism ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; RNA/chemistry ; RNA/metabolism ; SARS-CoV-2/physiology ; Spectrum Analysis ; Structure-Activity Relationship
Chemical Substances	Nucleic Acids ; Nucleocapsid Proteins ; RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2022-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.01.121
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Article ; Online: Factors associated with diet quality among Brazilian individuals with cardiovascular diseases.

Brito, Luciana / Sahade, Viviane / Weber, Bernardete / Bersch-Ferreira, Ângela Cristine / Marcadenti, Aline / Torreglosa, Camila / Kovacs, Cristiane / Moreira, Annie Seixas Bello / Torres, Rosileide de Souza / Marinho, Helyde / Matos, Cristina / Abib, Renata / Souza, Gabriela Correa / Shirmann, Gabriela da Silva / Nagano, Francisca Eugenia Zaina / Ramos, Maria Estela Monserrat / Poloni, Soraia / El Kik, Raquel Milani / Feres, Nauale Hassan /

Dutra, Eliane Said / Ferreira Carvalho, Ana Paula Perillo / David, Marta Marques / Galvão, Isa / Sousa, Antonio Carlos Sobral / Dantas, Clenise de Farias / Gonçalves, Amanda / Pinheiro, Josilene Maria Ferreira / Vasconcelos, Sandra Mary Lima / Penafort, Andreza / de Oliveira Carlos, Daniele Maria / Luna, Adriana / Neto, José Albuquerque de Figueiredo / Dias, Luciana / Moriguchi, Emilio Hideyuki / Bruscato, Neide / Izar, Maria Cristina / Lopes, Sonia / Backes, Luciano Marcelo / Bressan, Josefina / Raimondi, Simone / Kumbier, Magali / Daltro, Carla

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

2023 Volume 36, Issue 5, Page(s) 1713–1726

Abstract: Background: An individual's dietary pattern contributes in different ways to the prevention and control of recurrent cardiovascular events. However, the quality of the diet is influenced by several factors. The present study aimed to evaluate the ... ...

Abstract	Background: An individual's dietary pattern contributes in different ways to the prevention and control of recurrent cardiovascular events. However, the quality of the diet is influenced by several factors. The present study aimed to evaluate the quality of the diet of individuals with cardiovascular diseases and determine whether there is an association between sociodemographic and lifestyle factors. Methods: This is a cross-sectional study carried out with individuals with atherosclerosis (coronary artery disease, cerebrovascular disease or peripheral arterial disease) recruited from 35 reference centres for the treatment of cardiovascular disease in Brazil. Diet quality was assessed according to the Modified Alternative Healthy Eating Index (mAHEI) and stratified into tertiles. For comparing two groups, the Mann-Whitney or Pearson's chi-squared tests were used. However, for comparing three or more groups, analysis of variance or Kruskal-Wallis was used. For the confounding analysis, a multinomial regression model was used. p < 0.05 was considered statistically significant. Results: In total, 2360 individuals were evaluated: 58.5% male and 64.2% elderly. The median (interquartile range [IQR]) of the mAHEI was 24.0 (20.0-30.0), ranging from 0.4 to 56.0 points. When comparing the odds ratios (ORs) for the low (first tertile) and medium (second tertile) diet quality groups with the high-quality group (third tertile), it was observed that there was an association between diet quality with a family income of 1.885 (95% confidence intervals [CI] = 1.302-2.729) and 1.566 (95% CI = 1.097-2.235), as well as physical activity of 1.391 (95% CI = 1.107-1.749) and 1.346 (95% CI = 1.086-1.667), respectively. In addition, associations were observed between diet quality and region of residence. Conclusions: A low-quality diet was associated with family income, sedentarism and geographical area. These data are extremely relevant to assist in coping with cardiovascular disease because they enable an assessment of the distribution of these factors in different regions of the country.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Brazil ; Cross-Sectional Studies ; Diet ; Diet, Healthy
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645183-4
ISSN	1365-277X ; 0952-3871 ; 1465-8178
ISSN (online)	1365-277X
ISSN	0952-3871 ; 1465-8178
DOI	10.1111/jhn.13184
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Article: Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids

Caruso, Icaro Putinhon / dos Santos Almeida, Vitor / do Amaral, Mariana Juliani / de Andrade, Guilherme Caldas / de Araújo, Gabriela Rocha / de Araújo, Talita Stelling / de Azevedo, Jéssica Moreira / Barbosa, Glauce Moreno / Bartkevihi, Leonardo / Bezerra, Peter Reis / dos Santos Cabral, Katia Maria / de Lourenço, Isabella Otênio / Malizia-Motta, Clara L.F. / de Luna Marques, Aline / Mebus-Antunes, Nathane Cunha / Neves-Martins, Thais Cristtina / de Sá, Jéssica Maróstica / Sanches, Karoline / Santana-Silva, Marcos Caique /

Vasconcelos, Ariana Azevedo / da Silva Almeida, Marcius / de Amorim, Gisele Cardoso / Anobom, Cristiane Dinis / Da Poian, Andrea T. / Gomes-Neto, Francisco / Pinheiro, Anderson S. / Almeida, Fabio C.L.

