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  1. Book: Allgemeine Epileptologie

    Bien, Christian G.

    das Bethel-Praxisbuch

    (Neurologische Fallbesprechungen. Der Patient im Fokus)

    2021  

    Author's details Christian G. Bien (Hrsg.)
    Series title Neurologische Fallbesprechungen. Der Patient im Fokus
    Keywords Epileptologie
    Language German
    Size 292 Seiten, Illustrationen, Diagramme
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020668866
    ISBN 978-3-17-035074-8 ; 9783170350755 ; 9783170350762 ; 9783170350779 ; 3-17-035074-9 ; 3170350757 ; 3170350765 ; 3170350773
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 203 available for loan (reading room) Lesesaal EG

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  2. Book: Prächirurgische Diagnostik und chirurgische Epilepsietherapie

    Bien, Christian G.

    das Bethel-Praxisbuch

    (Neurologische Fallbesprechungen)

    2021  

    Author's details Christian G. Bien (Hrsg.)
    Series title Neurologische Fallbesprechungen
    Keywords Chirurgie ; Epilepsie ; Epileptischer Anfall ; Neurochirurgie ; Neurologie ; Neurologische Erkrankungen
    Subject Surgery ; Fallsucht
    Subject code 610
    Language German
    Size 234 Seiten, Illustrationen
    Edition 1. Auflage
    Publisher Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT021080520
    ISBN 978-3-17-035078-6 ; 3-17-035078-1 ; 9783170350793 ; 9783170350809 ; 317035079X ; 3170350803
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 1206 available for loan (reading room) Lesesaal EG

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  3. Article: Limbic encephalitis.

    Bien, Christian G

    Handbook of clinical neurology

    2022  Volume 187, Page(s) 467–487

    Abstract: Limbic encephalitis (LE) is a clinical syndrome defined by subacutely evolving limbic signs and symptoms with structural and functional evidence of mediotemporal damage in the absence of a better explanation than an autoimmune (or paraneoplastic) cause. ... ...

    Abstract Limbic encephalitis (LE) is a clinical syndrome defined by subacutely evolving limbic signs and symptoms with structural and functional evidence of mediotemporal damage in the absence of a better explanation than an autoimmune (or paraneoplastic) cause. There are features common to all forms of LE. In recent years, antibody(ab)-defined subtypes have been established. They are distinct regarding underlying pathophysiologic processes, clinical and magnetic resonance imaging courses, cerebrospinal fluid signatures, treatment responsivity, and likelihood of a chronic course. With immunotherapy, LE with abs against surface antigens has a better outcome than LE with abs to intracellular antigens. Diagnostic and treatment challenges are, on the one hand, to avoid overlooking and undertreatment and, on the other hand, to avoid overdiagnoses and overtreatment. LE can be conceptualized as a model disease for the consequences of new onset mediotemporal damage by different mechanisms in adult life. It may be studied as an example of mediotemporal epileptogenesis.
    MeSH term(s) Adult ; Autoantibodies ; Humans ; Immunotherapy ; Limbic Encephalitis/diagnosis ; Limbic Encephalitis/therapy ; Magnetic Resonance Imaging
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-08-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-12-823493-8.00024-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: What neuropathology teaches us about autoimmune encephalitides, autoimmune epilepsies, and encephalomyelitides.

    Bien, Christian G / Bauer, Jan

    Clinical neuropathology

    2023  Volume 42, Issue 3, Page(s) 87–92

    Abstract: Delineation of the autoimmune encephalitides with antibodies against neural surface antigens (anti- ...

    Abstract Delineation of the autoimmune encephalitides with antibodies against neural surface antigens (anti-
    MeSH term(s) Humans ; Encephalitis/pathology ; Epilepsy ; Brain/pathology ; Neuropathology ; Autoimmune Diseases of the Nervous System ; Autoantibodies
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-03-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/NP301536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Management of autoimmune encephalitis.

    Bien, Christian G

    Current opinion in neurology

    2021  Volume 34, Issue 2, Page(s) 166–171

    Abstract: Purpose of review: Autoimmune encephalitides are established diagnoses in contemporary neurology. Their management poses a regular challenge for almost all neurologists. One may ask if the concept of 1st line and 2nd line treatment is still up to date, ... ...

