Result 1 - 10 of total 214
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| Keywords | covid19 |
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| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1007/s12654-020-0735-6 |
| Database | COVID19 |
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| Keywords | covid19 |
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| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1007/s12654-020-0731-x |
| Database | COVID19 |
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2024
Abstract: Objective: The arteriovenous fistula (AVF) is the first choice for gaining vascular access for hemodialysis. However, 20% to 50% of AVFs fail within 4 months after creation. Although demographic risk factors have been described, there is little evidence ...
| Abstract | Objective: The arteriovenous fistula (AVF) is the first choice for gaining vascular access for hemodialysis. However, 20% to 50% of AVFs fail within 4 months after creation. Although demographic risk factors have been described, there is little evidence on the intraoperative predictors of AVF maturation failure. The aim of this study was to assess the predictive value of intraoperative transit time flow measurements (TTFMs) on AVF maturation failure. Methods: In this retrospective cohort study, intraoperative blood flow, measured using TTFM, was compared with AVF maturation after 6 weeks in 55 patients. Owing to its significantly higher prevalence and risk of nonmaturation, the radiocephalic AVF (RCAVF) was the main focus of this study. A recommended cutoff point for high vs low intraoperative blood flow was determined for RCAVFs, using a receiver operating characteristic curve. Results: The average intraoperative blood flow in RCAVFs was 156 mL/min. Patients with an intraoperative blood flow equal or lower than the determined cutoff point of 160 mL/min, showed a 3.03 times increased risk of AVF maturation failure after 6 weeks, compared with patients with a higher intraoperative blood flow (P < .001). Conclusions: The intraoperative blood flow in RCAVFs measured by TTFM provides an adequate means of predicting AVF nonmaturation 6 weeks after surgery. For RCAVFs, a cutoff point for intraoperative blood flow of 160 mL/min is recommended for maximum sensitivity and specificity to predict AVF maturation failure after 6 weeks. |
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| Language | English |
| Publishing date | 2024-03-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 605700-7 |
| ISSN | 1097-6809 ; 0741-5214 |
| ISSN (online) | 1097-6809 |
| ISSN | 0741-5214 |
| DOI | 10.1016/j.jvs.2024.02.028 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1933: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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ACS macro letters
2019 Volume 8, Issue 4, Page(s) 427–434
Abstract: Due to their great modularity, ease of implementation, and atom economy, multicomponent reactions (MCRs) are becoming increasingly popular macromolecular engineering tools. In this context, MCRs suitable in polymer synthesis are eagerly searched for. ... ...
| Abstract | Due to their great modularity, ease of implementation, and atom economy, multicomponent reactions (MCRs) are becoming increasingly popular macromolecular engineering tools. In this context, MCRs suitable in polymer synthesis are eagerly searched for. This work demonstrates the potential of the Ugi-three component reaction (Ugi-3CR) for the design of polymers and, in particular, of poly(α-amino amide)s. A series of polymers containing amino and amido groups within their backbone were obtained through a one-pot process by reacting aliphatic or aromatic diamines, diisocyanides, and aldehydes. The impact of temperature, concentration, catalyst loading, and substrates on polymerization efficiency is discussed. A preliminary study on the thermal properties and the solution behavior of these poly(α-amino amide)s was carried out. An aliphatic-rich derivative notably showed some pH-responsiveness in water via protonation-deprotonation of its amino groups. |
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| Language | English |
| Publishing date | 2019-03-28 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2161-1653 |
| ISSN (online) | 2161-1653 |
| DOI | 10.1021/acsmacrolett.9b00182 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Volume 37, Issue 8, Page(s) 1566–1575
Abstract: Background: In the general population, the seroconversion rate after primary vaccination with two doses of an anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) vaccine reaches nearly 100%, with significantly higher antibody ... ...
