LIVIVO - Search results -

Search results

Result 1 - 10 of total 78

Search options

Article ; Online: Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids.

Herschede, Sarah R / Gneid, Hassan / Dent, Taylor / Jaeger, Ellen B / Lawson, Louise B / Busschaert, Nathalie

2021 Volume 19, Issue 17, Page(s) 3838–3843

Abstract: An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid ... ...

Abstract	An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin.
MeSH term(s)	Phosphatidylethanolamines
Chemical Substances	Phosphatidylethanolamines ; phosphatidylethanolamine (39382-08-6)
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d1ob00263e
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Management of oesophagogastric and pancreatic cancers in a Western Australian Rural Regional Health Campus: A framework from referral to management.

Idrees, Marwan / Davies, Anna Louise / Dent, James Alistair / Maurel, Amelie / Jaques, Bryon / Bowles, Thomas Alexander

The Australian journal of rural health

2021 Volume 29, Issue 1, Page(s) 78–82

MeSH term(s)	Aged ; Aged, 80 and over ; Australia/epidemiology ; Esophageal Neoplasms/epidemiology ; Esophageal Neoplasms/therapy ; Female ; Gastrointestinal Neoplasms/epidemiology ; Gastrointestinal Neoplasms/therapy ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/therapy ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Rural Health ; Rural Health Services
Language	English
Publishing date	2021-02-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/ajr.12690
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: 'All Aboriginal and Torres Strait Islander children should have access to the ASQ-TRAK': Shared vision of an implementation support model for the ASQ-TRAK developmental screener.

D'Aprano, Anita / Hunter, Sue-Anne / Fry, Rebecca / Savaglio, Melissa / Carmody, Sarah / Boffa, John / Cooke, Louise / Dent, Abigail / Docksey, Amanda / Douglas, Josie / Dunn, Adam / Halfpenny, Nick / Hewett, Meg / Lipscomb, Adrienne / Manahan, Esmai / Morton, Belinda / Mosse, Holly / Ross, Dawn / Skouteris, Helen

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

2023 Volume 35, Issue 2, Page(s) 433–443

Abstract: Issue addressed: The ASQ-TRAK, a strengths-based approach to developmental screening, has high acceptability and utility across varied Aboriginal and Torres Strait Islander contexts. While substantive knowledge translation has seen many services utilise ...

Abstract	Issue addressed: The ASQ-TRAK, a strengths-based approach to developmental screening, has high acceptability and utility across varied Aboriginal and Torres Strait Islander contexts. While substantive knowledge translation has seen many services utilise ASQ-TRAK, we now need to move beyond distribution and support evidence-based scale-up to ensure access. Through a co-design approach, we aimed to (1) understand community partners' perspectives of barriers and enablers to ASQ-TRAK implementation and (2) develop an ASQ-TRAK implementation support model to inform scale-up. Methods: The co-design process had four phases: (i) partnership development with five community partners (two Aboriginal Community Controlled Organisations); (ii) workshop planning and recruitment; (iii) co-design workshops; and (iv) analysis, draft model and feedback workshops. Results: Seven co-design meetings and two feedback workshops with 41 stakeholders (17 were Aboriginal and Torres Strait Islander), identified seven key barriers and enablers, and a shared vision - all Aboriginal and Torres Strait Islander children and their families have access to the ASQ-TRAK. Implementation support model components agreed on were: (i) ASQ-TRAK training, (ii) ASQ-TRAK support, (iii) local implementation support, (iv) engagement and communications, (v) continuous quality improvement and (vi) coordination and partnerships. Conclusions: This implementation support model can inform ongoing processes necessary for sustainable ASQ-TRAK implementation nationally. This will transform the way services provide developmental care to Aboriginal and Torres Strait Islander children, ensuring access to high quality, culturally safe developmental care. SO WHAT?: Well-implemented developmental screening leads to more Aboriginal and Torres Strait Islander children receiving timely early childhood intervention services, improving developmental trajectories and optimising long-term health and wellbeing.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Australian Aboriginal and Torres Strait Islander Peoples ; Health Services, Indigenous ; Child Development
Language	English
Publishing date	2023-07-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2250864-8
ISSN	2201-1617 ; 1036-1073
ISSN (online)	2201-1617
ISSN	1036-1073
DOI	10.1002/hpja.773
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6384: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Treatment success in pragmatic randomised controlled trials

Dent Louise / Raftery James

Trials, Vol 12, Iss Suppl 1, p A

a review of trials funded by the UK Health Technology Assessment programme

2011 Volume 97

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2011-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Treatment success in pragmatic randomised controlled trials: a review of trials funded by the UK Health Technology Assessment programme.

