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  1. Article ; Online: L

    Dou, Mengying / Zhang, Yao / Shao, Qi / Zhu, Jiali / Li, Wang / Wang, Xueying / Zhang, Cai / Li, Yuanxiao

    Animal biotechnology

    2021  Volume 34, Issue 4, Page(s) 1005–1013

    Abstract: Heat stress (HS) has a negative impact on the health and performance of dairy cows, resulting in economic losses. Damage to the intestinal epithelium is the main cause of the adverse effects of heat stress on bovine health. This study investigated the ... ...

    Abstract Heat stress (HS) has a negative impact on the health and performance of dairy cows, resulting in economic losses. Damage to the intestinal epithelium is the main cause of the adverse effects of heat stress on bovine health. This study investigated the repair capability of
    MeSH term(s) Female ; Cattle ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Epithelial Cells/metabolism ; Arginine/pharmacology ; Arginine/metabolism ; Heat-Shock Response ; Inflammation/metabolism ; Cattle Diseases
    Chemical Substances Antioxidants ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2043243-4
    ISSN 1532-2378 ; 1049-5398
    ISSN (online) 1532-2378
    ISSN 1049-5398
    DOI 10.1080/10495398.2021.2009491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: L

    Zhang, Heng / Guo, Hongbo / Li, Shuangchen / Liu, Yanqiu / He, Xuelei / He, Xiaowei / Hou, Yuqing

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Volume 2021, Page(s) 3640–3645

    Abstract: ... distribution. In this paper, we proposed L ...

    Abstract Fluorescent Molecular Tomography (FMT) is a highly sensitive and noninvasive imaging method that provides three-dimensional distribution of biomarkers by noninvasive detection of fluorescent marker probes. However, due to the light scattering effect and ill-posedness of inverse problems, it is challenging to develop an efficient construction method that can provide the exact location and morphology of the fluorescence distribution. In this paper, we proposed L
    MeSH term(s) Algorithms ; Animals ; Computer Simulation ; Image Processing, Computer-Assisted ; Mice ; Tomography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9630236
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  3. Article ; Online: l

    Zheng, Wenming / Lu, Cheng / Lin, Zhouchen / Zhang, Tong / Cui, Zhen / Yang, Wankou

    IEEE transactions on neural networks and learning systems

    2018  Volume 30, Issue 10, Page(s) 2898–2915

    Abstract: ... criterion is based on the l ...

    Abstract Fisher's criterion is one of the most popular discriminant criteria for feature extraction. It is defined as the generalized Rayleigh quotient of the between-class scatter distance to the within-class scatter distance. Consequently, Fisher's criterion does not take advantage of the discriminant information in the class covariance differences, and hence, its discriminant ability largely depends on the class mean differences. If the class mean distances are relatively large compared with the within-class scatter distance, Fisher's criterion-based discriminant analysis methods may achieve a good discriminant performance. Otherwise, it may not deliver good results. Moreover, we observe that the between-class distance of Fisher's criterion is based on the l
    Language English
    Publishing date 2018-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2018.2863264
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  4. Article ; Online: L

    Hu, Yifang / Liu, Jie / Leng, Chengcai / An, Yu / Zhang, Shuang / Wang, Kun

    Molecular imaging and biology

    2016  Volume 18, Issue 6, Page(s) 830–837

    Abstract: ... we proposed a novel approach based on L : Procedures: The diffusion equation was used as the forward model ... Then, we defined the objective function of L : Results: The results of the simulations indicated that compared ... to minimize the L ...

    Abstract Purpose: Bioluminescence tomography (BLT) is a promising in vivo optical imaging technique in preclinical research at cellular and molecular levels. The problem of BLT reconstruction is quite ill-posed and ill-conditioned. In order to achieve high accuracy and efficiency for its inverse reconstruction, we proposed a novel approach based on L
    Procedures: The diffusion equation was used as the forward model. Then, we defined the objective function of L
    Results: The results of the simulations indicated that compared with the conjugate gradient and iterative shrinkage methods, the proposed method is more accurate and faster for multisource reconstructions. Furthermore, in vivo imaging suggested that it could clearly distinguish the viable and apoptotic tumor regions.
    Conclusions: The Split Bregman iteration method is able to minimize the L
    MeSH term(s) Algorithms ; Animals ; Computer Simulation ; Image Processing, Computer-Assisted ; Luminescent Measurements/methods ; Mice, Inbred BALB C ; Mice, Nude ; Phantoms, Imaging ; Tomography, Optical/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-016-0970-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6468: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Effects of L

    Zhang, Jiayan / Wang, Ping / Tan, Cui / Zhao, Yansheng / Zhu, Ying / Bai, Juan / Xiao, Xiang / Zhang, Lili / Teng, Donghai / Tian, Jing / Liu, Liangcheng / Zhang, Haibo

    Current research in food science

    2022  Volume 5, Page(s) 125–130

    Abstract: This article explored the effect ... ...

