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Article ; Online: T

Hu, Hao / Chen, Lu / Zhang, Jiu-Lou / Chen, Wen / Chen, Huan-Huan / Liu, Hu / Shi, Hai-Bin / Wu, Fei-Yun / Xu, Xiao-Quan

Journal of magnetic resonance imaging : JMRI

2022 Volume 56, Issue 3, Page(s) 862–872

Abstract: ... To investigate the value of T: Study type: Retrospective.: Population: A total of 110 patients (49 ± 12 ... validation (n = 32) cohorts.: Field strength/sequence: 3.0 T, T: Assessment: W.C. and H.H. (6 and 10 ... conclusion: T: Level of evidence: 3 TECHNICAL EFFICACY: Stage 4. ...

Abstract	Background: MR imaging has been applied to determine therapeutic response to glucocorticoid (GC) before treatment in thyroid-associated ophthalmopathy (TAO), while the performance was still poor. Purpose: To investigate the value of T Study type: Retrospective. Population: A total of 110 patients (49 ± 12 years; male/female, n = 48/62; responsive/unresponsive, n = 62/48), divided into training (n = 78) and validation (n = 32) cohorts. Field strength/sequence: 3.0 T, T Assessment: W.C. and H.H. (6 and 10 years of experience, respectively) performed the measurements. Maximum, mean, and minimum signal intensity ratios (SIRs) of extraocular muscle (EOM) bellies were collected to construct a semiquantitative imaging model. Radiomics features from volumes of interest covering EOM bellies were extracted and three machine learning-based (logistic regression [LR]; decision tree [DT]; support vector machine [SVM]) models were built. Statistical tests: The diagnostic performances of models were evaluated using receiver operating characteristic curve analyses, and compared using DeLong test. Two-sided P < 0.05 was considered statistically significant. Results: The responsive group showed higher minimum signal intensity ratio (SIR Data conclusion: T Level of evidence: 3 TECHNICAL EFFICACY: Stage 4.
MeSH term(s)	Female ; Glucocorticoids/therapeutic use ; Graves Ophthalmopathy/diagnostic imaging ; Graves Ophthalmopathy/drug therapy ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Retrospective Studies ; Support Vector Machine
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28088
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article ; Online: T

Maforo, Nyasha G / Magrath, Patrick / Moulin, Kévin / Shao, Jiaxin / Kim, Grace Hyun / Prosper, Ashley / Renella, Pierangelo / Wu, Holden H / Halnon, Nancy / Ennis, Daniel B

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2020 Volume 22, Issue 1, Page(s) 85

Abstract: ... contrast) T: Methods: Boys with DMD (N = 28, 13.2 ± 3.1 years) and healthy age-matched boys (N = 20, 13 ... imaging and T: Results: Boys with DMD had significantly increased global native T: Conclusions: Boys ... with DMD exhibit elevated native T ...

Abstract	Background: Cardiovascular disease is the leading cause of death in patients with Duchenne muscular dystrophy (DMD)-a fatal X-linked genetic disorder. Late gadolinium enhancement (LGE) imaging is the current gold standard for detecting myocardial tissue remodeling, but it is often a late finding. Current research aims to investigate cardiovascular magnetic resonance (CMR) biomarkers, including native (pre-contrast) T Methods: Boys with DMD (N = 28, 13.2 ± 3.1 years) and healthy age-matched boys (N = 20, 13.4 ± 3.1 years) were prospectively enrolled and underwent a 3T CMR exam including standard functional imaging and T Results: Boys with DMD had significantly increased global native T Conclusions: Boys with DMD exhibit elevated native T
MeSH term(s)	Adolescent ; Age Factors ; California ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/etiology ; Cardiomyopathies/pathology ; Cardiomyopathies/physiopathology ; Case-Control Studies ; Child ; Contrast Media/administration & dosage ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Meglumine/administration & dosage ; Meglumine/analogs & derivatives ; Muscular Dystrophy, Duchenne/complications ; Muscular Dystrophy, Duchenne/diagnosis ; Myocardium/pathology ; Organometallic Compounds/administration & dosage ; Predictive Value of Tests ; Prospective Studies ; Severity of Illness Index ; Ventricular Function, Left ; Ventricular Remodeling ; Young Adult
Chemical Substances	Contrast Media ; Organometallic Compounds ; gadobenic acid (15G12L5X8K) ; Meglumine (6HG8UB2MUY)
Language	English
Publishing date	2020-12-10
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-020-00687-z
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Zs.A 5045: Show issues

