Result 1 - 10 of total 82
The immune system in motion
2022
| Keywords | Life Science |
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| Language | English |
| Publisher | Wageningen University & Research |
| Publishing country | nl |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2022
| Language | English |
|---|---|
| Publishing date | 2022-04-21 |
| Publishing country | England |
| Document type | News |
| ZDB-ID | 120714-3 |
| ISSN | 1476-4687 ; 0028-0836 |
| ISSN (online) | 1476-4687 |
| ISSN | 0028-0836 |
| DOI | 10.1038/d41586-022-01096-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 26: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MG 9: Show issues | ||||
| Zs.MO 244: Show issues |
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Open research Europe
2021 Volume 1, Page(s) 138
Abstract: We would like to share data from a survey run by the Young Academy of Europe (YAE) from June to October 2020, with questions aiming to unravel the situation of early-career researchers (including early stage group leaders) working in Europe, during the ... ...
| Abstract | We would like to share data from a survey run by the Young Academy of Europe (YAE) from June to October 2020, with questions aiming to unravel the situation of early-career researchers (including early stage group leaders) working in Europe, during the COVID-19 pandemic. We were particularly interested in the impact of care activities (related to young children or other family members), and the impact of gender. We include the online survey and collected data, without identifying information. The survey is published in |
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| Language | English |
| Publishing date | 2021-11-17 |
| Publishing country | Belgium |
| Document type | Journal Article |
| ISSN | 2732-5121 |
| ISSN (online) | 2732-5121 |
| DOI | 10.12688/openreseurope.13935.1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
BJR open
2023 Volume 5, Issue 1, Page(s) 20230019
Abstract: Magnetic resonance imaging (MRI) plays a significant role in the routine imaging workflow, providing both anatomical and functional information. 19F MRI is an evolving imaging modality where instead of 1H, 19F nuclei are excited. As the signal from ... ...
| Abstract | Magnetic resonance imaging (MRI) plays a significant role in the routine imaging workflow, providing both anatomical and functional information. 19F MRI is an evolving imaging modality where instead of 1H, 19F nuclei are excited. As the signal from endogenous 19F in the body is negligible, exogenous 19F signals obtained by 19F radiofrequency coils are exceptionally specific. Highly fluorinated agents targeting particular biological processes ( |
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| Language | English |
| Publishing date | 2023-09-29 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ISSN | 2513-9878 |
| ISSN (online) | 2513-9878 |
| DOI | 10.1259/bjro.20230019 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 24, Issue 1, Page(s) 71–81
Abstract: Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in : Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in : Results: All three strategies result in ... ...
| Abstract | Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in Results: All three strategies result in complete ISO signal avoidance (p < 0.0001 for all methods). Using a narrow acquisition bandwidth can result in loss of signal to noise ratio and distortion of the image, and a frequency-selective suppression pulse can be incomplete when B Conclusion: We optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms and in vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful. |
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| MeSH term(s) | Artifacts ; Contrast Media/chemistry ; Isoflurane ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Reproducibility of Results |
| Chemical Substances | Contrast Media ; Isoflurane (CYS9AKD70P) |
| Language | English |
| Publishing date | 2021-10-20 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2079160-4 |
| ISSN | 1860-2002 ; 1536-1632 |
| ISSN (online) | 1860-2002 |
| ISSN | 1536-1632 |
| DOI | 10.1007/s11307-021-01653-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6468: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 15, Issue 44, Page(s) 18068–18079
Abstract: ... ...
| Abstract | 19 |
|---|---|
| MeSH term(s) | Gadolinium/chemistry ; Contrast Media/pharmacology ; Contrast Media/chemistry ; Protons ; Magnetic Resonance Imaging/methods ; Fluorocarbon Polymers ; Chelating Agents/pharmacology ; Fluorocarbons/chemistry ; Nanoparticles/chemistry |
| Chemical Substances | Gadolinium (AU0V1LM3JT) ; Contrast Media ; Protons ; Fluorocarbon Polymers ; Chelating Agents ; Fluorocarbons |
| Language | English |
| Publishing date | 2023-11-16 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2515664-0 |
| ISSN | 2040-3372 ; 2040-3364 |
| ISSN (online) | 2040-3372 |
| ISSN | 2040-3364 |
| DOI | 10.1039/d3nr04577c |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Open Research Europe
2021 Volume 1
Abstract: We would like to share data from a survey run by the Young Academy of Europe (YAE) from June to October 2020, with questions aiming to unravel the situation of early-career researchers (including early stage group leaders) working in Europe, during the ... ...
| Abstract | We would like to share data from a survey run by the Young Academy of Europe (YAE) from June to October 2020, with questions aiming to unravel the situation of early-career researchers (including early stage group leaders) working in Europe, during the COVID-19 pandemic. We were particularly interested in the impact of care activities (related to young children or other family members), and the impact of gender. We include the online survey and collected data, without identifying information. The survey is published in Nature Career Column (July, 2021) ( https://www.nature.com/articles/d41586-021-01952-6). |
|---|---|
| Keywords | Pandemic ; Researchers ; Survey ; Young academy |
| Language | English |
| Publishing country | nl |
| Document type | Article ; Online |
| ISSN | 2732-5121 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2022 Volume 24, Issue 1
Abstract: Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in 19F MRI of fluorine contrast agents, as ISO signals cause artifacts that interfere with unambiguous image interpretation and quantification; the ... ...
