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  1. Article: An Update on Treatment of Cognitive Impairment Associated with Schizophrenia.

    Horan, William P / Catalano, Lauren T / Green, Michael F

    Current topics in behavioral neurosciences

    2022  Volume 63, Page(s) 407–436

    Abstract: Cognitive impairment associated with schizophrenia (CIAS) is widely regarded as a critically important treatment target for schizophrenia. Despite major efforts and a number of promising findings, we do not yet have an approved drug for CIAS. Similarly, ... ...

    Abstract Cognitive impairment associated with schizophrenia (CIAS) is widely regarded as a critically important treatment target for schizophrenia. Despite major efforts and a number of promising findings, we do not yet have an approved drug for CIAS. Similarly, promising cognitive remediation approaches are limited in their ability to help patients achieve real-world functional gains on a wide scale. This article provides an update and critical evaluation of recent treatment development activities for CIAS. First, we provide update on pharmacological approaches, which include a glutamatergic drug that is currently in Phase III trials for CIAS, and discuss factors that may have impacted past efforts to identify efficacious drugs. Second, we review positive findings, limitations, and current trends involving cognitive remediation approaches. Third, we consider newer transdiagnostic approaches aimed at looking beyond, or identifying more homogenous subgroups within, the diagnostic category schizophrenia to advance treatment development. Despite its many challenges, treatment development for CIAS remains a major public health issue and research continues to push forward on several encouraging fronts.
    MeSH term(s) Humans ; Schizophrenia/drug therapy ; Cognition Disorders/complications ; Cognitive Dysfunction
    Language English
    Publishing date 2022-08-01
    Publishing country Germany
    Document type Review ; Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2022_382
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  2. Article ; Online: Predictors of Stone-Related Events in Asymptomatic Untreated Intrarenal Calculi.

    Daly, Killian F / Horan, Michelle T / Lincoln, Marc C / MacCraith, Eoin / Quinlan, Mark R / Walsh, Michael T / Skolarikos, Andreas / Davis, Niall F

    Journal of endourology

    2022  Volume 36, Issue 4, Page(s) 444–447

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Female ; Humans ; Kidney ; Kidney Calculi/complications ; Male ; Renal Colic/etiology ; Retrospective Studies ; Tomography, X-Ray Computed/adverse effects ; Ureter ; Ureteral Calculi/complications
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356931-7
    ISSN 1557-900X ; 0892-7790
    ISSN (online) 1557-900X
    ISSN 0892-7790
    DOI 10.1089/end.2021.0736
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  3. Article ; Online: Sir Rodney Sweetnam (1927-2013).

    T Horan, F

    The bone & joint journal

    2013  Volume 95-B, Issue 8, Page(s) 1149

    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.95B8.32675
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  4. Article ; Online: An ERP Study of Face Processing in Schizophrenia, Bipolar Disorder, and Socially Isolated Individuals from the Community.

    Catalano, Lauren T / Wynn, Jonathan K / Eisenberger, Naomi I / Horan, William P / Lee, Junghee / McCleery, Amanda / Miklowitz, David J / Reavis, Eric A / Reddy, L Felice / Green, Michael F

    Clinical EEG and neuroscience

    2024  , Page(s) 15500594231222979

    Abstract: People with schizophrenia (SCZ) and bipolar disorder (BD) have impairments in processing social information, including faces. The neural correlates of face processing are widely studied with the N170 ERP component. However, it is unclear whether N170 ... ...

