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  1. Article ; Online: Performance of 8- vs 16 ECG-gated reconstructions in assessing myocardial function using Rubidium-82 myocardial perfusion imaging: Findings in a young, healthy population.

    Lassen, Martin Lyngby / Wissenberg, Mads / Byrne, Christina / Kjaer, Andreas / Hasbak, Philip

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 4, Page(s) 1406–1413

    Abstract: Background: Current imaging guidelines recommend using at least 16 ECG gates when performing MUGA and cardiac SPECT to assess left ventricular ejection fraction (LVEF). However, for Rubidium-82 (: Methods: The study comprised 25 healthy volunteers ( ... ...

    Abstract Background: Current imaging guidelines recommend using at least 16 ECG gates when performing MUGA and cardiac SPECT to assess left ventricular ejection fraction (LVEF). However, for Rubidium-82 (
    Methods: The study comprised 25 healthy volunteers (median age 23 years) who underwent repeat MPI sessions employing
    Results: Similar LVEF and LVEF reserve estimates were found for the 8- and 16-gated reconstructions ([%] LVEF (8/16 gates): rest = 61 ± 6/64 ± 6, stress = 68 ± 7/71 ± 6, LVEF reserve (8/16 gates): 8 ± 3/6 ± 4, and all P ≥ 0.13). Similar test-retest repeatability measures were observed for rest and stress LVEF and their reserves [LVEF (8/16 gates); Rest = 4.5/4.6 (P = 0.81), Stress = 3.5/3.2 (P = 0.33), LVEF reserve = 46.7/49.3 (P = 0.13)].
    Conclusion: In healthy subjects, 8 and 16 ECG gates can be used interchangeably if only volumetric assessments are desired. However, if filling and emptying rates are of interest, a minimum of 16 ECG gates should be employed.
    MeSH term(s) Humans ; Young Adult ; Adult ; Ventricular Function, Left ; Stroke Volume ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Electrocardiography ; Perfusion ; Myocardial Perfusion Imaging/methods
    Chemical Substances Rubidium-82 (9K730EL8KU)
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-03193-0
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  2. Article ; Online: Optimization of the left ventricle ejection fraction estimate obtained during cardiac adenosine stress

    Lassen, Martin Lyngby / Wissenberg, Mads / Byrne, Christina / Kjaer, Andreas / Hasbak, Philip

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 29, Issue 6, Page(s) 3369–3378

    Abstract: Background: Left ventricular ejection fraction (LVEF) estimation using adenosine stress myocardial perfusion imaging (MPI) can be challenging. The short half-life of adenosine and the guideline-recommended adenosine infusion stop during Rubidium-82 ... ...

    Abstract Background: Left ventricular ejection fraction (LVEF) estimation using adenosine stress myocardial perfusion imaging (MPI) can be challenging. The short half-life of adenosine and the guideline-recommended adenosine infusion stop during Rubidium-82 acquisition protocol may affect the accuracy and repeatability of the LVEF measures.
    Methods: This study comprised 25 healthy volunteers (median age 23 years) who underwent repeat myocardial perfusion imaging (MPI) sessions employing Rubidium-82 PET/CT. A guideline-recommended reconstruction protocol was used for both rest and adenosine stress MPI (150-360 s post-radiotracer injection, standard
    Results: Differences in the LVEF assessments were observed between the guideline recommended and alternative reconstruction protocol (LVEF stress MPI: standard
    Conclusion: We recommend using the short
    MeSH term(s) Humans ; Young Adult ; Adult ; Ventricular Function, Left ; Stroke Volume ; Rubidium ; Adenosine ; Heart Ventricles/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Myocardial Perfusion Imaging/methods
    Chemical Substances Rubidium-82 (9K730EL8KU) ; Rubidium (MLT4718TJW) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-02946-1
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  3. Article ; Online: [Paradox embolism in a patient with pulmonary embolism and unknown patent foramen ovale].

    Berkfors, Alexander Skovbæk / Wissenberg, Mads / Alpin, Mark / Pecini, Redi / Grand, Johannes

    Ugeskrift for laeger

    2021  Volume 183, Issue 15

    Abstract: This case report describes a 64-year-old male patient, who presented with sudden onset dyspnoea. A chest CT-angiography revealed the presence of central bilateral pulmonary embolisms (PE), and he was admitted for anticoagulative treatment. Shortly after ... ...