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Article ; Online: t

Xu, Yulong / Shi, Xiaonan / Wu, Lipeng

RSC advances

2019 Volume 9, Issue 41, Page(s) 24025–24029

Abstract: Recently, inexpensive and readily ... ...

Abstract	Recently, inexpensive and readily available
Language	English
Publishing date	2019-08-02
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra04242c
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Article ; Online: T

Li, Jingjing / You, Jia / Wu, Chen / Dai, Yue / Shi, Meilin / Dong, Lina / Xu, Kai

International journal of nanomedicine

2018 Volume 13, Page(s) 4607–4625

Abstract: Background: The development of T: Methods: In this work, we constructed an Fe: Results ... The prepared Fe: Conclusion: A T ...

Abstract	Background: The development of T Methods: In this work, we constructed an Fe Results: The prepared Fe Conclusion: A T
MeSH term(s)	Animals ; Cattle ; Cell Death ; Cell Line, Tumor ; Cell Survival ; Contrast Media/chemistry ; Ferric Compounds/chemistry ; Gadolinium/chemistry ; Kidney Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Nanoparticles/chemistry ; Polyethylenes/chemistry ; Porosity ; Quaternary Ammonium Compounds/chemistry ; Serum Albumin, Bovine/metabolism ; Silicon Dioxide/chemistry ; Tissue Distribution ; Toxicity Tests
Chemical Substances	Contrast Media ; Ferric Compounds ; Polyethylenes ; Quaternary Ammonium Compounds ; ferric oxide (1K09F3G675) ; poly-N,N-dimethyl-N,N-diallylammonium chloride (26062-79-3) ; Serum Albumin, Bovine (27432CM55Q) ; Silicon Dioxide (7631-86-9) ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2018-08-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S168660
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Zs.A 6606: Show issues

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Article ; Online: T

Han, Xiaorui / Hong, Guoju / Chen, Leilei / Zhao, Man / Guo, Yuan / Xu, Ling / Wu, Mei / Leng, Xiaoming / Sun, Ping

Journal of magnetic resonance imaging : JMRI

2018 Volume 49, Issue 3, Page(s) 760–767

Abstract: ... Purpose: To investigate the diagnostic performance of T: Study type: Prospective.: Subjects: Forty ... gradient echo (MERGE), and T: Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 ... workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T: Statistical ...

Abstract	Background: In the future, biochemical MRI might provide a valuable noninvasive quantitative analysis of the biochemical composition of cartilage in osteonecrosis of the femoral head (ONFH). Purpose: To investigate the diagnostic performance of T Study type: Prospective. Subjects: Forty-seven patients with ONFH (stage I to III according to the ARCO criteria) and 24 volunteers (control group) were recruited for the prospective study. Sequence: Conventional MRI, multiple echo recalled gradient echo (MERGE), and T Assessment: Pseudocolor images and MERGE images were combined in the AW4.5 workstation. The region of interest (ROI) of the hip cartilage was 4-6 mm². The sagittal T Statistical tests: One-way analysis of variance (ANOVA), LSD t-tests, Pearson correlation analysis, and receiver operator characteristic (ROC) curves. The significance level was set at P < 0.05. Results: The T Data conclusion: Both T Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:760-767.
MeSH term(s)	Adolescent ; Adult ; Algorithms ; Cartilage, Articular/pathology ; Case-Control Studies ; Female ; Femur Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Osteonecrosis/diagnostic imaging ; Prospective Studies ; ROC Curve ; Reproducibility of Results ; Young Adult
Language	English
Publishing date	2018-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.26267
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Zs.MO 236: Show issues

