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  1. Article ; Online: [Healthcare, European Stability Mechanism and public funding following the Covid-19 pandemic].

    Spampinato, Luigi

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2020  Volume 37, Issue 3

    Abstract: The aim of this editorial is to illustrate the new public funding framework of the Italian National Health System following the Covid-19 pandemic. The document reviews the measures put in place by the Italian Government and European Institutions such as ... ...

    Abstract The aim of this editorial is to illustrate the new public funding framework of the Italian National Health System following the Covid-19 pandemic. The document reviews the measures put in place by the Italian Government and European Institutions such as the European Commission (EC), the European Central Bank (ECB) and the European Stability Mechanism (ESM) to deal with this health crisis and subsequent severe economic recession, with particular reference to sources and uses of resources. The use of new budgetary financial spaces
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Delivery of Health Care/economics ; Economic Recession ; Europe ; Financing, Government/economics ; Health Expenditures ; Health Resources ; Humans ; Italy/epidemiology ; National Health Programs/economics ; Pandemics/economics ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Public Health ; SARS-CoV-2
    Keywords covid19
    Language Italian
    Publishing date 2020-06-10
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Healthcare, European Stability Mechanism and public funding following the Covid-19 pandemic]

    Spampinato, Luigi

    Abstract: The aim of this editorial is to illustrate the new public funding framework of the Italian National Health System following the Covid-19 pandemic. The document reviews the measures put in place by the Italian Government and European Institutions such as ... ...

    Abstract The aim of this editorial is to illustrate the new public funding framework of the Italian National Health System following the Covid-19 pandemic. The document reviews the measures put in place by the Italian Government and European Institutions such as the European Commission (EC), the European Central Bank (ECB) and the European Stability Mechanism (ESM) to deal with this health crisis and subsequent severe economic recession, with particular reference to sources and uses of resources. The use of new budgetary financial spaces in deficit entails greater attention to the assessment of interventions and makes it necessary to keep expenditure under strict control. At the same time, the remodeling of expenditure within its aggregates, public investment in innovation, and the removal of administrative obstacles can strengthen the capacity of the healthcare system to meet the extraordinary needs deriving from the spread of Covid-19 and its resilience to future health shocks.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32530146
    Database COVID19

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  3. Article ; Online: Soggetti aggregatori e spending review negli acquisti in sanità.

    Spampinato, Luigi

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2017  Volume 34, Issue 1

    Abstract: The aim of this paper is to analyze the new model of centralization of purchases in Italy after the approval of the 2016 Stability Law, with particular reference to the health sector. In fact, the spending review process in Italy in the health sector has ...

    Title translation Central purchasing bodies and spending review in health sector.
    Abstract The aim of this paper is to analyze the new model of centralization of purchases in Italy after the approval of the 2016 Stability Law, with particular reference to the health sector. In fact, the spending review process in Italy in the health sector has had a strong evolution with the 2016 Stability Law, which has introduced the obligation for the institutions of the National Health Service to obtain supplies, exclusively, from aggregators subjects, for certain product categories of the health sector. The legislature, over the years, was mainly characterized by measures to reduce the spending limits for purchases of goods and services or by resetting the fees, including the provision of an obligation for the renegotiation of health goods and services contracts, in order to ensure the effective implementation of the expenditure rationalization by aggregation of goods and services. From 2016, the legislature has provided an innovative model of centralization of purchases based on a new network governance model on several levels, national and regional, which should ensure an efficiency of procurement processes. The proper functioning of the governance model adopted can be an important driver of economic policy in order to understand that it is important not only to spend less, but to spend better. This can be realized in the public administration with a strong innovation process in this administration and also with a strong investment in skills, in order to ensure the same service quality throughout the national territory to the health sector.
    MeSH term(s) Health Expenditures/legislation & jurisprudence ; Italy ; Models, Organizational
    Language Italian
    Publishing date 2017-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
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  4. Article: Editorial: Bio-Inspired Physiological Signal(s) and Medical Image(s) Neural Processing Systems Based on Deep Learning and Mathematical Modeling for Implementing Bio-Engineering Applications in Medical and Industrial Fields.

    Rundo, Francesco / Banna, Giuseppe Luigi / Spampinato, Concetto / Conoci, Sabrina

    Frontiers in neuroinformatics

    2021  Volume 15, Page(s) 763699

    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2021.763699
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  5. Article ; Online: Microglia Contributes to BAF-312 Effects on Blood-Brain Barrier Stability.

    Spampinato, Simona Federica / Costantino, Giuseppe / Merlo, Sara / Canonico, Pier Luigi / Sortino, Maria Angela

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Microglia, together with astrocytes and pericytes, cooperate to ensure blood-brain barrier (BBB) stability, modulating endothelial responses to inflammatory insults. Agonists of the sphingosine 1 phosphate (S1P) receptors, such as siponimod (BAF-312), ... ...

