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  1. Book: Radiology for PET/CT Reporting

    Nanni, Cristina / Golfieri, Rita / Zanoni, Lucia / Fanti, Stefano

    2022  

    Author's details Dr. Cristina Nanni is a Nuclear Medicine Physician who has been working at the PET Centre in Bologna, Italy, since 2007. She completed her residency in Nuclear Medicine at the University of Bologna (2004) and in Radiology in 2012. She worked in the field of pre-clinical PET imaging in 2005 and 2006, and is currently responsible for new radiotracer applications and the integration of morphological and functional imaging (PET/ceCT and PET/CT guided biopsy) into clinical practice. She is the author or co-author of more than 200 clinical and pre-clinical papers published in international journals, and of more than 200 abstracts presented at national and international congresses. Dr. Lucia Zanoni is a Nuclear Medicine Physician who has been working at the PET Centre in Bologna, Italy, since 2016. She completed her residency in Nuclear Medicine at the University of Bologna (2015). Chiefly active in the field of oncological PET/CT, she is the author or co-author of 30 clinical and pre-clin
    Keywords low dose CT ; contrast enhanced CT ; FDG-PET ; CT abnormalities ; Oncology ; ceCT ; PET/CT
    Language English
    Size 240 p.
    Edition 2
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_14
    Format 183 x 260 x 18
    ISBN 9783030876401 ; 3030876403
    Database PDA

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  2. Book: Radiology for PET, CT reporting

    Nanni, Cristina / Fanti, Stefano / Zanoni, Lucia

    2014  

    Author's details Cristina Nanni ; Stefano Fanti ; Lucia Zanoni
    Keywords Positronen-Emissions-Tomografie ; Computertomografie
    Subject Computertomographie ; CT ; Tomometrie ; Durchstrahlungscomputertomographie ; Durchstrahlungscomputertomografie ; Transmissionscomputertomographie ; Transmissionscomputertomografie ; Computerlaminographie ; Computerlaminografie ; CAT ; Computed axial tomography ; Computertomogramm ; Positronen-Emissions-Tomographie ; PET
    Language English
    Size VII, 149 S. : zahlr. Ill., 254 mm x 178 mm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018097963
    ISBN 978-3-642-40293-7 ; 3-642-40293-3 ; 9783642402944 ; 3642402941
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Radionuclide Theranostics in Neuroendocrine Neoplasms: An Update.

    Di Franco, Martina / Zanoni, Lucia / Fortunati, Emilia / Fanti, Stefano / Ambrosini, Valentina

    Current oncology reports

    2024  

    Abstract: Purpose of review: This paper aims to address the latest findings in neuroendocrine tumor (NET) theranostics, focusing on new evidence and future directions of combined diagnosis with positron emission tomography (PET) and treatment with peptide ... ...

    Abstract Purpose of review: This paper aims to address the latest findings in neuroendocrine tumor (NET) theranostics, focusing on new evidence and future directions of combined diagnosis with positron emission tomography (PET) and treatment with peptide receptor radionuclide therapy (PRRT).
    Recent findings: Following NETTER-1 trial, PRRT with [177Lu]Lu-DOTATATE was approved by FDA and EMA and is routinely employed in advanced G1 and G2 SST (somatostatin receptor)-expressing NET. Different approaches have been proposed so far to improve the PRRT therapeutic index, encompassing re-treatment protocols, combinations with other therapies and novel indications. Molecular imaging holds a potential added value in characterizing disease biology and heterogeneity using different radiopharmaceuticals (e.g., SST and FDG) and may provide predictive and prognostic parameters. Response assessment criteria are still an unmet need and new theranostic pairs showed preliminary encouraging results. PRRT for NET has become a paradigm of modern theranostics. PRRT holds a favorable toxicity profile, and it is associated with a prolonged time to progression, reduction of symptoms, and improved patients' quality of life. In light of further optimization, different new strategies have been investigated, along with the development of new radiopharmaceuticals.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-024-01526-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular imaging Theranostics of Neuroendocrine Tumors.