    Abstract This article explored the effect of
    Language English
    Publishing date 2022-01-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2021.12.005
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  6. Article ; Online: Enhancing l-Malic Acid Production in

    Yang, Dongdong / Xu, Yingyan / Mo, Li / Shi, Man / Wu, Na / Lu, Ling / Xue, Feng / Xu, Qing / Zhang, Chi

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 9, Page(s) 4869–4879

    Abstract: The efficient production of l-malic acid using ...

    Abstract The efficient production of l-malic acid using
    MeSH term(s) Aspergillus niger/genetics ; Aspergillus niger/metabolism ; Malates/metabolism ; Fermentation ; Escherichia coli/genetics ; Escherichia coli/metabolism ; NAD/metabolism ; Gene Expression ; Aspergillus
    Chemical Substances malic acid (817L1N4CKP) ; Malates ; NAD (0U46U6E8UK)
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c09321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Glycyl-l-histidyl-l-lysine-Cu

    Deng, Mingming / Zhang, Qin / Yan, Liming / Bian, Yiding / Li, Ruixia / Gao, Jinghan / Wang, Yingxi / Miao, Jinrui / Li, Jiaye / Zhou, Xiaoming / Hou, Gang

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 14, Issue 3, Page(s) 1365–1380

    Abstract: ... sectional area elevated (1055 ± 552.4 μm: Conclusions: Plasma glycyl-l-histidyl-l-lysine level ... associated with skeletal muscle mass. Exogenous administration of glycyl-l-histidyl-l-lysine-Cu ...

    Abstract Background: Skeletal muscle dysfunction is an important co-morbidity in patients with chronic obstructive pulmonary disease (COPD) and is significantly associated with increased mortality. Oxidative stress has been demonstrated an important trigger for COPD-related skeletal muscle dysfunction. Glycine-histidine-lysine (GHK) is an active tripeptide, which is a normal component of human plasma, saliva, and urine; promotes tissue regeneration; and acts as an anti-inflammatory and antioxidant properties. The purpose of this study was to determine whether GHK is involved in COPD-related skeletal muscle dysfunction.
    Methods: The plasma GHK level in patients with COPD (n = 9) and age-paired healthy subjects (n = 11) were detected using reversed-phase high-performance liquid chromatography. The complex GHK with Cu (GHK-Cu) was used in in vitro (C2C12 myotubes) and in vivo experiments (cigarette smoking [CS]-exposure mouse model) to explore the involvement of GHK in CS-induced skeletal muscle dysfunction.
    Results: Compared with healthy control, plasma GHK levels were decreased in patients with COPD (70.27 ± 38.87 ng/mL vs. 133.0 ± 54.54 ng/mL, P = 0.009). And plasma GHK levels in patients with COPD were associated with pectoralis muscle area (R = 0.684, P = 0.042), inflammatory factor TNF-α (R = -0.696, P = 0.037), and antioxidative stress factor SOD2 (R = 0.721, P = 0.029). GHK-Cu was found to rescue CSE-induced skeletal muscle dysfunction in C2C12 myotubes, as evidenced by increased expression of myosin heavy chain, reduced expression of MuRF1 and atrogin-1, elevated mitochondrial content, and enhanced resistance to oxidative stress. In CS-induced muscle dysfunction C57BL/6 mice, GHK-Cu treatment (0.2 and 2 mg/kg) reduces CS-induced muscle mass loss (skeletal muscle weight (1.19 ± 0.09% vs. 1.29 ± 0.06%, 1.40 ± 0.05%; P < 0.05) and muscle cross-sectional area elevated (1055 ± 552.4 μm
    Conclusions: Plasma glycyl-l-histidyl-l-lysine level in patients with chronic obstructive pulmonary disease was significantly decreased and was significantly associated with skeletal muscle mass. Exogenous administration of glycyl-l-histidyl-l-lysine-Cu
    MeSH term(s) Humans ; Mice ; Animals ; Lysine/metabolism ; Sirtuin 1/metabolism ; Cigarette Smoking ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; Pulmonary Disease, Chronic Obstructive/metabolism
    Chemical Substances Lysine (K3Z4F929H6) ; Sirtuin 1 (EC 3.5.1.-) ; Antioxidants
    Language English
    Publishing date 2023-03-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Arctium lappa L.