    Abstract Purpose of review: Autoimmune encephalitides are established diagnoses in contemporary neurology. Their management poses a regular challenge for almost all neurologists. One may ask if the concept of 1st line and 2nd line treatment is still up to date, which new data on the antibody-defined encephalitis types exist, and how to organize long-term management.
    Recent findings: The 1st line/2nd line concept of initial immunological intervention is accepted worldwide. A randomized controlled trial confirmed that one 1st line compound (intravenous immunoglobulins) is superior to a placebo in patients with antibodies against leucine-rich glioma inactivated protein 1. Rituximab, a 2nd line compound, is increasingly and apparently successfully used in treating different types of autoimmune encephalitis. It may find its place even earlier in the treatment cascade. Long-term management needs to be improved and is under development.
    Summary: There have been no groundbreaking new developments in the field. The published experience confirms existing suggestions. Aspects of long-term management including rehabilitation measures and counseling about driving eligibility require further research.
    MeSH term(s) Antibodies ; Encephalitis/diagnosis ; Encephalitis/drug therapy ; Hashimoto Disease/diagnosis ; Hashimoto Disease/drug therapy ; Humans ; Immunoglobulins, Intravenous ; Randomized Controlled Trials as Topic
    Chemical Substances Antibodies ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2021-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: What is autoimmune encephalitis-associated epilepsy? Proposal of a practical definition.

    Rada, Anna / Bien, Christian G

    Epilepsia

    2023  Volume 64, Issue 9, Page(s) 2249–2255

    Abstract: Seizures resulting from cerebral autoimmunity are either acutely symptomatic in the context of autoimmune encephalitis (AIE) with neural surface antibodies, or they are indicative of an enduring predisposition to seizures, that is, epilepsy. Here, we ... ...

    Abstract Seizures resulting from cerebral autoimmunity are either acutely symptomatic in the context of autoimmune encephalitis (AIE) with neural surface antibodies, or they are indicative of an enduring predisposition to seizures, that is, epilepsy. Here, we propose a practical definition for autoimmune encephalitis-associated epilepsy (AEAE): Seizures associated with antibodies against glutamic acid decarboxylase, paraneoplastic syndromes, or Rasmussen encephalitis are classified as AEAE. AEAE secondary to AIE with antibodies against the N-methyl-D-aspartate receptor, leucine-rich glioma inactivated protein 1, contactin-associated protein-2, or γ-aminobutyric acid-B receptor can be diagnosed if the following criteria are met: seizures persist for at least 2 years after immunotherapy initiation; no signs of encephalitis on magnetic resonance imaging and no fluorodeoxyglucose positron emission tomography hypermetabolism; normal cerebrospinal fluid cell count; and a substantial decrease in antibody titers. This classification corresponds to different disease mechanisms. While AIE results from the pathogenic effects of neural antibodies, AEAE is probably the consequence of encephalitis-related tissue damage and thereby mainly structurally mediated. The distinction between AIE and AEAE also has practical consequences: In AIE, immunotherapy is usually highly beneficial, whereas anti-seizure medication has little effect. In AEAE, immunotherapy is less promising and the usual anti-seizure interventions are preferable. In addition, the diagnosis of AEAE has social consequences in terms of driving and professional limitations.
    MeSH term(s) Humans ; Encephalitis/complications ; Encephalitis/diagnosis ; Encephalitis/therapy ; Epilepsy/etiology ; Epilepsy/complications ; Hashimoto Disease/complications ; Hashimoto Disease/diagnosis ; Hashimoto Disease/therapy ; Autoimmune Diseases of the Nervous System/complications ; Autoimmune Diseases of the Nervous System/diagnosis ; Autoimmune Diseases of the Nervous System/therapy ; Autoantibodies
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  7. Article ; Online: Commentary: 2017 clinical Epilepsia prize.

    Bien, Christian G

    Epilepsia

    2018  Volume 59, Issue 6, Page(s) 1096–1097

    MeSH term(s) Awards and Prizes ; Epilepsy ; Humans
    Language English
    Publishing date 2018-05-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.14430
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  8. Article ; Online: Diagnosing autoimmune encephalitis based on clinical features and autoantibody findings.

    Bien, Christian G

    Expert review of clinical immunology

    2019  Volume 15, Issue 5, Page(s) 511–527

    Abstract: Introduction: Autoimmune encephalitides have been accepted as a reproducible and treatable new group of diseases. At present, there is concern that such diagnoses might be made too liberally. Areas covered: This article suggests how to make valid ... ...

    Abstract Introduction: Autoimmune encephalitides have been accepted as a reproducible and treatable new group of diseases. At present, there is concern that such diagnoses might be made too liberally. Areas covered: This article suggests how to make valid diagnoses. They should consist of three elements: the clinical syndrome, the associated antibody and the presumed cause or predisposition. Recently, an international consortium published formal clinical criteria for autoimmune encephalitides to enable diagnoses even if antibody testing is not (immediately) available and to prevent overinterpretation of questionable antibody results. Antibody testing has greatly benefitted from the introduction of cell-based assays for the demonstration of antibodies against surface antigens. Paraneoplastic or post-infectious situations, side effects of tumor therapies or genetic predispositions help to explain why a patient develops autoimmune encephalitis. Expert opinion: With the application of this three-fold diagnostic system, clinicians can counsel patients regarding therapy and prognosis, while researchers can form meaningful patient cohorts. An operationalization of criteria would be advantageous.
    MeSH term(s) Animals ; Autoantibodies/immunology ; Autoantigens/immunology ; Encephalitis/diagnosis ; Encephalitis/immunology ; Encephalitis/pathology ; Encephalitis/therapy ; Hashimoto Disease/diagnosis ; Hashimoto Disease/immunology ; Hashimoto Disease/pathology ; Hashimoto Disease/therapy ; Humans
    Chemical Substances Autoantibodies ; Autoantigens
    Language English
    Publishing date 2019-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2019.1573676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Ethosuximide lowers lamotrigine serum concentrations: Evidence for a clinically relevant interaction.

