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  1. Article ; Online: Biomarker Research in World Journal of Oncology.

    Takabe, Kazuaki / Benesch, Matthew G K

    World journal of oncology

    2023  Volume 14, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2023-02-26
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: ASO Author Reflections: How Does Cholestasis Worsen Pancreatic Cancer Progression?

    Sarkar, Joy / Takabe, Kazuaki

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3505

    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13408-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Types of Cancer and Research Covered in

    Takabe, Kazuaki / Benesch, Matthew G K

    World journal of oncology

    2022  Volume 13, Issue 6, Page(s) 325–328

    Language English
    Publishing date 2022-12-24
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biology of Mesothelin and Clinical Implications: A Review of Existing Literature.

    Hagerty, Brendan L / Takabe, Kazuaki

    World journal of oncology

    2023  Volume 14, Issue 5, Page(s) 340–349

    Abstract: Since its discovery in 1992, mesothelin (MSLN) has generated significant interest as a therapeutic target. A number of characteristics make it ideal for this purpose. First, it is not expressed on the parenchyma of any vital organs. Second, it is ... ...

    Abstract Since its discovery in 1992, mesothelin (MSLN) has generated significant interest as a therapeutic target. A number of characteristics make it ideal for this purpose. First, it is not expressed on the parenchyma of any vital organs. Second, it is differentially expressed on a number of cancer types that have relatively poor prognosis and lack effective systemic options. Third, it is expressed on the cell membrane making it accessible to large molecule targeted therapies. However, unlike other drug targets that have been exploited for therapeutic benefit, the precise function of MSLN, why it is expressed in certain cancers, and its biological role have not been clearly elucidated. Here the existing literature on the cellular function and expression patterns of MSLN across tumor types is reviewed in order to gain further understanding of this intriguing molecule. In doing so, we conclude that there remains significant ambiguity surrounding its function and role in cellular and tumor biology. Furthermore, the expression of MSLN and its relation of prognosis seems to depend on the type of tumor. Finally, the unified mechanism by which MSLN acts as a protein that conveys tumor aggressiveness remains elusive. What is clear is that there is much yet to be discovered in this realm and doing so may have large implications for treatment of otherwise lethal malignancies.
    Language English
    Publishing date 2023-09-20
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ASO Author Reflections: How Does Cholestasis Worsen Pancreatic Cancer Progression?

    Sarkar, Joy / Takabe, Kazuaki

    Annals of surgical oncology

    2022  Volume 30, Issue 3, Page(s) 1642–1643

    MeSH term(s) Humans ; Pancreatic Neoplasms/complications ; Pancreas ; Cholestasis/etiology ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-12-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12946-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: World Journal of Oncology Has Gained an Impact Factor of 5.2 by Journal Citation Reports.

    Takabe, Kazuaki / Benesch, Matthew G K / Chida, Kohei

    World journal of oncology

    2023  Volume 14, Issue 4, Page(s) 231–233

    Language English
    Publishing date 2023-08-04
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer.

    Benesch, Matthew G K / Tang, Xiaoyun / Brindley, David N / Takabe, Kazuaki

    World journal of oncology

    2024  Volume 15, Issue 1, Page(s) 1–13

    Abstract: Overcoming and preventing cancer therapy resistance is the most pressing challenge in modern breast cancer management. Consequently, most modern breast cancer research is aimed at understanding and blocking these therapy resistance mechanisms. One ... ...

    Abstract Overcoming and preventing cancer therapy resistance is the most pressing challenge in modern breast cancer management. Consequently, most modern breast cancer research is aimed at understanding and blocking these therapy resistance mechanisms. One increasingly promising therapeutic target is the autotaxin (ATX)-lysophosphatidate (LPA)-lipid phosphate phosphatase (LPP) axis. Extracellular LPA, produced from albumin-bound lysophosphatidylcholine by ATX and degraded by the ecto-activity of the LPPs, is a potent cell-signaling mediator of tumor growth, invasion, angiogenesis, immune evasion, and resistance to cancer treatment modalities. LPA signaling in the post-natal organism has central roles in physiological wound healing, but these mechanisms are subverted to fuel pathogenesis in diseases that arise from chronic inflammatory processes, including cancer. Over the last 10 years, our understanding of the role of LPA signaling in the breast tumor microenvironment has begun to mature. Tumor-promoting inflammation in breast cancer leads to increased ATX production within the tumor microenvironment. This results in increased local concentrations of LPA that are maintained in part by decreased overall cancer cell LPP expression that would otherwise more rapidly break it down. LPA signaling through six G-protein-coupled LPA receptors expressed by cancer cells can then activate virtually every known tumorigenic pathway. Consequently, to target therapy resistance and tumor growth mediated by LPA signaling, multiple inhibitors against the LPA signaling axis are entering clinical trials. In this review, we summarize recent developments in LPA breast cancer biology, and illustrate how these novel therapeutics against the LPA signaling pathway may be excellent adjuncts to extend the efficacy of evolving breast cancer treatments.
    Language English
    Publishing date 2024-01-20
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Dimensions of Reports From Around the World That Address Diversity in Oncology.

    Takabe, Kazuaki / Day, Vidalina / Benesch, Matthew G K

    World journal of oncology

    2022  Volume 13, Issue 5, Page(s) 241–243

    Language English
    Publishing date 2022-10-22
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: High

    Nelson, Erek D / Benesch, Matthew Gk / Wu, Rongrong / Ishikawa, Takashi / Takabe, Kazuaki

    American journal of cancer research

    2024  Volume 14, Issue 1, Page(s) 227–242

    Abstract: Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) is regulated by the mTOR (mammalian target of rapamycin) signaling pathway. Phosphorylated EIF4EBP1 protein leads to pathway activation and correlates with aggressive breast cancer ... ...

    Abstract Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) is regulated by the mTOR (mammalian target of rapamycin) signaling pathway. Phosphorylated EIF4EBP1 protein leads to pathway activation and correlates with aggressive breast cancer features. However, the clinical relevance of
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunotherapy: Recent Advances and Its Future as a Neoadjuvant, Adjuvant, and Primary Treatment in Colorectal Cancer.

    Yu, Irene / Dakwar, Anthony / Takabe, Kazuaki

    Cells

    2023  Volume 12, Issue 2

    Abstract: Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade. Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly improve patient outcomes in mismatch repair-deficient (dMMR) CRC. Now, they ... ...

    Abstract Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade. Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly improve patient outcomes in mismatch repair-deficient (dMMR) CRC. Now, they are part of the standard of care for this subset of CRC. Because of this, there has been a growing interest in the efficacy and timing of immunotherapy for other subsets of CRC, including locally advanced, metastatic, and microsatellite stable (MSS). In this review, we aim to examine the three main classes of immunotherapy for CRC-immune checkpoint inhibitors (ICIs), adoptive cell transfer therapy (ACT), and tumor vaccines-and discuss the most recent advances and future directions for each.
    MeSH term(s) Humans ; Neoadjuvant Therapy ; Immune Checkpoint Inhibitors ; Immunotherapy ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Colorectal Neoplasms/therapy
    Chemical Substances Immune Checkpoint Inhibitors ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic
    Language English
    Publishing date 2023-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12020258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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