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Article ; Online: Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity.

Liu, Chang / Luo, Jinghui

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 23, Page(s) e202216480

Abstract: Prevalent in nature, protein oligomers play critical roles both physiologically and pathologically. The multimeric nature and conformational transiency of protein oligomers greatly complicate a more detailed glimpse into the molecular structure as well ... ...

Abstract	Prevalent in nature, protein oligomers play critical roles both physiologically and pathologically. The multimeric nature and conformational transiency of protein oligomers greatly complicate a more detailed glimpse into the molecular structure as well as function. In this minireview, the oligomers are classified and described on the basis of biological function, toxicity, and application. We also define the bottlenecks in recent oligomer studies and further review numerous frontier methods for engineering protein oligomers. Progress is being made on many fronts for a wide variety of applications, and protein grafting is highlighted as a promising and robust method for oligomer engineering. These advances collectively allow the engineering and design of stabilized oligomers that bring us one step closer to understanding their biological functions, toxicity, and a wide range of applications.
MeSH term(s)	Amyloid beta-Peptides/metabolism ; Amyloid/chemistry ; Protein Engineering ; Molecular Conformation ; Molecular Structure
Chemical Substances	Amyloid beta-Peptides ; Amyloid
Language	English
Publishing date	2023-04-12
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202216480
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health-related quality of life among patients with knee osteoarthritis in Guangzhou, China

Jinghui Chang / Yuxin Yuan / Manru Fu / Dong Wang

Health and Quality of Life Outcomes, Vol 21, Iss 1, Pp 1-

a multicenter cross-sectional study

2023 Volume 12

Abstract: Abstract Purposes To investigate health-related quality of life (HRQoL) of patients with knee osteoarthritis (KOA) in Guangzhou, China, and examine its association with selected sociodemographic characteristics as well as knee function. Methods This ... ...

Abstract	Abstract Purposes To investigate health-related quality of life (HRQoL) of patients with knee osteoarthritis (KOA) in Guangzhou, China, and examine its association with selected sociodemographic characteristics as well as knee function. Methods This multicenter cross-sectional study included 519 patients with KOA in Guangzhou from April 1 to December 30, 2019. Data on sociodemographic characteristics were obtained using the General Information Questionnaire. The disability was measured using the KOOS-PS, resting pain using the Pain-VAS, and HRQoL using the EQ-5D-5L. The association of selected sociodemographic factors, KOOS-PS and Pain-VAS scores with HRQoL (EQ-5D-5L utility and EQ-VAS scores) were analyzed using linear regression analyses. Results The median (interquartile range [IQR]) of EQ-5D-5L utility and EQ-VAS scores were 0.744 (0.571–0.841) and 70 (60–80) respectively, lower than the average HRQoL in the general population. Only 3.661% of KOA patients reported no problems in all EQ-5D-5L dimensions, with Pain/Discomfort being the most frequently affected dimension (78.805%). The correlation analysis showed that the KOOS-PS score, Pain-VAS score and HRQoL were moderately or strongly correlated. Patients with cardiovascular disease, no daily exercise, and high KOOS-PS or Pain-VAS scores had lower EQ-5D-5L utility scores; and patients with body mass index (BMI) > 28 ,high KOOS-PS or Pain-VAS scores had lower EQ-VAS scores. Conclusions Patients with KOA had relatively low HRQoL. Various sociodemographic characteristics as well as knee function were associated with HRQoL in regression analyses. Providing social support and improving their knee function through methods such as total knee arthroplasty might be crucial to improve their HRQoL.
Keywords	Health-related quality of life ; Knee osteoarthritis ; Knee function ; EQ-5D-5L ; Guangzhou ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health-related quality of life among patients with knee osteoarthritis in Guangzhou, China: a multicenter cross-sectional study.

Chang, Jinghui / Yuan, Yuxin / Fu, Manru / Wang, Dong

Health and quality of life outcomes

2023 Volume 21, Issue 1, Page(s) 50

Abstract: Purposes: To investigate health-related quality of life (HRQoL) of patients with knee osteoarthritis (KOA) in Guangzhou, China, and examine its association with selected sociodemographic characteristics as well as knee function.: Methods: This ... ...

