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  1. Article ; Online: ASO Author Reflections: Comparison of Two-Step Methods for Targeted Axillary Dissection in Denmark.

    Munck, Frederikke / Kroman, Niels / Tvedskov, Tove

    Annals of surgical oncology

    2023  Volume 30, Issue 11, Page(s) 6370–6371

    MeSH term(s) Humans ; Female ; Lymph Node Excision ; Sentinel Lymph Node Biopsy ; Denmark ; Axilla ; Breast Neoplasms/surgery
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13804-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Christmas article: Unexpected complication during COVID-19 swabbing].

    Munck, Frederikke / Tolver, Mette

    Ugeskrift for laeger

    2020  Volume 182, Issue 50

    Abstract: During the coronavirus disease 2019 (Covid-19) pandemic a vast number of oropharyngeal swabs have been sampled. A patient was referred to a surgical department after accidentially ingesting part of a testing swab. Since the swab posed a perforation risk, ...

    Abstract During the coronavirus disease 2019 (Covid-19) pandemic a vast number of oropharyngeal swabs have been sampled. A patient was referred to a surgical department after accidentially ingesting part of a testing swab. Since the swab posed a perforation risk, an urgent upper gastrointestinal (GI) endoscopy was performed. It revealed no swab, and the patient was discharged to out-patient care. At two-week follow-up, the patient was well. The Covid-19 test, despite the hassle in obtaining it, was negative. Pointy object, magnets, and batteries should be removed urgently from the GI tract. If passed beyond the duodenum, individual approach is acceptable.
    MeSH term(s) COVID-19/diagnosis ; Endoscopy ; Foreign Bodies/diagnosis ; Humans
    Language Danish
    Publishing date 2020-12-07
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Targeted Axillary Dissection with

    Munck, Frederikke / Andersen, Inge S / Vejborg, Ilse / Gerlach, Maria K / Lanng, Charlotte / Kroman, Niels T / Tvedskov, Tove H F

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 4135–4142

    Abstract: Background: Targeted axillary dissection (TAD), with marking of the metastatic lymph node before neoadjuvant chemotherapy (NACT), is increasingly used for breast cancer axillary staging. In the case of axillary pathological complete response (ax-pCR), ... ...

    Abstract Background: Targeted axillary dissection (TAD), with marking of the metastatic lymph node before neoadjuvant chemotherapy (NACT), is increasingly used for breast cancer axillary staging. In the case of axillary pathological complete response (ax-pCR), axillary lymph node clearance can be omitted. Several marking methods exist, most using re-marking before surgery. Feasibility, learning curve, and identification rate (IR) vary. Marking with
    Methods: Patients staged with
    Results: 142 patients were included. The IR of the MLN was 99.3%, and the IR of the SLNB was 91.5%. TAD success was 91.5%. Minor challenges in marking or removal of the MLN were noted in three patients. In 72.3% of the patients, the MLN was a sentinel node. Overall, 40.8% had axillary pCR.
    Conclusion: TAD with
    MeSH term(s) Humans ; Female ; Neoadjuvant Therapy/methods ; Sentinel Lymph Node Biopsy/methods ; Neoplasm Staging ; Lymph Node Excision/methods ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Axilla/pathology ; Denmark
    Chemical Substances Iodine-125 (GVO776611R)
    Language English
    Publishing date 2023-04-16
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13432-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Membrane fouling monitoring by 3ω sensing.

    Jørgensen, Mads Koustrup / Paulsen, Frederikke Kildeberg / Bentien, Anders / Kjul, Astrid Ræbild / Poulsen, Maiken / Mikkelsen, Louise Mailund / Thavaneswaran, Nikitha / Hansen, Simon Abildgaard / Jensen, Pernille Krogsager / Andersen, Jacob / Østedgaard-Munck, David N / Bendtsen, Jan Dimon / Christensen, Morten Lykkegaard

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15237

    Abstract: Membrane fouling significantly reduces membrane permeability, leading to higher operational expenses. In situ monitoring of membrane fouling can potentially be used to reduce operation cost by optimizing operational parameters and cleaning conditions. In ...

    Abstract Membrane fouling significantly reduces membrane permeability, leading to higher operational expenses. In situ monitoring of membrane fouling can potentially be used to reduce operation cost by optimizing operational parameters and cleaning conditions. In this study, a platinum wire with a diameter of 20 µm was attached to the surface of a ceramic ultrafiltration membrane, and by measuring the voltage across the wire while applying an AC current, the amplitude of the third harmonic wave, the so-called 3ω signal, was obtained. Results showed increasing 3ω signals during formation of fouling layers, which correlates directly to the hydraulic resistance of the formed fouling layer in semi-dead end filtration of polymeric core shell particles and crossflow filtration of diluted milk. This is explained by the insulating effect of the fouling layers which reduces heat convection by crossflow and the different thermal conductivity in the fouling layer compared with the feed. After membrane cleaning, the permeability and the magnitude of the 3ω signal were partly restored, showing that the 3ω method can be used to monitor the effect of cleaning. The frequency of the AC current was varied so it was possible to measure the heat conductivity in the fouling layer (high frequency) and heat convection due to cross-flow (low frequency). This may potentially be used to get information of the type of fouling (heat conductivity) and thickness of the fouling layer (AC frequency where heat conductivity becomes dominating).
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42337-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparing Methods for Targeted Axillary Dissection in Breast Cancer Patients: A Nationwide, Retrospective Study.

    Munck, Frederikke / Jepsen, Pernille / Zeuthen, Pernille / Carstensen, Lena / Hauerslev, Katrine / Paaskesen, Christian K / Andersen, Inge S / Høyer, Ute / Lanng, Charlotte / Gerlach, Maria K / Vejborg, Ilse / Kroman, Niels T / Tvedskov, Tove H F

    Annals of surgical oncology

    2023  Volume 30, Issue 11, Page(s) 6361–6369

    Abstract: Background: Several techniques exist for performing targeted axillary dissection (TAD) after neoadjuvant chemotherapy with the removal of the sentinel node and a marked metastatic lymph node (LN). Two-step methods include coil-marking of the metastatic ... ...

    Abstract Background: Several techniques exist for performing targeted axillary dissection (TAD) after neoadjuvant chemotherapy with the removal of the sentinel node and a marked metastatic lymph node (LN). Two-step methods include coil-marking of the metastatic LN at diagnosis and re-marking with an intraoperatively identifiable marker before surgery. Because nondetection of the marked lymph node (MLN) warrants axillary clearance and many patients achieve axillary pathological complete response (ax-pCR), the success of TAD is crucial. We compare various two-step TAD methods in a Danish national cohort.
    Methods: We included patients who received two-step TAD between January 1, 2016 and August 31, 2021. Patients were identified from the Danish Breast Cancer Group database and cross-checked with locally accessible lists. Data were extracted from the patient's medical files.
    Results: We included 543 patients. In 79.4%, preoperative, ultrasound-guided re-marking was possible. Nonidentification of the coil-marked LN was more likely in patients with ax-pCR. The second markers used were hook-wire, iodine seeds, or ink marking on the axillary skin. Of patients with successful secondary marking, the MLN identification rate (IR) was 91%, and the sentinel node (SN) IR was 95%. Marking with iodine seeds was significantly more successful than ink marking with an odds ratio of 5.34 (95% confidence interval 1.62-17.60). The success rate of the complete TAD with the removal of MLN and SN was 82.3%.
    Conclusions: With two-step TAD, nonidentification of the coiled LN before surgery is frequent, especially in patients with ax-pCR. Despite successful remarking, the IR of the MLN at surgery is inferior to one-step TAD.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Retrospective Studies ; Lymphatic Metastasis/pathology ; Neoplasm Staging ; Lymph Node Excision/methods ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Sentinel Lymph Node Biopsy/methods ; Neoadjuvant Therapy/methods ; Lymphadenopathy/surgery ; Axilla/pathology ; Iodine/therapeutic use
    Chemical Substances Iodine (9679TC07X4)
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13792-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention.

    Hansen, Anders E / Henriksen, Jonas R / Jølck, Rasmus I / Fliedner, Frederikke P / Bruun, Linda M / Scherman, Jonas / Jensen, Andreas I / Munck Af Rosenschöld, Per / Moorman, Lilah / Kurbegovic, Sorel / de Blanck, Steen R / Larsen, Klaus R / Clementsen, Paul F / Christensen, Anders N / Clausen, Mads H / Wang, Wenbo / Kempen, Paul / Christensen, Merete / Viby, Niels-Erik /
    Persson, Gitte / Larsen, Rasmus / Conradsen, Knut / McEvoy, Fintan J / Kjaer, Andreas / Eriksen, Thomas / Andresen, Thomas L

    Science advances

    2020  Volume 6, Issue 34, Page(s) eabb5353

    Abstract: Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore ... ...

    Abstract Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.
    MeSH term(s) Fiducial Markers ; Magnetic Resonance Imaging/methods ; Needles ; Phantoms, Imaging ; Radiotherapy, Image-Guided/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abb5353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

    Hansen, Anders E / Henriksen, Jonas R / Jølck, Rasmus I / Fliedner, Frederikke P / Bruun, Linda M / Scherman, Jonas / Jensen, Andreas I / Munck Af Rosenschöld, Per / Moorman, Lilah / Kurbegovic, Sorel / de Blanck, Steen R / Larsen, Klaus R / Clementsen, Paul F / Christensen, Anders N / Clausen, Mads H / Wang, Wenbo / Kempen, Paul / Christensen, Merete / Viby, Niels-Erik /
    Persson, Gitte / Larsen, Rasmus / Conradsen, Knut / McEvoy, Fintan J / Kjaer, Andreas / Eriksen, Thomas / Andresen, Thomas L

    Sci. Adv

    Abstract: Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore ... ...

    Abstract Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32937350
    Database COVID19

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