| Abstract | Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in 19F MRI of fluorine contrast agents, as ISO signals cause artifacts that interfere with unambiguous image interpretation and quantification; the two most attractive properties of heteronuclear MRI. We aimed to avoid these artifacts using MRI strategies that can be applied by any pre-clinical researcher. Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in 19F MRI are described and demonstrated with measurements of 19F-containing agents in phantoms and in vivo (n = 3 for all strategies). The success of these strategies is compared to a standard Rapid Acquisition with Relaxation Enhancement (RARE) sequence, with phantom and in vivo validation. ISO artifacts can successfully be avoided by (1) shifting them outside the region of interest using a narrow signal acquisition bandwidth, (2) suppression of ISO by planning a frequency-selective suppression pulse before signal acquisition or by (3) preventing ISO excitation with a 3D sequence with a narrow excitation bandwidth. Results: All three strategies result in complete ISO signal avoidance (p < 0.0001 for all methods). Using a narrow acquisition bandwidth can result in loss of signal to noise ratio and distortion of the image, and a frequency-selective suppression pulse can be incomplete when B1-inhomogeneities are present. Preventing ISO excitation with a narrow excitation pulse in a 3D sequence yields the most robust results (relative SNR 151 ± 28% compared to 2D multislice methods, p = 0.006). Conclusion: We optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms and in vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful. |
|---|---|
| Keywords | Anesthesia ; Artifacts ; Chemical shift ; Fluorine-19 Magnetic Resonance Imaging ; Imaging ; Isoflurane |
| Subject code | 610 |
| Language | English |
| Publishing country | nl |
| Document type | Article ; Online |
| ZDB-ID | 2079160-4 |
| ISSN | 1860-2002 ; 1536-1632 |
| ISSN (online) | 1860-2002 |
| ISSN | 1536-1632 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
| Zs.A 6468: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2021 Volume 8, Issue 11, Page(s) e2100067
Abstract: Spraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million-ton scale. A sustainable alternative is target-specific, on-demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier ... ...
| Abstract | Spraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million-ton scale. A sustainable alternative is target-specific, on-demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier dispersions can overcome the biological size barriers of roots and leaves and allow distributing the nanocarriers through the plant. To date, the fate of polymeric nanocarriers inside a plant is widely unknown. Here, the in planta conditions in grapevine plants are simulated and the colloidal stability of a systematic series of nanocarriers composed of polystyrene (well-defined model) and biodegradable lignin and polylactic-co-glycolic acid by a combination of different techniques is studied. Despite the adsorption of carbohydrates and other biomolecules onto the nanocarriers' surface, they remain colloidally stable after incubation in biological fluids (wood sap), suggesting a potential transport via the xylem. The transport is tracked by fluorine- and ruthenium-labeled nanocarriers inside of grapevines by |
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| MeSH term(s) | Agrochemicals/chemistry ; Agrochemicals/pharmacology ; Colloids/chemistry ; Crop Protection ; Drug Carriers/chemistry ; Drug Carriers/pharmacology ; Drug Delivery Systems ; Fertilizers/adverse effects ; Humans ; Lignin ; Nanoparticles/chemistry ; Nanostructures ; Pesticides/adverse effects ; Pesticides/chemistry ; Plants/drug effects ; Polymers/chemistry ; Polymers/pharmacology |
| Chemical Substances | Agrochemicals ; Colloids ; Drug Carriers ; Fertilizers ; Pesticides ; Polymers ; Lignin (9005-53-2) |
| Language | English |
| Publishing date | 2021-03-19 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2808093-2 |
| ISSN | 2198-3844 ; 2198-3844 |
| ISSN (online) | 2198-3844 |
| ISSN | 2198-3844 |
| DOI | 10.1002/advs.202100067 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2019 Volume 32, Issue 1, Page(s) 1–3
| MeSH term(s) | Biomedical Research/trends ; Capsules ; Contrast Media/chemistry ; Fluorine/chemistry ; Fluorine-19 Magnetic Resonance Imaging ; Humans ; Image Enhancement ; Magnetic Fields ; Translational Medical Research/trends |
|---|---|
| Chemical Substances | Capsules ; Contrast Media ; Fluorine (284SYP0193) |
| Language | English |
| Publishing date | 2019-02-07 |
| Publishing country | Germany |
| Document type | Editorial ; Introductory Journal Article |
| ZDB-ID | 1160826-2 |
| ISSN | 1352-8661 ; 0968-5243 |
| ISSN (online) | 1352-8661 |
| ISSN | 0968-5243 |
| DOI | 10.1007/s10334-019-00741-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3788: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.