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Article ; Online: Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera.

Bozza, Angela / Bernardi, Martina / Catanzaro, Daniela / Chieregato, Katia / Merlo, Anna / Astori, Giuseppe

2023 Volume 28, Issue 1, Page(s) 2182056

Abstract: Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (: ... ...

Abstract	Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 ( Methods: We assessed the clonogenic potential by colony-forming unit (CFU) assay of mononuclear cells isolated from PV JAK2 positive or JAK2 negative patients with erythrocytosis treated with enalaprilat or losartan. Results: Treatment with drugs led to a decrease of erythroid precursor frequency both in the presence and absence of JAK2 mutation, with a high extent in JAK2 positive cells and without affecting other types of precursors. No dose-dependent effect was observed. Conclusions: Our results demonstrate that ACE inhibition reduces erythroid precursor frequency, confirming the involvement of ACE in erythrocytosis despite the presence of JAK2 mutation and encouraging the hypothesis that ACE inhibitors and AT1R antagonists could help in directly managing erythrocytosis in PV.
MeSH term(s)	Humans ; Polycythemia Vera ; Enalaprilat ; Polycythemia ; Losartan ; Erythrocytes
Chemical Substances	Enalaprilat (GV0O7ES0R3) ; Losartan (JMS50MPO89)
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1341428-8
ISSN	1607-8454 ; 1024-5332 ; 1024-5340
ISSN (online)	1607-8454
ISSN	1024-5332 ; 1024-5340
DOI	10.1080/16078454.2023.2182056
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Zs.A 4538: Show issues

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Article ; Online: Social Skills and Cognitive Training to Support Work-Related Skills and Job Placement in a Group of Autistic Adults : Effectiveness of a Neuropsychological and Social Skills Intervention: A Case Series Study on a Pilot Program.

Brighenti, S / Mustacchia, L / Cicinelli, G / Chieregato, S / Comella, C / Torrero, L / Granata, F / Keller, R

Community mental health journal

2023 Volume 59, Issue 8, Page(s) 1610–1618

Abstract: Autistic people may have difficulties in finding and keeping a job. Studies highlight that only 34% of autistic people are employed compared to 54% of people with disability. 58% of people with ASD have never had a job. Social cognition and cognitive ... ...

Abstract	Autistic people may have difficulties in finding and keeping a job. Studies highlight that only 34% of autistic people are employed compared to 54% of people with disability. 58% of people with ASD have never had a job. Social cognition and cognitive strains may also have a significant impact on working life. The primary goal of our project is supporting autistic people through a training program focused on neuropsychological and social skills training to improve participant' job skills. Through an Individual Placement and Support model the project involved various Partners to guide, identify skills and interests, provide cognitive and psychological support for autistic people. Results highlighted neuropsychological training efficacy, especially in inhibitory control and good rate of employment status at the end of the project. Findings are encouraging and underline the importance of a multidisciplinary approach to support autistic people in their work life considering their expectations, needs and inclinations.
MeSH term(s)	Humans ; Adult ; Autistic Disorder/psychology ; Social Skills ; Cognitive Training ; Pilot Projects ; Employment/psychology
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-023-01152-8
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Article: Endovascular treatment of acute ischemic stroke in childhood: A comprehensive literature review based on the experience of a single center.

Pero, Guglielmo / Ruggieri, Francesco / Macera, Antonio / Piano, Mariangela / Gladin, Caroline Regna / Motto, Cristina / Cervo, Amedeo / Chieregato, Arturo

European journal of radiology open

2023 Volume 11, Page(s) 100528

Abstract: Acute ischemic stroke (AIS) in childhood is a relatively rare but significant condition that can result in long-term disabilities. There is a lack of standardized strategies for diagnosing and treating pediatric AIS due to limited evidence-based data on ... ...