International journal of biological macromolecules. 2022 Apr. 01, v. 203

2022

Abstract	The SARS-CoV-2 nucleocapsid protein (N) is a multifunctional promiscuous nucleic acid-binding protein, which plays a major role in nucleocapsid assembly and discontinuous RNA transcription, facilitating the template switch of transcriptional regulatory sequences (TRS). Here, we dissect the structural features of the N protein N-terminal domain (N-NTD) and N-NTD plus the SR-rich motif (N-NTD-SR) upon binding to single and double-stranded TRS DNA, as well as their activities for dsTRS melting and TRS-induced liquid-liquid phase separation (LLPS). Our study gives insights on the specificity for N-NTD(-SR) interaction with TRS. We observed an approximation of the triple-thymidine (TTT) motif of the TRS to β-sheet II, giving rise to an orientation difference of ~25° between dsTRS and non-specific sequence (dsNS). It led to a local unfavorable energetic contribution that might trigger the melting activity. The thermodynamic parameters of binding of ssTRSs and dsTRS suggested that the duplex dissociation of the dsTRS in the binding cleft is entropically favorable. We showed a preference for TRS in the formation of liquid condensates when compared to NS. Moreover, our results on DNA binding may serve as a starting point for the design of inhibitors, including aptamers, against N, a possible therapeutic target essential for the virus infectivity.
Keywords	DNA ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; dissociation ; liquids ; nucleocapsid ; nucleocapsid proteins ; oligonucleotides ; pathogenicity ; separation ; therapeutics ; thermodynamics ; transcription (genetics) ; viruses
Language	English
Dates of publication	2022-0401
Size	p. 466-480.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.01.121
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Article ; Online: Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology.

Arnone, Marcelo / Takahashi, Maria Denise Fonseca / Carvalho, André Vicente Esteves de / Bernardo, Wanderley Marques / Bressan, Aline Lopes / Ramos, Andrea Machado Coelho / Terena, Aripuanã Cobério / Souza, Cacilda da Silva / Nunes, Daniel Holthausen / Bortoletto, Maria Cecília de Carvalho / Oliveira, Maria de Fátima Santos Paim de / Neffá, Jane Marcy / Fieri, Luciana Cristina / Azulay-Abulafia, Luna / Felix, Paulo Antônio Oldani / Magalhaes, Renata Ferreira / Romiti, Ricardo / Jaime, Tatiana Jerez

Anais brasileiros de dermatologia

2019 Volume 94, Issue 2 Suppl 1, Page(s) 76–107

Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving ... ...

Abstract	Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Anthralin/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Brazil ; Calcineurin Inhibitors/therapeutic use ; Comorbidity ; Cyclosporine/therapeutic use ; Dermatologic Agents/therapeutic use ; Dermatology ; Drug Combinations ; Female ; Humans ; Male ; Methotrexate/therapeutic use ; Phototherapy/methods ; Psoriasis/diagnosis ; Psoriasis/epidemiology ; Psoriasis/therapy ; Severity of Illness Index ; Societies, Medical ; Time Factors ; Vitamin D/analysis
Chemical Substances	Adrenal Cortex Hormones ; Antibodies, Monoclonal ; Calcineurin Inhibitors ; Dermatologic Agents ; Drug Combinations ; Vitamin D (1406-16-2) ; Cyclosporine (83HN0GTJ6D) ; Anthralin (U8CJK0JH5M) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2019-06-30
Publishing country	Spain
Document type	Journal Article ; Practice Guideline
ZDB-ID	433655-0
ISSN	1806-4841 ; 0365-0596
ISSN (online)	1806-4841
ISSN	0365-0596
DOI	10.1590/abd1806-4841.2019940211
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Article ; Online: Assessment of psoriasis severity in Brazilian patients with chronic plaque psoriasis attending outpatient clinics: a multicenter, population-based cross-sectional study (APPISOT).

Romiti, Ricardo / Fabrício, Lincoln Helder Zambaldi / Souza, Cacilda da Silva / Galvão, Leticia Oba / de Castro, Caio Cesar Silva / Terena, Aripuanã Cobério / Carneiro, Francisca Regina Oliveira / Oyafuso, Luiza Keiko Matsuka / Carneiro, Sueli / Gontijo, Bernardo / Kobata, Clarice Marie / de Oliveira, Maria de Fátima Paim / Cestari, Tania / Antônio, João Roberto / Martins, Gladys Aires / Marques, Silvio Alencar / Chaibub, Sulamita Costa Wirth / Arruda, Ana Carolina Belini Bazán / Félix, Paulo Antonio Oldani /

Magalhães, Renata Ferreira / Abulafia, Luna Azulay / Ferreira, Karine A / Medeiros da Silva, Aline / Silva, Bruno Leonardo / Souza, Juliano

The Journal of dermatological treatment

2018 Volume 29, Issue 8, Page(s) 775–785

Abstract: Purpose: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further ... ...

Abstract	Purpose: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further objectives included evaluating potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life (HRQOL), and work productivity. Materials and methods: This observational (non-interventional) cross-sectional study was conducted in 26 dermatologic clinics across 11 Brazilian states. Psoriasis severity was assessed using investigator judgment and Finlay's Rule of Tens: a Psoriasis Area and Severity Index (PASI) score >10, a Body Surface Area (BSA) > 10%, or a Dermatology Life Quality Index (DLQI) score >10. Results: Among 1125 patients, 205 (18.2%) had moderate-to-severe disease. On multiple regression analyses, psoriasis severity was significantly (directly) associated with the presence of physical inactivity and comorbid pain, anxiety, and depression; and significantly (inversely) associated with HRQOL and work productivity. Limitations: Cross-sectional studies cannot assess temporal trends, and observational studies cannot conclusively determine causality or exclude biases and confounding due to unmeasured variables. Conclusions: Among Brazilian patients with moderate-to-severe psoriasis, disease severity had far-reaching adverse impacts on lifestyle, comorbidities, HRQOL, and work productivity.
MeSH term(s)	Adult ; Aged ; Ambulatory Care Facilities ; Brazil ; Cross-Sectional Studies ; Depression/etiology ; Female ; Humans ; Male ; Middle Aged ; Psoriasis/complications ; Psoriasis/pathology ; Psoriasis/psychology ; Quality of Life ; Regression Analysis ; Severity of Illness Index
Language	English
Publishing date	2018-06-17
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2018.1466023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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