    Abstract People with schizophrenia (SCZ) and bipolar disorder (BD) have impairments in processing social information, including faces. The neural correlates of face processing are widely studied with the N170 ERP component. However, it is unclear whether N170 deficits reflect neural abnormalities associated with these clinical conditions or differences in social environments. The goal of this study was to determine whether N170 deficits would still be present in SCZ and BD when compared with socially isolated community members. Participants included 66 people with SCZ, 37 with BD, and 125 community members (76 "Community-Isolated"; 49 "Community-Connected"). Electroencephalography was recorded during a face processing task in which participants identified the gender of a face, the emotion of a face (angry, happy, neutral), or the number of stories in a building. We examined group differences in the N170 face effect (greater amplitudes for faces vs buildings) and the N170 emotion effect (greater amplitudes for emotional vs neutral expressions). Groups significantly differed in levels of social isolation (Community-Isolated > SCZ > BD = Community-Connected). SCZ participants had significantly reduced N170 amplitudes to faces compared with both community groups, which did not differ from each other. The BD group was intermediate and did not differ from any group. There were no significant group differences in the processing of specific emotional facial expressions. The N170 is abnormal in SCZ even when compared to socially isolated community members. Hence, the N170 seems to reflect a social processing impairment in SCZ that is separate from level of social isolation.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2140201-2
    ISSN 2169-5202 ; 0009-9155 ; 1550-0594
    ISSN (online) 2169-5202
    ISSN 0009-9155 ; 1550-0594
    DOI 10.1177/15500594231222979
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  5. Article ; Online: A brief history of The Journal of Bone & Joint Surgery (British Volume).

    Horan, F T

    The Journal of bone and joint surgery. British volume

    2012  Volume 94, Issue 12, Page(s) 1586–1588

    MeSH term(s) Bone and Bones/surgery ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Joints/surgery ; Orthopedics/history ; Periodicals as Topic/history
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 220626-2
    ISSN 2044-5377 ; 0301-620X ; 0447-9076
    ISSN (online) 2044-5377
    ISSN 0301-620X ; 0447-9076
    DOI 10.1302/0301-620X.94B12.31157
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  6. Article ; Online: The bone and joint decade 2000 to 2010.

    Horan, F T

    The Journal of bone and joint surgery. British volume

    2011  Volume 93, Issue 2, Page(s) 143–144

    MeSH term(s) Health Promotion/organization & administration ; History, 21st Century ; Humans ; International Cooperation/history ; Musculoskeletal Diseases/history ; Musculoskeletal Diseases/therapy ; Orthopedics/history ; Orthopedics/organization & administration
    Language English
    Publishing date 2011-02
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 220626-2
    ISSN 2044-5377 ; 0301-620X ; 0447-9076
    ISSN (online) 2044-5377
    ISSN 0301-620X ; 0447-9076
    DOI 10.1302/0301-620X.93B2.26190
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  7. Article ; Online: Joint registries.

    Horan, F T

    The Journal of bone and joint surgery. British volume

    2010  Volume 92, Issue 6, Page(s) 749–750

    MeSH term(s) Arthroplasty, Replacement/statistics & numerical data ; Humans ; Registries ; Treatment Outcome
    Language English
    Publishing date 2010-06
    Publishing country England
    Document type Editorial
    ZDB-ID 220626-2
    ISSN 2044-5377 ; 0301-620X ; 0447-9076
    ISSN (online) 2044-5377
    ISSN 0301-620X ; 0447-9076
    DOI 10.1302/0301-620X.92B6.24549
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  8. Article: Radiogenomics: Contemporary Applications in the Management of Rectal Cancer.

    O'Sullivan, Niall J / Temperley, Hugo C / Horan, Michelle T / Corr, Alison / Mehigan, Brian J / Larkin, John O / McCormick, Paul H / Kavanagh, Dara O / Meaney, James F M / Kelly, Michael E

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic ... ...

    Abstract Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic testing via the development of 'imaging biomarkers' that have the potential to serve as an alternative 'liquid-biopsy' in the determination of tumour biological characteristics. Radiogenomics also harnesses the potential to unlock aspects of tumour biology which are not possible to assess by conventional biopsy-based methods, such as full tumour burden, intra-/inter-lesion heterogeneity and the possibility of providing the information of tumour biology longitudinally. Several studies have shown the feasibility of developing a radiogenomic-based signature to predict treatment outcomes and tumour characteristics; however, many lack prospective, external validation. We performed a systematic review of the current literature surrounding the use of radiogenomics in rectal cancer to predict underlying tumour biology.
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245816
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  9. Article ; Online: Validating inborn error of immunity prevalence and risk with nationally representative electronic health record data.

