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Article ; Online: Cortical spreading depression: culprits and mechanisms.

Mathew, Aparna Ann / Panonnummal, Rajitha

2022 Volume 240, Issue 3, Page(s) 733–749

Abstract: Cortical spreading depression or CSD is an electrophysiological phenomenon affecting various perspectives of brain physiology such as ionic balance, neurotransmitter level, and blood flow in the brain. This phenomenon has greater impact on the brain ... ...

Abstract	Cortical spreading depression or CSD is an electrophysiological phenomenon affecting various perspectives of brain physiology such as ionic balance, neurotransmitter level, and blood flow in the brain. This phenomenon has greater impact on the brain function and results in the pathological contribution of many diseases in humans such as migraine with aura, stroke, and traumatic brain injury. Various factors such as nutrition, stress, sleep, age, alcohol, inflammation and oxidative stress worsen the condition and affect CSD susceptibility. The underlying mechanisms such as ionic imbalance and neurotransmitters' alteration are interconnected and may worsen the condition of CSD. Thus, correction of these main culprits might ameliorate the cumbersome effect of CSD, thereby providing benefits in diseases associated with CSD. This review collates most of the triggering factors that makes one prone to the CSD condition along with its underlying mechanisms.
MeSH term(s)	Brain ; Cortical Spreading Depression/physiology ; Humans ; Migraine Disorders ; Migraine with Aura
Language	English
Publishing date	2022-01-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1201-4
ISSN	1432-1106 ; 0014-4819
ISSN (online)	1432-1106
ISSN	0014-4819
DOI	10.1007/s00221-022-06307-9
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Zs.A 278: Show issues

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Article ; Online: A Mini Review on the Various Facets Effecting Brain Delivery of Magnesium and Its Role in Neurological Disorders.

Mathew, Aparna Ann / Panonnummal, Rajitha

Biological trace element research

2022 Volume 201, Issue 9, Page(s) 4238–4253

Abstract: Magnesium is an essential cation present in the body that participates in the regulation of various vital body functions. Maintaining normal level of magnesium is essential for proper brain functions by regulating the activities of numerous ... ...

Abstract	Magnesium is an essential cation present in the body that participates in the regulation of various vital body functions. Maintaining normal level of magnesium is essential for proper brain functions by regulating the activities of numerous neurotransmitters and their receptors. Various studies have been reported that magnesium level is found to be declined in both neurological and psychiatric diseases. Declined magnesium level in the brain initiates various cumbersome effects like excitotoxicity, altered blood-brain permeability, oxidative stress, and inflammation, which may further worsen the disease condition. Shreds of evidence from the experimental and clinical studies proved that exogenous administration of magnesium is useful for correcting disease-induced alterations in the brain. But one of the major limiting factors in the use of magnesium for treatment purposes is its poor blood-brain barrier permeability. Various approaches like the administration of its organic salts as pidolate and threonate forms, and the combination with polyethylene glycol or mannitol have been tried to improve its permeability to make magnesium as a suitable drug for different neurological disorders. These results have shown their experimental efficacy in diseased animal models, but studies regarding the safety and efficacy in human subjects are currently underway. We present a comprehensive review on the role of magnesium in the maintenance of normal functioning of the brain and various approaches for improving its BBB permeability.
MeSH term(s)	Animals ; Humans ; Magnesium/therapeutic use ; Magnesium/pharmacology ; Brain ; Blood-Brain Barrier ; Nervous System Diseases/drug therapy ; Biological Transport
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2022-12-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-022-03517-8
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Zs.B 2323: Show issues

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Article ; Online: 'Magnesium'-the master cation-as a drug-possibilities and evidences.

Mathew, Aparna Ann / Panonnummal, Rajitha

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2021 Volume 34, Issue 5, Page(s) 955–986

Abstract: Magnesium ( ... ...

Abstract	Magnesium (Mg
MeSH term(s)	Calcium ; Cations ; Magnesium ; Potassium ; Sodium
Chemical Substances	Cations ; Sodium (9NEZ333N27) ; Magnesium (I38ZP9992A) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-07-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-021-00328-7
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Zs.A 2515: Show issues

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Article ; Online: Tandem Reactions of Electrophilic Indoles toward Indolizines and Their Subsequent Transformations through Pd(II)-Mediated C-H Functionalization to Access Polyring-Fused

Babu, Sheba Ann / A, Aparna / Mohan, Malavika / Paul, Namitha / Mathew, Jomon / John, Jubi

ACS omega

2024 Volume 9, Issue 14, Page(s) 16196–16206

Abstract: A simple and efficient synthetic approach for generating a library of structurally novel indolizines has been developed via sequential 1,3-dipolar cycloaddition-ring opening processes. Using this methodology, a series of indolizines bearing different ... ...