    Abstract This case report describes a 64-year-old male patient, who presented with sudden onset dyspnoea. A chest CT-angiography revealed the presence of central bilateral pulmonary embolisms (PE), and he was admitted for anticoagulative treatment. Shortly after admission, he developed discomfort and pulselessness in the right leg, and a limb CT-angiography revealed a femoral artery thrombus. PE in conjunction with acute limb ischaemia raised suspicion of a paradoxical mechanism of systemic embolism, which was confirmed by echocardiography with thrombus straddling a patent foramen ovale.
    MeSH term(s) Echocardiography ; Embolism, Paradoxical/complications ; Embolism, Paradoxical/diagnostic imaging ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; Thrombosis
    Language Danish
    Publishing date 2021-04-28
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  4. Article ; Online: Image-derived and physiological markers to predict adequate adenosine-induced hyperemic response in Rubidium-82 myocardial perfusion imaging.

    Lassen, Martin Lyngby / Wissenberg, Mads / Byrne, Christina / Sheykhzade, Majid / Hurry, Preetee Kapisha / Schmedes, Anne Vibeke / Kjær, Andreas / Hasbak, Philip

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 29, Issue 6, Page(s) 3207–3217

    Abstract: Aims: This study aimed to investigate the potential of different markers to identify adequate stressing in subjects with and without caffeine intake prior to Rubidium-82 myocardial imaging.: Methods and results: This study comprised 40 healthy ... ...

    Abstract Aims: This study aimed to investigate the potential of different markers to identify adequate stressing in subjects with and without caffeine intake prior to Rubidium-82 myocardial imaging.
    Methods and results: This study comprised 40 healthy subjects who underwent four serial Rubidium-82 rest/adenosine stress MPI; two with 0mg caffeine consumption (baseline MPIs) and two with controlled consumption of caffeine (arm 1: 100 and 300mg, or arm 2: 200 and 400mg). We report the sensitivity and specificity of seven markers ability to predict adequate adenosine-induced hyperemic response: (1) the splenic response ratio (SRR); (2) splenic stress-to-rest intensity ratios (SIR); (3) changes in heart rate (ΔHR); (4) percentwise change in heart rate (Δ%HR); (5) changes in the rate pressure product (ΔRPP); (6) changes in the systolic blood pressure (ΔSBP); and (7) changes in the cardiovascular resistance (ΔCVR). Adequate stressing was determined as stress myocardial blood flow > 3ml/g/min and a corresponding myocardial flow reserve >68% of the individual maximum myocardial flow reserve obtained in the baseline MPIs.
    Results: 129 MPI sessions (obtained in 39 subjects) were considered for this study. The following sensitivities were obtained: SSR = 72.7%, SIR = 63.6%, ΔHR = 45.5%, Δ%HR = 77.3%, ΔRPP = 54.5%, ΔSBP = 47.7%, and ΔCVR =40.9%, while the specificities were SSR = 80.9%, SIR = 85.0%, ΔHR = 90.4%, Δ%HR = 81.6%, ΔRPP=81.1%, ΔSBP = 86.4%, and ΔCVR =90.4%.
    Conclusion: The image-derived and physiological markers all provide acceptable sensitivities and specificities when patients follow the caffeine pausation before MPI. However, their use warrants great care when caffeine consumption cannot be ruled out.
    MeSH term(s) Humans ; Adenosine/pharmacology ; Vasodilator Agents/pharmacology ; Caffeine/pharmacology ; Myocardial Perfusion Imaging/methods ; Coronary Circulation ; Tomography, X-Ray Computed ; Rubidium Radioisotopes ; Biomarkers ; Positron-Emission Tomography
    Chemical Substances Adenosine (K72T3FS567) ; Vasodilator Agents ; Caffeine (3G6A5W338E) ; Rubidium-82 (9K730EL8KU) ; Rubidium Radioisotopes ; Biomarkers
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-02906-9
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  5. Article ; Online: Comparative outcomes in patients with preexisting heart failure to those without heart failure after out-of-hospital cardiac arrest: A nationwide registry study.

