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  1. Article ; Online: Rheumatic and other musculoskeletal manifestations and autoantibodies in childhood and adolescent leprosy: significance and relevance.

    Chopra, Arvind

    Jornal de pediatria

    2014  Volume 90, Issue 5, Page(s) 431–436

    MeSH term(s) Adolescent ; Autoantibodies/immunology ; Brazil ; Child ; Humans ; India ; Leprosy/complications ; Leprosy/immunology ; Musculoskeletal Diseases/etiology ; Musculoskeletal Diseases/immunology ; Rheumatic Diseases/etiology ; Rheumatic Diseases/immunology
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2014-06-25
    Publishing country Brazil
    Document type Editorial ; Review
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2014.06.003
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    Zs.B 1265: Show issues Location:
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  2. Article ; Online: The COPCORD world of musculoskeletal pain and arthritis.

    Chopra, Arvind

    Rheumatology (Oxford, England)

    2013  Volume 52, Issue 11, Page(s) 1925–1928

    MeSH term(s) Arthritis/epidemiology ; Developing Countries ; Health Surveys ; Humans ; Musculoskeletal Pain/epidemiology ; Prevalence
    Language English
    Publishing date 2013-11
    Publishing country England
    Document type Editorial
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/ket222
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  3. Article: The Long-Term Effects of Short-Period Adalimumab Biosimilar Usage in Ankylosing Spondylitis.

    Chopra, Arvind / Khadke, Nagnath / Saluja, Manjit / Kianifard, Toktam / Venugopalan, Anuradha / Gharia, Mihir

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36444

    Abstract: Background Cost and drug toxicity frequently deter the long-term use of anti-tumor necrosis factor (TNF) agents in ankylosing spondylitis (AS). Therefore, this study was conducted to observe long-term relief after the short-term administration of an anti- ...

    Abstract Background Cost and drug toxicity frequently deter the long-term use of anti-tumor necrosis factor (TNF) agents in ankylosing spondylitis (AS). Therefore, this study was conducted to observe long-term relief after the short-term administration of an anti-TNF agent. Methodology A one-year, prospective, interventional, uncontrolled, single-center trial was conducted. There were 50 patients with symptomatic active chronic AS who received rheumatology therapy and were anti-TNF naive. Every two weeks, 40 mg of standard biosimilar adalimumab (Bs-ADA, Exemptia™) was administered subcutaneously for six injections (10 weeks) or to continue with standard follow-up if they did not achieve an Assessment in Ankylosing Spondylitis Response Criteria (ASAS 20) index response by week 12. Standard indicators (Assessment Spondyloarthritis International Society/ASAS and Bath) were used to evaluate progress. In addition, TNF-alpha, interleukin (IL)-6, and IL-17 were tested using a commercially available enzyme-linked immunosorbent assay kit from Bio Legend (Bengaluru, India). Results Patients experienced early and significant improvement in pain, non-steroidal anti-inflammatory drugs (NSAIDs) requirement, function, and several indices (ASAS 20 and 40, ASAS partial remission, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Ankylosing Spondylitis Disease Activity Score) after discontinuing injections. At weeks 12 and 48, 84% and 52% of patients showed ASAS 20 improvement, with 34% and 24% showing ASAS partial remission. Over half of the patients continued to improve and provided proof of concept. Conclusions In difficult-to-treat AS, a 10-week course of biosimilar adalimumab demonstrated significant early improvement that often lasted for 24 weeks. This unconventional method proved to be economically appealing. It merits further confirmation and acceptance, especially in resource-constrained contexts.
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36444
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  4. Article ; Online: Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis.

    Chopra, Arvind / Srikanth, Narayanam / Patwardhan, Bhushan

    Complementary therapies in medicine

    2021  Volume 62, Page(s) 102768

    Abstract: Objectives: To study the efficacy and safety of Withania somnifera (WS, Ashwagandha) in the prophylaxis against COVID-19 in high risk health care workers (HCW) in comparison to hydroxychloroquine (HCQ). To evaluate the general physical and mental health ...

