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Article: Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from

Zou, Jian / Qiu, Zuo-Cheng / Yu, Qiang-Qiang / Wu, Jia-Ming / Wang, Yong-Heng / Shi, Ke-Da / Li, Yi-Fang / He, Rong-Rong / Qin, Ling / Yao, Xin-Sheng / Wang, Xin-Luan / Gao, Hao

ACS central science

2024 Volume 10, Issue 3, Page(s) 628–636

Abstract: ... Angelica ... ...

Abstract	Angelica sinensis
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.3c01414
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Article ; Online: Several Alkaloids in Chinese Herbal Medicine Exert Protection in Acute Kidney Injury: Focus on Mechanism and Target Analysis.

Rui, Yixin / Li, Sheng / Luan, Fei / Li, Dan / Liu, Rong / Zeng, Nan

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 2427802

Abstract: Objectives: Acute kidney injury (AKI) is a loose set of kidney diseases accompanied by a variety of syndromes, which is a serious threat to human life and health. Some alkaloids are derived from various Chinese herbs have been widely concerned in the ... ...

Abstract	Objectives: Acute kidney injury (AKI) is a loose set of kidney diseases accompanied by a variety of syndromes, which is a serious threat to human life and health. Some alkaloids are derived from various Chinese herbs have been widely concerned in the improvement of AKI. This review provides the research progress of alkaloids in AKI experimental models and discusses the related molecular mechanisms. Conclusion: Alkaloids have been shown to significantly improve AKI, but only in pharmacological studies. This paper summarizes the main experimental models currently used in AKI research and describes some representative alkaloids based on recent research. Their potential roles in the prevention and treatment of AKI through different mechanisms are highlighted.
MeSH term(s)	Acute Kidney Injury/drug therapy ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/prevention & control ; Alkaloids/pharmacology ; Alkaloids/therapeutic use ; Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Kidney/metabolism ; NF-kappa B/metabolism ; Signal Transduction
Chemical Substances	Alkaloids ; Drugs, Chinese Herbal ; NF-kappa B
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/2427802
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Article: [Bibliometric analysis of literatures on the oral poliomyelitis attenuated live vaccine mass immunization campaign in China].

Zhang, Li / Luan, Rong-sheng

Zhongguo yi miao he mian yi

2009 Volume 15, Issue 3, Page(s) 251–254

Abstract: Objective: To explore the present situation on the strategy of oral polio vaccine (OPV) supplementary immunization for eliminating polio and to analyses new trends and directions of these studies in China.: Methods: Literatures on the strategy of OPV ...

Abstract	Objective: To explore the present situation on the strategy of oral polio vaccine (OPV) supplementary immunization for eliminating polio and to analyses new trends and directions of these studies in China. Methods: Literatures on the strategy of OPV supplementary immunization for eliminating polio in china from 1993-2007 were analysed by quantitative study. Results: 279 papers were identified through searching papers, which were gradually increasing between 1993-2007. There were a group of active and talented authors whose papers were mainly distributed in Beijing, Guangdong, Shandong, Zhejiang province, etc. Most of papers were published in Chinese journal of vaccines and immunization, Chinese journal of public health, Chinese journal of epidemiology, etc. The review on the OPV supplementary immunization, monitoring the GMT and maintaining the progress of free-polio, etc. were involved. Conclusion: There were also problems on the imbalance of the region distribution, the limitation of institution, the lower level of study methods and the insufficient study content about the strategy of OPV supplementary immunization. The coorporation between CDC and the medicine institution should be conducted. It is very important to evaluate the cost-effective and the methods of the strategy of OPV supplementary immunization.
MeSH term(s)	Bibliometrics ; China ; Humans ; Mass Vaccination ; Poliomyelitis/immunology ; Poliomyelitis/prevention & control ; Poliovirus Vaccine, Oral/administration & dosage ; Poliovirus Vaccine, Oral/immunology ; Population Surveillance ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/immunology
Chemical Substances	Poliovirus Vaccine, Oral ; Vaccines, Attenuated
Language	Chinese
Publishing date	2009-06
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1006-916X
ISSN	1006-916X
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Article ; Online: A microbiological assay for biotin determination in insects.

Ren, Fei-Rong / Bai, Bing / Hong, Ji-Sheng / Huang, Yan-Zhen / Luan, Jun-Bo

Insect science

2020 Volume 28, Issue 2, Page(s) 415–418

Language	English
Publishing date	2020-07-30
Publishing country	Australia
Document type	Letter
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.12827
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Article ; Online: Epidemiological and spatiotemporal analyses of HIV/AIDS prevalence among older adults in Sichuan, China between 2008 and 2019: A population-based study.

