LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 334657

Search options

  1. Article ; Online: Neuropeptide Y Y

    Li, Juan / Tian, Yuchen / Shan, Dingying / Gong, An / Zeng, Leyong / Ren, Wenzhi / Xiang, Lingchao / Gerhard, Ethan / Zhao, Jinshun / Yang, Jian / Wu, Aiguo

    Biomaterials

    2017  Volume 116, Page(s) 106–117

    Abstract: Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent ... ...

    Abstract Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2016.11.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Correction: A Y

    Wang, Yinjie / Jiang, Zhenqi / Yuan, Bo / Tian, Yuchen / Xiang, Lingchao / Li, Yanying / Yang, Yong / Li, Juan / Wu, Aiguo

    Biomaterials science

    2024  Volume 12, Issue 8, Page(s) 2165–2166

    Abstract: Correction for 'A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer' by Yinjie ... ...

    Abstract Correction for 'A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer' by Yinjie Wang
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d4bm90022g
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Structural basis for ligand recognition of the neuropeptide Y Y

    Tang, Tingting / Hartig, Christin / Chen, Qiuru / Zhao, Wenli / Kaiser, Anette / Zhang, Xuefeng / Zhang, Hui / Qu, Honge / Yi, Cuiying / Ma, Limin / Han, Shuo / Zhao, Qiang / Beck-Sickinger, Annette G / Wu, Beili

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 737

    Abstract: The human neuropeptide Y (NPY) Y ...

    Abstract The human neuropeptide Y (NPY) Y
    MeSH term(s) Benzamides/pharmacology ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Mutagenesis/genetics ; Mutagenesis/physiology ; Peptide Hormones/pharmacology ; Piperazines/pharmacology ; Protein Structure, Secondary ; Pyridines/pharmacology ; Receptors, Neuropeptide Y/genetics ; Receptors, Neuropeptide Y/metabolism ; X-Ray Diffraction
    Chemical Substances Benzamides ; JNJ-31020028 ; Peptide Hormones ; Piperazines ; Pyridines ; Receptors, Neuropeptide Y ; neuropeptide Y2 receptor ; benzamide (6X80438640) ; pyridine (NH9L3PP67S)
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-21030-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A Y

    Wang, Yinjie / Jiang, Zhenqi / Yuan, Bo / Tian, Yuchen / Xiang, Lingchao / Li, Yanying / Yang, Yong / Li, Juan / Wu, Aiguo

    Biomaterials science

    2019  Volume 7, Issue 11, Page(s) 4748–4757

    Abstract: ... to develop a novel strategy for its treatment. Based on the high overexpression of Y ...

    Abstract Multidrug resistance (MDR) is one of the main reasons for the inefficiency of cancer chemotherapy. As a consequence of MDR, the expression level of membrane proteins might be changed, which can thus be used to develop a novel strategy for its treatment. Based on the high overexpression of Y
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Ligands ; MCF-7 Cells ; Mammary Neoplasms, Experimental/diagnostic imaging ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Nanoparticles/chemistry ; Optical Imaging ; Quinolines/chemistry ; Quinolines/pharmacology ; Receptors, Neuropeptide Y/antagonists & inhibitors ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents ; Ligands ; Micelles ; Quinolines ; Receptors, Neuropeptide Y ; Doxorubicin (80168379AG) ; tariquidar (J58862DTVD)
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/c9bm00337a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Y

    Li, Juan / Du, Yang / Jiang, Zhenqi / Tian, Yuchen / Qiu, Nianxiang / Wang, Yinjie / Lqbal, Muhammad Zubair / Hu, Menying / Zou, Ruifen / Luo, Lijia / Du, Shiyu / Tian, Jie / Wu, Aiguo

    Nanoscale

    2018  Volume 10, Issue 13, Page(s) 5845–5851

    Abstract: ... ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are ...

    Abstract Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Doxorubicin/administration & dosage ; Endothelial Cells ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Ligands ; Mice ; Mice, Nude ; Micelles ; Nanoparticles ; Neoplasms, Experimental/diagnostic imaging ; Neoplasms, Experimental/drug therapy ; Optical Imaging ; Protein Binding ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances Ligands ; Micelles ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c8nr00148k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Y

    Yu, Zhangsen / Xia, Yuanzhi / Xing, Jie / Li, Zihou / Zhen, Jianjun / Jin, Yinhua / Tian, Yuchen / Liu, Chuang / Jiang, Zhenqi / Li, Juan / Wu, Aiguo

    Nanoscale

    2018  Volume 10, Issue 36, Page(s) 17038–17052

    Abstract: Achieving efficient photodynamic therapy (PDT) in deeper biological tissue is still the biggest bottleneck that limits its widespread application in clinic. Although deeper biological tissue PDT could be realized through a combination of upconversion ... ...

