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Article: Prognosis of Implants with Implant-Supported Fixed Dental Prostheses in the Elderly Population: A Retrospective Study with a 5- to 10-Year Follow-Up.

Takahashi, Tomoyo / Kihara, Masafumi / Oki, Kyosuke / Matsuzaki, Tatsuya / Ayukawa, Yasunori / Matsushita, Yasuyuki / Koyano, Kiyoshi

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 7

Abstract: This retrospective study aimed to investigate the survival rate of implants from 5 to 10 years after the placement of implant-supported fixed dental prostheses (ISFDPs) and the management of implant loss in the elderly population. Elderly patients (≥65 ... ...

Abstract	This retrospective study aimed to investigate the survival rate of implants from 5 to 10 years after the placement of implant-supported fixed dental prostheses (ISFDPs) and the management of implant loss in the elderly population. Elderly patients (≥65 years old) who had been treated with ISFDPs and followed up with for at least 5 years between October 2009 and March 2020 were enrolled. Patient profiles and implant-related data were extracted. The survival rate of implants up to 5 years as well as the 10-year cumulative survival rate were evaluated. The management of implant loss and prosthetic interventions were also investigated. In total, 195 patients (mean age: 70.1 ± 4.5 years old) and 687 implants (287 ISFDPs) were assessed. The 5-year survival rate was 99.0% and the 10-year cumulative survival rate was 98.1%. Seven of the eleven implants lost were lost due to peri-implantitis. Only three implants in two patients were placed after the loss of the implants; most were restored using non-invasive procedures. Two patients underwent a conversion from ISFDPs to removable prostheses. This study showed that high survival rates were observed in an elderly population with ISFDPs and that non-invasive procedures were often applied after the loss of an implant.
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10071250
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Article ; Online: Osteosarcoma of the bladder: a case report.

Oka, Toshiki / Matsuzaki, Kyosuke / Izumi, Haruka / Nonomura, Daichi / Mori, Kiyoshi / Nishimura, Kensaku

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 118

Abstract: Background: Osteosarcoma arising from the bladder is extremely rare, with only 38 cases reported to our knowledge. It is often detected owing to hematuria, and is treated by surgery (for example, total cystectomy), radiation therapy, and chemotherapy; ... ...

Abstract	Background: Osteosarcoma arising from the bladder is extremely rare, with only 38 cases reported to our knowledge. It is often detected owing to hematuria, and is treated by surgery (for example, total cystectomy), radiation therapy, and chemotherapy; however, the prognosis is extremely poor. Case presentation: An 83-year-old Japanese man underwent cystoscopy for postoperative follow-up of urothelial carcinoma of the bladder, which revealed a 2-cm nodular tumor on the right wall. He had a history of abdominal aortic aneurysm and hypertension, and had been smoking 15 cigarettes per day for 45 years. Seven years previously, the patient underwent transurethral resection of bladder tumor for a 5-cm tumor on the right wall of the bladder. The histopathological diagnosis was urothelial carcinoma. No recurrence had been detected since then. Transurethral resection of bladder tumor was performed, and the histopathological diagnosis was cystosarcoma. Because of his advanced age, we decided that it would be difficult to perform total cystectomy. We therefore performed a second transurethral resection of bladder tumor and found no residual tumor. At 29 months after surgery, the patient remains alive without recurrence. Conclusion: Bladder osteosarcoma has a poor prognosis. However, our case was detected early, and treatment with transurethral resection of bladder tumor alone resulted in long-term survival without recurrence.
MeSH term(s)	Aged, 80 and over ; Bone Neoplasms ; Carcinoma, Transitional Cell ; Humans ; Male ; Osteosarcoma/diagnosis ; Osteosarcoma/surgery ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2022-03-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03346-2
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Article ; Online: Osteosarcoma of the bladder

Toshiki Oka / Kyosuke Matsuzaki / Haruka Izumi / Daichi Nonomura / Kiyoshi Mori / Kensaku Nishimura

Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-

a case report

2022 Volume 5

Abstract: Abstract Background Osteosarcoma arising from the bladder is extremely rare, with only 38 cases reported to our knowledge. It is often detected owing to hematuria, and is treated by surgery (for example, total cystectomy), radiation therapy, and ... ...