Yuan, Feng-Shun / Liu, Li / Liu, Lun-Hao / Zeng, Ya-Li / Zhang, Ling-Lin / He, Fang / Liu, Xiao-Jin / Li, Ju-Mei / Liu, Qian / Xu, Meng-Jiao / Zhuoma, Lacuo / Hu, Ying / Pei, Xiao-di / Luan, Rong-Sheng

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 105, Page(s) 769–775

Abstract: Objectives: To describe epidemiological trends and spatial distributions of HIV/AIDS among older adults (aged ≥50) in Sichuan Province, China during 2008-19, and provide scientific reference for HIV/AIDS prevention, intervention and treatment.: ... ...

Abstract	Objectives: To describe epidemiological trends and spatial distributions of HIV/AIDS among older adults (aged ≥50) in Sichuan Province, China during 2008-19, and provide scientific reference for HIV/AIDS prevention, intervention and treatment. Methods: Data on HIV/AIDS cases reported in 2008-19 was extracted from the Case Report System. The Cochran-Armitage trend test was used to determine epidemic trends. Spatial autocorrelation and space-time analysis were conducted with ArcGIS10.6 and ArcGIS Pro2.4, respectively. Results: A total of 77854 HIV/AIDS cases among older adults were included in the study. Newly reported cases increased from 320 in 2008 to 22189 in 2019, and the reported incidence rate (number of new reported cases/older adult population) rose from 0.001% to 0.077%. Infections through heterosexual transmission increased from 65.3% to 98.2% of total cases in older adults in this period. Spatial analysis at the county-level showed significant clustering throughout Sichuan, with the main hot spots concentrated in the southeast. Spatiotemporal analysis indicated that most of the southeastern counties/districts were Consecutive Hot Spots. Conclusions: Older adults have become a key population in the HIV/AIDS epidemic in Sichuan; comprehensive prevention and intervention measures targeted to older adults are urgently needed to control the spread of HIV/AIDS.
MeSH term(s)	Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/prevention & control ; Aged ; China/epidemiology ; Epidemics ; Female ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Spatial Analysis ; Spatio-Temporal Analysis
Language	English
Publishing date	2021-02-19
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.02.077
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Article: [Questions on establishing the case definition against the emergent events of public health].

Ying, Gui-ying / Luan, Rong-sheng

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2006 Volume 27, Issue 4, Page(s) 277–280

MeSH term(s)	Epidemiologic Methods ; Humans ; Population Surveillance ; Public Health
Language	Chinese
Publishing date	2006-04
Publishing country	China
Document type	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
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Zs.B 3276: Show issues

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Article: [Currency Survey and Influencing Factors Analysis on the Knowledge and Behavior Related to Brucellosis among Occupational Workers in Jianyang City].

Zhang, Wen-Qiang / Li, Si-Yi / Li, Xuan / Chen, Chao / Tang, Long-Mei / Hu, Jian-Xiong / Chen, Dong / Wang, Fu-Hua / Wang, Xiao-Hui / Luan, Rong-Sheng

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2019 Volume 50, Issue 4, Page(s) 551–555

Abstract: Objective: To investigate the status and influencing factors of the knowledge and behavior related to brucellosis among occupational workers in Jianyang city, and to provide basic information for developing regional specific strategies for brucellosis ... ...

Abstract	Objective: To investigate the status and influencing factors of the knowledge and behavior related to brucellosis among occupational workers in Jianyang city, and to provide basic information for developing regional specific strategies for brucellosis prevention and control. Methods: With multistage cluster random sampling, occupational workers aged ≥18 yr. who had been in contact with sheep and their products were interviewed through a questionnaire about demographic characteristic, knowledge, and behavior related to brucellosis. The knowledge and practice scores were described as frequency and percentage, and the awareness rate of knowledge about brucellosis was calculated. Unconditional logistic regression model was used to analyze the influencing factors of knowledge and behavior related to brucellosis. Results: In total, 378 workers were recruited. The minority (25.1%) of the workers had heard of brucellosis, and the awareness rate of brucellosis was 22.0%. Occupational protective behaviors were poor, and the scoring rates of wearing protective clothes, mask and gloves were 58.7%, 76.5%, 71.7% respectively. The results of multivariate logistic regression analysis revealed that the awareness rate of knowledge about brucellosis decreased with age, while the low educational level was found to be associated with low awareness of knowledge about brucellosis, and occupation type had association with the awareness rate of knowledge. Besides, the awareness of knowledge about brucellosis was a protective factor and occupation type were associated with the behavior related to brucellosis. Conclusions: The knowledge and behavior related to brucellosis are poor among occupational workers in Jianyang. It is necessary to continuously implement targeted health education and health promotion programs in this region, and the people with low education level and livestock farmers should be paid special attention to.
MeSH term(s)	Animals ; Brucellosis ; Health Knowledge, Attitudes, Practice ; Humans ; Logistic Models ; Occupational Exposure/prevention & control ; Sheep ; Surveys and Questionnaires
Language	Chinese
Publishing date	2019-10-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
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Article: [Epidemiology, Treatment, and Epidemic Prevention and Control of the Coronavirus Disease 2019: a Review].

