LIVIVO - Search results -

Search results

Result 1 - 10 of total 39979

Article ; Online: L

Ren, Liang-Rui / Gao, Ying-Lian / Liu, Jin-Xing / Zhu, Rong / Kong, Xiang-Zhen

Computational biology and chemistry

2020 Volume 89, Page(s) 107368

Abstract: ... the robustness of ELM, in this paper, a novel ELM method based on L ...

Abstract	With the development of cancer research, various gene expression datasets containing cancer information show an explosive growth trend. In addition, due to the continuous maturity of single-cell RNA sequencing (scRNA-seq) technology, the protein information and pedigree information of a single cell are also continuously mined. It is a technical problem of how to classify these high-dimensional data correctly. In recent years, Extreme Learning Machine (ELM) has been widely used in the field of supervised learning and unsupervised learning. However, the traditional ELM does not consider the robustness of the method. To improve the robustness of ELM, in this paper, a novel ELM method based on L
MeSH term(s)	Algorithms ; Databases, Nucleic Acid/statistics & numerical data ; Humans ; Machine Learning ; Neoplasms/classification
Language	English
Publishing date	2020-09-01
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2020.107368
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: L

Cui, Zhen / Gao, Ying-Lian / Liu, Jin-Xing / Dai, Ling-Yun / Yuan, Sha-Sha

BMC bioinformatics

2019 Volume 20, Issue Suppl 8, Page(s) 287

Abstract: Background: Predicting drug-target interactions is time-consuming and expensive. It is important to present the accuracy of the calculation method. There are many algorithms to predict global interactions, some of which use drug-target networks for ... ...

Abstract	Background: Predicting drug-target interactions is time-consuming and expensive. It is important to present the accuracy of the calculation method. There are many algorithms to predict global interactions, some of which use drug-target networks for prediction (ie, a bipartite graph of bound drug pairs and targets known to interact). Although these algorithms can predict some drug-target interactions to some extent, there is little effect for some new drugs or targets that have no known interaction. Results: Since the datasets are usually located at or near low-dimensional nonlinear manifolds, we propose an improved GRMF (graph regularized matrix factorization) method to learn these flow patterns in combination with the previous matrix-decomposition method. In addition, we use one of the pre-processing steps previously proposed to improve the accuracy of the prediction. Conclusions: Cross-validation is used to evaluate our method, and simulation experiments are used to predict new interactions. In most cases, our method is superior to other methods. Finally, some examples of new drugs and new targets are predicted by performing simulation experiments. And the improved GRMF method can better predict the remaining drug-target interactions.
MeSH term(s)	Algorithms ; Databases as Topic ; Drug Interactions ; Humans ; Reproducibility of Results
Language	English
Publishing date	2019-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-019-2768-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: l

Zheng, Wenming / Lu, Cheng / Lin, Zhouchen / Zhang, Tong / Cui, Zhen / Yang, Wankou

IEEE transactions on neural networks and learning systems

2018 Volume 30, Issue 10, Page(s) 2898–2915

Abstract: ... criterion is based on the l ...

Abstract	Fisher's criterion is one of the most popular discriminant criteria for feature extraction. It is defined as the generalized Rayleigh quotient of the between-class scatter distance to the within-class scatter distance. Consequently, Fisher's criterion does not take advantage of the discriminant information in the class covariance differences, and hence, its discriminant ability largely depends on the class mean differences. If the class mean distances are relatively large compared with the within-class scatter distance, Fisher's criterion-based discriminant analysis methods may achieve a good discriminant performance. Otherwise, it may not deliver good results. Moreover, we observe that the between-class distance of Fisher's criterion is based on the l
Language	English
Publishing date	2018-08-29
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2018.2863264
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A comprehensive review and comparison of L-tryptophan biosynthesis in

Ren, Xinru / Wei, Yue / Zhao, Honglu / Shao, Juanjuan / Zeng, Fanli / Wang, Zhen / Li, Li

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1261832

Abstract: L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and ... feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls ... for an effective cell factory. The mechanism of L-tryptophan biosynthesis in ...

Abstract	L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1261832
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: An M cell-targeting recombinant L. lactis vaccine against four H. pylori adhesins.

Zhang, Furui / Shi, Tianyi / Zhang, Zhen / Wang, Shue / Liu, Jing / Li, Yonghong / Wang, Xuequan / Liu, Kunmei / Guo, Le

Applied microbiology and biotechnology

2024 Volume 108, Issue 1, Page(s) 231

Abstract: ... In the present study, an M cell-targeting L. lactis surface display system (plSAM) was built to favor ... pylori already present in the gastrointestinal tract. KEY POINTS: • M-cell-targeting L. lactis surface ...

