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Article ; Online: A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish.

Kondo, Hidehiro / Kamei, Haruka / Murotani, Fuyuka / Nozaki, Reiko / Yazawa, Ryosuke / Tani, Reoto / Koiwai, Keiichiro / Hirono, Ikuo

Fish and shellfish immunology reports

2023 Volume 5, Page(s) 100102

Abstract: We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded ... ...

Abstract	We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark
Language	English
Publishing date	2023-06-17
Publishing country	England
Document type	Journal Article
ISSN	2667-0119
ISSN (online)	2667-0119
DOI	10.1016/j.fsirep.2023.100102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Practical Use of Transient Elastography in Screening for Nonalcoholic Steatohepatitis in a Japanese Population.

Hirono, Haruka / Watanabe, Kazuhiko / Hasegawa, Katsuhiko / Ohkoshi, Shogo

Journal of clinical and translational hepatology

2019 Volume 7, Issue 2, Page(s) 127–131

Abstract: Background and Aims: ...

Abstract	Background and Aims:
Language	English
Publishing date	2019-06-25
Publishing country	China
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2018.00048
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Article ; Online: Effects of Concomitant Administration of PXR Ligand Drugs on the Anticoagulant Effects of Warfarin.

Mito, Ayane / Hirono, Keiichi / Ide, Haruka / Ozawa, Sayaka / Ichida, Fukiko / Taguchi, Masato

Biological & pharmaceutical bulletin

2022 Volume 45, Issue 6, Page(s) 703–708

Abstract: We encountered cases in which the anticoagulant effects of warfarin (CYP2C9 substrate) were reversibly attenuated by the concomitant administration of rifampicin or bosentan, which are potent pregnane X receptor (PXR) ligands. The purpose of the present ... ...

Abstract	We encountered cases in which the anticoagulant effects of warfarin (CYP2C9 substrate) were reversibly attenuated by the concomitant administration of rifampicin or bosentan, which are potent pregnane X receptor (PXR) ligands. The purpose of the present study is to report the previous case with rifampicin, and to evaluate the changes in the warfarin anticoagulant effects when withdrawing or switching bosentan treatment. The former is a case study of a 4-year-old girl undergoing warfarin treatment. The latter is a longitudinal study of 20 pediatric patients receiving stable warfarin treatment. The prothrombin time and international normalized ratio (PT-INR) values were extracted from the medical records and normalized by the daily-dose per body size as an index for the warfarin anticoagulant effects. Rifampicin treatment resulted in a 52.0% decrease in the anticoagulant index. On the other hand, 10 of 20 patients started bosentan and their anticoagulant index was reduced by a median of 2.00. Bosentan was withdrawn in 4 of 20 patients and their anticoagulant index increased by a median of 3.67. Six of 20 patients switched from bosentan to macitentan, which is considered not to activate PXR in clinical settings. However, switching from bosentan to macitentan resulted in a median of 2.25 reduction of the anticoagulant index rather than recovery of the response to warfarin. This study suggests not only the possibility of heterogeneity in the response to PXR activation and deactivation, but also the importance of long-term monitoring of drug-drug interactions when switching from bosentan to macitentan.
MeSH term(s)	Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Bosentan ; Child ; Child, Preschool ; Female ; Humans ; International Normalized Ratio ; Ligands ; Longitudinal Studies ; Pharmaceutical Preparations ; Pregnane X Receptor ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Warfarin/pharmacology ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Ligands ; Pharmaceutical Preparations ; Pregnane X Receptor ; Warfarin (5Q7ZVV76EI) ; Bosentan (Q326023R30) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2022-04-02
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b21-00853
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Article ; Online: A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish

Hidehiro Kondo / Haruka Kamei / Fuyuka Murotani / Reiko Nozaki / Ryosuke Yazawa / Reoto Tani / Keiichiro Koiwai / Ikuo Hirono

Fish and Shellfish Immunology Reports, Vol 5, Iss , Pp 100102- (2023)

2023

Abstract: We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis. The tsIgH gene showed less than 30% of amino acid identities to Ig genes of ... ...

