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Article ; Online: [Anosmia and ageusia as primary symptoms of COVID-19].

Haldrup, Mette / Johansen, Mikkel Illemann / Fjaeldstad, Alexander Wieck

2020 Volume 182, Issue 18

Abstract: This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly runny nose when coming from cold to warm air, the only symptom was a sudden onset of ...

Abstract	This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly runny nose when coming from cold to warm air, the only symptom was a sudden onset of persistent anosmia and ageusia. Two weeks after normalisation of the mild sino-nasal symptoms, the patient was tested positive for SARS-CoV-2, and anosmia was verified with Sniffin' Sticks tests. Hypogeusia was verified with taste screening and two validated taste tests. Olfactory and gustatory loss may be underestimated symptoms of COVID-19.
MeSH term(s)	Adult ; Ageusia/virology ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Humans ; Olfaction Disorders/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
Keywords	covid19
Language	Danish
Publishing date	2020-05-11
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: Descriptive registry study on outcome and complications of external ventricular drainage treatment of intraventricular haemorrhage in a Danish cohort: a study protocol.

Gu, Chenghao / Haldrup, Mette / Rasmussen, Mads / Dyrskog, Stig / Simonsen, Claus Ziegler / Grønhøj, Mads Hjortdal / Poulsen, Frantz Rom / Busse, Thor / Wismann, Joakim / Debrabant, Birgit / Korshoej, Anders Rosendal

BMJ open

2024 Volume 14, Issue 1, Page(s) e075997

Abstract: Introduction: Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated ... ...

Abstract	Introduction: Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated patients with IVH are not fully elucidated. This study aims to describe EVD complication rates and outcomes in patients with primary and secondary IVH at two university hospitals in Denmark. The study will provide a historical reference of relevant endpoints for use in future clinical trials involving patients with IVH. Methods and analysis: This descriptive, multicentre registry study included adult patients (age 18+) with primary or secondary IVH and treated with at least one EVD between 2017 and 2021 at Aarhus University Hospital or Odense University Hospital. Patients are identified using the Danish National Patient Register. Data are collected and recorded from patient medical records. Relevant descriptive statistics and correlation analyses will be applied. Ethics and dissemination: Ethical approval and authorisation to access, store and analyse data have been obtained (Central Denmark Region Committee on Health Research Ethics). The research lead will present the results of the study. Data will be reported according to the Strengthening the Reporting of Observational Studies in Epidemiology and results submitted for publication in peer-reviewed journals.
MeSH term(s)	Adult ; Humans ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/surgery ; Denmark/epidemiology ; Drainage/adverse effects ; Drainage/methods ; Multicenter Studies as Topic ; Registries ; Treatment Outcome
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075997
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Article ; Online: Reliability and performance of the IRRAflow® system for intracranial lavage and evacuation of hematomas-A technical note.

Haldrup, Mette / Nazari, Mojtaba / Gu, Chenghao / Rasmussen, Mads / Dyrskog, Stig / Ziegler Simonsen, Claus / Grønhøj, Mads / Poulsen, Frantz Rom / Ur Rehman, Naveed / Rosendal Korshoej, Anders

PloS one

2024 Volume 19, Issue 4, Page(s) e0297131

Abstract: Background: Intraventricular hemorrhage (IVH) is a severe condition with poor outcomes and high mortality. IRRAflow® (IRRAS AB) is a new technology introduced to accelerate IVH clearance by minimally invasive wash-out. The IRRAflow® system performs ... ...