    Abstract Microglia, together with astrocytes and pericytes, cooperate to ensure blood-brain barrier (BBB) stability, modulating endothelial responses to inflammatory insults. Agonists of the sphingosine 1 phosphate (S1P) receptors, such as siponimod (BAF-312), are important pharmacological tools in multiple sclerosis and other inflammatory diseases. Modulation of S1P receptors may result in a reduced inflammatory response and increased BBB stability. An in vitro BBB model was reproduced using human-derived endothelial cells, astrocytes and microglia. Co-cultures were exposed to inflammatory cytokines (TNFα, 10 UI and IFNγ, 5 UI) in the presence of BAF-312 (100 nM), and the BBB properties and microglia role were evaluated. The drug facilitated microglial migration towards endothelial/astrocyte co-cultures, involving the activity of the metalloprotease 2 (MMP2). Microglia actively cooperated with astrocytes in the maintenance of endothelial barrier stability: in the triple co-culture, selective treatment of microglial cells with BAF-312 significantly prevented cytokines' effects on the endothelial barrier. In conclusion, BAF-312, modulating S1P receptors in microglia, may contribute to the reinforcement of the endothelial barrier at the BBB, suggesting an additional effect of the drug in the treatment of multiple sclerosis.
    MeSH term(s) Azetidines ; Benzyl Compounds ; Blood-Brain Barrier ; Cytokines ; Endothelial Cells ; Humans ; Matrix Metalloproteinase 2 ; Microglia ; Multiple Sclerosis/drug therapy ; Phosphates ; Sphingosine/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology
    Chemical Substances Azetidines ; Benzyl Compounds ; Cytokines ; Phosphates ; Tumor Necrosis Factor-alpha ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Sphingosine (NGZ37HRE42) ; siponimod (RR6P8L282I)
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Petrographic and Chemical Characterization of the Frescoes by Saturnino Gatti (Central Italy, 15th Century)

    Luigi Germinario / Lorena C. Giannossa / Marco Lezzerini / Annarosa Mangone / Claudio Mazzoli / Stefano Pagnotta / Marcello Spampinato / Alfonso Zoleo / Giacomo Eramo

    Applied Sciences, Vol 13, Iss 7223, p

    2023  Volume 7223

    Abstract: This study presents the petrographic and chemical characterization of the frescoes in the Church of San Panfilo in Tornimparte (AQ, Italy) by Saturnino Gatti, a prominent painter of the late 15th–early 16th century, known for his exquisite technique, ... ...

    Abstract This study presents the petrographic and chemical characterization of the frescoes in the Church of San Panfilo in Tornimparte (AQ, Italy) by Saturnino Gatti, a prominent painter of the late 15th–early 16th century, known for his exquisite technique, composition, and use of color. The characterization of the frescoes is essential for understanding the materials and techniques used by Gatti, as well as for identifying the stratigraphy and painting phases. Eighteen samples were collected from the original paint layers, later additions (17th century), and restored surfaces, and analyzed by optical microscopy, cathodoluminescence microscopy, scanning electron microscopy (SEM-EDS), μ-Raman, and electron paramagnetic resonance (EPR). The analyses revealed a microstratigraphy often made of three main layers: (1) preparation, consisting of lime plaster and sand; (2) pigmented lime, applied by the fresco technique; and (3) additional pigmented layer on the surface. The most often recurring pigments are black, red, yellow (all generally linked with the fresco technique), and blue (applied “a secco”). The presence of two painting phases was also noted in one sample, probably resulting from a rethinking or restoration. These findings contribute to the understanding of the history and past restoration works of this cultural heritage site, providing important insights not only for conservators and restorers, but also for a broader understanding of Italian fresco painting and art history of the late 15th and early 16th centuries.
    Keywords lime plaster ; fresco painting ; pigments ; paint stratigraphy ; mineralogy ; petrography ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 700
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Dosimetric changes with computed tomography automatic tube-current modulation techniques.

    Spampinato, Sofia / Gueli, Anna Maria / Milone, Pietro / Raffaele, Luigi Angelo

    Radiological physics and technology

    2018  Volume 11, Issue 2, Page(s) 184–191

    Abstract: The study is aimed at a verification of dose changes for a computed tomography automatic tube-current modulation (ATCM) technique. For this purpose, anthropomorphic phantom and ... ...

    Abstract The study is aimed at a verification of dose changes for a computed tomography automatic tube-current modulation (ATCM) technique. For this purpose, anthropomorphic phantom and Gafchromic
    MeSH term(s) Algorithms ; Automation ; Humans ; Phantoms, Imaging ; Quality Control ; Radiometry ; Tomography, X-Ray Computed/instrumentation
    Language English
    Publishing date 2018-04-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2433581-2
    ISSN 1865-0341 ; 1865-0333
    ISSN (online) 1865-0341
    ISSN 1865-0333
    DOI 10.1007/s12194-018-0454-5
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  8. Article: Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood-Brain Barrier Integrity.