    Abstract Objectives: To study the efficacy and safety of Withania somnifera (WS, Ashwagandha) in the prophylaxis against COVID-19 in high risk health care workers (HCW) in comparison to hydroxychloroquine (HCQ). To evaluate the general physical and mental health benefits of Ashwagandha.
    Methods: A 16 week randomized prospective, open-label, parallel efficacy, two arm, multi-centre study. The primary efficacy measure was 'failure of prophylaxis' as confirmed COVID-19 by quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) at any time during the study period. This study on 400 participants from three centres was designed to establish non-inferiority for WS to HCQ for prophylaxis against COVID-19 at 80 % power and significance p < 0.025, one-sided. The interim analysis was carried out on 160 participants after completion of 8 weeks.
    Results: Participants in both the arms were well-matched at the baseline characteristics. Forty participants in the HCQ group and 26 participants in the WS group reported mild AE. The symptoms of confirmed COVID-19 were found to be 3.7 % (95 % CI 1.3-10.5 %) in the HCQ and 1.3 % (95 % CI 0.02-6.7 %) in the WS arm amongst the first 160 participants completing 8 weeks.
    Conclusion: Our intent was to explore a safer option to HCQ. We report that WS was not found inferior to HCQ and its efficacy was within the 15 % non-inferiority margin set a priori. WS as an immunomodulator has other clinical benefits including reducing mental stress. The final report of this study is expected by end of August 2021.
    MeSH term(s) Adult ; COVID-19/prevention & control ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Withania/adverse effects
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-08-18
    Publishing country Scotland
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1155895-7
    ISSN 1873-6963 ; 0965-2299
    ISSN (online) 1873-6963
    ISSN 0965-2299
    DOI 10.1016/j.ctim.2021.102768
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    Zs.A 3726: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Public Health Approach of Ayurveda and Yoga for COVID-19 Prophylaxis.

    Tillu, Girish / Chaturvedi, Sarika / Chopra, Arvind / Patwardhan, Bhushan

    Journal of alternative and complementary medicine (New York, N.Y.)

    2020  Volume 26, Issue 5, Page(s) 360–364

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Medicine, Ayurvedic ; Meditation ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Yoga
    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237383-7
    ISSN 1557-7708 ; 1075-5535
    ISSN (online) 1557-7708
    ISSN 1075-5535
    DOI 10.1089/acm.2020.0129
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    Zs.A 4366: Show issues Location:
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  6. Article: When treating rheumatoid arthritis be vigilant for influenza (& pneumonia): Don't ignore, don't neglect.

    Chopra, Arvind / Joshi, Vaijayanti Lagoo

    The Indian journal of medical research

    2017  Volume 145, Issue 4, Page(s) 420–423

    Language English
    Publishing date 2017
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_62_17
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    Ua VI Zs.143: Show issues Location:
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  7. Article ; Online: The WHO ILAR COPCORD Latin America: consistent with the world and setting a new perspective.

    Chopra, Arvind

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2012  Volume 18, Issue 4, Page(s) 167–169

    MeSH term(s) Ethnic Groups/statistics & numerical data ; Female ; Humans ; Male ; Rheumatic Diseases/ethnology ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e31825d929b
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    Zs.A 4815: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Clinical Profile of Primary Sjogren's Syndrome with Hypokalemic Periodic Paralysis.

    Kulkarni, Nachiket / Chopra, Arvind

    The Journal of the Association of Physicians of India

    2018  Volume 66, Issue 5, Page(s) 69–70

    Abstract: Introduction: Primary Sjogren's Syndrome (pSS) with Hypokalemic Periodic Paralysis(HPP) whether an association or a different clinical subset needs review.: Methods: Cross-sectional retrospective study of subjects of Primary Sjogren's Syndrome with ... ...