Abstract	Background: Intraventricular hemorrhage (IVH) is a severe condition with poor outcomes and high mortality. IRRAflow® (IRRAS AB) is a new technology introduced to accelerate IVH clearance by minimally invasive wash-out. The IRRAflow® system performs active and controlled intracranial irrigation and aspiration with physiological saline, while simultaneously monitoring and maintaining a stable intracranial pressure (ICP). We addressed important aspects of the device implementation and intracranial lavage. Method: To allow versatile investigation of multiple device parameters, we designed an ex vivo lab setup. We evaluated 1) compatibility between the IRRAflow® catheter and the Silverline f10 bolt (Spiegelberg), 2) the physiological and hydrodynamic effects of varying the IRRAflow® settings, 3) the accuracy of the IRRAflow® injection volumes, and 4) the reliability of the internal ICP monitor of the IRRAflow®. Results: The IRRAflow® catheter was not compatible with Silverline bolt fixation, which was associated with leakage and obstruction. Design space exploration of IRRAflow® settings revealed that appropriate settings included irrigation rate 20 ml/h with a drainage bag height at 0 cm, irrigation rate 90 ml/h with a drainage bag height at 19 cm and irrigation rate 180 ml/h with a drainage bag height at 29 cm. We found the injection volume performed by the IRRAflow® to be stable and reliable, while the internal ICP monitor was compromised in several ways. We observed a significant mean drift difference of 3.16 mmHg (variance 0.4, p = 0.05) over a 24-hour test period with a mean 24-hour drift of 3.66 mmHg (variance 0.28) in the pressures measured by the IRRAflow® compared to 0.5 mmHg (variance 1.12) in the Raumedic measured pressures. Conclusion: Bolting of the IRRAflow® catheter using the Medtronic Silverline® bolt is not recommendable. Increased irrigation rates are recommendable followed by a decrease in drainage bag level. ICP measurement using the IRRAflow® device was unreliable and should be accompanied by a control ICP monitor device in clinical settings.
MeSH term(s)	Humans ; Reproducibility of Results ; Therapeutic Irrigation ; Intracranial Pressure/physiology ; Monitoring, Physiologic ; Cerebral Hemorrhage/therapy ; Hematoma
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297131
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Article ; Online: Descriptive registry study on outcome and complications of external ventricular drainage treatment of intraventricular haemorrhage in a Danish cohort

Mads Rasmussen / Claus Ziegler Simonsen / Chenghao Gu / Mette Haldrup / Stig Dyrskog / Mads Hjortdal Grønhøj / Frantz Rom Poulsen / Thor Busse / Joakim Wismann / Birgit Debrabant / Anders Rosendal Korshoej

BMJ Open, Vol 14, Iss

a study protocol

2024 Volume 1

Abstract: Introduction Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated patients ...

Abstract	Introduction Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated patients with IVH are not fully elucidated. This study aims to describe EVD complication rates and outcomes in patients with primary and secondary IVH at two university hospitals in Denmark. The study will provide a historical reference of relevant endpoints for use in future clinical trials involving patients with IVH.Methods and analysis This descriptive, multicentre registry study included adult patients (age 18+) with primary or secondary IVH and treated with at least one EVD between 2017 and 2021 at Aarhus University Hospital or Odense University Hospital. Patients are identified using the Danish National Patient Register. Data are collected and recorded from patient medical records. Relevant descriptive statistics and correlation analyses will be applied.Ethics and dissemination Ethical approval and authorisation to access, store and analyse data have been obtained (Central Denmark Region Committee on Health Research Ethics). The research lead will present the results of the study. Data will be reported according to the Strengthening the Reporting of Observational Studies in Epidemiology and results submitted for publication in peer-reviewed journals.
Keywords	Medicine ; R
Subject code	170
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical occlusion of middle meningeal artery in treatment of chronic subdural haematoma: anatomical and technical considerations.

Haldrup, Mette / Munyemana, Paulin / Ma'aya, Alhareth / Jensen, Thorbjørn Søren Rønn / Fugleholm, Kåre

Acta neurochirurgica

2021 Volume 163, Issue 4, Page(s) 1075–1081

Abstract: Background: The primary aim of chronic subdural haematoma (CSDH) treatment is to relieve pressure to improve neurological symptoms. The secondary aim is to avoid recurrence. The blood supply from the middle meningeal artery (MMA) to the haematoma ... ...

Abstract	Background: The primary aim of chronic subdural haematoma (CSDH) treatment is to relieve pressure to improve neurological symptoms. The secondary aim is to avoid recurrence. The blood supply from the middle meningeal artery (MMA) to the haematoma membranes has recently become a research target, to enhance our understanding of the processes leading to growth and re-growth of a CSDH. Several studies indicate that endovascular embolization of the MMA (eMMA) reduces recurrence rates, but this effect must be confirmed in a randomized controlled setting. Endovascular embolization is an advanced and costly procedure carrying a significant risk of embolism in the elderly. The aim of this study was to assess anatomical and technical aspects of surgical occlusion of the MMA (soMMA) via a single same-procedure burr hole, as an alternative to eMMA. Method: Technical aspects of soMMA were assessed using cadaver head dissection. MMA anatomy was examined by mapping the branching pattern and distribution of MMA in dry skulls, and CSDH position was investigated by analysis of computed tomography (CT) of CSDHs. Finally, we evaluated the possibility of CT-guided navigation to mark the branching point of the anterior MMA division on the skin. Results: We established anatomical landmarks to locate the MMA and found that particularly the anterior MMA branch can be occluded through a single burr hole at the pterion during the same procedure as haematoma decompression. CT of 1454 CSDHs in 1162 patients showed that the CSDH was anteriorly located in 57.5% compared with posteriorly in only 3%. This correlated with the anterior branch of the MMA being dominant in 58% of dry skull samples examined. We further confirmed that the MMA can be localized by neuronavigation as an alternative to using anatomical landmarks and average measurements. Conclusion: A CSDH is mainly anteriorly located and supposedly primarily supplied by the anterior MMA branch. In a simulated setting, soMMA can be performed during the same procedure as haematoma decompression. A few reservations notwithstanding, we find that soMMA may be a viable alternative to eMMA in most CSDH cases and that soMMA should be further evaluated in a clinical setting.
MeSH term(s)	Aged ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Female ; Hematoma, Subdural, Chronic/surgery ; Hematoma, Subdural, Chronic/therapy ; Humans ; Male ; Meningeal Arteries/anatomy & histology ; Meningeal Arteries/surgery ; Middle Aged ; Trephining/adverse effects ; Trephining/methods
Language	English
Publishing date	2021-02-08
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-021-04754-x
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Article: [Anosmia and ageusia as primary symptoms of COVID-19]

Haldrup, Mette / Johansen, Mikkel Illemann / Fjaeldstad, Alexander Wieck

Ugeskr. laeg

Abstract	This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly runny nose when coming from cold to warm air, the only symptom was a sudden onset of persistent anosmia and ageusia. Two weeks after normalisation of the mild sino-nasal symptoms, the patient was tested positive for SARS-CoV-2, and anosmia was verified with Sniffin' Sticks tests. Hypogeusia was verified with taste screening and two validated taste tests. Olfactory and gustatory loss may be underestimated symptoms of COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32400371
Database	COVID19

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Article ; Online: Early clinical predictors of functional recovery following traumatic spinal cord injury: a population-based study of 143 patients.

Wichmann, Thea Overgaard / Jensen, Mette Haldrup / Kasch, Helge / Rasmussen, Mikkel Mylius

Acta neurochirurgica

2021 Volume 163, Issue 8, Page(s) 2289–2296

Abstract: Background: Traumatic spinal cord injuries (TSCI) are associated with uncertainty regarding the prognosis of functional recovery. The aim of the present study was to evaluate the potential of early clinical variables to predict the degree of functional ... ...

Abstract	Background: Traumatic spinal cord injuries (TSCI) are associated with uncertainty regarding the prognosis of functional recovery. The aim of the present study was to evaluate the potential of early clinical variables to predict the degree of functional independence assessed by Spinal Cord Independence Measure III (SCIM-III) up to 1 year after injury. Methods: Prospectively collected data from 143 SCI patients treated in Western Denmark during 2012-2019 were retrospectively analysed. Data analysis involved univariate methods and multivariable linear regression modelling total SCIM-III scores against age, gender, body mass index (BMI), comorbidity, American Spinal Injury Association (ASIA) Impairment Scale (AIS) grades A-B and C-D, ASIA Motor Score (AMS), timing of surgical treatment and occurrence of medical complications. Statistical significance was set at p < .05. Results: Univariate analyses indicated that variables significantly associated with decreased functional independence included increased age (p = .023), increased BMI (p = .012), pre-existing comorbidity (p = .001), AIS grades A-B (p < .001), decreased AMS (p < .001) and occurrence of medical complications (p < .001). However, in the multivariable regression model were pre-existing comorbidity (p = .010), AIS grades A-B (p < .001), low AMS (p < .001) and late surgical treatment (p = .018) significant predictors of decreased functional independence 1 year after injury. Conclusion: TSCI patients with greatest potential for functional recovery up to 1 year after injury seem to be patients that immediately after trauma present with few or no comorbidities, who sustain motor-incomplete injuries and undergo early decompressive surgery.
MeSH term(s)	Humans ; Prognosis ; Recovery of Function ; Retrospective Studies ; Spinal Cord Injuries/epidemiology ; Spinal Cord Injuries/surgery
Language	English
Publishing date	2021-01-11
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-020-04701-2
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Article ; Online: Treatment of Intraventricular Hemorrhage with External Ventricular Drainage and Fibrinolysis: A Comprehensive Systematic Review and Meta-Analysis of Complications and Outcome.

Haldrup, Mette / Miscov, Rares / Mohamad, Niwar / Rasmussen, Mads / Dyrskog, Stig / Simonsen, Claus Ziegler / Grønhøj, Mads / Poulsen, Frantz Rom / Bjarkam, Carsten Reidies / Debrabant, Birgit / Korshøj, Anders Rosendal

World neurosurgery

2023 Volume 174, Page(s) 183–196.e6

Abstract: Background: External ventricular drainage (EVD) is a key factor in the treatment of intraventricular hemorrhage (IVH) but associated with risks and complications. Intraventricular fibrinolysis (IVF) has been proposed to improve clinical outcome and ... ...

Abstract	Background: External ventricular drainage (EVD) is a key factor in the treatment of intraventricular hemorrhage (IVH) but associated with risks and complications. Intraventricular fibrinolysis (IVF) has been proposed to improve clinical outcome and reduce complications of EVD treatment. The following review and metaanalysis provides a comprehensive evaluation of IVH treatment with external ventricular drainage (EVD) and intraventricular fibrinolysis (IVF) with regards to complications and clinical outcomes. Methods: The PRISMA guidelines were followed preparing this review. Studies included in the meta-analysis were compared using forest plots and the related odds ratios. Results: After a literature search, 980 articles were identified and 65 and underwent full-text review. Forty-two articles were included in the review and meta-analysis. We found that bolted and antibiotic-coated catheters were superior to tunnelled/uncoated catheters (P < 0.001) and antibiotic- vs. silver-impregnated catheters (P < 0.001]) in preventing infection. Shunt dependency was related to the volume of blood in the ventricles but unaffected by IVF (P = 0.98). IVF promoted hematoma clearance, decreased mortality (22.4% vs. 40.9% with IVF vs. no IVF, respectively, P < 0.00001), improved good functional outcomes (47.2% [IVF] vs. 38.3% [no IVF], P = 0.03), and reduced the rate of catheter occlusion from 37.3% without IVF to 10.6% with IVF (P = 0.0003). Conclusions: We present evidence and best practice recommendations for the treatment of IVH with EVD and intraventricular fibrinolysis. Our analysis further provides a comprehensive quantitative reference of the most relevant clinical endpoints for future studies on novel IVH technologies and treatments.
MeSH term(s)	Humans ; Cerebral Hemorrhage/therapy ; Cerebral Ventricles/surgery ; Drainage/adverse effects ; Fibrinolytic Agents/therapeutic use ; Treatment Outcome
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.01.021
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Article ; Online: Lugte- og smagstab som primære symptom på COVID-19 ; Anosmia and ageusia as primary symptoms of COVID-19

Haldrup, Mette / Johansen, Mikkel Illemann / Fjaeldstad, Alexander Wieck

Haldrup , M , Johansen , M I & Fjaeldstad , A W 2020 , ' Lugte- og smagstab som primære symptom på COVID-19 ' , Ugeskift for Læger , bind 182 , nr. 18 , V04200205 .

2020

Abstract: Coronavirus har den forgangne måned fået et altoverskyggende sundhedsfagligt fokus. Den potentielt dødelige virus har skabt vidtrækkende konsekvenser, hvor der gøres en lang række foranstaltninger for at reducere smittespredning. Nøglen i denne indsats ... ...