    Tayal, Bhupendar / Rørth, Rasmus / Kristensen, Søren Lund / Wissenberg, Mads / Dutta, Abhishek / Gislason, Gunnar / Køber, Lars / Lippert, Freddy / Torp-Pedersen, Christian / Søgaard, Peter / Kragholm, Kristian H

    International journal of cardiology

    2023  Volume 398, Page(s) 131595

    Abstract: Background: The knowledge of prognosis following out-of-hospital cardiac arrest (OHCA) in patients with heart failure heart failure (HF) is sparse. The objective of this study was to compare the outcome after OHCA among patients with and without HF.: ... ...

    Abstract Background: The knowledge of prognosis following out-of-hospital cardiac arrest (OHCA) in patients with heart failure heart failure (HF) is sparse. The objective of this study was to compare the outcome after OHCA among patients with and without HF.
    Methods: We studied 45,293 patients who were included for the Danish cardiac arrest registry between 2001 and 2014. Patients were stratified into two groups based on the presence of HF prior to cardiac arrest. The primary outcome was 30-day survival and secondary outcome was anoxic brain damage or permanent nursing home admission at 1-year among 30-day survivors.
    Results: Among the final 28,955 patients included, 6675 (23%) patients had prior HF and 22,280 (77%) patients had no prior HF. At 30 days, 616 (9.2%) patients survived among the patients with HF and 1916 (8.6%) among the patients without HF. There was a significant interaction between atrial fibrillation (AF) and HF for primary outcome and therefore it was assessed separately between the two study groups stratified based on AF. Among patients without AF a significantly higher odds of 30-day survival were observed among patients with HF (OR 2.69, 95% CI 2.34-3.08, P < 0.001), but no difference was observed among the patients from two study groups with no AF. No significant difference in risk for secondary outcome was observed among the two study groups. In multivariable average treatment effect modeling, all the results largely remain unchanged.
    Conclusions: Outcome following OHCA among patients with and without HF is found to be similar in this large Danish OHCA registry.
    MeSH term(s) Humans ; Out-of-Hospital Cardiac Arrest/diagnosis ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/complications ; Hospitalization ; Atrial Fibrillation ; Registries
    Language English
    Publishing date 2023-11-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131595
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  6. Article ; Online: [Fatal outcome of coronavirus disease 2019 in a previously healthy 50-year-old man].

    Wissenberg, Mads / Andersen, Lars Peter Kloster / Pallisgaard, Jannik Langtved / Lawson-Smith, Pia

    Ugeskrift for laeger

    2020  Volume 182, Issue 16

    Abstract: In this case report, a 50-year-old man who had no medical history, presented with multiple cardiac arrests following a week with progressing symptoms of pneumonia. After achieving return of spontaneous circulation he presented with respiratory failure ... ...

    Abstract In this case report, a 50-year-old man who had no medical history, presented with multiple cardiac arrests following a week with progressing symptoms of pneumonia. After achieving return of spontaneous circulation he presented with respiratory failure with severe hypoxia, septic shock, and multiple organ failure. A chest X-ray showed signs of acute respiratory distress syndrome. Despite aggressive intensive care management, the patient died 7.5 hours after admission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was later confirmed, and the presumed cause of death was SARS-CoV-2 pneumonia. In conclusion: coronavirus disease 2019 (COVID-19) can lead to a fatal outcome in younger healthy residents, who are not treated timely in case of severe symptoms like dyspnoea.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Fatal Outcome ; Heart Arrest/etiology ; Humans ; Hypoxia/etiology ; Male ; Middle Aged ; Multiple Organ Failure/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Respiratory Insufficiency/etiology ; SARS-CoV-2 ; Shock, Septic/etiology
    Keywords covid19
    Language Danish
    Publishing date 2020-04-14
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  7. Article ; Online: Sex Differences and Caffeine Impact in Adenosine-Induced Hyperemia.

    Lassen, Martin Lyngby / Byrne, Christina / Sheykhzade, Majid / Wissenberg, Mads / Hurry, Preetee Kapisha / Schmedes, Anne Vibeke / Kjaer, Andreas / Hasbak, Philip

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 63, Issue 3, Page(s) 431–437

    Abstract: Caffeine consumption before adenosine stress myocardial perfusion imaging (MPI) is known to affect the hemodynamic response and, thus, reduce the stress myocardial blood flow (MBF) and myocardial flow reserve (MFR) assessments. However, it is not clear ... ...

