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  1. Article: Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation.

    Giannitsi, Sofia / Bougiakli, Maria / Bechlioulis, Aris / Naka, Katerina

    JRSM cardiovascular disease

    2019  Volume 8, Page(s) 2048004019843047

    Abstract: Heart failure affects 1-2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30-50%, mortality rates remain ... ...

    Abstract Heart failure affects 1-2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30-50%, mortality rates remain high. A complex blend of structural and functional alterations accounts for the genesis and progression of heart failure, but the exact underlying pathophysiology remains poorly understood. The aim of this review is to summarize endothelial dysfunction and its role in the pathogenesis and progression of heart failure. Moreover, it sums up all the appropriate methods of assessing endothelial dysfunction emphasizing on flow-mediated dilation and introduces endothelium as a potential target for new therapeutic development and research in the wide spectrum of the syndrome called heart failure.
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Bibliography ; Journal Article ; Review
    ISSN 2048-0040
    ISSN 2048-0040
    DOI 10.1177/2048004019843047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Trimetazidine in the Prevention of Tissue Ischemic Conditions.

    Kallistratos, Manolis S / Poulimenos, Leonidas E / Giannitsi, Sofia / Tsinivizov, Pavlos / Manolis, Athanasios J

    Angiology

    2018  Volume 70, Issue 4, Page(s) 291–298

    Abstract: Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the required ... ...

    Abstract Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the required energy production with less oxygen consumption, an effect necessary in cases of myocardi. Trimetazidine was recently reaccredited as add-on therapy for symptomatic treatment in patients with stable angina, not adequately controlled or intolerant to first-line therapy. Trimetazidine was included in the European Society of Cardioloy 2013 guidelines for the management of stable coronary artery disease. Although TMZ has been used in cardiology for >40 years, only a few studies have assessed its effects in patients with acute ischemic conditions. This review summarizes the current literature regarding the addition of TMZ in patients with acute ischemic conditions (acute myocardial infarction, ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting). There is growing evidence from recent studies that the addition of TMZ in patients with such conditions is beneficial in terms of myocardial damage and major cardiac events as well as decreasing reperfusion injury and contrast-induced nephropathy.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Acute Kidney Injury/prevention & control ; Animals ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/therapeutic use ; Contrast Media/administration & dosage ; Coronary Artery Bypass/adverse effects ; Energy Metabolism/drug effects ; Glucose/metabolism ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/prevention & control ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Percutaneous Coronary Intervention/adverse effects ; Risk Factors ; Treatment Outcome ; Trimetazidine/adverse effects ; Trimetazidine/therapeutic use
    Chemical Substances Cardiovascular Agents ; Contrast Media ; Glucose (IY9XDZ35W2) ; Trimetazidine (N9A0A0R9S8)
    Language English
    Publishing date 2018-06-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/0003319718780551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Case Report] Stress induced (Takotsubo) cardiomyopathy triggered by the COVID-19 pandemic.

    Giannitsi, Sofia / Tsinivizov, Pavlos / Poulimenos, Leonidas E / Kallistratos, Manolis S / Varvarousis, Dimitris / Manolis, Athanasios J / Tsamakis, Konstantinos / Rizos, Emmanouil / Spandidos, Demetrios A / Tsiptsios, Dimitrios / Triantafyllis, Andreas S

    Experimental and therapeutic medicine

    2020  Volume 20, Issue 3, Page(s) 2812–2814

    Abstract: Stress induced (Takotsubo) cardiomyopathy (TC) represents an acute heart failure syndrome triggered by physical or emotional stressors. COVID-19 pandemic has caused an unprecedented health crisis resulting in fear, distress and anxiety, with emerging ... ...

    Abstract Stress induced (Takotsubo) cardiomyopathy (TC) represents an acute heart failure syndrome triggered by physical or emotional stressors. COVID-19 pandemic has caused an unprecedented health crisis resulting in fear, distress and anxiety, with emerging cardiovascular implications. COVID-19 related stress can act as potential trigger for TC. We present a case of an elderly female who developed TC due to stress surrounding COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2020.8968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Case Report] Stress induced (Takotsubo) cardiomyopathy triggered by the COVID-19 pandemic

    Giannitsi, Sofia / Tsinivizov, Pavlos / Poulimenos, Leonidas E / Kallistratos, Manolis S / Varvarousis, Dimitris / Manolis, Athanasios J / Tsamakis, Konstantinos / Rizos, Emmanouil / Spandidos, Demetrios A / Tsiptsios, Dimitrios / Triantafyllis, Andreas S

    Exp Ther Med

    Abstract: Stress induced (Takotsubo) cardiomyopathy (TC) represents an acute heart failure syndrome triggered by physical or emotional stressors. COVID-19 pandemic has caused an unprecedented health crisis resulting in fear, distress and anxiety, with emerging ... ...

    Abstract Stress induced (Takotsubo) cardiomyopathy (TC) represents an acute heart failure syndrome triggered by physical or emotional stressors. COVID-19 pandemic has caused an unprecedented health crisis resulting in fear, distress and anxiety, with emerging cardiovascular implications. COVID-19 related stress can act as potential trigger for TC. We present a case of an elderly female who developed TC due to stress surrounding COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #695714
    Database COVID19

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  5. Article ; Online: Serial Multimodality Evaluation of Aortocoronary Bypass Grafts During the First Year After CABG Surgery.

    Kotsia, Anna P / Papafaklis, Michail I / Michael, Tesfaldet T / Rangan, Bavana V / Peltz, Matthias / Roesle, Michele / Jessen, Michael / Willis, Bernice / Christopoulos, Georgios / Nakas, Georgios / Giannitsi, Sofia / Michalis, Lampros K / Fotiadis, Dimitris I / Banerjee, Subhash / Brilakis, Emmanouil S

    JACC. Cardiovascular imaging

    2015  Volume 8, Issue 11, Page(s) 1341–1343

    MeSH term(s) Coronary Angiography ; Coronary Artery Bypass/adverse effects ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Double-Blind Method ; Humans ; Multimodal Imaging/methods ; Neointima ; Predictive Value of Tests ; Saphenous Vein/diagnostic imaging ; Saphenous Vein/pathology ; Saphenous Vein/surgery ; Time Factors ; Tomography, Optical Coherence ; Treatment Outcome ; Ultrasonography, Interventional ; Vascular Remodeling
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Letter ; Randomized Controlled Trial
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2014.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6846: Show issues Location:
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