Luan, Rong-Sheng / Wang, Xin / Sun, Xin / Chen, Xing-Shu / Zhou, Tao / Liu, Quan-Hui / Lü, Xin / Wu, Xian-Ping / Gu, Dong-Qing / Tang, Ming-Shuang / Cui, Hui-Jie / Shan, Xue-Feng / Ouyang, Jing / Zhang, Ben / Zhang, Wei / Sichuan University Covid-, Emergency Research Group

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2020 Volume 51, Issue 2, Page(s) 131–138

Abstract: This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 ( ... ...

Abstract	This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. SARS-CoV-2 may be originated from bats, and the patients and asymptomatic carriers are the source of epidemic infection. The virus can be transmitted human-to-human through droplets and close contact, and people at all ages are susceptible to this virus. The main clinical symptoms of the patients are fever and cough, accompanied with leukocytopenia and lymphocytopenia. Effective drugs have been not yet available thus far. In terms of the prevention and control strategies, vaccine development as the primary prevention should be accelerated. Regarding the secondary prevention, ongoing efforts of the infected patients and close contacts quarantine, mask wearing promotion, regular disinfection in public places should be continued. Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. In addition, public health education on this disease and prevention should be enhanced so as to mitigate panic and mobilize the public to jointly combat the epidemic.
MeSH term(s)	Asymptomatic Diseases ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Cough/etiology ; Early Diagnosis ; Fever/etiology ; Humans ; Influenza A Virus, H1N1 Subtype ; Leukopenia/etiology ; Lymphopenia/etiology ; Middle East Respiratory Syndrome Coronavirus ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS Virus ; SARS-CoV-2 ; Secondary Prevention ; Viral Vaccines
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines
Keywords	covid19
Language	Chinese
Publishing date	2020-03-01
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20200360505
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Article ; Online: Molecular characterization of enterovirus 71 sibling strains for thermal adaption in Vero cells with adaptive laboratory evolution.

Chen, Heng / Cheng, Yue / Liang, Xian / Meng, Jian-Tong / Zuo, Hao-Jiang / Su, Li-Yuan / Wang, Xi-Xi / Yang, Cai-Bin / Luan, Rong-Sheng

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2018 Volume 67, Page(s) 44–50

Abstract: Enterovirus 71 is the main pathogen that causes severe and fatal hand-foot-mouth-disease (HFMD) cases. As the enterovirus virus mutation has implications for pathogenesis, vaccine development, antiviral therapy, and epidemiological disease management of ... ...

Abstract	Enterovirus 71 is the main pathogen that causes severe and fatal hand-foot-mouth-disease (HFMD) cases. As the enterovirus virus mutation has implications for pathogenesis, vaccine development, antiviral therapy, and epidemiological disease management of the virus. In this study, we investigated the variations of enterovirus 71 in thermal adaption, using the method of adaptive laboratory evolution. The sibling virus strains were isolated from a 2-year-old severe case of HFMD (#100) and her symptomless close contact (#101). Both strains were cultured in Vero cells by serial passage of 36 generations at the temperatures of 28.0 °C, 33.0 °C and 39.5 °C to construct adaptive lineages. According to the comparative analysis of phenotypes between adapted strains and parental strains, differences in growth rate were observed in the sibling lineages and a larger plaque was found mainly in the hot adapted strains for lineage #101. Two sets of adaptive strains from six time points (parental, 12th 17th, 31st, 35th passage and endpoint) were sequenced and analyzed by both Sanger sequencing and Next Generation Sequencing. Several variations in most coding genes and one reverse mutation in 5'UTR was observed, along with the identity of 99.8% for complete genome for both lineages. Notably, thermal specific non-synonymous mutations were found in the gene of VP1\VP3\3A\2C\3C. Moreover, the concurrent mutations A292G, A434G and A355C/T of sibling lineages in VP1 showed quantificational trace with distinguishing patterns for different temperatures, which were suspected to be the thermo-sensitive mutation hotspots. These results highlight the possible rules of thermal adaption in enterovirus 71, produce a novel picture of genome evolution of the virus, and shed light on viral variation and evolution.
MeSH term(s)	5' Untranslated Regions ; Adaptation, Biological ; Animals ; Biological Evolution ; Cells, Cultured ; Cercopithecus aethiops ; Enterovirus A, Human/classification ; Enterovirus A, Human/genetics ; Enterovirus Infections/virology ; Genome, Viral ; Humans ; Sequence Analysis, DNA ; Temperature ; Vero Cells ; Viral Plaque Assay ; Virus Replication
Chemical Substances	5' Untranslated Regions
Language	English
Publishing date	2018-10-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2018.10.012
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Zs.A 5645: Show issues

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Article: [Analysis of influencing factors of decision making of emergent public health events].

Ying, Gui-Ying / Su, Wei / Luan, Rong-Sheng

Zhonghua yi xue za zhi

2006 Volume 86, Issue 17, Page(s) 1161–1164

MeSH term(s)	Health Policy ; Humans ; Policy Making ; Public Health/legislation & jurisprudence ; Public Health/methods
Language	Chinese
Publishing date	2006-05-09
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
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