    Abstract Introduction: Primary Sjogren's Syndrome (pSS) with Hypokalemic Periodic Paralysis(HPP) whether an association or a different clinical subset needs review.
    Methods: Cross-sectional retrospective study of subjects of Primary Sjogren's Syndrome with Hypokalemic Periodic Paralysis(HPP) identified from database maintained at Centre For Rheumatic Diseases, Pune since 1996 with records of over 50000 patients. The diagnosis was clinical. Clinical and investigations data was extracted pertaining to initial examination and follow up. Standard investigations & ELISA, immunoblot and nephelometry to assay autoantibodies (AAb) were done.
    Results: 16 patients of Primary Sjogren's Syndrome (pSS) with Hypokalemic Periodic Paralysis (HPP) were identified in the period 2000-2014. Presenting feature was HPP in 86% with Dry eye (4%) and Arthralgias (10%) in remaining. Distal Renal Tubular Acidosis was identified in all. All were females with average age of 26 years. Symptomatic ocular sicca noted in 60% & Oral sicca in 50% patients. Other features - Arthralgias (91%), arthritis (42%), mucositis (38%), Neuropathy (30%), skin rash (20%) cytopenias (19%), Erosive arthritis (10%), interstitial lung disease (10%) and Raynaud Phenomenon (10%). 100% were positive for ANA. SSA was positive in 100%, SSB in 50% of patients & Rheumatoid Factor in 70 %. Hypothyroidism was associated in 70% patients.
    Conclusion: We present a large series of Primary Sjogren's Syndrome with Hypokalemic Periodic Paralysis(HPP) from India. Prominent features of female dominance, younger age of onset and SSA positivity noted in this cohort of patients on Routine clinical and serology phenotype suggests existence of a distinct subset. HPP was presenting feature in majority.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Female ; Humans ; Hypokalemic Periodic Paralysis ; India ; Retrospective Studies ; Sjogren's Syndrome
    Language English
    Publishing date 2018-11-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
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  9. Article ; Online: A perspective from India on the 2010 rheumatoid arthritis classification criteria: comment on the article by Aletaha et al.

    Chopra, Arvind

    Arthritis and rheumatism

    2011  Volume 63, Issue 2, Page(s) 570; author reply 570–1

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/classification ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Early Diagnosis ; Humans ; Metatarsophalangeal Joint/pathology ; Rheumatology/methods ; Rheumatology/trends ; Synovitis/complications ; Synovitis/pathology ; Time Factors
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2011-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.30168
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    Zs.MO 523: Show issues

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  10. Article ; Online: In the absence of specific advice, what do patients eat and avoid? Results from a community based diet study in patients suffering from rheumatoid arthritis (RA) with a focus on potassium.

    Kianifard, Toktam / Chopra, Arvind

    Clinical nutrition ESPEN

    2018  Volume 28, Page(s) 214–221

    Abstract: Rheumatoid arthritis (RA) is a painful disabling difficult to treat disease. Clinicians and guidelines invariably focus on drugs. Diet is important but lacks robust data. We carried out a comprehensive analytical study in Indian (Asian) patients.: ... ...

    Abstract Rheumatoid arthritis (RA) is a painful disabling difficult to treat disease. Clinicians and guidelines invariably focus on drugs. Diet is important but lacks robust data. We carried out a comprehensive analytical study in Indian (Asian) patients.
    Methods: 141 consenting symptomatic chronic RA patients [mean age 46 years) center and 165 unrelated healthy control subjects (mean age 36 years) completed a a-priori validated food frequency questionnaire in a cross-sectional non-random design study under the supervision of a nutritionist. All patients were under standard rheumatology care. A 3 day retrospective recall record captured dietary data for all subjects. National Indian guidelines were adopted for diet analytics. Standard statistical analysis was carried out; significant p < 0.05.
    Results: Daily diet was found to be significantly deficient in calories and consumption of proteins, calcium and potassium when compared to healthy subjects. It was also inadequate for several nutrients when compacted to recommended daily allowance. The proportion of carbohydrates (65%), proteins (15%) and fat (25%) in daily diet was consistent with Indian standards (healthy). Women patients reported higher deficiency. 44% patients consumed vegetarian diet and showed lesser pain and better function compared to non-vegetarians (not significant). 44% patients reported dietary restriction; higher swollen joint counts in patients following any dietary restriction (p = 0.01) or Ayurveda (ancient Indian medicinal system) advise (p = 0.01) or consuming night shade vegetables (p = 0.002).
    Conclusion: Dietary inadequacy and in particular for protein and potassium was identified in patients of RA. Any form of dietary restriction did not seem to improve RA. Specific dietary needs of RA patients and in particular impact of potassium deficiency needs further research.
    MeSH term(s) Adult ; Arthritis, Rheumatoid/diet therapy ; Arthritis, Rheumatoid/ethnology ; Asian Continental Ancestry Group ; Case-Control Studies ; Cross-Sectional Studies ; Diet Records ; Energy Intake ; Female ; Humans ; India ; Male ; Middle Aged ; Potassium/administration & dosage
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2018.07.008
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