Abstract	Abstract Background Osteosarcoma arising from the bladder is extremely rare, with only 38 cases reported to our knowledge. It is often detected owing to hematuria, and is treated by surgery (for example, total cystectomy), radiation therapy, and chemotherapy; however, the prognosis is extremely poor. Case presentation An 83-year-old Japanese man underwent cystoscopy for postoperative follow-up of urothelial carcinoma of the bladder, which revealed a 2-cm nodular tumor on the right wall. He had a history of abdominal aortic aneurysm and hypertension, and had been smoking 15 cigarettes per day for 45 years. Seven years previously, the patient underwent transurethral resection of bladder tumor for a 5-cm tumor on the right wall of the bladder. The histopathological diagnosis was urothelial carcinoma. No recurrence had been detected since then. Transurethral resection of bladder tumor was performed, and the histopathological diagnosis was cystosarcoma. Because of his advanced age, we decided that it would be difficult to perform total cystectomy. We therefore performed a second transurethral resection of bladder tumor and found no residual tumor. At 29 months after surgery, the patient remains alive without recurrence. Conclusion Bladder osteosarcoma has a poor prognosis. However, our case was detected early, and treatment with transurethral resection of bladder tumor alone resulted in long-term survival without recurrence.
Keywords	Bladder ; Osteosarcoma ; TURBT ; Extraskeletal osteosarcoma ; Case report ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Prognosis of Implants with Implant-Supported Fixed Dental Prostheses in the Elderly Population

Tomoyo Takahashi / Masafumi Kihara / Kyosuke Oki / Tatsuya Matsuzaki / Yasunori Ayukawa / Yasuyuki Matsushita / Kiyoshi Koyano

Healthcare, Vol 10, Iss 7, p

A Retrospective Study with a 5- to 10-Year Follow-Up

2022 Volume 1250

Abstract	This retrospective study aimed to investigate the survival rate of implants from 5 to 10 years after the placement of implant-supported fixed dental prostheses (ISFDPs) and the management of implant loss in the elderly population. Elderly patients (≥65 years old) who had been treated with ISFDPs and followed up with for at least 5 years between October 2009 and March 2020 were enrolled. Patient profiles and implant-related data were extracted. The survival rate of implants up to 5 years as well as the 10-year cumulative survival rate were evaluated. The management of implant loss and prosthetic interventions were also investigated. In total, 195 patients (mean age: 70.1 ± 4.5 years old) and 687 implants (287 ISFDPs) were assessed. The 5-year survival rate was 99.0% and the 10-year cumulative survival rate was 98.1%. Seven of the eleven implants lost were lost due to peri-implantitis. Only three implants in two patients were placed after the loss of the implants; most were restored using non-invasive procedures. Two patients underwent a conversion from ISFDPs to removable prostheses. This study showed that high survival rates were observed in an elderly population with ISFDPs and that non-invasive procedures were often applied after the loss of an implant.
Keywords	elderly population ; implant-supported fixed dental prostheses (ISFDPs) ; prosthetic intervention ; survival rate ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Primary Pulmonary Cryptococcosis Mimicking Lung Metastases of Bladder Cancer : A Case Report].

Yamamoto, Tetsuya / Matsuzaki, Kyosuke / Katayama, Kinzo / Tei, Norihide / Nishimura, Kensaku

Hinyokika kiyo. Acta urologica Japonica

2020 Volume 66, Issue 11, Page(s) 393–395

Abstract: A 70-year-old woman was diagnosed with bladder cancer (muscle invasive adenocarcinoma) via transurethral resection of bladder tumor in 2013. A month after the procedure, she underwent total cystectomy and ileal conduit diversion. Histopathological ... ...

Abstract	A 70-year-old woman was diagnosed with bladder cancer (muscle invasive adenocarcinoma) via transurethral resection of bladder tumor in 2013. A month after the procedure, she underwent total cystectomy and ileal conduit diversion. Histopathological diagnosis was adenocarcinoma pTis pN0. In 2019, a computed tomography showed multiple nodules, each up to 1 cm in diameter, mainly in the right lower lobe. Metastatic lung cancer was suspected. She underwent thorascopic partial resection of the right lung, and was diagnosed with primary pulmonary cryptococcosis.
MeSH term(s)	Aged ; Cryptococcosis ; Cystectomy ; Female ; Humans ; Lung Neoplasms ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion
Language	Japanese
Publishing date	2020-12-03
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604331-8
ISSN	0018-1994
ISSN	0018-1994
DOI	10.14989/ActaUrolJap_66_11_393
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Article ; Online: Response to Editorial Comment to Is it necessary to carry out intraoperative retrograde upper urinary tract cytology examination in bladder cancer patients with normal upper urinary tract appearance and suspicious or positive voided urine cytology?

Fujita, Kazutoshi / Matsuzaki, Kyosuke

International journal of urology : official journal of the Japanese Urological Association

2016 Volume 23, Issue 7, Page(s) 625–626

MeSH term(s)	Carcinoma, Transitional Cell ; Cytodiagnosis ; Humans ; Sensitivity and Specificity ; Urinary Bladder Neoplasms ; Urine
Language	English
Publishing date	2016-05-30
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13132
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Article ; Online: EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis.

Nanba, Daisuke / Toki, Fujio / Asakawa, Kyosuke / Matsumura, Hiroyuki / Shiraishi, Ken / Sayama, Koji / Matsuzaki, Kyoichi / Toki, Hiroshi / Nishimura, Emi K

The Journal of cell biology

2021 Volume 220, Issue 11

Abstract: Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth factor receptor (EGFR) signaling and type XVII collagen (COL17A1) proteolysis on age- ... ...

Abstract	Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth factor receptor (EGFR) signaling and type XVII collagen (COL17A1) proteolysis on age-associated alteration of keratinocyte stem cell dynamics in skin regeneration. Live-imaging and computer simulation experiments predicted that human keratinocyte stem cell motility is coupled with self-renewal and epidermal regeneration. Receptor tyrosine kinase array identified the age-associated decline of EGFR signaling in mouse skin wound healing. Culture experiments proved that EGFR activation drives human keratinocyte stem cell motility with increase of COL17A1 by inhibiting its proteolysis through the secretion of tissue inhibitor of metalloproteinases 1 (TIMP1). Intriguingly, COL17A1 directly regulated keratinocyte stem cell motility and collective cell migration by coordinating actin and keratin filament networks. We conclude that EGFR-COL17A1 axis-mediated keratinocyte stem cell motility drives epidermal regeneration, which provides a novel therapeutic approach for age-associated impaired skin regeneration.
MeSH term(s)	3T3 Cells ; Animals ; Autoantigens/metabolism ; Cell Line ; Cell Movement/physiology ; Epidermal Cells/metabolism ; Epidermal Growth Factor/metabolism ; ErbB Receptors/metabolism ; Hair Follicle/metabolism ; Humans ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Non-Fibrillar Collagens/metabolism ; Proteolysis ; Regeneration/physiology ; Signal Transduction/physiology ; Skin/metabolism ; Stem Cells/metabolism ; Wound Healing/physiology ; Collagen Type XVII
Chemical Substances	Autoantigens ; Non-Fibrillar Collagens ; Epidermal Growth Factor (62229-50-9) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2021-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202012073
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Article ; Online: Universal HPLC Detector for Hydrophilic Organic Compounds by Means of Total Organic Carbon Detection.

Ohira, Shin-Ichi / Kaneda, Kyosuke / Matsuzaki, Toru / Mori, Shuta / Mori, Masanobu / Toda, Kei

Analytical chemistry

2018 Volume 90, Issue 11, Page(s) 6461–6467

Abstract: Most quantifications are achieved by comparison of the signals obtained with the sample to those from a standard. Thus, the purity and stability of the standard are key in chemical analysis. Furthermore, if an analyte standard cannot be obtained, ... ...

