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  1. Article ; Online: Open peer commentary on "Prescribing anti-amyloid immunotherapies to treat Alzheimer's disease: Fully informing patient decisions".

    Gandy, Sam

    Alzheimer's & dementia (New York, N. Y.)

    2023  Volume 9, Issue 4, Page(s) e12437

    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832891-7
    ISSN 2352-8737 ; 2352-8737
    ISSN (online) 2352-8737
    ISSN 2352-8737
    DOI 10.1002/trc2.12437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer's disease in 2023.

    Gandy, Sam

    Molecular neurodegeneration

    2023  Volume 18, Issue 1, Page(s) 66

    MeSH term(s) Humans ; Alzheimer Disease ; Amyloidogenic Proteins
    Chemical Substances Amyloidogenic Proteins
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-023-00656-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer's Aβ oligomers.

    Gandy, Sam

    Trends in molecular medicine

    2023  Volume 29, Issue 7, Page(s) 487–488

    Abstract: Alcadeins are among the 90 known substrates for γ-secretase, the aspartyl proteinase complex that liberates the amyloid β (Aβ) peptide by intramembranous cleavage of the ß-carboxy terminal fragment of the Alzheimer's amyloid precursor protein (APP). A ... ...

    Abstract Alcadeins are among the 90 known substrates for γ-secretase, the aspartyl proteinase complex that liberates the amyloid β (Aβ) peptide by intramembranous cleavage of the ß-carboxy terminal fragment of the Alzheimer's amyloid precursor protein (APP). A new study by Hata et al. provides some surprising results regarding a potential role for alcadeins and their fragments in the prevention and/or treatment of the dementia of Alzheimer's disease (AD).
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Brain/metabolism
    Chemical Substances Amyloid beta-Peptides ; peptide P3 ; Amyloid beta-Protein Precursor ; Intercellular Signaling Peptides and Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.04.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
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  4. Article ; Online: A Letter Concerning "Aducanumab: What about the Patient?"

    Gandy, Sam

    Annals of neurology

    2022  Volume 91, Issue 5, Page(s) 732–733

    MeSH term(s) Alzheimer Disease ; Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans
    Chemical Substances Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; aducanumab (105J35OE21)
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26333
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    Zs.A 1370: Show issues Location:
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    Zs.MO 478: Show issues

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  5. Article ; Online: Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer's amyloidopathy.

    Gandy, Sam / Ehrlich, Michelle E

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 288

    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02954-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Moving the Needle on Alzheimer's Disease with an Anti-Oligomer Antibody.

    Gandy, Sam / Ehrlich, Michelle E

    The New England journal of medicine

    2023  Volume 388, Issue 1, Page(s) 80–81

    MeSH term(s) Humans ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/antagonists & inhibitors ; Antibodies, Monoclonal/therapeutic use ; Peptide Fragments/antagonists & inhibitors
    Chemical Substances Amyloid beta-Peptides ; Antibodies, Monoclonal ; Peptide Fragments
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2214981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer's amyloidopathy.

    Gandy, Sam / Ehrlich, Michelle E

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 214

    Abstract: Studies of microglial gene manipulation in mouse models of Alzheimer's disease (AD) amyloidopathy can cause unpredictable effects on various key endpoints, including amyloidosis, inflammation, neuritic dystrophy, neurodegeneration, and learning behavior. ...

    Abstract Studies of microglial gene manipulation in mouse models of Alzheimer's disease (AD) amyloidopathy can cause unpredictable effects on various key endpoints, including amyloidosis, inflammation, neuritic dystrophy, neurodegeneration, and learning behavior. In this Correspondence, we discuss three examples, microRNA 155 (miR155), TREM2, and INPP5D, in which observed results have been difficult to reconcile with predicted results based on precedent, because these six key endpoints do not reliably track together. The pathogenesis of AD involves multiple cell types and complex events that may change with disease stage. We propose that cell-type targeting and timing of intervention are responsible for the sometimes impossibility of predicting whether any prospective therapeutic intervention should aim at increasing or decreasing the level or activity of a particular molecular target.
    MeSH term(s) Animals ; Mice ; Alzheimer Disease/genetics ; Cell Movement ; Amyloidosis/genetics ; Disease Models, Animal ; MicroRNAs/genetics
    Chemical Substances Mirn155 microRNA, mouse ; MicroRNAs
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Letter
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02895-7
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  8. Article ; Online: The Golgi apparatus: Site for convergence of COVID-19 brain fog and Alzheimer's disease?

    Wang, Yanzhuang / Gandy, Sam

    Molecular neurodegeneration

    2022  Volume 17, Issue 1, Page(s) 67

    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; COVID-19 ; Golgi Apparatus ; Protein Transport ; Brain
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-022-00568-2
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  9. Article ; Online: Alzheimer mutant speeds APP transport.

    Gandy, Sam / Ehrlich, Michelle E

    The Journal of experimental medicine

    2021  Volume 218, Issue 6

    Abstract: APPS198P segregates with rare familial forms of Alzheimer's disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210313) show that the ... ...

    Abstract APPS198P segregates with rare familial forms of Alzheimer's disease and resides within exon 5, unlike 27 other mutations that reside in exons 16 or 17. In this issue, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210313) show that the brains of APPS198P transgenic mice accumulate excess levels of Aβ. In cultured cells, APPS198P undergoes accelerated ER folding, leading to early arrival in late vesicular compartments, thereby enhancing generation of Aβ.
    MeSH term(s) Alzheimer Disease/genetics ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Exons ; Mice ; Mice, Transgenic
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20210511
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    Ua VI Zs.107: Show issues Location:
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  10. Article ; Online: Seeding hope: restoring nature to restore ourselves. Nature restoration as an essential mental health intervention.

    Mellor, Catriona / Botchway, Stella / Barnes, Nicholas / Gandy, Sam

    International review of psychiatry (Abingdon, England)

    2022  Volume 34, Issue 5, Page(s) 541–545

    Abstract: This commentary offers stories of hope and regeneration in the face of the interconnected crises we face. Those of us in the health sector have the opportunity to undo the false separation that has arisen between the care we offer ourselves and the care ... ...

    Abstract This commentary offers stories of hope and regeneration in the face of the interconnected crises we face. Those of us in the health sector have the opportunity to undo the false separation that has arisen between the care we offer ourselves and the care we offer our natural spaces. Access to a healthy environment offers myriad health benefits and has been declared a human right. Beyond this, cultivating a sense of kinship with the natural world unlocks further mental health benefits and promotes a deep sense of meaning and vitality. Widespread restoration of nature, combined with the equitable reconnection of people to these restored environments, must become one of the most important aspects of public health in this century. This paper, written from a UK perspective, describes examples where people are already weaving these strands together and offers practical suggestions for healthcare professionals who want to know how this relates to their role and their everyday practice.
    MeSH term(s) Humans ; Mental Health ; Public Health
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018090-4
    ISSN 1369-1627 ; 0954-0261
    ISSN (online) 1369-1627
    ISSN 0954-0261
    DOI 10.1080/09540261.2022.2092391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2819: Show issues Location:
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