    Spampinato, Simona Federica / Bortolotto, Valeria / Canonico, Pier Luigi / Sortino, Maria Angela / Grilli, Mariagrazia

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 1346

    Abstract: Astrocytes are essential for proper regulation of the central nervous system (CNS). Importantly, these cells are highly secretory in nature. Indeed they can release hundreds of molecules which play pivotal physiological roles in nervous tissues and whose ...

    Abstract Astrocytes are essential for proper regulation of the central nervous system (CNS). Importantly, these cells are highly secretory in nature. Indeed they can release hundreds of molecules which play pivotal physiological roles in nervous tissues and whose abnormal regulation has been associated with several CNS disorders. In agreement with these findings, recent studies have provided exciting insights into the key contribution of astrocyte-derived signals in the pleiotropic functions of these cells in brain health and diseases. In the future, deeper analysis of the astrocyte secretome is likely to further increase our current knowledge on the full potential of these cells and their secreted molecules not only as active participants in pathophysiological events, but as pharmacological targets or even as therapeutics for neurological and psychiatric diseases. Herein we will highlight recent findings in our and other laboratories on selected molecules that are actively secreted by astrocytes and contribute in two distinct functions with pathophysiological relevance for the astroglial population: i) regulation of neural stem cells (NSCs) and their progeny within adult neurogenic niches; ii) modulation of the blood-brain barrier (BBB) integrity and function.
    Language English
    Publishing date 2019-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.01346
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  9. Article: The 2004–2005 Mt. Etna Compound Lava Flow Field: A Retrospective Analysis by Combining Remote and Field Methods

    Fornaciai, Alessandro / Andronico, Daniele / Favalli, Massimiliano / Spampinato, Letizia / Branca, Stefano / Lodato, Luigi / Bonforte, Alessandro / Nannipieri, Luca

    Journal of geophysical research. 2021 Mar., v. 126, no. 3

    2021  

    Abstract: Mapping lava flows frequently during effusive eruptions provides crucial parameters to better understand their dynamics, in turn improving our ability to model lava flow behavior. New photogrammetric methods have recently been developed, shifting the ... ...

    Abstract Mapping lava flows frequently during effusive eruptions provides crucial parameters to better understand their dynamics, in turn improving our ability to model lava flow behavior. New photogrammetric methods have recently been developed, shifting the paradigm of photogrammetry from pure method to a multidisciplinary approach able to reduce the cost of volcanic monitoring and widen the potential spectrum of application. In this work, we demonstrate how multi‐view and single‐view photogrammetry methods can be used effectively to extract accurate quantitative information from photographs taken during routine surveys over an active lava flow. One intriguing advantage of these methods is that they can re‐use images acquired previously to extract new data from past eruptions. In particular, we reconstructed quantitatively the evolution of the lava flow field emplaced during 2004–2005 at Mt. Etna, subdivided in five eruptive phases from the earliest simple lava flows to the final compound lava field about 6 months later. Our results show that, in the first week of eruption, lava field formation was characterized by an increasing lava length that followed a power law growth and by a decreasing front velocity that followed a power law as well. Thereafter, the length increasing became almost constant until the developed lava tube system was able to drain the lava for long distances, with the area inundated by lava that grew linearly in the first 20 days. Finally, we demonstrate the crucial role that the syn‐eruptive DEMs acquisition could have to improve our understanding of the emplacement dynamics of complex lava fields.
    Keywords geophysics ; lava ; photogrammetry ; research ; retrospective studies
    Language English
    Dates of publication 2021-03
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2020JB020499
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The MIS-COVID-AGICT Study: Trend of Minimally Invasive Surgery for Gastrointestinal Cancer Treatment During the First Waves of the COVID-19 Pandemic in Italy. Subgroup Analysis from the COVID-AGICT Study: COVID-19 and Advanced Gastrointestinal Cancer Surgical Treatment.

    Giuliani, Giuseppe / Coletta, Diego / Guerra, Francesco / Esposito, Sofia / Esposito, Alessandro / De Pastena, Matteo / Rega, Daniela / Delrio, Paolo / La Raja, Carlotta / Spinelli, Antonino / Massaron, Simonetta / De Nardi, Paola / Kauffmann, Emanuele Federico / Boggi, Ugo / Deidda, Simona / Zorcolo, Luigi / Marano, Alessandra / Borghi, Felice / Piccoli, Micaela /
    Depalma, Norma / D'Ugo, Stefano / Spampinato, Marcello / Cozzani, Federico / Del Rio, Paolo / Marcellinaro, Rosa / Carlini, Massimo / De Rosa, Raffaele / Scabini, Stefano / Maiello, Fabio / Polastri, Roberto / Turri, Giulia / Pedrazzani, Corrado / Zese, Monica / Parini, Dario / Coratti, Andrea

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 33, Issue 6, Page(s) 579–585

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; COVID-19 ; Gastrointestinal Neoplasms/surgery ; Minimally Invasive Surgical Procedures/methods ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Clinical Study ; Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2023.0058
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