    Fortunati, Emilia / Bonazzi, Norma / Zanoni, Lucia / Fanti, Stefano / Ambrosini, Valentina

    Seminars in nuclear medicine

    2023  Volume 53, Issue 4, Page(s) 539–554

    Abstract: Neuroendocrine neoplasms (NEN) are rare and heterogeneous tumors, originating mostly from the gastro-entero-pancreatic (GEP) tract followed by the lungs. Multidisciplinary discussion is mandatory for optimal diagnostic and therapeutic management. Well- ... ...

    Abstract Neuroendocrine neoplasms (NEN) are rare and heterogeneous tumors, originating mostly from the gastro-entero-pancreatic (GEP) tract followed by the lungs. Multidisciplinary discussion is mandatory for optimal diagnostic and therapeutic management. Well-differentiated NEN (NET) present a high expression of somatostatin receptors (SSTR) and can be studied with [68Ga]-DOTA-peptides ([68Ga]Ga-DOTANOC, [68Ga]Ga-DOTATOC, [68Ga]Ga-DOTATATE) PET/CT to assess disease extension and the eligibility for peptide receptor radionuclide therapy (PRRT). SSTR-analogues labelled with 90Y or 177Lu have been used since mid-90s for NET therapy. PRRT is now considered an effective and safe treatment option for SSTR-expressing NET: following the approval of 177Lu-DOTATATE by FDA and EMA, PRRT is now part of the therapeutic algorithms of the main scientific societies. New strategies to improve PRRT efficacy and to reduce its toxicity are under evaluation (eg, personalization of treatment schemes, the selection of the most suitable patients, improvement of response assessment criteria, optimization of treatment sequencing, feasibility of PRRT-retreatment, combination of PRRT with other treatments options). Recently, several emerging radiopharmaceuticals showed encouraging results for both imaging and therapy (eg, SSTR-analogues labelled with 18F, SSTR-antagonists for both diagnosis and therapy, alpha-labelling for therapy, radiopharmaceuticals binding to new cellular targets). Aim of this review is to focus on current knowledge and to outline emerging perspectives for NEN's diagnosis and therapy.
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Yttrium Radioisotopes ; Radiopharmaceuticals/therapeutic use ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/radiotherapy ; Precision Medicine ; Molecular Imaging ; Receptors, Somatostatin/metabolism
    Chemical Substances Yttrium-90 (1K8M7UR6O1) ; Yttrium Radioisotopes ; Radiopharmaceuticals ; Receptors, Somatostatin
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Typification of Juniperus barbadensis L. and J. bermudiana L. and rediscovery of J. barbadensis from St. Lucia, BWI (Cupressaceae)

    Adams, R.P / Jarvis, C.E / Slane, V / Zanoni, T.A

    Taxon. May 1987. v. 36 (2)

    1987  

    Keywords Juniperus ; taxonomy ; neotypes ; Saint Lucia
    Language English
    Dates of publication 1987-05
    Size p. 441-445., ill.
    Document type Article
    ZDB-ID 204216-2
    ISSN 0040-0262
    ISSN 0040-0262
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A Peculiar 18 F-FDG Spinal Uptake Helps Diagnosis and Effective Treatment of Polymyalgia Rheumatica : "The Corset Sign".

    Lanzafame, Helena / Zanoni, Lucia / Allegri, Vincenzo / Mulè, Rita / Fanti, Stefano

    Clinical nuclear medicine

    2022  Volume 47, Issue 8, Page(s) e550–e551

    Abstract: Abstract: Polymyalgia rheumatica is the most common inflammatory rheumatic disease in elderly people, usually develops in patients older than 50 years, more frequently in females. An emerging imaging tool in the diagnostic workup of this condition is ... ...

    Abstract Abstract: Polymyalgia rheumatica is the most common inflammatory rheumatic disease in elderly people, usually develops in patients older than 50 years, more frequently in females. An emerging imaging tool in the diagnostic workup of this condition is whole-body PET/CT, which allows an overall assessment of the articular and extra-articular structures involved.
    MeSH term(s) Aged ; Female ; Fluorodeoxyglucose F18 ; Giant Cell Arteritis ; Humans ; Polymyalgia Rheumatica/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Actionable imaging findings in the daily PET/CT scenario.