Abstract	We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis. The tsIgH gene showed less than 30% of amino acid identities to Ig genes of the shark. The gene encodes one variable domain (VH) and three conserved domains (CH1-CH3) with a predicted signal peptide. Interestingly, this protein has only one cysteine residue in a linker region between VH and CH1 other than those required for the formation of the immunoglobulin domain. Genome sequencing revealed that each of the domains was encoded by a corresponding single exon, and the exon-intron structures of the homologues are conserved in the other cartilaginous fishes. By RT-qPCR analysis, the transcript of the tsIgH gene was observed only in the liver, while that of the IgM was mainly detected in the epigonal organ, liver, and spleen. The novel Ig-heavy chain-like gene in cartilaginous fish may provide new clues to the evolution of immunoglobulin genes.
Keywords	Cartilaginous fish ; Expression ; Immunoglobulin heavy chain gene ; Triakis scyllium ; Zoology ; QL1-991
Subject code	572
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Using patient storytelling to improve medical students’ empathy in Japan

Yumi Kagawa / Hirono Ishikawa / Daisuke Son / Tsuyoshi Okuhara / Hiroko Okada / Haruka Ueno / Eiko Goto / Aiko Tsunezumi / Takahiro Kiuchi

BMC Medical Education, Vol 23, Iss 1, Pp 1-

a pre-post study

2023 Volume 8

Abstract: Abstract Background Empathy for patients is now internationally accepted as one of the competencies of physicians for patient-centered medical practice and an essential component of medical education. Recently, “patient storytelling” has attracted ... ...

Abstract	Abstract Background Empathy for patients is now internationally accepted as one of the competencies of physicians for patient-centered medical practice and an essential component of medical education. Recently, “patient storytelling” has attracted attention in empathy education for medical students to understand patients’ experiences, feelings, and perspectives. This study aimed to quantitatively evaluate how patient storytelling enhanced undergraduate medical students’ empathy in Japan to the extent that they sustained it for six months. Methods Participants were 159 fourth-year undergraduate medical students in Tokyo in academic years 2018 and 2019. The questionnaire surveys were conducted three times: at the beginning of the class, immediately after the class, and six months after the class. The Japanese version of the Jefferson Scale of Empathy-Student Version was used in this study. Gender, age, and clinical orientation were also obtained through the self-reported questionnaire. We invited a male patient storyteller who was diagnosed with chronic kidney disease to the classes on “Professionalism.” The title of his storytelling was “The Power of Medical Professionals’ Words.” Results JSE-S scores improved significantly immediately after listening to patient storytelling. The scores remained improved six months after the class. Interest of specialty was significantly positively associated with an immediate change in JSE-S scores. However, gender had no significant association with changes in JSE-S scores either immediately or six months after education. Conclusions Our findings may suggest that patient storytelling would be useful to cultivate empathy among undergraduate medical students. It is to be expected that more medical schools will use patient storytelling to educate medical students in humanistic and communication education.
Keywords	Patient storytelling ; Empathy ; Perspective-taking ; Patient-centered practice ; Humanistic education ; Jefferson Scale of Empathy-Student version ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	390
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Using patient storytelling to improve medical students' empathy in Japan: a pre-post study.

Kagawa, Yumi / Ishikawa, Hirono / Son, Daisuke / Okuhara, Tsuyoshi / Okada, Hiroko / Ueno, Haruka / Goto, Eiko / Tsunezumi, Aiko / Kiuchi, Takahiro

BMC medical education

2023 Volume 23, Issue 1, Page(s) 67

Abstract: Background: Empathy for patients is now internationally accepted as one of the competencies of physicians for patient-centered medical practice and an essential component of medical education. Recently, "patient storytelling" has attracted attention in ... ...