Abstract	Acute ischemic stroke (AIS) in childhood is a relatively rare but significant condition that can result in long-term disabilities. There is a lack of standardized strategies for diagnosing and treating pediatric AIS due to limited evidence-based data on thrombolytic and endovascular treatments in children. This comprehensive literature review focuses on the experience of a single center in Italy and aims to highlight the main peculiarities of endovascular treatment (EVT) for AIS in childhood. The review covers the diagnostic workup, the endovascular procedures, and the need for a specific thrombectomy program for pediatric AIS. The review discusses the indications and considerations for thrombectomy in children, including the risk of complications and the challenges of extrapolating results from adult studies. The diagnostic protocols for pediatric AIS are also discussed, emphasizing the use of MRI to avoid X-ray and contrast medium exposure in children. The combination of intravenous thrombolysis and mechanical thrombectomy has been examined, considering the differences between pediatric and adult thrombi. Technical considerations related to the size of pediatric patients are addressed, including the use of large bore catheters and potential concerns with access points. The organization of a thrombectomy program for pediatric AIS is discussed, emphasizing the need for specialized facilities and expertise. Although evidence for EVT in the pediatric population is based on case series, the importance of specialized centers and the lack of validated guidelines are evident.
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2810314-2
ISSN	2352-0477
ISSN	2352-0477
DOI	10.1016/j.ejro.2023.100528
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Article ; Online: Reliability of Respiratory System Compliance Calculation During Assisted Mechanical Ventilation: A Retrospective Study.

Bastia, Luca / Amendolagine, Liliana / Pozzi, Federico / Carenini, Stefano / Cipolla, Cristiana / Curto, Francesco / Bellani, Giacomo / Fumagalli, Roberto / Chieregato, Arturo

Critical care medicine

2023 Volume 51, Issue 10, Page(s) e201–e205

Abstract: Objectives: To compare respiratory system compliance (C rs ) calculation during controlled mechanical ventilation (MV) and, subsequently, during assisted MV.: Design: This is a single-center, retrospective, observational study.: Setting: This ... ...

Abstract	Objectives: To compare respiratory system compliance (C rs ) calculation during controlled mechanical ventilation (MV) and, subsequently, during assisted MV. Design: This is a single-center, retrospective, observational study. Setting: This study was conducted on patients admitted to Neuro-ICU of Niguarda Hospital (tertiary referral hospital). Patients: We analyzed every patient greater than or equal to 18 years old having a C rs measurement in controlled and in assisted MV within 60 minutes. Plateau pressure (P plat ) was considered reliable if it was deemed visually stable for at least 2 seconds. Interventions: Inspiratory pause was incorporated to detect P plat in controlled and assisted MV. Calculation of C rs and driving pressure were achieved. Measurements and main results: A total of 101 patients were studied. An acceptable agreement was found (Bland-Altman plot bias -3.9, level of agreement upper 21.6, lower -29.6). C rs in assisted MV was 64.1 (52.6-79.3) and in controlled MV it was 61.2 (50-71.2) mL/cm H 2o ( p = 0.006). No statistical difference was found in C rs (assisted vs controlled MV) when peak pressure was lower than P plat nor when peak pressure was higher than P plat . Conclusions: A P plat visually stable for at least 2 seconds leads to reliable C rs calculation during assisted MV.
MeSH term(s)	Humans ; Respiration, Artificial ; Retrospective Studies ; Reproducibility of Results ; Respiratory System ; Tidal Volume
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000005964
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Zs.A 1261: Show issues

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Article ; Online: A Model Predicting the 6-Month Disability of Patients With Traumatic Brain Injury to Assess the Quality of Care in Intensive Care Units: Results from the CREACTIVE Study.

Nattino, Giovanni / Lemeshow, Stanley / Carrara, Greta / Rossi, Carlotta / Brissy, Obou / Chieregato, Arturo / Csomos, Akos / Fleming, Joanne M / Giugni, Aimone / Gradisek, Primoz / Kaps, Rafael / Kyprianou, Theodoros / Lazar, Isaac / Mikaszewska-Sokolewicz, Malgorzata / Paci, Giulia / Xirouchaki, Nektaria / Bertolini, Guido

Journal of neurotrauma

2024

Abstract: Assessing quality of care is essential for improving the management of patients experiencing traumatic brain injury (TBI). This study aimed at devising a rigorous framework to evaluate the quality of TBI care provided by intensive care units (ICUs) and ... ...