    Mattana, Francesco / Zanoni, Lucia / Nanni, Cristina / Mosconi, Cristina / Brocchi, Stefano / Golfieri, Rita / Fanti, Stefano

    Clinical and translational imaging

    2023  Volume 11, Issue 2, Page(s) 127–139

    Abstract: Background and aim: The American College of Radiology (ACR) defines "actionable findings" the ones requiring a special communication between radiologists and referring clinicians, suggesting to organize their categorization in a three-degree scale on ... ...

    Abstract Background and aim: The American College of Radiology (ACR) defines "actionable findings" the ones requiring a special communication between radiologists and referring clinicians, suggesting to organize their categorization in a three-degree scale on the basis of the risk for the patient to develop complications. These cases may fall in a grey-zone communication between different care figures with the risk of being underestimated or even not being considered at all. In this paper, our aim is to adapt the ACR categorization to the most frequent actionable findings encountered when reporting PET/CT images in a Nuclear Medicine Department, describing the most frequent and relevant imaging features and presenting the modalities of communication and the related clinical interventions that can be modulated by the prognostic severity of the clinical cases.
    Materials and methods: We performed a descriptive, observational and critical analysis of the most relevant literature on the topic of "actionable findings", in particular, starting from the reports of the ACR Actionable Reporting Work Group, we categorised and described, in a narrative review, the most relevant "actionable findings" encountered in the Nuclear Medicine PET/CT daily practice.
    Results: To the best of our knowledge, to date there are no clear indications on this selective PET/CT topic, considering that the current recommendations target mainly radiologists and assume a certain level of radiological expertise. We resumed and classified the main imaging conditions under the term of "actionable findings" according to the corresponding anatomical districts, and we described their most relevant imaging features (independently of PET avidity or not). Furthermore, a different communication timing and strategy was suggested on the basis of the findings' urgency.
    Conclusion: A systematic categorization of the actionable imaging findings according to their prognostic severity may help the reporting physician to choose how and when to communicate with the referring clinician or to identify cases requiring a prompt clinical evaluation. Effective communication is a critical component of diagnostic imaging: timely receipt of the information is more important than the method of delivery.
    Language English
    Publishing date 2023-02-18
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2712000-4
    ISSN 2281-7565 ; 2281-5872
    ISSN (online) 2281-7565
    ISSN 2281-5872
    DOI 10.1007/s40336-023-00544-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms.

    Fortunati, Emilia / Argalia, Giulia / Zanoni, Lucia / Fanti, Stefano / Ambrosini, Valentina

    Current treatment options in oncology

    2022  Volume 23, Issue 5, Page(s) 703–720

    Abstract: Opinion statement: Neuroendocrine neoplasms (NEN) are a heterogeneous group of tumours derived from cells of neuroendocrine origin and can potentially arise everywhere in the human body. The diagnostic assessment of NEN can be performed using a variety ... ...