Abstract	Purposes: To investigate health-related quality of life (HRQoL) of patients with knee osteoarthritis (KOA) in Guangzhou, China, and examine its association with selected sociodemographic characteristics as well as knee function. Methods: This multicenter cross-sectional study included 519 patients with KOA in Guangzhou from April 1 to December 30, 2019. Data on sociodemographic characteristics were obtained using the General Information Questionnaire. The disability was measured using the KOOS-PS, resting pain using the Pain-VAS, and HRQoL using the EQ-5D-5L. The association of selected sociodemographic factors, KOOS-PS and Pain-VAS scores with HRQoL (EQ-5D-5L utility and EQ-VAS scores) were analyzed using linear regression analyses. Results: The median (interquartile range [IQR]) of EQ-5D-5L utility and EQ-VAS scores were 0.744 (0.571-0.841) and 70 (60-80) respectively, lower than the average HRQoL in the general population. Only 3.661% of KOA patients reported no problems in all EQ-5D-5L dimensions, with Pain/Discomfort being the most frequently affected dimension (78.805%). The correlation analysis showed that the KOOS-PS score, Pain-VAS score and HRQoL were moderately or strongly correlated. Patients with cardiovascular disease, no daily exercise, and high KOOS-PS or Pain-VAS scores had lower EQ-5D-5L utility scores; and patients with body mass index (BMI) > 28 ,high KOOS-PS or Pain-VAS scores had lower EQ-VAS scores. Conclusions: Patients with KOA had relatively low HRQoL. Various sociodemographic characteristics as well as knee function were associated with HRQoL in regression analyses. Providing social support and improving their knee function through methods such as total knee arthroplasty might be crucial to improve their HRQoL.
MeSH term(s)	Humans ; Quality of Life ; Cross-Sectional Studies ; Osteoarthritis, Knee ; China/epidemiology ; Surveys and Questionnaires ; Pain ; Health Status
Language	English
Publishing date	2023-05-27
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2098765-1
ISSN	1477-7525 ; 1477-7525
ISSN (online)	1477-7525
ISSN	1477-7525
DOI	10.1186/s12955-023-02133-x
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Article ; Online: Multifunctional Luminescent 3D Ln-MOFs with High Sensitivity for Trace Detection of Micronutrients.

Qiao, Yu / Sun, Chang / Jian, Juan / Zhou, Tianyu / Xue, Xiangxin / Shi, Jinghui / Zhao, Lina / Liao, Guangfu

Inorganic chemistry

2024 Volume 63, Issue 4, Page(s) 2060–2071

Abstract: The synthesis of two versatile fluorescent metal-organic frameworks (MOFs), [Eu(4-NCP)(1,4-bdc)] ...

Abstract	The synthesis of two versatile fluorescent metal-organic frameworks (MOFs), [Eu(4-NCP)(1,4-bdc)]
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c03838
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Article ; Online: The characteristics and medical applications of antler stem cells.

Liu, Qi / Li, Jiannan / Chang, Jinghui / Guo, Yu / Wen, Dacheng

Stem cell research & therapy

2023 Volume 14, Issue 1, Page(s) 225

Abstract: Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same ... ...

Abstract	Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for self-renewal and multidirectional differentiation, immunomodulatory functions, and the maintenance of stem cell characteristics after multiple passages. Several preclinical studies have shown that ASCs exhibit promising potential in wound healing, bone repair, osteoarthritis, anti-tissue fibrosis, anti-aging, and hair regeneration. Medical applications based on ASCs and ASC-derived molecules provide a new source of stem cells and therapeutic modalities for regenerative medicine. This review begins with a brief description of antler regeneration and the role of ASCs. Then, the properties and advantages of ASCs are described. Finally, medical research advances regarding ASCs are summarized, and the prospects and challenges of ASCs are highlighted.
MeSH term(s)	Animals ; Antlers ; Mesenchymal Stem Cells ; Embryonic Stem Cells ; Aging ; Biomedical Research ; Mammals
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03456-8
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Article ; Online: Controllable preparation of Ti

Xue, Xiangxin / Chen, Lei / Zhao, Cuimei / Lu, Ming / Qiao, Yu / Wang, Jing / Shi, Jinghui / Chang, Limin

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 302, Page(s) 123019

Abstract: Currently, metal carbonitride (MXene) has been identified as a hot research topic in the research area of surface-enhanced Raman scattering (SERS). In this study, ... ...

Abstract	Currently, metal carbonitride (MXene) has been identified as a hot research topic in the research area of surface-enhanced Raman scattering (SERS). In this study, Ti
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.123019
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Article ; Online: Correction: Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer.

Zhang, Jinghui / Fan, Jiajun / Zeng, Xian / Nie, Mingming / Chen, Wei / Wang, Yichen / Luan, Jingyun / Zhu, Zeguo / Chang, Xusheng / Ju, Dianwen / Feng, Li / Yin, Kai

Cell death & disease

2023 Volume 14, Issue 9, Page(s) 633

Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Published Erratum
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-06061-y
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Article ; Online: Media Use Behavior Mediates the Association Between Family Health and Intention to Use Mobile Health Devices Among Older Adults: Cross-Sectional Study.

Chang, Jinghui / Mai, Yanshan / Zhang, Dayi / Yang, Xixi / Li, Anqi / Yan, Wende / Wu, Yibo / Chen, Jiangyun

Journal of medical Internet research

2024 Volume 26, Page(s) e50012

Abstract: Background: With the advent of a new era for health and medical treatment, characterized by the integration of mobile technology, a significant digital divide has surfaced, particularly in the engagement of older individuals with mobile health (mHealth). ...