Abstract	Background: Empathy for patients is now internationally accepted as one of the competencies of physicians for patient-centered medical practice and an essential component of medical education. Recently, "patient storytelling" has attracted attention in empathy education for medical students to understand patients' experiences, feelings, and perspectives. This study aimed to quantitatively evaluate how patient storytelling enhanced undergraduate medical students' empathy in Japan to the extent that they sustained it for six months. Methods: Participants were 159 fourth-year undergraduate medical students in Tokyo in academic years 2018 and 2019. The questionnaire surveys were conducted three times: at the beginning of the class, immediately after the class, and six months after the class. The Japanese version of the Jefferson Scale of Empathy-Student Version was used in this study. Gender, age, and clinical orientation were also obtained through the self-reported questionnaire. We invited a male patient storyteller who was diagnosed with chronic kidney disease to the classes on "Professionalism." The title of his storytelling was "The Power of Medical Professionals' Words." Results: JSE-S scores improved significantly immediately after listening to patient storytelling. The scores remained improved six months after the class. Interest of specialty was significantly positively associated with an immediate change in JSE-S scores. However, gender had no significant association with changes in JSE-S scores either immediately or six months after education. Conclusions: Our findings may suggest that patient storytelling would be useful to cultivate empathy among undergraduate medical students. It is to be expected that more medical schools will use patient storytelling to educate medical students in humanistic and communication education.
MeSH term(s)	Humans ; Male ; Empathy ; Students, Medical ; Japan ; Education, Medical ; Communication
Language	English
Publishing date	2023-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04054-1
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Article: Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea.

Hirono, Haruka / Watanabe, Kazuhiko / Hasegawa, Katsuhiko / Kohno, Masaki / Terai, Shuji / Ohkoshi, Shogo

World journal of clinical cases

2021 Volume 9, Issue 19, Page(s) 5112–5125

Abstract: Background: Obstructive sleep apnea (OSA) has been suggested as an independent risk factor for nonalcoholic fatty liver disease (NAFLD), and continuous positive airway pressure (CPAP) is the first-line therapy for OSA.: Aim: To clarify the efficacy ... ...

Abstract	Background: Obstructive sleep apnea (OSA) has been suggested as an independent risk factor for nonalcoholic fatty liver disease (NAFLD), and continuous positive airway pressure (CPAP) is the first-line therapy for OSA. Aim: To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography (TE) using FibroScan Methods: We prospectively enrolled 123 consecutive patients with OSA who met the indications for CPAP. Liver fibrosis and steatosis were assessed using TE. Before and after 6 mo of CPAP therapy, serum markers and TE were assessed for all patients. The mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as "mean compliance index" (m-CI). Results: In 50 OSA patients with NAFLD, both aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly decreased after 6 mo of CPAP therapy. Univariate analysis showed that decreased body weight (BW), decreased body mass index (BMI), decreased AST level, decreased hemoglobin A1c, and high m-CI were significantly related with improved ALT level. In multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy, high m-CI tended to improve ALT level ( Conclusion: Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW changes. In those cases, adequate reoxygenation from effective CPAP therapy may improve NAFLD.
Language	English
Publishing date	2021-07-07
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i19.5112
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Article: Dental pulp cell bank as a possible future source of individual hepatocytes.

Ohkoshi, Shogo / Hirono, Haruka / Nakahara, Taka / Ishikawa, Hiroshi

World journal of hepatology

2018 Volume 10, Issue 10, Page(s) 702–707

Abstract: Mesenchymal stem cells (MSCs) as a source for regenerative medicine are now the subject of much clinical attention. There are high expectations due to their safety, low tumorigenic risk, and low ethical concerns. MSC therapy has been approved for acute ... ...