    Abstract Opinion statement: Neuroendocrine neoplasms (NEN) are a heterogeneous group of tumours derived from cells of neuroendocrine origin and can potentially arise everywhere in the human body. The diagnostic assessment of NEN can be performed using a variety of PET radiopharmaceuticals. Well-differentiated NEN (NET) present a high expression of SSTR (somatostatin receptors) and can therefore be studied with 68Ga-DOTA-peptides ([68Ga]Ga-DOTANOC, [68Ga]Ga-DOTATOC, [68Ga]Ga-DOTATATE). Current guidelines recommend the use of SSTR imaging to assess disease extension at staging/restaging, follow-up, assessment of response to therapy and selection of patients who may benefit from radionuclide therapy (PRRT). [18F]F-FDG is used for the assessment of high-grade tumours (high-grade G2, G3 and NEC) and in every case, there is one or more mismatched lesions between diagnostic CT (positive) and SSTR-PET/CT (negative). [18F]F-DOPA is currently used for the assessment of medullary thyroid carcinoma, neuroblastoma, primary pheochromocytoma and abdominal paraganglioma. In recent years, however, several new tracers were designed exploiting the many potential targets of the neuroendocrine cell and were employed in clinical trials for both imaging and therapy. Currently, the real-life clinical impact of these tracers is still mostly not known; however, the favourable biodistribution (e.g. [68Ga]Ga-FAPI, SSTR antagonists) and the possibility to use new theranostic pairs may provide novel diagnostic as well as therapeutic options (e.g. [68Ga]Ga-PSMA, [64Cu]Cu-SARTATE, [68Ga]Ga-CXCR4) for NEN patients.
    MeSH term(s) Copper Radioisotopes ; Humans ; Neuroendocrine Tumors/pathology ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radionuclide Imaging ; Radiopharmaceuticals/therapeutic use ; Receptors, Somatostatin/metabolism ; Tissue Distribution
    Chemical Substances Copper Radioisotopes ; Copper-64 ; Radiopharmaceuticals ; Receptors, Somatostatin ; copper dotatate CU-64
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-022-00967-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Case Report: Pulmonary Actinomyces Infection Mimics Lung Cancer on [

    Cuzzani, Giulia / Fortunati, Emilia / Zanoni, Lucia / Nanni, Cristina / Antonacci, Filippo / Giunchi, Francesca / Bandelli, Gian Piero / Brusa, Irene / Solli, Piergiorgio / Fanti, Stefano

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.267155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID-19: A systematic review and meta-analysis.

    Pontiroli, Antonio E / Scovenna, Francesco / Carlini, Valentina / Tagliabue, Elena / Martin-Delgado, Jimmy / La Sala, Lucia / Tanzi, Elisabetta / Zanoni, Ivan

    Journal of medical virology

    2024  Volume 96, Issue 1, Page(s) e29343

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has brought a huge burden in terms of human lives. Strict social distance and influenza vaccination have been recommended to avoid co-infections between influenza viruses ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has brought a huge burden in terms of human lives. Strict social distance and influenza vaccination have been recommended to avoid co-infections between influenza viruses and SARS-CoV-2. Scattered reports suggested a protective effect of influenza vaccine on COVID-19 development and severity. We analyzed 51 studies on the capacity of influenza vaccination to affect infection with SARS-CoV-2, hospitalization, admission to Intensive Care Units (ICU), and mortality. All subjects taken into consideration did not receive any anti-SARS-CoV-2 vaccine, although their status with respect to previous infections with SARS-CoV-2 is not known. Comparison between vaccinated and not-vaccinated subjects for each of the four endpoints was expressed as odds ratio (OR), with 95% confidence intervals (CIs); all analyses were performed by DerSimonian and Laird model, and Hartung-Knapp model when studies were less than 10. In a total of 61 029 936 subjects from 33 studies, influenza vaccination reduced frequency of SARS-CoV-2 infection [OR plus 95% CI = 0.70 (0.65-0.77)]. The effect was significant in all studies together, in health care workers and in the general population; distance from influenza vaccination and the type of vaccine were also of importance. In 98 174 subjects from 11 studies, frequency of ICU admission was reduced with influenza vaccination [OR (95% CI) = 0.71 (0.54-0.94)]; the effect was significant in all studies together, in pregnant women and in hospitalized subjects. In contrast, in 4 737 328 subjects from 14 studies hospitalization was not modified [OR (95% CI) = 1.05 (0.82-1.35)], and in 4 139 660 subjects from 19 studies, mortality was not modified [OR (95% CI) = 0.76 (0.26-2.20)]. Our study emphasizes the importance of influenza vaccination in the protection against SARS-CoV-2 infection.
    MeSH term(s) Female ; Humans ; Pregnancy ; COVID-19/epidemiology ; COVID-19/mortality ; Hospitalization ; Influenza Vaccines/administration & dosage ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; SARS-CoV-2 ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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