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  1. Book ; Thesis: Epithelial calcium and magnesium channels in health and disease

    Nijenhuis, Tom

    2006  

    Author's details door Tom Nijenhuis
    Language English ; Dutch
    Size 221 S. : Ill., graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nijmegen, Univ., Diss., 2006
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT015549995
    ISBN 978-90-9020730-8 ; 90-9020730-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 E 673 order for loan Magazin

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  2. Article ; Online: Thiazidediuretica ter preventie van recidiverende nierstenen.

    Verploegen, Maartje F A / Nijenhuis, Tom

    Nederlands tijdschrift voor geneeskunde

    2023  Volume 167

    Abstract: Thiazides are widely used to prevent recurrence of calcium-containing kidney stones. However, the recent NOSTONE trial reported no benefit of hydrochlorothiazide on the composite outcome of symptomatic or radiologic recurrence. Higher doses (25 and 50mg ... ...

    Title translation Thiazides to prevent recurrence of kidney stones: is hydrochlorothiazide still indicated?
    Abstract Thiazides are widely used to prevent recurrence of calcium-containing kidney stones. However, the recent NOSTONE trial reported no benefit of hydrochlorothiazide on the composite outcome of symptomatic or radiologic recurrence. Higher doses (25 and 50mg daily) resulted in a decrease of radiologic recurrence, but no difference in symptomatic stones. Current guidelines preserve the use of hydrochlorothiazide to patients with overt hypercalciuria, while NOSTONE also included patients without hypercalciuria. This might have underestimated the effect of hydrochlorothiazide. While patients received dietary counseling, results suggest adherence was poor e.g. with respect to oxalate and salt consumption, possibly mitigating a potential beneficial hypocalciuric effect of hydrochlorothiazide. Furthermore, previous studies that did show an effect of thiazides on stone recurrence used higher doses. Thus, while hydrochlorothiazide might not be effective in all patients with calcium-containing kidney stones, it should not be written off, as its efficacy in overt hypercalciuria needs to be further elucidated.
    MeSH term(s) Humans ; Hydrochlorothiazide/therapeutic use ; Thiazides/therapeutic use ; Calcium ; Hypercalciuria ; Kidney Calculi/prevention & control
    Chemical Substances Hydrochlorothiazide (0J48LPH2TH) ; Thiazides ; Calcium (SY7Q814VUP)
    Language Dutch
    Publishing date 2023-11-01
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.

    't Hart, Daan C / van der Vlag, Johan / Nijenhuis, Tom

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Excessive activation of the immune system is the cause of a wide variety of renal diseases. However, the pathogenic mechanisms underlying the aberrant activation of the immune system in the kidneys often remain unknown. TRPC6, a member of the ... ...

    Abstract Excessive activation of the immune system is the cause of a wide variety of renal diseases. However, the pathogenic mechanisms underlying the aberrant activation of the immune system in the kidneys often remain unknown. TRPC6, a member of the Ca
    MeSH term(s) Humans ; TRPC6 Cation Channel/genetics ; TRPC Cation Channels/genetics ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Glomerulus/pathology ; Podocytes/pathology
    Chemical Substances TRPC6 Cation Channel ; TRPC Cation Channels ; TRPC6 protein, human
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Minimal Change Disease: More Than a Podocytopathy?

    Maas, Rutger J / Nijenhuis, Tom / van der Vlag, Johan

    Kidney international reports

    2022  Volume 7, Issue 4, Page(s) 675–677

    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Editorial
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Laminar flow substantially affects the morphology and functional phenotype of glomerular endothelial cells.

    't Hart, Daan C / van der Vlag, Johan / Nijenhuis, Tom

    PloS one

    2021  Volume 16, Issue 5, Page(s) e0251129

    Abstract: Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusive. ... ...