| Abstract | Background: In the general population, the seroconversion rate after primary vaccination with two doses of an anti-severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) vaccine reaches nearly 100%, with significantly higher antibody titers after mRNA-1273 vaccination compared to BNT162b2 vaccination. Here we performed a systematic review and meta-analysis to compare the antibody response after two-dose mRNA-1273 versus BNT162b2 vaccination in solid organ transplant (SOT) recipients. Methods: A systematic literature review was performed using PubMed, Web of Science and the Cochrane Library and original research papers were included for a meta-analysis to calculate vaccine-specific seroconversion rates for each of the mRNA vaccines. Next, the pooled relative seroconversion rate was estimated. Results: Eight studies that described the development of antibodies against receptor-binding domain (RBD) and/or spike protein were eligible for meta-analysis. Two of these studies also reported antibody titers. The meta-analysis revealed lower seroconversion rates in SOT recipients vaccinated with two doses of BNT162b2 {44.3% [95% confidence interval (CI) 34.1-54.7]} as compared with patients vaccinated with two doses of mRNA-1273 [58.4% (95% CI 47.2-69.2)]. The relative seroconversion rate was 0.795 (95% CI 0.732-0.864). Conclusions: This systematic review and meta-analysis indicates that in SOT recipients, higher seroconversion rates were observed after vaccination with mRNA-1273 compared with BNT162b2. |
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| MeSH term(s) | 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; Humans ; Organ Transplantation ; RNA, Messenger ; Seroconversion ; Transplant Recipients ; Vaccination ; Vaccines |
| Chemical Substances | Antibodies, Viral ; RNA, Messenger ; Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU) |
| Language | English |
| Publishing date | 2022-05-11 |
| Publishing country | England |
| Document type | Journal Article ; Meta-Analysis ; Systematic Review |
| ZDB-ID | 90594-x |
| ISSN | 1460-2385 ; 0931-0509 |
| ISSN (online) | 1460-2385 |
| ISSN | 0931-0509 |
| DOI | 10.1093/ndt/gfac174 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2198: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 329: Show issues |
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Arthritis & rheumatology (Hoboken, N.J.)
2021 Volume 73, Issue 12, Page(s) 2352–2353
| Language | English |
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| Publishing date | 2021-10-25 |
| Publishing country | United States |
| Document type | Letter ; Comment |
| ZDB-ID | 2756371-6 |
| ISSN | 2326-5205 ; 2326-5191 |
| ISSN (online) | 2326-5205 |
| ISSN | 2326-5191 |
| DOI | 10.1002/art.41908 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 24: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2021 Volume 37, Issue 4, Page(s) 799–803
| MeSH term(s) | 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; Renal Dialysis ; Transplant Recipients |
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| Chemical Substances | Antibodies, Viral ; COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU) |
| Language | English |
| Publishing date | 2021-12-09 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 90594-x |
| ISSN | 1460-2385 ; 0931-0509 |
| ISSN (online) | 1460-2385 |
| ISSN | 0931-0509 |
| DOI | 10.1093/ndt/gfab352 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2198: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 329: Show issues |
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JHEP reports : innovation in hepatology
2021 Volume 4, Issue 2, Page(s) 100412
Abstract: Background & aims: Intrahepatic vascular resistance is increased in early non-alcoholic fatty liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease progression. Hepatic vascular hyperreactivity to vasoconstrictors has been ... ...
| Abstract | Background & aims: Intrahepatic vascular resistance is increased in early non-alcoholic fatty liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease progression. Hepatic vascular hyperreactivity to vasoconstrictors has been identified as an underlying mechanism. This study investigates vasoconstrictive agonism and antagonism in 2 models of early NAFLD and in non-alcoholic steatohepatitis (NASH). Methods: The effects of endothelin-1 (ET-1), angiotensin II (ATII) and thromboxane A Results: The THPG and consequent portal pressure were significantly increased in both models of steatosis and in NASH. ET-1, ATII and TxA Conclusions: Antagonism of vasoconstrictive mediators improves intrahepatic vascular function. Both ET-1 and ATII antagonists showed additional benefit and bosentan even mitigated steatosis and structural liver damage. In conclusion, vasoconstrictive antagonism is a potentially promising therapeutic option for the treatment of early NAFLD. Lay summary: In non-alcoholic fatty liver disease (NAFLD), hepatic blood flow is impaired and the blood pressure in the liver blood vessels is increased as a result of an increased response of the liver vasculature to vasoconstrictors. Using drugs to block the constriction of the intrahepatic vasculature, the resistance of the liver blood vessels decreases and the increased portal pressure is reduced. Moreover, blocking the vasoconstrictive endothelin-1 pathway restored parenchymal architecture and reduced disease severity. |
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| Language | English |
| Publishing date | 2021-11-25 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ISSN | 2589-5559 |
| ISSN (online) | 2589-5559 |
| DOI | 10.1016/j.jhepr.2021.100412 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2023 Volume 41, Issue 28, Page(s) 4535–4547
Abstract: Purpose: The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network meta-analysis (NMA) of randomized ...