Abstract	The acidic environment and enzyme degradation lead to oral vaccines often having little immune effect. Therefore, it is an attractive strategy to study an effective and safe oral vaccine delivery system that can promote gastrointestinal mucosal immune responses and inhibit antigen degradation. Moreover, the antigens uptake by microfold cells (M cells) is the determining step in initiating efficient immune responses. Therefore, M cell-targeting is one promising approach for enhancing oral vaccine potency. In the present study, an M cell-targeting L. lactis surface display system (plSAM) was built to favor the multivalent epitope vaccine antigen (FAdE) to achieve effective gastrointestinal mucosal immunity against Helicobacter pylori. Therefore, a recombinant Lactococcus lactic acid vaccine (LL-plSAM-FAdE) was successfully prepared, and its immunological properties and protective efficacy were analyzed. The results showed that LL-plSAM-FAdE can secretively express the recombinant proteins SAM-FAdE and display the SAM-FAdE on the bacterial cell surface. More importantly, LL-plSAM-FAdE effectively promoted the phagocytosis and transport of vaccine antigen by M cells in the gastrointestinal tract of mice, and simulated high levels of cellular and humoral immune responses against four key H. pylori adhesins (Urease, CagL, HpaA, and Lpp20) in the gastrointestinal tract, thus enabling effective prevention of H. pylori infection and to some extent eliminating H. pylori already present in the gastrointestinal tract. KEY POINTS: • M-cell-targeting L. lactis surface display system LL- plSAM was designed • This system displays H. pylori vaccine-promoted phagocytosis and transport of M cell • A promising vaccine candidate for controlling H. pylori infection was verified.
MeSH term(s)	Animals ; Mice ; Helicobacter pylori/genetics ; M Cells ; Antigens, Bacterial ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Vaccines, Synthetic ; Bacterial Vaccines ; Helicobacter Infections/prevention & control ; Mice, Inbred BALB C ; Antibodies, Bacterial ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism
Chemical Substances	Antigens, Bacterial ; Adhesins, Bacterial ; Vaccines, Synthetic ; Bacterial Vaccines ; Antibodies, Bacterial
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-024-13070-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification candidate genes for salt resistance through quantitative trait loci-sequencing in Brassica napus L.

Zhang, Yan / Guo, Zhiting / Chen, Xiaoqin / Li, Xinru / Shi, Yiji / Xu, Liang / Yu, Chengyu / Jing, Bing / Li, Weiwei / Xu, Aixia / Shi, Xue / Li, Keqi / Huang, Zhen

Journal of plant physiology

2024 Volume 294, Page(s) 154187

Abstract: Rapeseed (Brassica napus L.) is one of the most important oil crops worldwide. However, its yield ...

Abstract	Rapeseed (Brassica napus L.) is one of the most important oil crops worldwide. However, its yield is greatly limited by salt stress, one of the primary abiotic stresses. Identification of salt-tolerance genes and breeding salt-tolerant varieties is an effective approach to address this issue. Unfortunately, little is known about the salt-tolerance quantitative trait locus (QTL) and the identification of salt tolerance genes in rapeseed. In this study, high-throughput quantitative trait locus sequencing (QTL-seq) was applied to identifying salt-tolerant major QTLs based on two DNA pools from an F
MeSH term(s)	Quantitative Trait Loci/genetics ; Chromosome Mapping ; Brassica napus/genetics ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2024-02-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2024.154187
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 46/302: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: S-adenosyl-L-methionine alleviates the senescence of MSCs through the PI3K/AKT/FOXO3a signaling pathway.

Shang, Lipeng / Li, Xiaoxia / Ding, Xiaoyan / Liu, Guoxiang / Pan, Zhen / Chen, Xiangyan / Wang, Yuelei / Li, Bing / Wang, Ting / Zhao, Robert Chunhua

Stem cells (Dayton, Ohio)

2024

Abstract: ... including drug-based approaches, are active areas of research. In this context, S-adenosyl-L-methionine (SAM ...

Abstract	Cellular senescence significantly affects the proliferative and differentiation capacities of mesenchymal stem cells (MSCs). Identifying key regulators of senescence and exploring potential intervention strategies, including drug-based approaches, are active areas of research. In this context, S-adenosyl-L-methionine (SAM), a critical intermediate in sulfur amino acid metabolism, emerges as a promising candidate for mitigating MSC senescence. In a hydrogen peroxide-induced MSC aging model (100μM for 2h), SAM (50μM and 100μM) was revealed to alleviate the senescence of MSCs, and also attenuated the level of ROS and enhanced the adipogenic and osteogenic differentiation in senescent MSCs. In a premature aging mouse model (subcutaneously injected with 150 mg/kg/d D-galactose in the neck and back for 7 weeks), SAM (30 mg/kg/d by gavage for 5 weeks) was shown to delay the overall aging process while increasing the number and thickness of bone trabeculae in the distal femur. Mechanistically, activation of PI3K/AKT signaling and increased phosphorylation of FOXO3a was proved to be associated with the anti-senescence role of SAM. These findings highlight that the PI3K/AKT/FOXO3a axis in MSCs could play a crucial role in MSCs senescence and suggest that SAM may be a potential therapeutic drug for MSCs senescence and related diseases.
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1093/stmcls/sxae010
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1894: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification and characterization of candidate genes for primary root length in Asiatic cotton (Gossypium arboreum L.).

