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Article ; Online: Y

Li, Juan / Du, Yang / Jiang, Zhenqi / Tian, Yuchen / Qiu, Nianxiang / Wang, Yinjie / Lqbal, Muhammad Zubair / Hu, Menying / Zou, Ruifen / Luo, Lijia / Du, Shiyu / Tian, Jie / Wu, Aiguo

Nanoscale

2018 Volume 10, Issue 13, Page(s) 5845–5851

Abstract: ... ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are ...

Abstract	Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.
MeSH term(s)	Animals ; Blood-Brain Barrier ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Doxorubicin/administration & dosage ; Endothelial Cells ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Ligands ; Mice ; Mice, Nude ; Micelles ; Nanoparticles ; Neoplasms, Experimental/diagnostic imaging ; Neoplasms, Experimental/drug therapy ; Optical Imaging ; Protein Binding ; Receptors, Neuropeptide Y/metabolism
Chemical Substances	Ligands ; Micelles ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Doxorubicin (80168379AG)
Language	English
Publishing date	2018-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c8nr00148k
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Article: On-Line pH Measurement Cation Exchange Kinetics of Y

Liu, Lingyu / Zhou, Fengchen / Zhang, Yuxiang / Sun, Yanhua / Zhang, Shixing / Cai, Kun / Qiu, Ruichong / Lin, Yi / Fa, Wenjun / Wang, Zihua

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 8

Abstract: A new sol-gel method that employs cation exchange from an aqueous metal ion solution with ... ...

Abstract	A new sol-gel method that employs cation exchange from an aqueous metal ion solution with H
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14080696
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Book ; Online: $\mathcal{Y}$-Tuning

Liu, Yitao / An, Chenxin / Qiu, Xipeng

An Efficient Tuning Paradigm for Large-Scale Pre-Trained Models via Label Representation Learning

2022

Abstract: ... resources to compute the gradients in the training phase. In this paper, we propose $\mathcal{Y}$-Tuning ... an efficient yet effective paradigm to adapt frozen large-scale PTMs to specific downstream tasks. $\mathcal{Y ... tuning learns dense representations for labels $\mathcal{Y}$ defined in a given task and aligns ...

Abstract	With the success of large-scale pre-trained models (PTMs), how efficiently adapting PTMs to downstream tasks has attracted tremendous attention, especially for PTMs with billions of parameters. Although some parameter-efficient tuning paradigms have been proposed to address this problem, they still require large resources to compute the gradients in the training phase. In this paper, we propose $\mathcal{Y}$-Tuning, an efficient yet effective paradigm to adapt frozen large-scale PTMs to specific downstream tasks. $\mathcal{Y}$-tuning learns dense representations for labels $\mathcal{Y}$ defined in a given task and aligns them to fixed feature representation. Without tuning the features of input text and model parameters, $\mathcal{Y}$-tuning is both parameter-efficient and training-efficient. For $\text{DeBERTa}_\text{XXL}$ with 1.6 billion parameters, $\mathcal{Y}$-tuning achieves performance more than $96\%$ of full fine-tuning on GLUE Benchmark with only $2\%$ tunable parameters and much fewer training costs.
Keywords	Computer Science - Computation and Language ; Computer Science - Machine Learning
Subject code	004
Publishing date	2022-02-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation of Y-Doped La

Cao, Yi / Tang, Peiyuan / Qiu, Wenfeng / Zhao, Tong

ACS omega

2020 Volume 5, Issue 46, Page(s) 29722–29732

Abstract: ... of wearable electronic equipments. Herein, we have succeeded in synthesizing a series of Y-doped lanthanum ...

Abstract	Flexible all-solid-state supercapacitors have drawn more attention owing to the rapid growth of wearable electronic equipments. Herein, we have succeeded in synthesizing a series of Y-doped lanthanum titanate flexible self-supporting films (LSF-
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c03402
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Article ; Online: A 12-Connected [Y

Li, Juan / Wang, Airong / Qiu, Shiming / Wang, Xiaoli / Li, Jiaming

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Fluoride ion ( ... ...

Abstract	Fluoride ion (F
MeSH term(s)	Luminescence ; Metal-Organic Frameworks ; Biphenyl Compounds ; Crystallography, X-Ray
Chemical Substances	4,4'-biphenyldicarboxylic acid ; Metal-Organic Frameworks ; Biphenyl Compounds
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041893
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Article: Tuning the Surface Characteristics and Mechanical Properties of Y

Liu, Hao / Chen, Ping-Hu / Chen, Yong / Wu, Wen-Xing / Li, Sheng / Qiu, Chang-Jun

Materials (Basel, Switzerland)

2022 Volume 15, Issue 15

Abstract: ... micromelting, the crystal phase of Y ...