| Abstract | Purpose: The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network meta-analysis (NMA) of randomized controlled trials (RCTs) to study the effect of chemotherapy or chemoradiotherapy, with a focus on tumor location and histology subgroups. Patients and methods: All, published or unpublished, RCTs closed to accrual before December 31, 2015 and having compared at least two of the following strategies were eligible: upfront surgery (S), chemotherapy followed by surgery (CS), and chemoradiotherapy followed by surgery (CRS). All analyses were conducted on IPD obtained from investigators. The primary end point was overall survival (OS). The IPD-NMA was analyzed by a one-step mixed-effect Cox model adjusted for age, sex, tumor location, and histology. The NMA was registered in PROSPERO (CRD42018107158). Results: IPD were obtained for 26 of 35 RCTs (4,985 of 5,807 patients) corresponding to 12 comparisons for CS-S, 12 for CRS-S, and four for CRS-CS. CS and CRS led to increased OS when compared with S with hazard ratio (HR) = 0.86 (0.75 to 0.99), Conclusion: Neoadjuvant chemotherapy and chemoradiotherapy were consistently better than S alone across histology, but with some variation in the magnitude of treatment effect by sex for CRS and tumor location for CS. A strong OS difference between CS and CRS was not identified. |
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| MeSH term(s) | Female ; Humans ; Carcinoma/drug therapy ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/pathology ; Neoadjuvant Therapy ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Male |
| Language | English |
| Publishing date | 2023-07-12 |
| Publishing country | United States |
| Document type | Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 604914-x |
| ISSN | 1527-7755 ; 0732-183X |
| ISSN (online) | 1527-7755 |
| ISSN | 0732-183X |
| DOI | 10.1200/JCO.22.02279 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1847: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 650: Show issues |
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2022 Volume 13, Issue 1, Page(s) e0326421
Abstract: The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases but not for neglected tropical diseases (NTDs). Here, we explored and demonstrated the ... ...
| Abstract | The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases but not for neglected tropical diseases (NTDs). Here, we explored and demonstrated the importance of this approach using as paradigms Leishmania donovani, the etiological agent of visceral leishmaniasis (VL), and TCMDC-143345, a promising compound of the GlaxoSmithKline (GSK) "Leishbox" to treat VL. We experimentally selected resistance to TCMDC-143345 |
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| MeSH term(s) | Humans ; Antiprotozoal Agents/immunology ; Dynamin I/genetics ; Dynamin I/immunology ; Genomics ; Leishmania donovani/genetics ; Leishmania donovani/immunology ; Leishmania donovani/parasitology ; Leishmaniasis, Visceral/genetics ; Leishmaniasis, Visceral/immunology ; Leishmaniasis, Visceral/parasitology ; Phylogeny ; Retrospective Studies ; Drug Resistance/genetics ; Drug Resistance/immunology |
| Chemical Substances | Antiprotozoal Agents ; Dynamin I (EC 3.5.1.50) |
| Language | English |
| Publishing date | 2022-01-11 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2557172-2 |
| ISSN | 2150-7511 ; 2161-2129 |
| ISSN (online) | 2150-7511 |
| ISSN | 2161-2129 |
| DOI | 10.1128/mbio.03264-21 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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