    Rider, Nicholas L / Truxton, Ahuva / Ohrt, Tracy / Margolin-Katz, Irene / Horan, Mary / Shin, Harold / Davila, Roger / Tenembaum, Vanessa / Quinn, Jessica / Modell, Vicki / Modell, Fred / Orange, Jordan S / Branner, Almut / Senerchia, Cynthia

    The Journal of allergy and clinical immunology

    2024  

    Abstract: Background: The 10 Warning Signs of Primary Immunodeficiency were created 30 years ago to advance recognition of inborn errors of immunity (IEI). However, no population-level assessment of their utility applied to electronic health record (EHR) data has ...

    Abstract Background: The 10 Warning Signs of Primary Immunodeficiency were created 30 years ago to advance recognition of inborn errors of immunity (IEI). However, no population-level assessment of their utility applied to electronic health record (EHR) data has been conducted.
    Objective: We sought to quantify the value of having ≥2 warning signs (WS) toward diagnosing IEI using a highly representative real-world US cohort. A secondary goal was estimating the US prevalence of IEI.
    Methods: In this cohort study, we accessed normalized and de-identified EHR data on 152 million US patients. An IEI cohort (n = 41,080), in which patients were defined by having at least 1 verifiable IEI diagnosis placed ≥2 times in their record, was compared with a matched set of controls (n = 250,262). WS were encoded along with relevant diagnoses, relative weights were calculated, and the proportion of IEI cases versus controls with ≥2 WS was compared.
    Results: The proportion of IEI cases with ≥2 WS significantly differed from controls (0.33 vs 0.031; P < .0005, χ
    Conclusions: This nationally representative US-based cohort study demonstrates that presence of WS and associated clinical diagnoses can facilitate identification of patients with IEI from EHR data. In addition, we estimate that 6 in 10,000, or approximately 150,000 to 200,000 individuals are affected by IEI across the United States.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.01.011
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  10. Article ; Online: Transportation, childcare, lodging, and meals: Key for participant engagement and inclusion of historically underrepresented populations in the healthy brain and child development birth cohort.

    Zgierska, Aleksandra E / Gramly, Tatum / Prestayko, Nicholas / Symons Downs, Danielle / Murray, Traci M / Yerby, Lea G / Howell, Brittany / Stahlman, Barbara / Cruz, Jennifer / Agolli, Arjola / Horan, Holly / Hilliard, Florence / Croff, Julie M

    Journal of clinical and translational science

    2024  Volume 8, Issue 1, Page(s) e38

    Abstract: Introduction: Participant recruitment and retention (R&R) are well-documented challenges in longitudinal studies, especially those involving populations historically underrepresented in research and vulnerable groups (e.g., pregnant people or young ... ...

    Abstract Introduction: Participant recruitment and retention (R&R) are well-documented challenges in longitudinal studies, especially those involving populations historically underrepresented in research and vulnerable groups (e.g., pregnant people or young children and their families), as is the focus of the HEALthy Brain and Child Development (HBCD) birth cohort study. Subpar access to transportation, overnight lodging, childcare, or meals can compromise R&R; yet, guidance on how to overcome these "logistical barriers" is sparse. This study's goal was to learn about the HBCD sites' plans and develop best practice recommendations for the HBCD consortium for addressing these logistical barriers.
    Methods: The HBCD's workgroups developed a survey asking the HBCD sites about their plans for supporting research-related transportation, lodging, childcare, and meals, and about the presence of institutional policies to guide their approach. Descriptive statistics described the quantitative survey data. Qualitative survey responses were brief, not warranting formal qualitative analysis; their content was summarized.
    Results: Twenty-eight respondents, representing unique recruitment locations across the U.S., completed the survey. The results indicated substantial heterogeneity across the respondents in their approach toward supporting research-related transportation, lodging, childcare, and meals. Three respondents were aware of institutional policies guiding research-related transportation (10.7%) or childcare (10.7%).
    Conclusions: This study highlighted heterogeneity in approaches and scarcity of institutional policies regarding research-related transportation, lodging, childcare, and meals, underscoring the need for guidance in this area to ensure equitable support of participant R&R across different settings and populations, so that participants are representative of the larger community, and increase research result validity and generalizability.
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2024.4
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