Abstract	The effects of laser parameters on the microstructure and properties of plasma-sprayed yttrium oxide coating on the graphite matrix were investigated. Tensile strength, porosity, roughness, and scratch meter tests were carried out to evaluate the critical load and mechanical properties of the coating after spraying and laser micro-melting. When the porosity and surface roughness of the coating are minimum, the critical load of the coating is 7.85 N higher than that of the spraying surface. After laser micromelting, the crystal phase of Y
Language	English
Publishing date	2022-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15155443
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Article: [Multiplex fluorescence PCR for detection of Y Chromesome microdeletions].

Li, Wei-Wei / Han, Ying / Yin, Yu-Ling / Wu, Qiu-Yue / Zhang, W U / Jiang, Wei-Jun / Xia, Xin-Yi

Zhonghua nan ke xue = National journal of andrology

2020 Volume 24, Issue 11, Page(s) 1011–1015

Abstract: Objective: Detection of azoospermia factor (AZF) microdeletions on the Y chromosome is one ... samples of Y chromosomal AZF microdeletions from 238 patients with azoospermia or oligozoospermia and 62 ... normal males, identified the 14 short tandem repeat (STR) loci in the AZF region of the Y chromosome ...

Abstract	Objective: Detection of azoospermia factor (AZF) microdeletions on the Y chromosome is one of the auxiliary strategies recognized at home and abroad for the examination of male infertility. Traditional PCR gel electrophoresis fails to meet the clinical needs due to its shortcomings. The purpose of this study was to explore the feasibility of multiplex fluorescence PCR in the detection of AZF microdeletions. Methods: We collected samples of Y chromosomal AZF microdeletions from 238 patients with azoospermia or oligozoospermia and 62 normal males, identified the 14 short tandem repeat (STR) loci in the AZF region of the Y chromosome by multiplex PCR gel electrophoresis and multiplex fluorescence PCR, and analyzed the consistency in the results of the two methods by Kappa test. Results: There was a perfect consistency between multiplex PCR gel electrophoresis and multiplex fluorescence PCR in the detection rate of the STR loci in the 300 samples. Kappa test showed both P and Kappa values to be 1 for the 6 loci in the AZFa, AZFb and AZFc regions of the Y chromosome, with no statistically significant difference between the two methods. Conclusions: Multiplex fluorescence PCR can save a lot of time, reduce workload and improve laboratory efficiency and therefore is preferable to multiplex PCR gel electrophoresis in detecting Y chromosome microdeletions.
MeSH term(s)	Azoospermia/genetics ; Chromosome Deletion ; Chromosomes, Human, Y/genetics ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Male ; Multiplex Polymerase Chain Reaction ; Oligospermia/genetics
Language	Chinese
Publishing date	2020-03-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article ; Online: Microhaplotype and Y-SNP/STR (MY): A novel MPS-based system for genotype pattern recognition in two-person DNA mixtures.

Fan, Haoliang / Xie, Qiqian / Wang, Lingxiang / Ru, Kai / Tan, Xiaohui / Ding, Jiuyang / Wang, Xiao / Huang, Jian / Wang, Zhuo / Li, Yanning / Wang, Xiaohan / He, Yitong / Gu, Cihang / Liu, Min / Ma, Shiwen / Wen, Shaoqing / Qiu, Pingming

Forensic science international. Genetics

2022 Volume 59, Page(s) 102705

Abstract: Backgrounds: Y-chromosomal haplotypes based on Y-short tandem repeats (STRs) and Y ... of unknown male trace donors. However, Y-chromosomal genetic markers are not currently sufficient for precise ... panel, Microhaplotype and Y-SNP/STR (MY), by multiplex PCR and 150-bp paired-end sequencing, including ...

Abstract	Backgrounds: Y-chromosomal haplotypes based on Y-short tandem repeats (STRs) and Y-single nucleotide polymorphisms/insertion and deletion polymorphisms (SNPs/InDels) are used to characterize paternal lineages of unknown male trace donors. However, Y-chromosomal genetic markers are not currently sufficient for precise individual identification. Microhaplotype (MH), generally < 200 bp on autosomes and consisting of two or more SNPs, was recently introduced in forensic genetics with the development of massive parallel sequencing technology and may facilitate identification and DNA mixture deconvolution. Therefore, combining the two kinds of genetic markers may be beneficial in many forensic scenarios, especially crime scenes with male suspects, such as sexual assault cases. Methods: In the present study, we developed a novel MPS-based panel, Microhaplotype and Y-SNP/STR (MY), by multiplex PCR and 150-bp paired-end sequencing, including 114 Y-SNPs (twelve dominant Y-DNA haplogroups), 45 Y-STRs (N-1 stutter < 0.09; estimated mutation rate < 5 × 10 Results: The effective number of alleles (A Conclusion: The GPR can be used to deconvolute two-person DNA mixtures (application range: 1:10-1:2) for individual identification.
MeSH term(s)	DNA/analysis ; DNA/genetics ; DNA Fingerprinting/methods ; Genetic Markers ; Genotype ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Microsatellite Repeats ; Polymorphism, Single Nucleotide
Chemical Substances	Genetic Markers ; DNA (9007-49-2)
Language	English
Publishing date	2022-04-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2022.102705
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Zs.A 6764: Show issues

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Article ; Online: Has recombination changed during the recent evolution of the guppy Y chromosome?