Hu, Daowu / Zhao, Zibo / Nazir, Mian Faisal / Sun, Gaofei / Peng, Zhen / Jia, Yinhua / Geng, Xiaoli / Wang, Liru / Pan, Zhaoe / Li, Hongge / Chen, Baojun / Sun, Fenglei / He, Shoupu / Du, Xiongming

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

2024 Volume 137, Issue 3, Page(s) 52

Abstract: Key message: One major gene controlling primary root length (PRL) in Gossypium arboreum is identified and this research provides a theoretical basis for root development for cotton. Primary root elongation is an essential process in plant root system ... ...

Abstract	Key message: One major gene controlling primary root length (PRL) in Gossypium arboreum is identified and this research provides a theoretical basis for root development for cotton. Primary root elongation is an essential process in plant root system structure. Here, we investigated the primary root length (PRL) of 215 diploid cotton (G. arboreum) accessions at 5, 8, 10, 15 days after sowing. A Genome-wide association study was performed for the PRL, resulting in 49 significant SNPs associated with 32 putative candidate genes. The SNP with the strongest signal (Chr07_8047530) could clearly distinguish the PRLs between accessions with two haplotypes. GamurG is the only gene that showed higher relative expression in the long PRL genotypes than the short PRL genotypes, which indicated it was the most likely candidate gene for regulating PRL. Moreover, the GamurG-silenced cotton seedlings showed a shorter PRL, while the GamurG-overexpressed Arabidopsis exhibited a significantly longer PRL. Our findings provide insight into the regulation mechanism of cotton root growth and will facilitate future breeding programs to optimize the root system structure in cotton.
MeSH term(s)	Gossypium ; Genome-Wide Association Study ; Plant Breeding ; Genotype ; Haplotypes ; Gene Expression Regulation, Plant
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2170-2
ISSN	1432-2242 ; 0040-5752
ISSN (online)	1432-2242
ISSN	0040-5752
DOI	10.1007/s00122-023-04471-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1692: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1.

Xie, Xiong / Lan, Qiaoshuai / Zhao, Jinyi / Zhang, Sulin / Liu, Lu / Zhang, Yumin / Xu, Wei / Shao, Maolin / Peng, Jingjing / Xia, Shuai / Zhu, Yan / Zhang, Keke / Zhang, Xianglei / Zhang, Ruxue / Li, Jian / Dai, Wenhao / Ge, Zhen / Hu, Shulei / Yu, Changyue /

Wang, Jiang / Ma, Dakota / Zheng, Mingyue / Yang, Haitao / Xiao, Gengfu / Rao, Zihe / Lu, Lu / Zhang, Leike / Bai, Fang / Zhao, Yao / Jiang, Shibo / Liu, Hong

Signal transduction and targeted therapy

2024 Volume 9, Issue 1, Page(s) 54

Abstract: ... of emerging coronaviruses. Cathepsin L (CTSL) and calpain-1 (CAPN1) are host cysteine proteases which play ...

Abstract	Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2 variants, might be compromised. Host-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging coronaviruses. Cathepsin L (CTSL) and calpain-1 (CAPN1) are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune response. Here, two peptidomimetic α-ketoamide compounds, 14a and 14b, were identified as potent dual target inhibitors against CTSL and CAPN1. The X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of α-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of CAPN1. Both showed potent and broad-spectrum anticoronaviral activities in vitro, and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern (VOCs) with EC
MeSH term(s)	Humans ; Animals ; Mice ; Rats ; Dogs ; Calpain ; Cathepsin L ; Antiviral Agents/pharmacology ; Hepatitis C, Chronic ; COVID-19 ; COVID-19 Vaccines ; Disease Models, Animal ; Mice, Transgenic ; Anti-Inflammatory Agents
Chemical Substances	Calpain (EC 3.4.22.-) ; Cathepsin L (EC 3.4.22.15) ; Antiviral Agents ; COVID-19 Vaccines ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-024-01758-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification and Characterization of a Novel α-L-Fucosidase from

Zhang, Ziyu / Li, Yuting / Wu, Mujunqi / Gao, Zhen / Wu, Bin / He, Bingfang

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: ... microbiota and prevents infection. α-L-fucosidase is a promising component for 2'FL synthesis. In this study ... a soil-oriented α-L-fucosidase-producing strain from ...

Abstract	2'-fucosyllactose (2'FL) is an important nutrient in human milk that stimulates beneficial microbiota and prevents infection. α-L-fucosidase is a promising component for 2'FL synthesis. In this study, a soil-oriented α-L-fucosidase-producing strain from
MeSH term(s)	Humans ; Oligosaccharides ; alpha-L-Fucosidase/genetics ; Trisaccharides ; Milk, Human/chemistry ; Escherichia coli
Chemical Substances	2'-fucosyllactose (XO2533XO8R) ; Oligosaccharides ; alpha-L-Fucosidase (EC 3.2.1.51) ; Trisaccharides
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411555
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito