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  1. Article ; Online: N

    Zhu, Mengjie / Wu, Nan / Zhong, Jiayi / Chen, Chen / Liu, Wenwen / Ren, Yingdang / Wang, Xifeng / Jin, Huaibing

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113821

    Abstract: ... shown to be downregulated by increased levels of N ...

    Abstract The titer of viruses that persist and propagate in their insect vector must be high enough for transmission yet not harm the insect, but the mechanism of this dynamic balance is unclear. Here, expression of inosine monophosphate dehydrogenase (LsIMPDH), a rate-limiting enzyme for guanosine triphosphate (GTP) synthesis, is shown to be downregulated by increased levels of N
    MeSH term(s) Animals ; Insect Vectors ; Guanosine Triphosphate ; RNA, Messenger/genetics ; Cell Proliferation ; Adenosine/analogs & derivatives
    Chemical Substances N-methyladenosine (CLE6G00625) ; Guanosine Triphosphate (86-01-1) ; RNA, Messenger ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N

    Li, Chunyang / Zhu, Maoshu / Gao, Chuane / Lu, Fuhua / Chen, Huoshu / Liu, Jiancheng / Zhong, Weimin

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 33

    MeSH term(s) Humans ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; B7-H1 Antigen ; Tumor Microenvironment/genetics ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Methylation
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2024-02-10
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: N

    Hu, Zhensheng / Lu, Yunkun / Cao, Jie / Lin, Lianyu / Chen, Xi / Zhou, Ziyu / Pu, Jiaqi / Chen, Guo / Ma, Xiaojie / Deng, Qian / Jin, Yan / Jiang, Liling / Li, Yuhan / Li, Tengwei / Liu, Jianzhao / Zhu, Saiyong

    Science advances

    2024  Volume 10, Issue 2, Page(s) eadh9871

    Abstract: Cell fate transition involves dynamic changes of gene regulatory network and chromatin landscape, requiring multiple levels of regulation, yet the cross-talk between epitranscriptomic modification and chromatin signaling remains largely unknown. Here, we ...

    Abstract Cell fate transition involves dynamic changes of gene regulatory network and chromatin landscape, requiring multiple levels of regulation, yet the cross-talk between epitranscriptomic modification and chromatin signaling remains largely unknown. Here, we uncover that suppression of
    MeSH term(s) Humans ; Acetylation ; Acetyltransferases/metabolism ; Chromatin/genetics ; Cytidine ; N-Terminal Acetyltransferases/genetics ; N-Terminal Acetyltransferases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Cell Differentiation/genetics
    Chemical Substances Acetyltransferases (EC 2.3.1.-) ; Chromatin ; Cytidine (5CSZ8459RP) ; N-Terminal Acetyltransferases (EC 2.3.1.88) ; NAT10 protein, human (EC 2.3.1.88) ; RNA, Messenger
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh9871
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  4. Article ; Online: N

    Yang, Hong / Xie, Chong / Wu, Yi-Fan / Cheng, Yuan / Zhu, De-Sheng / Guan, Yang-Tai

    Molecular neurobiology

    2023  Volume 61, Issue 3, Page(s) 1781–1793

    Abstract: Researchers have recently found that N ...

    Abstract Researchers have recently found that N
    MeSH term(s) Animals ; Humans ; Cerebral Hemorrhage/genetics ; RNA Methylation ; Adenosine/analogs & derivatives ; B-Lymphocytes ; Mammals
    Chemical Substances N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2023-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03643-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: N

    Li, Zhu / Liu, Yi / Zhang, Ling / Tian, Jiahua / Wang, Hongping / Ding, Hongwei / Nie, Jin / Pi, Hang / Wang, Bingyao / Liu, Daishun

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e15307

    Abstract: Background: Respiratory syncytial virus (RSV) is the second leading cause of death due to lower respiratory tract infections. Effective prevention and treatment measures are lacking, posing a huge socioeconomic burden to the world. : Methods: The ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is the second leading cause of death due to lower respiratory tract infections. Effective prevention and treatment measures are lacking, posing a huge socioeconomic burden to the world.
    Methods: The changes in m
    Results: The m
    Conclusions: We uncovered a significant role for m
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15307
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  6. Article ; Online: n

    Zhang, Peiwen / Pan, Yuheng / Wu, Shuang / He, Yuxu / Wang, Jinyong / Chen, Lei / Zhang, Shunhua / Zhang, Hui / Zhao, Ye / Niu, Lili / Gan, Mailin / Wang, Yan / Shen, Linyuan / Zhu, Li

    Nutrients

    2023  Volume 15, Issue 8

    Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenemia with multiple suspended sinus follicles, thickened cortical tissue, and excessive proliferation of ovarian granulosa cells that severely affects the fertility ... ...

