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  1. Article: Organocatalytic asymmetric tandem Michael-Henry reactions: a highly stereoselective synthesis of multifunctionalized cyclohexanes with two quaternary stereocenters.

    Tan, Bin / Chua, Pei Juan / Li, Yongxin / Zhong, Guofu

    Organic letters

    2008  Volume 10, Issue 12, Page(s) 2437–2440

    Abstract: A novel organocatalytic asymmetric tandem Michael-Henry reaction catalyzed by 9-amino-9 ... asymmetric Henry reaction of common ketones as acceptors is shown. ...

    Abstract A novel organocatalytic asymmetric tandem Michael-Henry reaction catalyzed by 9-amino-9-deoxyepiquinine (VI) has been developed. The reaction was efficiently catalyzed by catalyst VI to give highly functionalized cyclohexanes with four stereogenic carbons including two quaternary stereocenters in excellent enantioselectivities (97 to >99% ee) and high diastereoselectivities (93:7-99:1 dr). Thus, the first organocatalytic asymmetric Henry reaction of common ketones as acceptors is shown.
    MeSH term(s) Catalysis ; Cyclohexanes/chemical synthesis ; Cyclohexanes/chemistry ; Ketones/chemistry ; Models, Molecular ; Molecular Structure ; Quinolizines/chemistry ; Stereoisomerism
    Chemical Substances 9-amino-9-deoxyepiquinine ; Cyclohexanes ; Ketones ; Quinolizines
    Language English
    Publishing date 2008-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7060
    ISSN 1523-7060
    DOI 10.1021/ol8007183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction.

    Tan, Bin / Chua, Pei Juan / Zeng, Xiaofei / Lu, Min / Zhong, Guofu

    Organic letters

    2008  Volume 10, Issue 16, Page(s) 3489–3492

    Abstract: ... excellent enantioselectivities (88-96% ee) by the organocatalyzed asymmetric domino Michael-Henry reaction. ...

    Abstract Highly functionalized cyclopentanes with four stereogenic carbons including two quaternary stereocenters have been synthesized in excellent yields (90-95%) with complete diastereoselectivities and excellent enantioselectivities (88-96% ee) by the organocatalyzed asymmetric domino Michael-Henry reaction.
    MeSH term(s) Carbon/chemistry ; Catalysis ; Crystallography, X-Ray ; Cyclization ; Cyclopentanes/chemical synthesis ; Cyclopentanes/chemistry ; Ethylene Oxide/chemistry ; Models, Molecular ; Molecular Structure ; Stereoisomerism ; Toluene/chemistry
    Chemical Substances Cyclopentanes ; Toluene (3FPU23BG52) ; Carbon (7440-44-0) ; Ethylene Oxide (JJH7GNN18P)
    Language English
    Publishing date 2008-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/ol801273x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Relationship between Diet Quality and Maternal Stool Microbiota in the MUMS Australian Pregnancy Cohort.

    Gow, Megan L / Chua, Xin-Yi / El-Omar, Emad / Susic, Daniella / Henry, Amanda

    Nutrients

    2023  Volume 15, Issue 3

    Abstract: Dietary intake during pregnancy may influence the antenatal microbiome, which is proposed to impact maternal and infant health during the pregnancy and beyond. The aim of this sub-study was to examine associations between dietary intake and microbiota ... ...

    Abstract Dietary intake during pregnancy may influence the antenatal microbiome, which is proposed to impact maternal and infant health during the pregnancy and beyond. The aim of this sub-study was to examine associations between dietary intake and microbiota diversity during pregnancy using whole metagenomic sequencing and examine associations in low-risk versus high-risk pregnancies, as well as complicated versus uncomplicated pregnancies. Pregnancy data were analysed from women participating in the MUMS cohort study in Sydney, Australia (women followed from trimester 1 of pregnancy to 1-year postpartum), who had dietary intake data at either trimester 1 or 3, assessed using the Australian Eating Survey, and a matched stool sample (
    MeSH term(s) Humans ; Pregnancy ; Female ; Cohort Studies ; Australia ; Diet ; Postpartum Period ; Microbiota
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030689
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  4. Article ; Online: FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations.

    Qu, Yinghua / Lim, Jonathan Jun-Yong / An, Omer / Yang, Henry / Toh, Yi-Chin / Chua, John Jia En

    iScience

    2023  Volume 26, Issue 12, Page(s) 108497

    Abstract: Mutations in the human fasciculation and elongation protein zeta 1 ( ...

    Abstract Mutations in the human fasciculation and elongation protein zeta 1 (
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108497
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  5. Article ; Online: Surgical management of thyroglossal cysts: 10-year experience of a tertiary paediatric surgical unit.

    Chiang, Jayne Jie Yi / Tan, Bernard Wen Sheng / Chua, Andy Jian Kai / Ong, Lin Yin / Tan, Henry Kun Kiaang

    Singapore medical journal

    2023  

    Language English
    Publishing date 2023-10-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2019-111
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 589: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: Emergency front-of-neck airway in the COVID-19 patient: Cannula or surgical cricothyroidotomy?

    Chua, Henry / Wong, Theodore / Lim, Wan Yen / Wong, Patrick

    Anaesthesia, critical care & pain medicine

    2020  Volume 39, Issue 4, Page(s) 475–477

    MeSH term(s) Aerosols ; Airway Management/methods ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Cricoid Cartilage/surgery ; Emergencies ; Equipment Design ; Insufflation/adverse effects ; Insufflation/instrumentation ; Insufflation/methods ; Manikins ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Simulation Training ; Tracheostomy/methods
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2020.06.007
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  7. Article ; Online: "Closed" Supraglottic Airway-Guided Intubation During the COVID-19 Pandemic: A Glo Germ Follow-up.

    Chua, Henry / Lim, Wan Yen / Mok, May / Wong, Patrick

    Anesthesia and analgesia

    2020  Volume 131, Issue 3, Page(s) e168–e169

    MeSH term(s) Airway Management ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Follow-Up Studies ; Humans ; Laryngeal Masks ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005032
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    Uk I Zs.78: Show issues Location:
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  8. Article ; Online: Fission yeast RNA-binding proteins Puf2 and Puf4 are involved in repression of ferrireductase Frp1 expression in response to iron.

    Beaudoin, Jude / Normant, Vincent / Brault, Ariane / Henry, Darren J / Bachand, François / Massé, Éric / Chua, Gordon / Labbé, Simon

    Molecular microbiology

    2021  Volume 116, Issue 5, Page(s) 1361–1377

    Abstract: This study identifies a post-transcriptional mechanism of iron uptake regulation by Puf2 and Puf4 of the Pumilio and FBF (Puf) family of RNA-binding proteins in Schizosaccharomyces pombe. Cells expressing Puf2 and Puf4 stimulate decay of the ... ...

    Abstract This study identifies a post-transcriptional mechanism of iron uptake regulation by Puf2 and Puf4 of the Pumilio and FBF (Puf) family of RNA-binding proteins in Schizosaccharomyces pombe. Cells expressing Puf2 and Puf4 stimulate decay of the frp1
    MeSH term(s) 3' Untranslated Regions ; DNA, Fungal ; FMN Reductase/genetics ; FMN Reductase/metabolism ; Gene Expression Regulation, Fungal ; Iron/metabolism ; Mutation ; Promoter Regions, Genetic ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism
    Chemical Substances 3' Untranslated Regions ; DNA, Fungal ; RNA, Messenger ; RNA-Binding Proteins ; Schizosaccharomyces pombe Proteins ; Iron (E1UOL152H7) ; FMN Reductase (EC 1.5.1.38) ; ferric citrate iron reductase (EC 1.6.99.-)
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14829
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    Zs.A 2502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations

    Yinghua Qu / Jonathan Jun-Yong Lim / Omer An / Henry Yang / Yi-Chin Toh / John Jia En Chua

    iScience, Vol 26, Iss 12, Pp 108497- (2023)

    2023  

    Abstract: Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain ... ...