Dent, Louise / Raftery, James

Trials

2011 Volume 12, Page(s) 109

Abstract: Background: Previous research reviewed treatment success and whether the collective uncertainty principle is met in RCTs in the US National Cancer Institute portfolio. This paper classifies clinical trials funded by the UK HTA programme by results using ...

Abstract	Background: Previous research reviewed treatment success and whether the collective uncertainty principle is met in RCTs in the US National Cancer Institute portfolio. This paper classifies clinical trials funded by the UK HTA programme by results using the method applied to the US Cancer Institute trials, and compares the two portfolios. Methods: Data on all completed randomised controlled trials funded by the HTA programme 1993-2008 were extracted. Each trial's primary results was classified into six categories; 1) statistically significant in favour of the new treatment, 2) statistically significant in favour of the control treatment 3) true negative, 4) truly inconclusive, 5) inconclusive in favour of new treatment or 6) inconclusive in favour of control treatment. Trials were classified by comparing the 95% confidence interval for the difference in primary outcome to the difference specified in the sample size calculation. The results were compared with Djulbegovic's analysis of NCI trials. Results: Data from 51 superiority trials were included, involving over 48,000 participants and a range of diseases and interventions. 85 primary comparisons were available because some trials had more than two randomised arms or had several primary outcomes. The new treatment had superior results (whether significant or not) in 61% of the comparisons (52/85 95% CI 49.9% to 71.6%). The results were conclusive in 46% of the comparisons (19% statistically significant in favour of the new treatment, 5% statistically significant in favour of the control and 22% true negative). The results were classified as truly inconclusive (i.e. failed to answer the question asked) for 24% of comparisons (20/85). HTA trials included fewer truly inconclusive and statistically significant results and more results rated as true negative than NCI trials. Conclusions: The pattern of results in HTA trials is similar to that of the National Cancer Institute portfolio. Differences that existed were plausible given the differences in the types of trials -HTA trials are more pragmatic. The results indicate HTA trials are compatible with equipoise. This classification usefully summarises the results from clinical trials and enables comparisons of different portfolios of trials.
MeSH term(s)	Biomedical Technology/economics ; Evidence-Based Medicine/classification ; Evidence-Based Medicine/economics ; Humans ; National Cancer Institute (U.S.) ; Randomized Controlled Trials as Topic/classification ; Randomized Controlled Trials as Topic/economics ; Research Design ; Research Support as Topic ; Risk Assessment ; Terminology as Topic ; Therapeutic Equipoise ; Treatment Outcome ; United Kingdom ; United States
Language	English
Publishing date	2011-05-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/1745-6215-12-109
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Exploring the impact of virtual SPIKES training on genetic counselors' confidence to deliver difficult news.

Finley, Alexandra K / Andoni, Laila / May, Caitlyn A / Stark, Louisa A / Dent, Karin M

Journal of genetic counseling

2023 Volume 32, Issue 6, Page(s) 1266–1275

Abstract: Delivering difficult news is a common occurrence in genetic counseling. This is evidenced by widespread instruction among genetic counseling programs. There is a disconnect in the confidence level of being able to deliver difficult news (DDN) following ... ...