Abstract	Assessing quality of care is essential for improving the management of patients experiencing traumatic brain injury (TBI). This study aimed at devising a rigorous framework to evaluate the quality of TBI care provided by intensive care units (ICUs) and applying it to the Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe (CREACTIVE) consortium, which involved 83 ICUs from seven countries. The performance of the centers was assessed in terms of patients' outcomes, as measured by the 6-month Glasgow Outcome Scale-Extended (GOS-E). To account for the between-center differences in the characteristics of the admitted patients, we developed a multinomial logistic regression model estimating the probability of a four-level categorization of the GOS-E: good recovery (GR), moderate disability (MD), severe disability (SD), and death or vegetative state (D/VS). A total of 5928 patients admitted to the participating ICUs between March 2014 and March 2019 were analyzed. The model included 11 predictors and demonstrated good discrimination (area under the receiver operating characteristic [ROC] curve in the validation set for GR: 0.836, MD: 0.802, SD: 0.706, D/VS: 0.890) and calibration, both overall (Hosmer-Lemeshow test
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0529
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Article ; Online: The RAISE Score: A Possible Tool to Better Identify Subarachnoid Hemorrhage Patients Who Might Benefit From Early Tracheostomy?

Colombo, Jacopo / Perego, Matilde / Veronese, Giacomo / Zumbo, Fabrizio / Pressato, Lorenzo / Curto, Francesco / Finazzi, Stefano / Chieregato, Arturo

Critical care medicine

2022 Volume 50, Issue 3, Page(s) e329–e330

MeSH term(s)	Critical Care ; Humans ; Respiration, Artificial ; Subarachnoid Hemorrhage/surgery ; Tracheostomy
Language	English
Publishing date	2022-02-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000005367
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Article ; Online: SARS-CoV-2-related encephalitis with prominent parkinsonism: clinical and FDG-PET correlates in two patients.

Morassi, Mauro / Palmerini, Francesco / Nici, Stefania / Magni, Eugenio / Savelli, Giordano / Guerra, Ugo Paolo / Chieregato, Matteo / Morbelli, Silvia / Vogrig, Alberto

Journal of neurology

2021 Volume 268, Issue 11, Page(s) 3980–3987

Abstract: ... subsequent development of neurological disorders (e.g. encephalitis lethargica after the 1918 influenza ...

Abstract	Considering the similarities with other pandemics due to respiratory virus infections and subsequent development of neurological disorders (e.g. encephalitis lethargica after the 1918 influenza), there is growing concern about a possible new wave of neurological complications following the worldwide spread of SARS-CoV-2. However, data on COVID-19-related encephalitis and movement disorders are still limited. Herein, we describe the clinical and neuroimaging (FDG-PET/CT, MRI and DaT-SPECT) findings of two patients with COVID-19-related encephalopathy who developed prominent parkinsonism. None of the patients had previous history of parkinsonian signs/symptoms, and none had prodromal features of Parkinson's disease (hyposmia or RBD). Both developed a rapidly progressive form of atypical parkinsonism along with distinctive features suggestive of encephalitis. A possible immune-mediated etiology was suggested in Patient 2 by the presence of CSF-restricted oligoclonal bands, but none of the patients responded favorably to immunotherapy. Interestingly, FDG-PET/CT findings were similar in both cases and reminiscent of those observed in post-encephalitic parkinsonism, with cortical hypo-metabolism associated with hyper-metabolism in the brainstem, mesial temporal lobes, and basal ganglia. Patient's FDG-PET/CT findings were validated by performing a Statistical Parametric Mapping analysis and comparing the results with a cohort of healthy controls (n = 48). Cerebrum cortical thickness map was obtained in Patient 1 from MRI examinations to evaluate the structural correlates of the metabolic alterations detected with FDG-PET/CT. Hypermetabolic areas correlated with brain regions showing increased cortical thickness, suggesting their involvement during the inflammatory process. Overall, these observations suggest that SARS-CoV-2 infection may trigger an encephalitis with prominent parkinsonism and distinctive brain metabolic alterations.
MeSH term(s)	COVID-19 ; Encephalitis ; Fluorodeoxyglucose F18 ; Humans ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/etiology ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-04-21
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-021-10560-3
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Article ; Online: Tracheostomy in Patients With Acute Traumatic Spinal Cord Injury: Is It Really a Matter of Timing?

