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  1. Article ; Online: F

    Liu, Xiaogang / Chen, Wenjie / Wang, Wei

    ACS omega

    2021  Volume 6, Issue 51, Page(s) 35799–35809

    Abstract: Finding an effective strategy to promote the charge transfer and separation of ... ...

    Abstract Finding an effective strategy to promote the charge transfer and separation of TiO
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c05891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An F

    Yang, Qingliang / Zhou, Xuhui / Lou, Bang / Zheng, Ning / Chen, Jiale / Yang, Gensheng

    Acta biomaterialia

    2024  Volume 179, Page(s) 207–219

    Abstract: ... To tackle this challenge, herein we present a biomolecular motor (F ...

    Abstract Despite the booming progress of anticancer nanomedicines in the past two decades, precise tumor-targetability and sufficient tumor-accumulation are less successful and still require further research. To tackle this challenge, herein we present a biomolecular motor (F
    MeSH term(s) Humans ; Animals ; Endocytosis/drug effects ; HT29 Cells ; Mice ; Proton-Translocating ATPases/metabolism ; Tumor Microenvironment/drug effects ; Mice, Nude ; Robotics ; Neoplasms/drug therapy ; Neoplasms/pathology ; Mice, Inbred BALB C ; Drug Delivery Systems ; Hydrogen-Ion Concentration
    Chemical Substances Proton-Translocating ATPases (EC 3.6.3.14)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: f

    Chen, Xiaohong / Ma, Xie / Ren, Shenggang / Yuan, Baolong

    China economic review : an international journal Vol. 28 , p. 123-134

    a case study of Chinas industrial sectors

    2014  Volume 28, Page(s) 123–134

    Author's details Shenggang Ren; Baolong Yuan; Xie Ma; Xiaohong Chen
    Keywords International trade ; FDI ; Embodied CO2 emissions ; EKC hypothesis
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 1117248-4
    ISSN 1043-951X
    Database ECONomics Information System

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  4. Article ; Online: The F

    Li, Shuixiu / Liu, Yuting / Weng, Luobei / Zhao, Yajing / Zhang, Yishan / Zhang, Zhanpeng / Yang, Yang / Chen, Qiaoxin / Liu, Xiaocong / Zhang, Hong

    Virulence

    2023  Volume 14, Issue 1, Page(s) 2190645

    Abstract: Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously ... ...

    Abstract Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously demonstrated that a
    MeSH term(s) Mice ; Animals ; Candida albicans/genetics ; Candida albicans/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acids
    Chemical Substances Cytokines ; Adenosine Triphosphate (8L70Q75FXE) ; Amino Acids
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2023.2190645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of F

    Wang, Wei / Su, Zijin / Han, Wei / Chen, Jiayi / Li, Mei / Zhang, Meng / Liu, Rugeng

    Inorganic chemistry

    2023  Volume 62, Issue 26, Page(s) 10221–10231

    Abstract: To determine the effect of F ...

    Abstract To determine the effect of F
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00921
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  6. Article ; Online: Prostaglandin F

    Wang, Yi-Jun / Xie, Xiao-Li / Liu, Hong-Qun / Tian, Hui / Jiang, Xiao-Yu / Zhang, Jiu-Na / Chen, Sheng-Xiong / Liu, Ting / Wang, Shu-Ling / Zhou, Xue / Jin, Xiao-Xu / Liu, Shi-Mao / Jiang, Hui-Qing

    World journal of gastroenterology

    2023  Volume 29, Issue 39, Page(s) 5452–5470

    Abstract: ... Oxa resistance is crucial for treatment failure. Prostaglandin F: Aim: To explore the role and ...

    Abstract Background: Oxaliplatin (Oxa) is the first-line chemotherapy drug for colorectal cancer (CRC), and Oxa resistance is crucial for treatment failure. Prostaglandin F
    Aim: To explore the role and related mechanisms of PGFS in mediating Oxa resistance in CRC.
    Methods: The PGFS expression level was examined in 37 pairs of CRC tissues and paracancerous tissues at both the mRNA and protein levels. Overexpression or knockdown of PGFS was performed in CRC cell lines with acquired Oxa resistance (HCT116-OxR and HCT8-OxR) and their parental cell lines (HCT116 and HCT8) to assess its influence on cell proliferation, chemoresistance, apoptosis, and DNA damage. For determination of the underlying mechanisms, CRC cells were examined for platinum-DNA adducts and reactive oxygen species (ROS) levels in the presence of a PGFS inhibitor or its products.
    Results: Both the protein and mRNA levels of PGFS were increased in the 37 examined CRC tissues compared to the adjacent normal tissues. Oxa induced PGFS expression in the parental HCT116 and HCT8 cells in a dose-dependent manner. Furthermore, overexpression of PGFS in parental CRC cells significantly attenuated Oxa-induced proliferative suppression, apoptosis, and DNA damage. In contrast, knockdown of PGFS in Oxa-resistant HCT116 and HCT8 cells (HCT116-OxR and HCT8-OxR) accentuated the effect of Oxa treatment
    Conclusion: PGFS promotes resistance to Oxa in CRC
    MeSH term(s) Humans ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Platinum/pharmacology ; Platinum/therapeutic use ; DNA Adducts/pharmacology ; DNA Adducts/therapeutic use ; Reactive Oxygen Species ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; RNA, Messenger/metabolism ; Prostaglandins ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor
    Chemical Substances Oxaliplatin (04ZR38536J) ; Platinum (49DFR088MY) ; DNA Adducts ; Reactive Oxygen Species ; RNA, Messenger ; Prostaglandins
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i39.5452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  7. Book ; Online: F-Eval

    Sun, Yu / Chen, Keyu / Wang, Shujie / Guo, Qipeng / Yan, Hang / Qiu, Xipeng / Huang, Xuanjing / Lin, Dahua

    Asssessing Fundamental Abilities with Refined Evaluation Methods

    2024  

    Abstract: ... subtle differences. To bridge the gap, we propose F-Eval, a bilingual evaluation benchmark to evaluate ... the fundamental abilities, including expression, commonsense and logic. The tasks in F-Eval include multi-choice ... that F-Eval will facilitate the study of LLMs' fundamental abilities. ...

    Abstract Large language models (LLMs) garner significant attention for their unprecedented performance, leading to an increasing number of researches evaluating LLMs. However, these evaluation benchmarks are limited to assessing the instruction-following capabilities, overlooking the fundamental abilities that emerge during the pre-training stage. Previous subjective evaluation methods mainly reply on scoring by API models. However, in the absence of references, large models have shown limited ability to discern subtle differences. To bridge the gap, we propose F-Eval, a bilingual evaluation benchmark to evaluate the fundamental abilities, including expression, commonsense and logic. The tasks in F-Eval include multi-choice objective tasks, open-ended objective tasks, reference-based subjective tasks and reference-free subjective tasks. For reference-free subjective tasks, we devise new evaluation methods, serving as alternatives to scoring by API models. We conduct evaluations on 13 advanced LLMs. Results show that our evaluation methods show higher correlation coefficients and larger distinction than other evaluators. Additionally, we discuss the influence of different model sizes, dimensions, and normalization methods. We anticipate that F-Eval will facilitate the study of LLMs' fundamental abilities.

    Comment: 21 pages, 7 figures
    Keywords Computer Science - Computation and Language
    Subject code 006
    Publishing date 2024-01-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of F

    Wang, Hao / Han, Xuejiao / Chen, Yao / Guo, Wenjing / Zheng, Wenli / Cai, Nan / Guo, Qingwei / Zhao, Xiaoli / Wu, Fengchang

    The Science of the total environment

    2020  Volume 757, Page(s) 143962

    Abstract: The effect of ions on the colloidal behavior of magnetic nanoparticles (MNPs) is an important factor for determining the dispersibility of MNPs. Compared with the effects of cations and organic matter, the effect of anions on MNPs has rarely been studied. ...

    Abstract The effect of ions on the colloidal behavior of magnetic nanoparticles (MNPs) is an important factor for determining the dispersibility of MNPs. Compared with the effects of cations and organic matter, the effect of anions on MNPs has rarely been studied. Hence, in this study, the effect of anions on the aggregation of Fe
    Language English
    Publishing date 2020-12-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.143962
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    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: F. nucleatum

    Hong, Jie / Guo, Fangfang / Lu, Shi-Yuan / Shen, Chaoqin / Ma, Dan / Zhang, Xinyu / Xie, Yile / Yan, Tingting / Yu, TaChung / Sun, Tiantian / Qian, Yun / Zhong, Ming / Chen, Jinxian / Peng, Yanshen / Wang, Cheng / Zhou, Xiang / Liu, Jianjun / Liu, Qiang / Ma, Xiong /
    Chen, Ying-Xuan / Chen, Haoyan / Fang, Jing-Yuan

    Gut

    2020  Volume 70, Issue 11, Page(s) 2123–2137

    Abstract: ... We have found : Conclusion: F. nucleatum ...

    Abstract Objective: Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC). However, the potential correlation between the gut microbiota and glucose metabolism is unknown in CRC.
    Design: 18
    Results: We have found
    Conclusion: F. nucleatum
    MeSH term(s) Animals ; Biomarkers, Tumor ; Carcinogenesis/genetics ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/genetics ; DNA-Binding Proteins ; Fluorodeoxyglucose F18/pharmacokinetics ; Fusobacterium Infections/genetics ; Fusobacterium nucleatum ; Gastrointestinal Microbiome ; Gene Expression Regulation, Neoplastic ; Glycolysis/genetics ; Histone Acetyltransferases ; Humans ; Mice ; Phosphopyruvate Hydratase ; Positron Emission Tomography Computed Tomography ; Prognosis ; RNA, Long Noncoding/genetics ; Radiopharmaceuticals/pharmacokinetics ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Suppressor Proteins
    Chemical Substances Biomarkers, Tumor ; DNA-Binding Proteins ; RNA, Long Noncoding ; Radiopharmaceuticals ; Tumor Suppressor Proteins ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Histone Acetyltransferases (EC 2.3.1.48) ; KAT7 protein, human (EC 2.3.1.48) ; ENO1 protein, human (EC 4.2.1.11) ; Eno1 protein, mouse (EC 4.2.1.11) ; Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2020-322780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What the "F"?

    Chen, Donna / Epstein, Elizabeth / Almarode, Susan / Winter, Jameel / Marshall, Mary Faith

    The American journal of bioethics : AJOB

    2018  Volume 18, Issue 1, Page(s) 16–19

    MeSH term(s) Child ; Humans ; Patient Care/ethics ; Prognosis ; Treatment Failure
    Language English
    Publishing date 2018-01-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2017.1401178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6814: Show issues Location:
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