    Abstract Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenemia with multiple suspended sinus follicles, thickened cortical tissue, and excessive proliferation of ovarian granulosa cells that severely affects the fertility and quality of life of women. The addition of
    MeSH term(s) Humans ; Female ; Mice ; Animals ; Polycystic Ovary Syndrome/metabolism ; Hippo Signaling Pathway ; Ferroptosis ; NF-E2-Related Factor 2/metabolism ; Quality of Life ; Cell Proliferation
    Chemical Substances NF-E2-Related Factor 2
    Language English
    Publishing date 2023-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15081927
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  7. Article ; Online: N

    Chen, Xin / Zhu, Sai / Li, Hai-Di / Wang, Jia-Nan / Sun, Li-Jiao / Xu, Jin-Jin / Hui, Ya-Ru / Li, Xiao-Feng / Li, Liang-Yun / Zhao, Yu-Xin / Suo, Xiao-Guo / Xu, Chuan-Hui / Ji, Ming-Lu / Sun, Ying-Yin / Huang, Cheng / Meng, Xiao-Ming / Zhang, Lei / Lv, Xiong-Wen / Ye, Dong-Qing /
    Li, Jun

    International journal of biological macromolecules

    2023  Volume 248, Page(s) 125811

    Abstract: ... molecular mechanisms, while the effects of N ...

    Abstract Circular RNA (circRNA) has been implicated in liver fibrosis and modulated by multiple elusive molecular mechanisms, while the effects of N
    MeSH term(s) Mice ; Animals ; Humans ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Hepatic Stellate Cells/metabolism ; Liver Cirrhosis/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Transcription Factors/metabolism ; Forkhead Box Protein O3/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances RNA, Circular ; N-methyladenosine (CLE6G00625) ; MicroRNAs ; Transcription Factors ; FOXO3 protein, human ; Forkhead Box Protein O3 ; YTHDF2 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2023-07-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: N

    Shi, Ling-Zhu / Chen, Xi / Cao, Hui-Hui / Tian, Chun-Yang / Zou, Li-Fang / Yu, Jian-Hai / Lu, Zi-Bin / Zhao, Wei / Liu, Jun-Shan / Yu, Lin-Zhong

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Background: At present, about half of the world's population is at risk of being infected with dengue virus (DENV). However, there are no specific drugs to prevent or treat DENV infection. Glycyrrhizae Radix et Rhizome, a well-known traditional Chinese ... ...

    Abstract Background: At present, about half of the world's population is at risk of being infected with dengue virus (DENV). However, there are no specific drugs to prevent or treat DENV infection. Glycyrrhizae Radix et Rhizome, a well-known traditional Chinese medicine, performs multiple pharmacological activities, including exerting antiviral effects. The aim of this study was to investigate the anti-DENV effects of
    Methods: Compounds analysis of GRE was conducted via ultra-performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). The antiviral activities of GRE were determined by the CCK-8 assay, plaque assay, qRT-PCR, Western blotting, and the immunofluorescence assay. The DENV-infected suckling mice model was constructed to explore the antiviral effects of GRE in vivo.
    Results: Four components in GRE were analyzed by UHPLC-MS/MS, including glycyrrhizic acid, glycyrrhetnic acid, liquiritigenin, and isoliquiritigenin. GRE inhibited the attachment process of the virus replication cycle and reduced the expression of the E protein in cell models. In the in vivo study, GRE significantly relieved clinical symptoms and prolong survival duration. GRE also significantly decreased viremia, reduced the viral load in multiple organs, and inhibited the release of pro-inflammatory cytokines in DENV-infected suckling mice.
    Conclusions: GRE exhibited significant inhibitory activities in the adsorption stage of the DENV-2 replication cycle by targeting the envelope protein. Thus, GRE might be a promising candidate for the treatment of DENV infection.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: N

    Xu, Lauren / Qi, Qian / Zhu, Junjie / Ma, Xiaochao

    Chemical research in toxicology

    2022  Volume 35, Issue 12, Page(s) 2186–2193

    Abstract: N ...

    Abstract N
    MeSH term(s) Animals ; Porphyrins/pharmacology ; Protoporphyrins/metabolism ; Ferrochelatase/metabolism ; Heme/metabolism
    Chemical Substances protoporphyrin IX (C2K325S808) ; Porphyrins ; Protoporphyrins ; Ferrochelatase (EC 4.99.1.1) ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.2c00214
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
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  10. Article ; Online: N

    Zhu, Li-Li / Tian, Lifang / Sun, Kunhui / Li, Yiwen / Liu, Guanglu / Cai, Bin / Zhang, Hui / Wang, Yahui

    The Journal of organic chemistry

    2022  Volume 87, Issue 19, Page(s) 12963–12974

    Abstract: Herein, N ...

    Abstract Herein, N
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01519
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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