    Abstract Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusive. The glomerular endothelium, including its glycocalyx, is a crucial part of the glomerular filtration barrier, which is involved in blood filtration. We therefore investigated the influence of laminar flow-induced shear stress on the glomerular endothelium. Conditionally immortalized mouse glomerular endothelial cells were cultured for 7 days under a laminar flow of 5 dyn/cm2 to mimic the glomerular blood flow. The cells were subsequently analysed for changes in morphology, expression of shear stress-responsive genes, nitric oxide production, glycocalyx composition, expression of anti-oxidant genes and the inflammatory response. Culture under laminar flow resulted in cytoskeletal rearrangement and cell alignment compared to static conditions. Moreover, production of nitric oxide was increased and the expression of the main functional component of the glycocalyx, Heparan Sulfate, was enhanced in response to shear stress. Furthermore, glomerular endothelial cells demonstrated a quiescent phenotype under flow, characterized by a decreased expression of the pro-inflammatory gene ICAM-1 and increased expression of the anti-oxidant enzymes HO-1 and NQO1. Upon exposure to the inflammatory stimulus TNFα, however, glomerular endothelial cells cultured under laminar flow showed an enhanced inflammatory response. In conclusion, laminar flow extensively affects the morphology and functional phenotype of glomerular endothelial cells in culture. Furthermore, glomerular endothelial cells respond differently to shear stress compared to macrovascular endothelium. To improve the translation of future in vitro studies with glomerular endothelial cells to the in vivo situation, it appears therefore crucial to culture glomerular endothelial cells under physiological flow conditions.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Cells, Cultured ; Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiology ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Intercellular Adhesion Molecule-1/metabolism ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/physiology ; Mice ; Nitric Oxide/metabolism ; Phenotype ; Stress, Mechanical ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antioxidants ; Tumor Necrosis Factor-alpha ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0251129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improving a Rare Metabolic Disorder Through Kidney Transplantation: A Case Report of a Patient With Lysinuric Protein Intolerance.

    IJzermans, Ties / van der Meijden, Wilbert / Hoeks, Marlijn / Huigen, Marleen / Rennings, Alexander / Nijenhuis, Tom

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 81, Issue 4, Page(s) 493–496

    Abstract: Lysinuric protein intolerance (LPI) is a rare metabolic disorder with reduced renal and intestinal reabsorption of ornithine, lysine, and arginine. It is due to variants in SLC7A7, the gene encoding y+L amino acid transporter 1 (y+LAT1), which lead to ... ...

    Abstract Lysinuric protein intolerance (LPI) is a rare metabolic disorder with reduced renal and intestinal reabsorption of ornithine, lysine, and arginine. It is due to variants in SLC7A7, the gene encoding y+L amino acid transporter 1 (y+LAT1), which lead to urea cycle defects with protein intolerance. Chronic kidney disease in lysinuric protein intolerance is common and can progress to kidney failure and initiation of kidney replacement therapy. Kidney transplantation could in theory improve urine levels and, consequently, plasma levels of these amino acids and therefore improve clinical symptoms, as well as protein intolerance, in patients with lysinuric protein intolerance. However, data on kidney transplantation in patients with lysinuric protein intolerance are limited, and up until now no data on clinical and biochemical improvement after kidney transplantation have been reported. In this case report we describe a rare case of kidney transplantation in a lysinuric protein intolerance patient with substantial improvement in protein tolerance; in plasma and urine levels of ornithine, lysine, and arginine; and in lysinuric protein intolerance symptoms.
    MeSH term(s) Humans ; Lysine/urine ; Kidney Transplantation ; Amino Acid Metabolism, Inborn Errors/complications ; Amino Acid Metabolism, Inborn Errors/drug therapy ; Amino Acid Metabolism, Inborn Errors/genetics ; Metabolic Diseases ; Arginine/therapeutic use ; Arginine/metabolism ; Ornithine/therapeutic use ; Amino Acid Transport System y+L
    Chemical Substances Lysine (K3Z4F929H6) ; Arginine (94ZLA3W45F) ; Ornithine (E524N2IXA3) ; SLC7A7 protein, human ; Amino Acid Transport System y+L
    Language English
    Publishing date 2022-10-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 468: Show issues

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  7. Article: Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis.