Abstract	Delivering difficult news is a common occurrence in genetic counseling. This is evidenced by widespread instruction among genetic counseling programs. There is a disconnect in the confidence level of being able to deliver difficult news (DDN) following educational training across healthcare disciplines. Other healthcare professions have addressed this issue with simulation-based training based on the SPIKES protocol, a stepwise process for delivering difficult news. To our knowledge, there is limited research that investigates the impact of simulation-based training in delivering difficult news for genetic counselors. Our aim was to develop simulation-based training in how to deliver difficult news for genetic counselors and analyze the extent to which it increased their confidence to deliver difficult news. Board-certified genetic counselors from all specialties were recruited to participate in a 2-h training session which included the opportunity to practice delivering difficult news. We collected self-reported confidence scores in each of the SPIKES steps from 16 genetic counselors pre- and post-intervention. Participants answered open-ended evaluations about the program's strengths, weaknesses, and gaps in delivering difficult news content. Almost all participants (N = 15) stated that they had gained confidence in delivering difficult news following training completion. Confidence significantly improved in four of seven SPIKES steps. Participants found strengths of the training program to be in their ability to practice with a simulated patient, to reference concrete examples, and to follow the program easily. The results of this study suggest that post-graduate training in how to deliver difficult news using the SPIKES protocol may strengthen genetic counselors' confidence in performing this important skill.
MeSH term(s)	Humans ; Counselors/psychology ; Genetic Counseling ; Self Report ; Educational Status ; Communication
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1117799-8
ISSN	1573-3599 ; 1059-7700
ISSN (online)	1573-3599
ISSN	1059-7700
DOI	10.1002/jgc4.1794
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4263: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Treatment success in pragmatic randomised controlled trials

Raftery James / Dent Louise

Trials, Vol 12, Iss 1, p

a review of trials funded by the UK Health Technology Assessment programme

2011 Volume 109

Abstract: Abstract Background Previous research reviewed treatment success and whether the collective uncertainty principle is met in RCTs in the US National Cancer Institute portfolio. This paper classifies clinical trials funded by the UK HTA programme by ... ...

Abstract	Abstract Background Previous research reviewed treatment success and whether the collective uncertainty principle is met in RCTs in the US National Cancer Institute portfolio. This paper classifies clinical trials funded by the UK HTA programme by results using the method applied to the US Cancer Institute trials, and compares the two portfolios. Methods Data on all completed randomised controlled trials funded by the HTA programme 1993-2008 were extracted. Each trial's primary results was classified into six categories; 1) statistically significant in favour of the new treatment, 2) statistically significant in favour of the control treatment 3) true negative, 4) truly inconclusive, 5) inconclusive in favour of new treatment or 6) inconclusive in favour of control treatment. Trials were classified by comparing the 95% confidence interval for the difference in primary outcome to the difference specified in the sample size calculation. The results were compared with Djulbegovic's analysis of NCI trials. Results Data from 51 superiority trials were included, involving over 48,000 participants and a range of diseases and interventions. 85 primary comparisons were available because some trials had more than two randomised arms or had several primary outcomes. The new treatment had superior results (whether significant or not) in 61% of the comparisons (52/85 95% CI 49.9% to 71.6%). The results were conclusive in 46% of the comparisons (19% statistically significant in favour of the new treatment, 5% statistically significant in favour of the control and 22% true negative). The results were classified as truly inconclusive (i.e. failed to answer the question asked) for 24% of comparisons (20/85). HTA trials included fewer truly inconclusive and statistically significant results and more results rated as true negative than NCI trials. Conclusions The pattern of results in HTA trials is similar to that of the National Cancer Institute portfolio. Differences that existed were plausible given the differences in the types ...
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Junior researchers' experience of innovation in a multidisciplinary team environment

Seto, Iva / Dent, Louise

Knowledge management research & practice : KMRP ; a journal of the OR Society Vol. 9, No. 1 , p. 95-97

2011 Volume 9, Issue 1, Page(s) 95–97

Author's details	Iva Seto and Louise Dent
Language	English
Publisher	Palgrave Macmillan
Publishing place	Basingstoke
Document type	Article
ZDB-ID	2116287-6
ISSN	1477-8238
Database	ECONomics Information System

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Core requirements of frailty screening in the emergency department: an international Delphi consensus study.

Moloney, Elizabeth / O'Donovan, Mark R / Carpenter, Christopher R / Salvi, Fabio / Dent, Elsa / Mooijaart, Simon / Hoogendijk, Emiel O / Woo, Jean / Morley, John / Hubbard, Ruth E / Cesari, Matteo / Ahern, Emer / Romero-Ortuno, Roman / Mcnamara, Rosa / O'Keefe, Anne / Healy, Ann / Heeren, Pieter / Mcloughlin, Darren / Deasy, Conor /

Age and ageing

2024 Volume 53, Issue 2

Abstract: Introduction: Frailty is associated with adverse outcomes among patients attending emergency departments (EDs). While multiple frailty screens are available, little is known about which variables are important to incorporate and how best to facilitate ... ...