    Xiang, Wen / Wei, Jiayi / Lv, Lifei / Yu, Xinghui / Xie, Yan / Zhang, Li / Lu, Naiyan / Jiang, Wentao

    Natural product research

    2023  , Page(s) 1–6

    Abstract: In this study, water-soluble polysaccharides purified from burdock root were used to intervene in carbon tetrachloride ( ... ...

    Abstract In this study, water-soluble polysaccharides purified from burdock root were used to intervene in carbon tetrachloride (CCl
    Language English
    Publishing date 2023-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2272287
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  9. Article ; Online: 3D directional gradient L

    Shi, Yu / Wang, Yirong / Meng, Fanzhen / Zhou, Jianwei / Wen, Bo / Zhang, Xuexue / Liu, Yanyun / Li, Lei / Li, Juntao / Cao, Xu / Kang, Fei / Zhu, Shouping

    Computers in biology and medicine

    2023  Volume 161, Page(s) 107010

    Abstract: ... artifacts in the dual-panel PEM, we propose a 3D directional gradient L: Methods: The detailed derivation ...

    Abstract Background: Dual-panel PET is often used for local organ imaging, especially breast imaging, due to its simple structure, high sensitivity, good in-plane resolution, and straightforward fusion with other imaging modalities. Nevertheless, because of data loss caused by the dual-panel structure, using conventional image reconstruction methods results in limited-view artifacts and low image quality in dual-panel positron emission mammography (PEM), which may seriously affect the diagnosis. To mitigate the limited-view artifacts in the dual-panel PEM, we propose a 3D directional gradient L
    Methods: The detailed derivation and reasonable simplification of the 3D-DL
    Results: The qualitative and quantitative studies for phantom data and the blind reader study for clinical data show that the proposed method is more effective in reaching a balance between artifact elimination and image contrast improvement compared with various limited-view reconstruction methods. In addition, the iteration process of the method is proved convergent numerically.
    Conclusions: The image quality improvement confirms the potential value of the proposed reconstruction algorithm to address the limited-view problem, and thus improve diagnostic accuracy in dual-panel PEM imaging.
    MeSH term(s) Humans ; Electrons ; Mammography/methods ; Breast/diagnostic imaging ; Phantoms, Imaging ; Algorithms ; Artifacts ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: An L

    Wang, Bingyuan / Wan, Wenbo / Wang, Yihan / Ma, Wenjuan / Zhang, Limin / Li, Jiao / Zhou, Zhongxing / Zhao, Huijuan / Gao, Feng

    Biomedical engineering online

    2017  Volume 16, Issue 1, Page(s) 32

    Abstract: ... of non-negative prior information, designing differentiable objective functions for cases of L: Results ...

    Abstract Background: In diffuse optical tomography (DOT), the image reconstruction is often an ill-posed inverse problem, which is even more severe for breast DOT since there are considerably increasing unknowns to reconstruct with regard to the achievable number of measurements. One common way to address this ill-posedness is to introduce various regularization methods. There has been extensive research regarding constructing and optimizing objective functions. However, although these algorithms dramatically improved reconstruction images, few of them have designed an essentially differentiable objective function whose full gradient is easy to obtain to accelerate the optimization process.
    Methods: This paper introduces a new kind of non-negative prior information, designing differentiable objective functions for cases of L
    Results: Performance analyses are conducted using both numerical and phantom experiments. In terms of spatial resolution, quantitativeness, gray resolution and execution time, the proposed methods perform better than the conventional regularization methods without this non-negative prior information.
    Conclusions: The proposed methods improves the reconstruction images using the introduced non-negative prior information. Furthermore, the non-negative constraint facilitates the gradient computation, accelerating the minimization of the objective functions.
    MeSH term(s) Algorithms ; Breast/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Models, Theoretical ; Phantoms, Imaging ; Tomography, Optical/methods
    Language English
    Publishing date 2017-03-03
    Publishing country England
    Document type Journal Article
    ISSN 1475-925X
    ISSN (online) 1475-925X
    DOI 10.1186/s12938-017-0318-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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