    Abstract Caffeine consumption before adenosine stress myocardial perfusion imaging (MPI) is known to affect the hemodynamic response and, thus, reduce the stress myocardial blood flow (MBF) and myocardial flow reserve (MFR) assessments. However, it is not clear if any sex-specific differences in the hemodynamic response after caffeine consumption exist. This study aimed to evaluate if such differences exist and, if so, their impact on MBF and MFR assessments.
    MeSH term(s) Adenosine ; Caffeine/pharmacology ; Coronary Artery Disease ; Coronary Circulation ; Female ; Humans ; Hyperemia ; Male ; Myocardial Perfusion Imaging/methods ; Positron-Emission Tomography ; Sex Characteristics ; Tomography, X-Ray Computed
    Chemical Substances Caffeine (3G6A5W338E) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.261970
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  8. Article ; Online: Duration of resuscitation and long-term outcome after in-hospital cardiac arrest: A nationwide observational study.

    Yonis, Harman / Andersen, Mikkel Porsborg / Mills, Elisabeth Helen Anna / Winkel, Bo Gregers / Wissenberg, Mads / Køber, Lars / Gislason, Gunnar / Folke, Fredrik / Larsen, Jacob Moesgaard / Søgaard, Peter / Torp-Pedersen, Christian / Kragholm, Kristian Hay

    Resuscitation

    2022  Volume 179, Page(s) 267–273

    Abstract: Background: Prior studies have investigated the association between duration of resuscitation and short-term outcomes following in-hospital cardiac arrest (IHCA). However, it remains unknown whether there is an association between duration of ... ...

    Abstract Background: Prior studies have investigated the association between duration of resuscitation and short-term outcomes following in-hospital cardiac arrest (IHCA). However, it remains unknown whether there is an association between duration of resuscitation and long-term survival and functional outcomes.
    Method: We linked data from the Danish in-hospital cardiac arrest registry with nationwide registries and identified 8,727 patients between 2013 and 2019. Patients were stratified into four groups (A-D) according to quartiles of duration of resuscitation. Standardized average probability of outcomes was estimated using logistic regression.
    Results: Of 8,727 patients, 53.1% (n = 4,604) achieved return of spontaneous circulation. Median age was 74 (1st-3rd quartile [Q1-Q3] 65-81 years) and 63.1% were men. Among all IHCA patients the standardized 30-day survival was 62.0% (95% CI 59.8-64.2%) for group A (<5 minutes), 32.7% (30.8-34.6%) for group B (5-11 minutes), 14.4% (12.9-15.9%) for group C (12-20 minutes) and 8.1% (7.0-9.1%) for group D (21 minutes or more). Similarly, 1-year survival was also highest for group A (50.4%; 48.2-52.6%) gradually decreasing to 6.6% (5.6-7.6%) in group D. Among 30-day survivors, survival without anoxic brain damage or nursing home admission within one-year post-arrest was highest for group A (80.4%; 78.2-82.6%), decreasing to 73.3% (70.0-76.6%) in group B, 67.2% (61.7-72.6%) in group C and 73.3% (66.9-79.7%) in group D.
    Conclusion: Shorter duration of resuscitation attempt during an IHCA is associated with higher 30-day and 1-year survival. Furthermore, we found that the majority of 30-day survivors were still alive 1-year post-arrest without anoxic brain damage or nursing home admission despite prolonged resuscitation.
    MeSH term(s) Aged ; Cardiopulmonary Resuscitation ; Female ; Heart Arrest/therapy ; Hospitals ; Humans ; Hypoxia, Brain ; Male ; Registries ; Time Factors
    Language English
    Publishing date 2022-08-23
    Publishing country Ireland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2022.08.011
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  9. Article ; Online: Risk of out-of-hospital cardiac arrest in antidepressant drug users.