    Abstract Achieving efficient photodynamic therapy (PDT) in deeper biological tissue is still the biggest bottleneck that limits its widespread application in clinic. Although deeper biological tissue PDT could be realized through a combination of upconversion nanoparticles with a photosensitizer, issues with particle-size-induced upconversion fluorescence (UF) reduction and the related in vivo toxicity still cannot be solved properly. In this study, we synthesized Y1Rs-ligand [Pro30, Nle31, Bpa32, Leu34]NPY(28-36) (NPY)-modified and photosensitizer MC540-loaded LiLuF4:Yb,Er@nLiGdF4@mSiO2 multifunctional nanocomposites (MNPs) with a core-multishell structure and ultrasmall size. Their in vitro and in vivo breast tumor targeting, trimodality imaging performance, PDT therapeutic efficacy, and acute toxicity were evaluated. Our results demonstrated that the core-multishell MNPs(MC540) could achieve excellent UF imaging, and that doping with Gd3+ and Lu3+ rare earth ions could enhance the MR and CT imaging performance. In addition, the mSiO2 shell provided a higher loading rate for the photosensitizer MC540, and the DSPE-PEG thin layer coating outside the MNPs(MC540) further improved the water solubility and biocompatibility, reducing the acute toxicity of the nanocomposites. Finally, the NPY modification enhanced the targetability of MNPs(MC540)/DSPE-PEG-NPY to breast tumors, improving the trimodality UF, CT, and MR imaging performance and PDT efficacy for Y1-receptor-overexpressed breast cancer. In general, our developed multifunctional nanocomposites can serve as a theranostic agent with low toxicity, providing great potential for their use in clinical breast cancer diagnosis and therapy.
    MeSH term(s) Animals ; Cell Line, Tumor ; Female ; Humans ; MCF-7 Cells ; Mice, Inbred BALB C ; Mice, Inbred ICR ; Nanocomposites/chemistry ; Nanoparticles/chemistry ; Neoplasms, Experimental/drug therapy ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Xenograft Model Antitumor Assays
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2018-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c8nr02387e
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The Neuropeptide Y

    Wang, Yinjie / Cao, Yi / Jiang, Zhenqi / Li, Yanying / Yuan, Bo / Xing, Jie / Li, Mingli / Gao, Qianqian / Xu, Kaiwei / Akakuru, Ozioma Udochukwu / Wu, Aiguo / Li, Juan

    The journal of physical chemistry letters

    2021  Volume 12, Issue 46, Page(s) 11280–11287

    Abstract: ... nanovehicles, a neuropeptide Y ...

    Abstract Zeolitic imidazolate frameworks (ZIFs), widely regarded as promising materials for application in catalysis and separation, hold an increasingly significant position in drug delivery systems for their high drug loading capacity. Focused specifically on the rational design of targeting and bioresponsive nanovehicles, a neuropeptide Y
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Membrane/drug effects ; Cerium/chemistry ; Cerium/pharmacology ; Humans ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Ligands ; MCF-7 Cells ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Receptors, Neuropeptide Y/antagonists & inhibitors ; Receptors, Neuropeptide Y/metabolism ; Zeolites/chemistry ; Zeolites/pharmacology
    Chemical Substances Antineoplastic Agents ; Imidazoles ; Ligands ; Photosensitizing Agents ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Zeolites (1318-02-1) ; Cerium (30K4522N6T)
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.1c03562
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Structural basis of ligand binding modes at the neuropeptide Y Y

    Yang, Zhenlin / Han, Shuo / Keller, Max / Kaiser, Anette / Bender, Brian J / Bosse, Mathias / Burkert, Kerstin / Kögler, Lisa M / Wifling, David / Bernhardt, Guenther / Plank, Nicole / Littmann, Timo / Schmidt, Peter / Yi, Cuiying / Li, Beibei / Ye, Sheng / Zhang, Rongguang / Xu, Bo / Larhammar, Dan /
    Stevens, Raymond C / Huster, Daniel / Meiler, Jens / Zhao, Qiang / Beck-Sickinger, Annette G / Buschauer, Armin / Wu, Beili

    Nature

    2018  Volume 556, Issue 7702, Page(s) 520–524

    Abstract: Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have ...

    Abstract Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology
    MeSH term(s) Arginine/analogs & derivatives ; Arginine/chemistry ; Arginine/metabolism ; Arginine/pharmacology ; Binding Sites ; Crystallography, X-Ray ; Dihydropyridines/chemistry ; Dihydropyridines/metabolism ; Dihydropyridines/pharmacology ; Diphenylacetic Acids/chemistry ; Diphenylacetic Acids/metabolism ; Diphenylacetic Acids/pharmacology ; Humans ; Inositol Phosphates/metabolism ; Ligands ; Molecular Docking Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Mutation ; Neuropeptide Y/chemistry ; Neuropeptide Y/metabolism ; Neuropeptide Y/pharmacology ; Nuclear Magnetic Resonance, Biomolecular ; Phenylurea Compounds/chemistry ; Phenylurea Compounds/metabolism ; Phenylurea Compounds/pharmacology ; Protein Binding ; Receptors, Neuropeptide Y/agonists ; Receptors, Neuropeptide Y/antagonists & inhibitors ; Receptors, Neuropeptide Y/chemistry ; Receptors, Neuropeptide Y/metabolism ; Structure-Activity Relationship ; Substrate Specificity
    Chemical Substances BMS 193885 ; Dihydropyridines ; Diphenylacetic Acids ; Inositol Phosphates ; Ligands ; Mutant Proteins ; Nalpha-diphenylacetyl-Nomega-(propionylaminoethyl)aminocarbonyl-(4-hydroxybenzyl)argininamide ; Neuropeptide Y ; Phenylurea Compounds ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2018-04-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-018-0046-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Microstructure and Mechanical Properties of Y

    Wu, Yiheng / Huang, Qunying / Zhang, Ligang / Jiang, Yong / Zhu, Gaofan / Shen, Jingjie

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: ... material for nuclear applications. In this study, the microstructure and mechanical properties of Y ...

    Abstract Oxide-dispersion-strengthened (ODS) steel is considered as a promising candidate structural material for nuclear applications. In this study, the microstructure and mechanical properties of Y
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16062433
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Novel broadband NIR phosphors Y

    Wu, Shihao / Liang, Heng / Li, Yan / Zou, Wanfang / Liao, Zhijian / Wang, Wei / Ye, Xinyu

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 19, Page(s) 6569–6577

    Abstract: ... The ... ...

    Abstract The Cr
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00469d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top