    Abstract Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain development and is detectable in both neuroprogenitor subtypes and immature neurons. FEZ1 deletion disrupts expression of neuronal and synaptic development genes. Using single-cell RNA sequencing, we detected abnormal expansion of homeodomain-only protein homeobox (HOPX)- outer radial glia (oRG), concurrent with a reduction of HOPX+ oRG, in FEZ1-null hCOs. HOPX− oRGs show higher cell mobility as compared to HOPX+ oRGs. Ectopic localization of neuroprogenitors to the outer layer is seen in FEZ1-null hCOs. Anomalous encroachment of TBR2+ intermediate progenitors into CTIP2+ deep layer neurons further indicated abnormalities in cortical layer formation these hCOs. Collectively, our findings highlight the involvement of FEZ1 in early cortical brain development and how it contributes to neurodevelopmental disorders.
    Keywords neuroscience ; molecular neuroscience ; developmental neuroscience ; Science ; Q
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The MothersBabies Study, an Australian Prospective Cohort Study Analyzing the Microbiome in the Preconception and Perinatal Period to Determine Risk of Adverse Pregnancy, Postpartum, and Child-Related Health Outcomes: Study Protocol.

    Strout, Naomi / Pasic, Lana / Hicks, Chloe / Chua, Xin-Yi / Tashvighi, Niki / Butler, Phoebe / Liu, Zhixin / El-Assaad, Fatima / Holmes, Elaine / Susic, Daniella / Samaras, Katherine / Craig, Maria E / Davis, Gregory K / Henry, Amanda / Ledger, William L / El-Omar, Emad M

    International journal of environmental research and public health

    2023  Volume 20, Issue 18

    Abstract: The microbiome has emerged as a key determinant of human health and reproduction, with recent evidence suggesting a dysbiotic microbiome is implicated in adverse perinatal health outcomes. The existing research has been limited by the sample collection ... ...

    Abstract The microbiome has emerged as a key determinant of human health and reproduction, with recent evidence suggesting a dysbiotic microbiome is implicated in adverse perinatal health outcomes. The existing research has been limited by the sample collection and timing, cohort design, sample design, and lack of data on the preconception microbiome. This prospective, longitudinal cohort study will recruit 2000 Australian women, in order to fully explore the role of the microbiome in the development of adverse perinatal outcomes. Participants are enrolled for a maximum of 7 years, from 1 year preconception, through to 5 years postpartum. Assessment occurs every three months until pregnancy occurs, then during Trimester 1 (5 + 0-12 + 6 weeks gestation), Trimester 2 (20 + 0-24 + 6 weeks gestation), Trimester 3 (32 + 0-36 + 6 weeks gestation), and postpartum at 1 week, 2 months, 6 months, and then annually from 1 to 5 years. At each assessment, maternal participants self-collect oral, skin, vaginal, urine, and stool samples. Oral, skin, urine, and stool samples will be collected from children. Blood samples will be obtained from maternal participants who can access a study collection center. The measurements taken will include anthropometric, blood pressure, heart rate, and serum hormonal and metabolic parameters. Validated self-report questionnaires will be administered to assess diet, physical activity, mental health, and child developmental milestones. Medications, medical, surgical, obstetric history, the impact of COVID-19, living environments, and pregnancy and child health outcomes will be recorded. Multiomic bioinformatic and statistical analyses will assess the association between participants who developed high-risk and low-risk pregnancies, adverse postnatal conditions, and/or childhood disease, and their microbiome for the different sample types.
    MeSH term(s) Pregnancy ; Female ; Humans ; Child ; Prospective Studies ; Longitudinal Studies ; Australia/epidemiology ; COVID-19 ; Postpartum Period
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20186736
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