    Eroglu, Talip E / Barcella, Carlo A / Gerds, Thomas A / Kessing, Lars Vedel / Zylyftari, Nertila / Mohr, Grimur H / Kragholm, Kristian / Polcwiartek, Christoffer / Wissenberg, Mads / Folke, Fredrik / Tan, Hanno L / Torp-Pedersen, Christian / Gislason, Gunnar H

    British journal of clinical pharmacology

    2022  Volume 88, Issue 7, Page(s) 3162–3171

    Abstract: Conflicting results have been reported regarding the association between antidepressant use and out-of-hospital cardiac arrest (OHCA) risk. We investigated whether the use of antidepressants is associated with OHCA.: Methods: We conducted a nationwide ...

    Abstract Conflicting results have been reported regarding the association between antidepressant use and out-of-hospital cardiac arrest (OHCA) risk. We investigated whether the use of antidepressants is associated with OHCA.
    Methods: We conducted a nationwide nested case-control study to assess the association of individual antidepressant drugs within drug classes with the hazard of OHCA. Cases were defined as OHCA from presumed cardiac causes. Cox regression with time-dependent exposure and time-dependent covariates was conducted to calculate hazard ratios (HR) and 95% confidence intervals (95% CIs) overall and in subgroups defined by established cardiac disease and cardiovascular risk factors. Also, we studied antidepressants with and without sodium channel blocking or potassium channel blocking properties separately.
    Results: During the study period from 2001 to 2015 we observed 10 987 OHCA cases, and found increased OHCA rate for high-dose citalopram (>20 mg) and high-dose escitalopram (>10 mg; HR:1.46 [95% CI:1.27-1.69], HR:1.43 [95% CI:1.16-1.75], respectively) among selective serotonin reuptake inhibitors (reference drug sertraline), and for high-dose mirtazapine (>30; HR:1.59 [95% CI:1.18-2.14]) among the serotonin-norepinephrine reuptake inhibitors or noradrenergic and specific serotonergic antidepressants (reference drug duloxetine). Among tricyclic antidepressants (reference drug amitriptyline), no drug was associated with significantly increased OHCA rate. Increased OHCA rate was found for antidepressants with known potassium channel blocking properties (HR:1.14 [95% CI:1.05-1.23]), but for not those with sodium channel blocking properties. Citalopram, although not statistically significant, and mirtazapine were associated with increased OHCA rate in patients without cardiac disease and cardiovascular risk factors.
    Conclusion: Our findings indicate that careful titration of citalopram, escitalopram and mirtazapine dose may have to be considered due to drug safety issues.
    MeSH term(s) Antidepressive Agents/adverse effects ; Case-Control Studies ; Citalopram/adverse effects ; Humans ; Mirtazapine/adverse effects ; Norepinephrine ; Out-of-Hospital Cardiac Arrest/chemically induced ; Out-of-Hospital Cardiac Arrest/epidemiology ; Potassium Channels ; Serotonin Uptake Inhibitors/adverse effects
    Chemical Substances Antidepressive Agents ; Potassium Channels ; Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V) ; Mirtazapine (A051Q2099Q) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15224
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  10. Article ; Online: Dose-Dependent Effect of Caffeine on Adenosine-Induced Myocardial Stress Perfusion in Rubidium-82 Positron-Emission Tomography/Computed Tomography.

    Byrne, Christina / Kjaer, Andreas / Wissenberg, Mads / Hurry, Preetee Kapisha / Schmedes, Anne / Forman, Julie Lyng / Hasbak, Philip

    JACC. Cardiovascular imaging

    2019  Volume 12, Issue 6, Page(s) 1102–1103

    MeSH term(s) Adenosine/administration & dosage ; Administration, Oral ; Adult ; Caffeine/administration & dosage ; Coronary Circulation/drug effects ; Dose-Response Relationship, Drug ; Female ; Healthy Volunteers ; Humans ; Male ; Myocardial Perfusion Imaging/methods ; Positron Emission Tomography Computed Tomography ; Predictive Value of Tests ; Radiopharmaceuticals/administration & dosage ; Random Allocation ; Reproducibility of Results ; Rubidium Radioisotopes/administration & dosage ; Vasodilator Agents/administration & dosage ; Young Adult
    Chemical Substances Radiopharmaceuticals ; Rubidium Radioisotopes ; Vasodilator Agents ; Caffeine (3G6A5W338E) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Letter
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2018.10.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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