    Hagemann, Anne / Herting, Arne / Klimpel, Dennis / Bien, Christian G / Polster, Tilman

    Epilepsia

    2024  

    Abstract: We investigated the effect of comedication with ethosuximide (ESM) on lamotrigine (LTG) blood levels. Based on observations from clinical practice, we hypothesized that ESM reduces the LTG serum concentration. We additionally evaluated this effect in the ...

    Abstract We investigated the effect of comedication with ethosuximide (ESM) on lamotrigine (LTG) blood levels. Based on observations from clinical practice, we hypothesized that ESM reduces the LTG serum concentration. We additionally evaluated this effect in the presence of concomitant valproic acid (VPA). We retrospectively analyzed samples of inpatients from our department who had been treated with a combination of ESM and LTG between 2017 and 2021. We additionally used data on LTG serum concentrations from a previously published cohort from our center. Generalized estimation equations (GEEs) were used for statistical analyses. We included 523 samples from 209 patients. GEE analyses showed that LTG trough serum concentrations were significantly lower in samples with ESM comedication and significantly higher in samples with concomitant VPA. The effect of ESM was moderated by patients' age; in children and adolescents, LTG serum concentrations were 37% lower than in samples without ESM, whereas in adults, LTG serum concentrations were 14% lower. The effect we found in our data is relevant to daily clinical practice, if patients are not seizure-free despite typical daily LTG dosage, or if they develop side effects during ESM withdrawal. It should be considered especially in children and adolescents.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  10. Article ; Online: MRI evidence for material-specific encoding deficits and mesial-temporal alterations in presurgical frontal lobe epilepsy patients.

    Doll, Anna / Wegrzyn, Martin / Woermann, Friedrich G / Labudda, Kirsten / Bien, Christian G / Kissler, Johanna

    Epilepsia open

    2024  Volume 9, Issue 1, Page(s) 355–367

    Abstract: Objective: Neuroimaging studies reveal frontal lobe (FL) contributions to memory encoding. Accordingly, memory impairments are documented in frontal lobe epilepsy (FLE). Still, little is known about the structural or functional correlates of such ... ...

    Abstract Objective: Neuroimaging studies reveal frontal lobe (FL) contributions to memory encoding. Accordingly, memory impairments are documented in frontal lobe epilepsy (FLE). Still, little is known about the structural or functional correlates of such impairments. Particularly, material specificity of functional changes in cerebral activity during memory encoding in FLE is unclear.
    Methods: We compared 24 FLE patients (15 right-sided) undergoing presurgical evaluation with 30 healthy controls on a memory fMRI-paradigm of learning scenes, faces, and words followed by an out-of-scanner recognition task as well as regarding their mesial temporal lobe (mTL) volumes. We also addressed effects of FLE lateralization and performance level (normal vs. low).
    Results: FLE patients had poorer memory performance and larger left hippocampal volumes than controls. Volume increase seemed, however, irrelevant or even dysfunctional for memory performance. Further, functional changes in FLE patients were right-sided for scenes and faces and bilateral for words. In detail, during face encoding, FLE patients had, regardless of their performance level, decreased mTL activation, while during scene and word encoding only low performing FLE patients had decreased mTL along with decreased FL activation. Intact verbal memory performance was associated with higher right frontal activation in FLE patients but not in controls.
    Significance: Pharmacoresistant FLE has a distinct functional and structural impact on the mTL. Effects vary with the encoded material and patients' performance levels. Thus, in addition to the direct effect of the FL, memory impairment in FLE is presumably to a large part due to functional mTL changes triggered by disrupted FL networks.
    Plain language summary: Frontal lobe epilepsy (FLE) patients may suffer from memory impairment. Therefore, we asked patients to perform a memory task while their brain was scanned by MRI in order to investigate possible changes in brain activation during learning. FLE patients showed changes in brain activation during learning and also structural changes in the mesial temporal lobe, which is a brain region especially relevant for learning but not the origin of the seizures in FLE. We conclude that FLE leads to widespread changes that contribute to FLE patients' memory impairment.
    MeSH term(s) Humans ; Epilepsy, Frontal Lobe/diagnostic imaging ; Epilepsy, Frontal Lobe/surgery ; Epilepsy, Frontal Lobe/complications ; Memory/physiology ; Seizures ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/surgery ; Temporal Lobe/physiology ; Memory Disorders/diagnostic imaging ; Memory Disorders/complications ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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