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Article ; Online: T

Liu, Zixin / Xianyu, Yunlei / Zheng, Wenshu / Zhang, Jiangjiang / Luo, Yunjing / Chen, Yiping / Dong, Mingling / Wu, Jing / Jiang, Xingyu

Analytical chemistry

2018 Volume 90, Issue 4, Page(s) 2765–2771

Abstract: ... this challenge, we develop a longitudinal relaxation time (T ...

Abstract	Current magnetic relaxation switching (MRS) sensors for detection of trace targets in complex samples still suffer from limitations in terms of relatively low sensitivity and poor stability. To meet this challenge, we develop a longitudinal relaxation time (T
MeSH term(s)	Biosensing Techniques ; Humans ; Immunoassay ; Manganese/analysis ; Manganese Compounds/analysis ; Molecular Structure ; Nanoparticles/analysis ; Oxidation-Reduction ; Oxides/analysis ; Particle Size ; Surface Properties ; Time Factors
Chemical Substances	Manganese Compounds ; Oxides ; Manganese (42Z2K6ZL8P) ; manganese oxide (64J2OA7MH3)
Language	English
Publishing date	2018-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.7b04817
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Zs.A 4033: Show issues

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Article ; Online: T-REX17

eLife

2023 Volume 12

Abstract: Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs remains ...

Abstract	Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs remains incomplete and many known non-coding loci are still poorly characterized. Here, we report the discovery of a previously unannotated lncRNA that is transcribed 230 kb upstream of the
MeSH term(s)	Pregnancy ; Female ; Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Epithelial-Mesenchymal Transition ; Endoderm ; Gene Expression Regulation, Developmental ; SOXF Transcription Factors/genetics ; SOXF Transcription Factors/metabolism ; Cell Differentiation/genetics
Chemical Substances	RNA, Long Noncoding ; SOXF Transcription Factors
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.83077
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Article ; Online: Targeting T

Ma, Ning / Wu, Wei-Bing / Zhao, Xiang-Yu / Xu, Lan-Ping / Zhang, Xiao-Hui / Wang, Yu / Mo, Xiao-Dong / Zhang, Yuan-Yuan / Zhao, Xiao-Su / Sun, Yu-Qian / Cheng, Yi-Fei / Liu, Kai-Yan / Chang, Ying-Jun / Huang, Xiao-Jun

Haematologica

2024 Volume 109, Issue 4, Page(s) 1233–1246

Abstract: ... reports of failure. T-follicular helper (Tfh) cells assist B cells in differentiating into antibody ...

Abstract	The presence of donor-specific antibodies (DSA) are associated with graft failure either following human leukocyte antigen (HLA)-mismatched allogeneic stem cell transplantation or after organ transplantation. Although targeting B cells and plasma cells have been used for desensitization, there have been reports of failure. T-follicular helper (Tfh) cells assist B cells in differentiating into antibody-secreting plasma cells. We used haploidentical allograft as a platform to investigate the possibility of targeting Tfh cells to desensitize DSA. The quantities of circulating Tfh (cTfh) cell subsets in allograft candidates were abnormal, and these cells, including the cTfh2 and cTfhem cell subsets, were positively related to the production of anti-HLA antibodies. Ex vivo experiments showed that the cTfh cells of anti-HLA antibody-positive allograft candidates could induce B cells to differentiate into DSA-producing plasmablasts. The immune synapse could be involved in the assistance of cTfh cells to B cells in antibody production. In vitro experiments and in vivo clinical pilot studies indicated that targeting cTfh cells with sirolimus can inhibit their auxiliary function in assisting B cells. Ex vivo and in vivo studies demonstrated the effect of sirolimus and rituximab on DSA desensitization compared with either sirolimus or rituximab alone (60%, 43.75%, and 30%, respectively). Our findings provide new insight into the role of Tfh cells in the pathogenesis of DSA production in HLA-mismatched transplant candidates. Our data also indicate that targeting Tfh cells is a novel strategy for DSA desensitization and combination of sirolimus and rituximab might be a potential therapy. The prospective cohort of this study is registered at http://www.chictr.org.cn as #ChiCTR-OPC-15006672.
MeSH term(s)	Humans ; T-Lymphocytes, Helper-Inducer ; Rituximab ; Prospective Studies ; Antibodies ; HLA Antigens ; Histocompatibility Antigens Class II ; Allografts ; Sirolimus
Chemical Substances	Rituximab (4F4X42SYQ6) ; Antibodies ; HLA Antigens ; Histocompatibility Antigens Class II ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2024-04-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.283698
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Uh III Zs.76: Show issues