Abstract	A simple and efficient synthetic approach for generating a library of structurally novel indolizines has been developed via sequential 1,3-dipolar cycloaddition-ring opening processes. Using this methodology, a series of indolizines bearing different substituents were made in moderate to good yields. The presence of two functionalizable C-H bonds in these indolizine motifs makes them attractive for accessing fused indolizine scaffolds. In this line, we have introduced palladium-mediated site-selective C-H functionalizations, where the
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c10194
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Article ; Online: Formulation and evaluation of magnesium sulphate nanoparticles for improved CNS penetrability.

Mathew, Aparna Ann / Mohapatra, Sudeshna / Panonnummal, Rajitha

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 396, Issue 3, Page(s) 567–576

Abstract: Magnesium ( ... ...

Abstract	Magnesium (Mg
MeSH term(s)	Humans ; Rats ; Animals ; Magnesium Sulfate/pharmacology ; Magnesium Sulfate/metabolism ; Magnesium/metabolism ; Magnesium/pharmacology ; Spectroscopy, Fourier Transform Infrared ; Blood-Brain Barrier/metabolism ; Nervous System Diseases/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Magnesium Sulfate (7487-88-9) ; Magnesium (I38ZP9992A) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2022-12-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02356-7
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Article: Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications.

Treeza M, Minu / Augustine, Sanu / Mathew, Aparna Ann / Kanthlal, S K / Panonummal, Rajitha

Advanced pharmaceutical bulletin

2023 Volume 13, Issue 4, Page(s) 678–687

Abstract: Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2. The virus-induced ... ...

Abstract	Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2. The virus-induced pulmonary impairment and inflammatory cytokine storm are directly related to its clinical manifestations. But, the fundamental mechanisms of inflammatory responses are found to be the reason for the death of immune cells which render the host immune system failure. Apoptosis of immune cells is one of the most common forms of programmed cell death induced by the virus for its survival and virulence property. ORF3a, a SARS-CoV-2 accessory viral protein, induces apoptosis in host cells and suppress the defense mechanism. This suggests, inhibiting SARS-CoV-2 ORF3a protein is a good therapeutic strategy for the treatment in COVID-19 infection by promoting the host immune defense mechanism.
Language	English
Publishing date	2023-01-23
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2023.069
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Article ; Online: Cardioprotective Effect of

Mathew, Aparna Ann / Asirvatham, Raju / Tomy, Dawn V

Turkish journal of pharmaceutical sciences

2021 Volume 18, Issue 3, Page(s) 271–281

Abstract: Objectives: The major adverse effect of doxorubicin (DOX) in cancer treatment is cardiac toxicity. Murva is a controversial plant used in the Ayurvedic system, which consist of more than 12 medicinal plant roots found in different parts of India. : ... ...

Abstract	Objectives: The major adverse effect of doxorubicin (DOX) in cancer treatment is cardiac toxicity. Murva is a controversial plant used in the Ayurvedic system, which consist of more than 12 medicinal plant roots found in different parts of India. Materials and methods: A total of 48 rats were divided into 8 groups with 6 in each group. DOX 20 mg/kg, intraperitoneally (i.p.) was administered to all rats on the 13 Results: The combination that showed the most significant (p<0.001) effect on altered cardiac enzymes and antioxidant enzyme levels in both blood and tissues also corrected the extreme damage in cellular functional units. Dresgenin and lupeol showed binding scores of -8.2 (kcal/mol) and -9 (kcal/mol), respectively, with PPARα. HPTLC reports revealed that 17 and 12 peaks were found at 254 nm for dresgenin and lupeol, respectively. Conclusion: The study results concluded that the combination of MESR and MEMT and that of MESR and MEMT exerted cardioprotective activity via binding of dresgenin and lupeol to PPARα. The order of efficacy was the extract combination > MESR > MEMT.
Language	English
Publishing date	2021-06-22
Publishing country	Turkey
Document type	Journal Article
ISSN	2148-6247
ISSN (online)	2148-6247
DOI	10.4274/tjps.galenos.2020.27880
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Article ; Online: Apoptosis promoting activity of selected plant steroid in MRMT-1 breast cancer cell line by modulating mitochondrial permeation pathway.

Aslam, Muhammed / Augustine, Sanu / Ann Mathew, Aparna / Kanthlal, S K / Panonummal, Rajitha

Steroids

2022 Volume 190, Page(s) 109151

Abstract: Escape from apoptosis is one of the main demeanor characteristics of cancer cells. Mitochondria are key players in initiating and regulating the intrinsic apoptosis pathway. Hexokinase2 (HK2) is ubiquitously expressed in several cancer cells and is ... ...

