Article ; Online: H
2024 Volume 83, Page(s) 102006
Abstract: ... disability and mortality rates. Cystathionine γ-lyase (CSE)-produced hydrogen sulfide (H: Methods: C57/BL6 ... mice were subjected to 30-min renal ischemia followed by .24-h reperfusion injury (IRI). The H ... suggest that the CSE/H ...
Abstract | Background: Ischemia/reperfusion injury (IRI) can lead to acute kidney injury and result in high disability and mortality rates. Cystathionine γ-lyase (CSE)-produced hydrogen sulfide (H Methods: C57/BL6 mice were subjected to 30-min renal ischemia followed by .24-h reperfusion injury (IRI). The H Results: In a C57/BL6 mouse model of acute renal IRI, the application of IRI impaired the renal function, which was accompanied by elevated serum creatinine (P < 0.001) and urea nitrogen levels (P < 0.001). While NaHS pretreatment dramatically attenuated renal IRI, PAG administration exacerbated renal IRI (P < 0.001). Furthermore, NaHS treatment inhibited the ERS-induced increased LC3II/I protein ratio (P < 0.001); increased Beclin-1 protein expression (P < 0.001); PAG pretreatment exacerbated the effects of ERS on both the LC3II/I ratio (P < 0.001) and the Beclin-1 protein expression (P < 0.001). Conclusions: Our results suggest that the CSE/H |
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MeSH term(s) | Mice ; Animals ; Beclin-1/pharmacology ; Creatinine ; Reperfusion Injury/metabolism ; Autophagy ; Acute Kidney Injury ; Ischemia/complications ; Endoplasmic Reticulum Stress ; Nitrogen/pharmacology ; Urea ; Sulfides |
Chemical Substances | Beclin-1 ; Creatinine (AYI8EX34EU) ; sodium bisulfide (FWU2KQ177W) ; Nitrogen (N762921K75) ; Urea (8W8T17847W) ; Sulfides |
Language | English |
Publishing date | 2024-02-09 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 1160846-8 |
ISSN | 1878-5492 ; 0966-3274 |
ISSN (online) | 1878-5492 |
ISSN | 0966-3274 |
DOI | 10.1016/j.trim.2024.102006 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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