Abstract	Coronavirus har den forgangne måned fået et altoverskyggende sundhedsfagligt fokus. Den potentielt dødelige virus har skabt vidtrækkende konsekvenser, hvor der gøres en lang række foranstaltninger for at reducere smittespredning. Nøglen i denne indsats er at identificere smittede personer. For at denne indsats har effekt er det essentielt at genkende symptomer på smitte. De beskrevne symptomer på sygdommen COVID-19 forårsaget af severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spænder fra milde til svære tilfælde. De hyppigste symptomer er feber, hoste, muskelsmerter og træthed. Sjældnere symptomer er åndenød, hovedpine, diarré, hæmoptyse, rinitis og uproduktiv hoste. Der har desuden været beskrivelser fra flere lande, hvor læger har observeret tilfælde af lugte- og smagstab i forbindelse med COVID-19. Forbindelsen mellem COVID-19 og lugte-/smagstab er dog endnu ikke verificeret med testning af sanserne. Vi præsenterer en sygehistorie med en SARS-CoV-2 positiv patient med monosymptomatisk tabt lugtesans og reduceret smagssans som eneste symptomer ud over meget let løbenæse hos en ellers fuldstændig rask læge i starten af 30’erne. This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. Apart from a week of slightly runny nose when coming from cold to warm air, the only symptom was a sudden onset of persistent anosmia and ageusia. Two weeks after normalisation of the mild sino-nasal symptoms, the patient was tested positive for SARS-CoV-2, and anosmia was verified with Sniffin' Sticks tests. Hypogeusia was verified with taste screening and two validated taste tests. Olfactory and gustatory loss may be underestimated symptoms of COVID-19.
Keywords	Lugtesans ; Smagssans ; Olfaktion ; COVID-19 ; Lugtetab ; Smagstab ; covid19
Language	Danish
Publishing country	dk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Early decompressive surgery in patients with traumatic spinal cord injury improves neurological outcome.

Haldrup, Mette / Schwartz, Ole Søndergaard / Kasch, Helge / Rasmussen, Mikkel Mylius

Acta neurochirurgica

2019 Volume 161, Issue 10, Page(s) 2223–2228

Abstract: Background: The role and timing of a decompressive surgical intervention in patients with traumatic spinal cord injury (SCI) remain controversial. Given the impact of SCI on the individual and society, decompressive surgery to reduce the extent of ... ...

Abstract	Background: The role and timing of a decompressive surgical intervention in patients with traumatic spinal cord injury (SCI) remain controversial. Given the impact of SCI on the individual and society, decompressive surgery to reduce the extent of tissue destruction and improving neurological outcome after initial spinal cord trauma are needed. Objective: To evaluate any possible correlation between the time of a decompressive procedure after traumatic SCI and end-neurologic outcome for traumatic SCI patients. Methods: A retrospective cohort study on patients with traumatic SCI in Western Denmark from 2010 to 2017. Data on date and time of injury and time of surgery and data on neurologic status at admission and one-year post-trauma were found in the Electronic Patients Journal (EPJ) and in paper journals. Patients were divided into 4 groups (< 6 h, < 12 h, < 24 h, and > 24 h) based on the time between injury and surgery. Further, patients were separated into two groups depending on whether they did or did not achieve neurological improvement one-year post-trauma. We used Fisher's exact test to compare the abovementioned groups to examine an eventual correlation between time from injury to operation and change in neurological outcome one-year post-trauma. Results: Patients undergoing surgery < 24 h after trauma obtained a significantly better neurological outcome as compared with patients who underwent surgery > 24 h after trauma (p < 0.001). This result did not change for subgroups of incomplete SCI patients (p = 0.002). However, complete SCI patients operated < 24 h as compared with > 24 h did not obtain better outcome (p = 0.14). We did not find a statistically significant correlation when time from trauma to surgery was reduced further to < 6 or < 12 h post-trauma. Furthermore, stratification on patients undergoing surgery before and after 24 h was made regarding gender, completeness, and years of age. The groups did not differ concerning gender and SCI completeness, but significant difference in age was found (44 and 58 years of age, respectively, p < 0.001). The chance of improved outcome was significantly higher for patients < 50 years of age (42% versus 24%, p = 0.05). Patients under the age of 50 seemed to benefit from early intervention (50% improvement versus 23%); however, difference was not statistically significant (p = 0.08). In patients aged above 50, the trend was similar, but significant correlation was found (40% versus 16%, p = 0.05). Conclusion: The present study reports a beneficial effect of early decompression surgery, especially for incomplete SCI patients; however, surgical decision-making is complex, and all cases of acute spinal cord injury should be cautiously interpreted and handled on an individual basis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Decision Making ; Decompression, Surgical/methods ; Denmark ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Neurosurgical Procedures/methods ; Retrospective Studies ; Spinal Cord Injuries/surgery ; Time Factors ; Time-to-Treatment ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-08-11
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-019-04031-y
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