Abstract	Escape from apoptosis is one of the main demeanor characteristics of cancer cells. Mitochondria are key players in initiating and regulating the intrinsic apoptosis pathway. Hexokinase2 (HK2) is ubiquitously expressed in several cancer cells and is essential for cell survival and death. The binding of HK2 to mitochondria promotes cell proliferation, while AKT-1 mediated pathway is crucial in this process. Peimine, a steroidal alkaloid derived from plant steroids, is screened for docking properties, ADMET properties, and drug-likeness. Apoptosis targets are predicted by network pharmacology using 47 genes associated with apoptosis. According to in silico study, peimine has the potential for dual Targeting on HK2 and AKT1. For further confirmation, peimine was subjected to Cell culture studies using MRMT-1 rat breast cancer cells. The elevated levels of cytochrome c and Caspase 9 activity indicate that the intrinsic apoptosis pathway causes cell death. The decreased glucose uptake by the MRMT-1 cells indicates that pimine inhibits glucose transport by inhibiting the membrane HK2.
MeSH term(s)	Humans ; Rats ; Animals ; Apoptosis ; Cell Death ; Signal Transduction ; MCF-7 Cells ; Cell Proliferation ; Mitochondria/metabolism ; Cell Line, Tumor ; Neoplasms/metabolism
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2022.109151
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Zs.A 87: Show issues

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Article ; Online: Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16

Colbert, Lauren E / El, Molly B / Lynn, Erica J / Bronk, Julianna / Karpinets, Tatiana V / Wu, Xiaogang / Chapman, Bhavana V / Sims, Travis T / Lin, Daniel / Kouzy, Ramez / Sammouri, Julie / Biegert, Greyson / Delgado Medrano, Andrea Y / Olvera, Adilene / Sastry, K Jagannadha / Eifel, Patricia J / Jhingran, Anuja / Lin, Lilie / Ramondetta, Lois M /

Futreal, Andrew P / Jazaeri, Amir A / Schmeler, Kathleen M / Yue, Jingyan / Mitra, Aparna / Yoshida-Court, Kyoko / Wargo, Jennifer A / Solley, Travis N / Hegde, Venkatesh / Nookala, Sita S / Yanamandra, Ananta V / Dorta-Estremera, Stephanie / Mathew, Geena / Kavukuntla, Rohit / Papso, Cassidy / Ahmed-Kaddar, Mustapha / Kim, Minsoo / Zhang, Jianhua / Reuben, Alexandre / Holliday, Emma B / Minsky, Bruce D / Koong, Albert C / Koay, Eugene J / Das, Prajnan / Taniguchi, Cullen M / Klopp, Ann

Cancer immunology research

2022 Volume 10, Issue 2, Page(s) 259–271

Abstract: Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during ... ...

Abstract	Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy or affects survival. Using T cells from 2 HPV16
MeSH term(s)	Chemoradiotherapy ; Female ; Human papillomavirus 16 ; Humans ; Oncogene Proteins, Viral ; Papillomavirus E7 Proteins ; Papillomavirus Infections ; Prognosis ; Repressor Proteins ; T-Lymphocytes ; Tumor Microenvironment ; Uterine Cervical Neoplasms
Chemical Substances	Oncogene Proteins, Viral ; Papillomavirus E7 Proteins ; Repressor Proteins
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-21-0119
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Zs.A 7022: Show issues

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Article ; Online: Quality of life in Schizophrenia patients with and without adequate pharmaceutical care

Aparna Joshi / Jovin Joshy / Keziah Anna Mathew / Saloni R. Jain / Aishwarya C. Hiremath / Bheemsain V. Tekkalaki / M.S. Ganachari

Clinical Epidemiology and Global Health, Vol 20, Iss , Pp 101208- (2023)

A randomized controlled study

2023

Abstract: Introduction: Schizophrenia is a complicated mental illness manifesting in a variety of disturbing clinical presentations in an individual, resulting in varying treatment results and poor Quality of Life (QoL). This study was aimed at assessment and ... ...

Abstract	Introduction: Schizophrenia is a complicated mental illness manifesting in a variety of disturbing clinical presentations in an individual, resulting in varying treatment results and poor Quality of Life (QoL). This study was aimed at assessment and comparison of QoL in patients with and without provision of pharmaceutical care and evaluation of the drug utilisation pattern among the patients. Materials and methods: A randomized controlled study was conducted among 104 patients fulfilling the eligibility criteria, randomly assigned to control and interventional group, with 52 patients in each group. At baseline and follow up, QoL scores were compared using the WHOQOL-BREF questionnaire for each group. Patient counselling was provided to the intervention group. Results: Schizophrenia was prevalent in females (56.2%) and 34.4% were below 30 years. Factors such as marital, employment, education, socio-economic status were influenced. Post-follow up WHOQOL-BREF scores among the intervention group were found to be significant as compared to that of the control group. Conclusion: There is improvement in the domain wise mean and total QoL scores in Schizophrenia patients in the interventional group as compared to that of the control group at the follow up.
Keywords	Schizophrenia ; Psychotropic drugs ; Prescribing indicators ; Quality of life ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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