    Buijsers, Baranca / Maciej-Hulme, Marissa / Jacobs, Maaike / Bebber, Marinka Bakker-van / de Graaf, Mark / Salmenov, Rustem / Parr, Naomi / Rabelink, Ton J / Nijenhuis, Tom / van der Vlag, Johan

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1223972

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1223972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury.

    't Hart, Daan / Li, Jinhua / van der Vlag, Johan / Nijenhuis, Tom

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: Increased expression and activity of the ... ...

    Abstract Increased expression and activity of the Ca
    MeSH term(s) Animals ; Calcium Signaling/drug effects ; Cyclic GMP/genetics ; Drug Repositioning ; Endothelial Cells/drug effects ; Guanylate Cyclase/genetics ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/pathology ; Mice ; Nitric Oxide/genetics ; Paracrine Communication/drug effects ; Podocytes/drug effects ; Podocytes/pathology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; TRPC6 Cation Channel/genetics
    Chemical Substances Pyrazoles ; Pyrimidines ; TRPC6 Cation Channel ; Nitric Oxide (31C4KY9ESH) ; Guanylate Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU) ; riociguat (RU3FE2Y4XI)
    Language English
    Publishing date 2021-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Laminar flow substantially affects the morphology and functional phenotype of glomerular endothelial cells.

    Daan C 't Hart / Johan van der Vlag / Tom Nijenhuis

    PLoS ONE, Vol 16, Iss 5, p e

    2021  Volume 0251129

    Abstract: Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusive. ... ...

    Abstract Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusive. The glomerular endothelium, including its glycocalyx, is a crucial part of the glomerular filtration barrier, which is involved in blood filtration. We therefore investigated the influence of laminar flow-induced shear stress on the glomerular endothelium. Conditionally immortalized mouse glomerular endothelial cells were cultured for 7 days under a laminar flow of 5 dyn/cm2 to mimic the glomerular blood flow. The cells were subsequently analysed for changes in morphology, expression of shear stress-responsive genes, nitric oxide production, glycocalyx composition, expression of anti-oxidant genes and the inflammatory response. Culture under laminar flow resulted in cytoskeletal rearrangement and cell alignment compared to static conditions. Moreover, production of nitric oxide was increased and the expression of the main functional component of the glycocalyx, Heparan Sulfate, was enhanced in response to shear stress. Furthermore, glomerular endothelial cells demonstrated a quiescent phenotype under flow, characterized by a decreased expression of the pro-inflammatory gene ICAM-1 and increased expression of the anti-oxidant enzymes HO-1 and NQO1. Upon exposure to the inflammatory stimulus TNFα, however, glomerular endothelial cells cultured under laminar flow showed an enhanced inflammatory response. In conclusion, laminar flow extensively affects the morphology and functional phenotype of glomerular endothelial cells in culture. Furthermore, glomerular endothelial cells respond differently to shear stress compared to macrovascular endothelium. To improve the translation of future in vitro studies with glomerular endothelial cells to the in vivo situation, it appears therefore crucial to culture glomerular endothelial cells under physiological flow conditions.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 570
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Urine Acidification After Ammonium Chloride.

    Bech, Anneke P / Nijenhuis, Tom / Wetzels, Jack F M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2018  Volume 72, Issue 6, Page(s) 909–911

    MeSH term(s) Acid-Base Imbalance ; Acidosis/urine ; Adult ; Ammonium Chloride/administration & dosage ; Creatinine/urine ; Female ; Healthy Volunteers ; Humans ; Hydrogen-Ion Concentration ; Kidney Function Tests ; Male ; Reference Values ; Urinalysis ; Urine/chemistry
    Chemical Substances Ammonium Chloride (01Q9PC255D) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2018.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 468: Show issues

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