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Article ; Online: Reproducibility of T

Lartey, R / Nanavati, A / Kim, J / Li, M / Xu, K / Nakamura, K / Shin, W / Winalski, C S / Obuchowski, N / Bahroos, E / Link, T M / Hardy, P A / Peng, Q / Liu, K / Fung, M / Wu, C / Li, X

Osteoarthritis and cartilage

2022 Volume 31, Issue 2, Page(s) 249–257

Abstract: ... echo spin-echo (MESE) T: Methods: Phantoms and volunteers (n = 5 from each site, n = 20 in total ... were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens ... of variation (CVs) were calculated to evaluate reproducibility.: Results: For baseline 2D MESE T ...

Abstract	Objective: To evaluate the multi-vendor multi-site reproducibility of two-dimensional (2D) multi-echo spin-echo (MESE) T Methods: Phantoms and volunteers (n = 5 from each site, n = 20 in total) were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens, General Electric, and Phillips). Two traveling volunteers (3 knees) scanned at all 4 sites at baseline and 6-month follow-up. Data was transferred to one site for centralized processing. Coefficients of variation (CVs) were calculated to evaluate reproducibility. Results: For baseline 2D MESE T Conclusion: This study demonstrated excellent intra-site reproducibility of 2D MESE T
MeSH term(s)	Humans ; Reproducibility of Results ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Cartilage, Articular
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2022.10.017
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Zs.A 3828: Show issues

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Book ; Online: t-SMILES

Wu, Juan-Ni / Wang, Tong / Chen, Yue / Tang, Li-Juan / Wu, Hai-Long / Yu, Ru-Qin

A Scalable Fragment-based Molecular Representation Framework for De Novo Molecule Generation

2023

Abstract: ... framework called t-SMILES (tree-based SMILES) with three code algorithms: TSSA (t-SMILES with Shared Atom ... TSDY (t-SMILES with Dummy Atom) and TSID (t-SMILES with ID). It describes molecules using SMILES-type ...

Abstract	Effective representation of molecules is a crucial factor affecting the performance of artificial intelligence models. This study introduces a flexible, fragment-based, multiscale molecular representation framework called t-SMILES (tree-based SMILES) with three code algorithms: TSSA (t-SMILES with Shared Atom), TSDY (t-SMILES with Dummy Atom) and TSID (t-SMILES with ID). It describes molecules using SMILES-type strings obtained by performing a breadth-first search on a full binary tree formed from a fragmented molecular graph. Systematic evaluations using JTVAE, BRICS, MMPA, and Scaffold show the feasibility to construct a multi-code molecular description system, where various descriptions complement each other, enhancing the overall performance. Additionally, it exhibits impressive performance on low-resource datasets, whether the model is original, data augmented, or pre-training fine-tuned. It significantly outperforms classical SMILES, DeepSMILES, SELFIES and baseline models in goal-directed tasks. Furthermore, it surpasses start-of-the-art fragment, graph and SMILES based approaches on ChEMBL, Zinc, and QM9.
Keywords	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Quantitative Biology - Biomolecules
Subject code	006
Publishing date	2023-01-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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