Abstract	Background: With the advent of a new era for health and medical treatment, characterized by the integration of mobile technology, a significant digital divide has surfaced, particularly in the engagement of older individuals with mobile health (mHealth). The health of a family is intricately connected to the well-being of its members, and the use of media plays a crucial role in facilitating mHealth care. Therefore, it is important to examine the mediating role of media use behavior in the connection between the family health of older individuals and their inclination to use mHealth devices. Objective: This study aims to investigate the impact of family health and media use behavior on the intention of older individuals to use mHealth devices in China. The study aims to delve into the intricate dynamics to determine whether media use behavior serves as a mediator in the relationship between family health and the intention to use mHealth devices among older adults. The ultimate goal is to offer well-founded and practical recommendations to assist older individuals in overcoming the digital divide. Methods: The study used data from 3712 individuals aged 60 and above, sourced from the 2022 Psychology and Behavior Investigation of Chinese Residents study. Linear regression models were used to assess the relationships between family health, media use behavior, and the intention to use mHealth devices. To investigate the mediating role of media use behavior, we used the Sobel-Goodman Mediation Test. This analysis focused on the connection between 4 dimensions of family health and the intention to use mHealth devices. Results: A positive correlation was observed among family health, media use behavior, and the intention to use mHealth devices (r=0.077-0.178, P<.001). Notably, media use behavior was identified as a partial mediator in the relationship between the overall score of family health and the intention to use mHealth devices, as indicated by the Sobel test (z=5.451, P<.001). Subgroup analysis further indicated that a complete mediating effect was observed specifically between family health resources and the intention to use mHealth devices in older individuals with varying education levels. Conclusions: The study revealed the significance of family health and media use behavior in motivating older adults to adopt mHealth devices. Media use behavior was identified as a mediator in the connection between family health and the intention to use mHealth devices, with more intricate dynamics observed among older adults with lower education levels. Going forward, the critical role of home health resources must be maximized, such as initiatives to develop digital education tailored for older adults and the creation of media products specifically designed for them. These measures aim to alleviate technological challenges associated with using media devices among older adults, ultimately bolstering their inclination to adopt mHealth devices.
MeSH term(s)	Aged ; Humans ; Asian People ; Cross-Sectional Studies ; Family Health ; Intention ; Telemedicine/instrumentation ; Telemedicine/methods
Language	English
Publishing date	2024-02-19
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/50012
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Article: Giraffa camelopardalis.

Liu, Chang / Gao, Jianbo / Huang, Jinghui / Wang, Wen / Heller, Rasmus / Qiu, Qiang

Trends in genetics : TIG

2021 Volume 37, Issue 9, Page(s) 860–861

MeSH term(s)	Animals ; Genome ; Giraffes/classification ; Giraffes/genetics ; Giraffes/physiology
Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	619240-3
ISSN	1362-4555 ; 0168-9525 ; 0168-9479
ISSN (online)	1362-4555
ISSN	0168-9525 ; 0168-9479
DOI	10.1016/j.tig.2021.05.004
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Article ; Online: Detection of Single Nucleotide Polymorphisms of Circulating Tumor DNA by Strand Displacement Amplification Coupled with Liquid Chromatography.

Ma, Ziyu / Xu, Junjie / Hou, Weilin / Lei, Zi / Li, Tingting / Shen, Wei / Yu, Hui / Liu, Chang / Zhang, Jinghui / Tang, Sheng

Analytical chemistry

2024 Volume 96, Issue 13, Page(s) 5195–5204

Abstract: The detection of multiple single nucleotide polymorphisms (SNPs) of circulating tumor DNA (ctDNA) is still a great challenge. In this study, we designed enzyme-assisted nucleic acid strand displacement amplification combined with high-performance liquid ... ...

Abstract	The detection of multiple single nucleotide polymorphisms (SNPs) of circulating tumor DNA (ctDNA) is still a great challenge. In this study, we designed enzyme-assisted nucleic acid strand displacement amplification combined with high-performance liquid chromatography (HPLC) for the simultaneous detection of three ctDNA SNPs. First, the trace ctDNA could be hybridized to the specially designed template strand, which initiated the strand displacement nucleic acid amplification process under the synergistic action of DNA polymerase and restriction endonuclease. Then, the targets would be replaced with G-quadruplex fluorescent probes with different tail lengths. Finally, the HPLC-fluorescence assay enabled the separation and quantification of multiple signals. Notably, this method can simultaneously detect both the wild type (WT) and mutant type (MT) of multiple ctDNA SNPs. Within a linear range of 0.1 fM-0.1 nM, the detection limits of BRAF V600E-WT, EGFR T790M-WT, and KRAS 134A-WT and BRAF V600E-MT, EGFR T790M-MT, and KRAS 134A-MT were 29, 31, and 11 aM and 22, 29, and 33 aM, respectively. By using this method, the mutation rates of multiple ctDNA SNPs in blood samples from patients with lung or breast cancer can be obtained in a simple way, providing a convenient and highly sensitive analytical assay for the early screening and monitoring of lung cancer.
MeSH term(s)	Humans ; Circulating Tumor DNA/genetics ; Mutation ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins B-raf/genetics ; ErbB Receptors/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Protein Kinase Inhibitors ; Chromatography, Liquid
Chemical Substances	Circulating Tumor DNA ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; ErbB Receptors (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Protein Kinase Inhibitors
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c05500
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