Abstract	Most quantifications are achieved by comparison of the signals obtained with the sample to those from a standard. Thus, the purity and stability of the standard are key in chemical analysis. Furthermore, if an analyte standard cannot be obtained, quantification cannot be achieved, even if the chemical structures are identified by a qualification method (e.g., high-resolution mass spectrometry). Herein, we describe a universal and analyte standard-free detector for aqueous-eluent-based high-performance liquid chromatography. This universal carbon detector (UCD) was developed based on total organic carbon detection. Separated analytes were oxidized in-line and converted to carbon dioxide (CO
Language	English
Publishing date	2018-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.7b04849
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Article ; Online: A comparative study on nivolumab and axitinib as secondary treatment in patients with metastatic renal cell carcinoma: A multi-institutional retrospective study in Japan.

Kato, Taigo / Yumiba, Satoru / Nakata, Wataru / Nakano, Kosuke / Nagahara, Akira / Matsuzaki, Kyosuke / Hayashi, Yujiro / Hatano, Koji / Kawashima, Atsunari / Takao, Tetsuya / Nishimura, Kensaku / Nakai, Yasutomo / Nakayama, Masashi / Nishimura, Kazuo / Takada, Shingo / Tsujihata, Masao / Uemura, Motohide / Nonomura, Norio / Imamura, Ryoichi

International journal of urology : official journal of the Japanese Urological Association

2022 Volume 30, Issue 9, Page(s) 723–729

Abstract: Objectives: When primary treatment has been inadequate, nivolumab and axitinib are often used as a secondary treatments for patients with metastatic renal cell carcinoma (mRCC). However, there have been few reports comparing the efficacy and safety of ... ...

Abstract	Objectives: When primary treatment has been inadequate, nivolumab and axitinib are often used as a secondary treatments for patients with metastatic renal cell carcinoma (mRCC). However, there have been few reports comparing the efficacy and safety of these drugs. Methods: We retrospectively investigated 58 patients treated with nivolumab and 57 patients treated with axitinib as secondary treatment between April 2013 and December 2019. We then assessed the clinical efficacy and safety of the treatments in both groups. Results: The most common primary therapy was sunitinib (61.7%). Both nivolumab and axitinib groups showed no significant differences in terms of the objective response rate and disease control rate (p = 0.280 and p = 0.518, respectively). Importantly, progression-free survival (PFS) and overall survival (OS) seemed to be similar in patients treated with nivolumab and axitinib (p = 0.527 and p = 0.266, respectively), irrespective of the objective response to primary therapy. Furthermore, a Cox proportional hazards model showed that pretreatment Karnofsky Performance Status was significantly associated with PFS and OS. Although the incidence of adverse events was significantly higher in the patients treated with axitinib, there was no significant difference in time to treatment failure between the two groups. Conclusions: Nivolumab and axitinib showed similar clinical benefits as secondary treatment in patients with mRCC; thus, they should be an option in sequential therapy following treatment with tyrosine kinase inhibitors (TKIs). Future studies and feasible therapeutic biomarkers would help predict the clinical response to TKIs or immune checkpoint inhibitors in patients with mRCC.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/pathology ; Axitinib/adverse effects ; Nivolumab/adverse effects ; Retrospective Studies ; Antineoplastic Agents/adverse effects ; Japan ; Kidney Neoplasms/pathology
Chemical Substances	Axitinib (C9LVQ0YUXG) ; Nivolumab (31YO63LBSN) ; Antineoplastic Agents
Language	English
Publishing date	2022-12-28
Publishing country	Australia
Document type	Multicenter Study ; Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15130
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Article ; Online: Is it necessary to carry out intraoperative retrograde upper urinary tract cytology examination in bladder cancer patients with normal upper urinary tract appearance and suspicious or positive voided urine cytology?

Matsuzaki, Kyosuke / Fujita, Kazutoshi / Ujike, Takeshi / Uemura, Motohide / Nonomura, Norio / Miyagawa, Yasushi

International journal of urology : official journal of the Japanese Urological Association

2016 Volume 23, Issue 7, Page(s) 623–624

MeSH term(s)	Carcinoma, Transitional Cell/pathology ; Cytodiagnosis ; Humans ; Sensitivity and Specificity ; Urinary Bladder Neoplasms/pathology ; Urine
Language	English
Publishing date	2016
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13100
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