Abstract	Mesenchymal stem cells (MSCs) as a source for regenerative medicine are now the subject of much clinical attention. There are high expectations due to their safety, low tumorigenic risk, and low ethical concerns. MSC therapy has been approved for acute graft-versus host diseases since 2015. Tooth-derived MSCs are known to have a great potential in their proliferation and differentiation capacities, even when compared with bone-marrow-derived MSCs. In particular, stem cells from human exfoliated deciduous teeth (SHEDs) are the best candidates for personal cell banking (dental pulp cell bank), because they can be obtained less invasively in the natural process of individual growth. SHEDs are known to differentiate into hepatocytes. There have been several studies showing the effectiveness of SHEDs on the treatment of liver failure in animal models. They may exert their effects either by repopulation of cells in injured liver or by paracrine mechanisms due to their immune-regulatory functions. Moreover, it may be possible to use each individuals' dental pulp cells as a future source of tailor-made differentiated hepatocytes in the context of a bioartificial liver or liver-on-a-chip to screen for drug toxicity.
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v10.i10.702
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Article ; Online: Examining Long-Term Effects of Human Papillomavirus Vaccine Recommendation Messages

Tsuyoshi Okuhara / Hirono Ishikawa / Haruka Ueno / Hiroko Okada / Takahiro Kiuchi

Healthcare, Vol 8, Iss 549, p

A 4-Month Follow-Up Survey of a Randomized Controlled Study in Japan

2020 Volume 549

Abstract: We previously conducted a randomized controlled study to examine persuasive messages recommending HPV vaccination to mothers with daughters in Japan. That study showed that the three types of intervention message used (statistical information only, a ... ...

Abstract	We previously conducted a randomized controlled study to examine persuasive messages recommending HPV vaccination to mothers with daughters in Japan. That study showed that the three types of intervention message used (statistical information only, a patient’s narrative in addition to statistical information, and a mother’s narrative in addition to statistical information) all significantly improved mothers’ intention to have their daughter(s) receive the HPV vaccine, in comparison with mothers who received no messaging. The present study is a follow-up survey to assess the long-term effect of the intervention. Four months after the initial study, in January 2018, participants in the previous study were contacted and queried about their current intention to have their daughter(s) receive the HPV vaccine. Statistical analysis was conducted using the paired t -test and analysis of variance. A total of 978 mothers participated in the current survey. Vaccination intention 4 months after intervention had decreased to a level that did not differ significantly from the level prior to intervention in all three intervention conditions. The amount of change in vaccination intention 4 months after intervention did not differ significantly among the three intervention groups ( p = 0.871). A single exposure to messaging was insufficient to produce a persistent intervention effect.
Keywords	human papillomavirus (HPV) vaccination ; anti-vaccination movement ; narrative ; persuasion ; long-term effect ; health communication ; Medicine ; R
Subject code	796
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dual-process theories to counter the anti-vaccination movement

Tsuyoshi Okuhara / Hirono Ishikawa / Hiroko Okada / Haruka Ueno / Takahiro Kiuchi

Preventive Medicine Reports, Vol 20, Iss , Pp 101205- (2020)

2020

Abstract: Vaccine hesitancy is a problem attracting growing attention and concern. In this paper, we discuss why anti-vaccination messages are influential and which pro-vaccine messages can be effective to address vaccine hesitancy from the perspective of dual- ... ...

Abstract	Vaccine hesitancy is a problem attracting growing attention and concern. In this paper, we discuss why anti-vaccination messages are influential and which pro-vaccine messages can be effective to address vaccine hesitancy from the perspective of dual-process theories of cognitive functioning. The functioning of the human brain can be characterized by two different types of cognitive functioning: intuitive System 1, which is evolutionarily old, fast, and automatic; and analytical System 2, which is evolutionarily recent, slow, and deliberative. Anti-vaccination messages that inspire fear activate System 1, and vaccine recommendation messages that use statistics activate System 2. System 1 has a greater influence on judgment than System 2. The processing of System 1 is called “trajectory.” Even if adequate knowledge about the effectiveness and safety of vaccination is input to System 2, vaccine hesitancy cannot be easily erased once it is generated by System 1. We suggest that vaccine recommendation messages should target System 1 in addition to System 2, to counter anti-vaccination messages and address vaccine hesitancy.
Keywords	Anti-vaccination movement ; Vaccine hesitancy ; Dual-process theories ; Health communication ; Medicine ; R
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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