Pozzi, Federico / Palazzo, Nadia / Veronese, Giacomo / Stagni, Giuliana / Sattin, Luca / Bastia, Luca / Curto, Francesco / Chieregato, Arturo

Anesthesia and analgesia

2021 Volume 133, Issue 4, Page(s) e49–e50

MeSH term(s)	Cervical Vertebrae ; Humans ; Spinal Cord Injuries/diagnosis ; Tracheostomy/adverse effects
Language	English
Publishing date	2021-09-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000005669
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Article: A flow cytometric assay for the quantification of MSC lysis by peripheral blood mononucleated cells.

Chieregato, Katia / Bernardi, Martina / Alghisi, Alberta / Giordano, Rosaria / Lazzari, Lorenza / Perbellini, Omar / Rassu, Mario / Ruggeri, Marco / Astori, Giuseppe

Heliyon

2021 Volume 7, Issue 2, Page(s) e06036

Abstract: Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally ... ...

Abstract	Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally immunoprivileged. Data suggest that MSC undergo apoptosis after infusion in presence of cytotoxic cells and their death could drive immunosuppression. In GvHD patients, that activity was associated with clinical response. It is mandatory to develop an
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06036
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Article ; Online: Aggressive medical management of acute traumatic subdural hematomas before emergency craniotomy in patients presenting with bilateral unreactive pupils. A cohort study.

Chieregato, Arturo / Venditto, Alessandra / Russo, Emanuele / Martino, Costanza / Bini, Giovanni

Acta neurochirurgica

2017 Volume 159, Issue 8, Page(s) 1553–1559

Abstract: ... of treatment: (1) a "basic" level of treatment characterized by a single conventional dose (18 to 36 g), (2 ... reinforced" treatment landmarked by a single high dose (54 to 72 g), and (3) "aggressive" treatment ... landmarked by a single high dose (90 to 106 g). Doses above 36 g were administered intravenously over ...

Abstract	Background: The outcome of patients with severe traumatic brain injury (TBI) and acute traumatic subdural hematoma (aSDH) admitted to the emergency room with bilaterally dilated, unreactive pupils (bilateral mydriasis) is notoriously poor. Methods: Of 2074 TBI patients consecutively admitted to our facility between 1997 and 2012, 115 had a first CT scan with aSDH, unreactive bilateral mydriasis, and a Glasgow Coma Score of 3 or 4. Sixty-two patients were unoperated and died within hours or a few days. The remaining 53 patients (2.5% of the 2074 consecutive patients) were scheduled for emergent evacuation of the aSDH. We compared three different dosages of mannitol to landmark different comprehensive levels of treatment: (1) a "basic" level of treatment characterized by a single conventional dose (18 to 36 g), (2) "reinforced" treatment landmarked by a single high dose (54 to 72 g), and (3) "aggressive" treatment landmarked by a single high dose (90 to 106 g). Doses above 36 g were administered intravenously over a period of 5 min. Results: Of the 53 selected patients, 7 were aggressively managed (13.2%) and 24 (45.3%) received reinforced treatment. Rates of hyperventilation and barbiturate bolus administration were appropriately associated with increasing doses of mannitol. After adjustment for age, aggressive management was significantly associated with a lower risk of death and persistent vegetative state [adjusted OR 0.016 (95% 0.001-0.405)]. Patients surviving after aggressive management suffered more severe disability at 1 year. Conclusion: The study shows an association between reduced mortality and persistent vegetative state, albeit at the cost of increased long-term severe disability in survivors, and aggressive medical preoperative management of mydriatic patients with aSDH following TBI.
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Craniotomy/adverse effects ; Craniotomy/methods ; Female ; Hematoma, Subdural, Acute/pathology ; Hematoma, Subdural, Acute/surgery ; Humans ; Male ; Middle Aged ; Persistent Vegetative State/epidemiology ; Postoperative Complications/epidemiology ; Preoperative Period
Language	English
Publishing date	2017-04-24
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-017-3190-4
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