Charlesworth, Deborah / Qiu, Suo / Bergero, Roberta / Gardner, Jim / Keegan, Karen / Yong, Lengxob / Hastings, Abigail / Konczal, Mateusz

Genetics

2023 Volume 226, Issue 1

Abstract: Genome sequencing and genetic mapping of molecular markers have demonstrated nearly complete Y ... linkage across much of the guppy (Poecilia reticulata) XY chromosome pair. Predominant Y-linkage ... crossovers in males can explain the failure to detect fully Y-linked variants. ...

Abstract	Genome sequencing and genetic mapping of molecular markers have demonstrated nearly complete Y-linkage across much of the guppy (Poecilia reticulata) XY chromosome pair. Predominant Y-linkage of factors controlling visible male-specific coloration traits also suggested that these polymorphisms are sexually antagonistic (SA). However, occasional exchanges with the X are detected, and recombination patterns also appear to differ between natural guppy populations, suggesting ongoing evolution of recombination suppression under selection created by partially sex-linked SA polymorphisms. We used molecular markers to directly estimate genetic maps in sires from 4 guppy populations. The maps are very similar, suggesting that their crossover patterns have not recently changed. Our maps are consistent with population genomic results showing that variants within the terminal 5 Mb of the 26.5 Mb sex chromosome, chromosome 12, are most clearly associated with the maleness factor, albeit incompletely. We also confirmed occasional crossovers proximal to the male-determining region, defining a second, rarely recombining, pseudo-autosomal region, PAR2. This fish species may therefore have no completely male-specific region (MSY) more extensive than the male-determining factor. The positions of the few crossover events suggest a location for the male-determining factor within a physically small repetitive region. A sex-reversed XX male had few crossovers in PAR2, suggesting that this region's low crossover rate depends on the phenotypic, not the genetic, sex. Thus, rare individuals whose phenotypic and genetic sexes differ, and/or occasional PAR2 crossovers in males can explain the failure to detect fully Y-linked variants.
MeSH term(s)	Humans ; Animals ; Male ; Poecilia/genetics ; Y Chromosome/genetics ; Sex Chromosomes/genetics ; Chromosome Mapping ; Chromosomes, Human, Y ; Recombination, Genetic
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyad198
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Article ; Online: Neuropeptide Y-Mediated Gut Microbiota Alterations Aggravate Postmenopausal Osteoporosis.

Chen, Zhijie / Lv, Mengyuan / Liang, Jing / Yang, Kai / Li, Fan / Zhou, Zhi / Qiu, Minglong / Chen, Haoyi / Cai, Zhengwei / Cui, Wenguo / Li, Zhanchun

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 33, Page(s) e2303015

Abstract: ... neuroendocrine signal neuropeptide Y (NPY) mediated brain-gut-bone axis has come to light. Herein, it is reported ...

Abstract	Postmenopausal osteoporosis (PMO) is often accompanied by neuroendocrine changes in the hypothalamus, which closely associates with the microbial diversity, community composition, and intestinal metabolites of gut microbiota (GM). With the emerging role of GM in bone metabolism, a potential neuroendocrine signal neuropeptide Y (NPY) mediated brain-gut-bone axis has come to light. Herein, it is reported that exogenous overexpression of NPY reduced bone formation, damaged bone microstructure, and up-regulated the expressions of pyroptosis-related proteins in subchondral cancellous bone in ovariectomized (OVX) rats, but Y1 receptor antagonist (Y1Ra) reversed these changes. In addition, it is found that exogenous overexpression of NPY aggravated colonic inflammation, impaired intestinal barrier integrity, enhanced intestinal permeability, and increased serum lipopolysaccharide (LPS) in OVX rats, and Y1Ra also reversed these changes. Most importantly, NPY and Y1Ra modulated the microbial diversity and changed the community composition of GM in OVX rats, and thereby affecting the metabolites of GM (e.g., LPS) entering the blood circulation. Moreover, fecal microbiota transplantation further testified the effect of NPY-mediated GM changes on bone. In vitro, LPS induced pyroptosis, reduced viability, and inhibited differentiation of osteoblasts. The study demonstrated the existence of NPY-mediated brain-gut-bone axis and it might be a novel emerging target to treat PMO.
MeSH term(s)	Female ; Humans ; Rats ; Animals ; Neuropeptide Y/metabolism ; Osteoporosis, Postmenopausal ; Gastrointestinal Microbiome ; Lipopolysaccharides ; Hypothalamus/metabolism
Chemical Substances	Neuropeptide Y ; Lipopolysaccharides
Language	English
Publishing date	2023-10-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202303015
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