Abstract	Introduction: Frailty is associated with adverse outcomes among patients attending emergency departments (EDs). While multiple frailty screens are available, little is known about which variables are important to incorporate and how best to facilitate accurate, yet prompt ED screening. To understand the core requirements of frailty screening in ED, we conducted an international, modified, electronic two-round Delphi consensus study. Methods: A two-round electronic Delphi involving 37 participants from 10 countries was undertaken. Statements were generated from a prior systematic review examining frailty screening instruments in ED (logistic, psychometric and clinimetric properties). Reflexive thematic analysis generated a list of 56 statements for Round 1 (August-September 2021). Four main themes identified were: (i) principles of frailty screening, (ii) practicalities and logistics, (iii) frailty domains and (iv) frailty risk factors. Results: In Round 1, 13/56 statements (23%) were accepted. Following feedback, 22 new statements were created and 35 were re-circulated in Round 2 (October 2021). Of these, 19 (54%) were finally accepted. It was agreed that ideal frailty screens should be short (<5 min), multidimensional and well-calibrated across the spectrum of frailty, reflecting baseline status 2-4 weeks before presentation. Screening should ideally be routine, prompt (<4 h after arrival) and completed at first contact in ED. Functional ability, mobility, cognition, medication use and social factors were identified as the most important variables to include. Conclusions: Although a clear consensus was reached on important requirements of frailty screening in ED, and variables to include in an ideal screen, more research is required to operationalise screening in clinical practice.
MeSH term(s)	Humans ; Frailty/diagnosis ; Delphi Technique ; Consensus ; Risk Factors ; Emergency Service, Hospital
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afae013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 448: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: "Flogging dead horses": evaluating when have clinical trials achieved sufficiency and stability? A case study in cardiac rehabilitation.

Dent, Louise / Taylor, Rod / Jolly, Kate / Raftery, James

Trials

2011 Volume 12, Page(s) 83

Abstract: Background: Most systematic reviews conclude that another clinical trial is needed. Measures of sufficiency and stability may indicate whether this is true.: Objectives: To show how evidence accumulated on centre-based versus home-based cardiac ... ...

Abstract	Background: Most systematic reviews conclude that another clinical trial is needed. Measures of sufficiency and stability may indicate whether this is true. Objectives: To show how evidence accumulated on centre-based versus home-based cardiac rehabilitation, including estimates of sufficiency and stability Methods: Systematic reviews of clinical trials of home versus centre-based cardiac rehabilitation were used to develop a cumulative meta-analysis over time. We calculated the standardised mean difference (SMD) in effect, confidence intervals and indicators of sufficiency and stability. Sufficiency refers to whether the meta-analytic database adequately demonstrates that an intervention works - is statistically superior to another. It does this by assessing the number of studies with null results that would be required to make the meta-analytic effect non-statistically significant. Stability refers to whether the direction and size of the effect is stable as new studies are added to the meta-analysis. Results: The standardised mean effect difference reduced over fourteen comparisons from a non-significant difference favouring home-based cardiac rehabilitation to a very small difference favouring hospital (SMD -0.10, 95% CI -0.32 to 0.13). This difference did not reach the sufficiency threshold (failsafe ratio 0.039<1) but did achieve the criteria for stability (cumulative slope 0.003<0.005). Conclusions: The evidence points to a relatively small effect difference which was stable but not sufficient in terms of the suggested thresholds. Sufficiency should arguably be based on substantive significance and decided by patients. Research on patient preferences should be the priority. Sufficiency and stability measures are useful tools that need to be tested in further case studies.
MeSH term(s)	Clinical Trials as Topic/statistics & numerical data ; Community Health Services/statistics & numerical data ; Data Interpretation, Statistical ; Evidence-Based Medicine/statistics & numerical data ; Heart Diseases/rehabilitation ; Home Care Services/statistics & numerical data ; Humans ; Outpatient Clinics, Hospital/statistics & numerical data ; Research Design ; Treatment Outcome
Language	English
Publishing date	2011-03-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/1745-6215-12-83
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito