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  1. Article ; Online: Striatal dopamine D

    Chen, Kao Chin / Yang, Yen Kuang / Howes, Oliver D / Lee, I Hui / Yeh, Tzung Lieh / Chiu, Nan Tsing / Chen, Po See / David, Anthony S / Bramon, Elvira

    Psychological medicine

    2021  Volume 52, Issue 14, Page(s) 3251–3259

    Abstract: ... naïve patients with recent-onset schizophrenia have similar D ...

    Abstract Background: The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of
    Methods: We focused on the role of dopamine postsynaptic regulation using [
    Result: The mean specific striatal binding showed no significant difference between patients and controls (estimated difference = 0.001; 95% CI -0.11 to 0.11;
    Conclusions: Medication-naïve patients with recent-onset schizophrenia have similar D
    MeSH term(s) Humans ; Infant, Newborn ; Schizophrenia ; Dopamine Antagonists/pharmacology ; Dopamine/metabolism ; Receptors, Dopamine D2/metabolism ; Corpus Striatum ; Tomography, Emission-Computed, Single-Photon/methods
    Chemical Substances 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide (84226-06-2) ; Dopamine Antagonists ; Dopamine (VTD58H1Z2X) ; Iodine-123 (8YWR746RPQ) ; Receptors, Dopamine D2
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291720005413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1003: Show issues Location:
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  2. Article ; Online: An emerging role of vitamin D

    Zhang, Yao / Li, Chao-Nan / Jiang, Wei-Dan / Wu, Pei / Liu, Yang / Kuang, Sheng-Yao / Tang, Ling / Li, Shu-Wei / Jin, Xiao-Wan / Ren, Hong-Mei / Zhou, Xiao-Qiu / Feng, Lin

    Animal nutrition (Zhongguo xu mu shou yi xue hui)

    2022  Volume 10, Page(s) 305–318

    Abstract: Vitamin D ...

    Abstract Vitamin D
    Language English
    Publishing date 2022-05-28
    Publishing country China
    Document type Journal Article
    ISSN 2405-6383
    ISSN (online) 2405-6383
    DOI 10.1016/j.aninu.2022.05.004
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  3. Article ; Online: Modulating the d-Band Center Enables Ultrafine Pt

    Kuang, Panyong / Ni, Zhenrui / Zhu, Bicheng / Lin, Yue / Yu, Jiaguo

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 41, Page(s) e2303030

    Abstract: By providing dual active sites to synergistically accelerate ... ...

    Abstract By providing dual active sites to synergistically accelerate H
    Language English
    Publishing date 2023-08-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202303030
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  4. Article ; Online: Association between serum vitamin D levels and

    Kuang, Wei-Ming / Ren, Yu-Jie / Chen, Xu / Luo, Qi / Chen, Weijing / Pan, Huai-Geng / Li, Ru-Liu / Hu, Ling

    BMJ open

    2022  Volume 12, Issue 4, Page(s) e058164

    Abstract: Objective: To assess the association of serum vitamin D (VD) levels and : Design ... as serum 25(OH)D concentrations<20 ng/mL. Logistic regression models were used to assess the association ...

    Abstract Objective: To assess the association of serum vitamin D (VD) levels and
    Design: Cross-sectional study.
    Setting: Data from phase I of the National Health and Nutrition Examination Survey (NHANES III, 1988-1991) led by the Center for Disease Control and Prevention.
    Participants: A total of 3512 US adults (≥20 years) with both serum VD levels and
    Methods: VD deficiency was defined as serum 25(OH)D concentrations<20 ng/mL. Logistic regression models were used to assess the association of serum VD levels and
    Results: There was no significant association of VD-
    Conclusions: Racial/ethnic differences and different serum ferritin or serum folate levels may be effect modifiers for the association of VD-
    MeSH term(s) Adult ; Antibodies, Bacterial ; Antigens, Bacterial/blood ; Bacterial Proteins/blood ; Cross-Sectional Studies ; Ferritins ; Folic Acid ; Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Nutrition Surveys ; Vitamin D/blood
    Chemical Substances Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Proteins ; cagA protein, Helicobacter pylori ; Vitamin D (1406-16-2) ; Ferritins (9007-73-2) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-058164
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  5. Article: PDGF-D-induced immunoproteasome activation and cell-cell interactions.

    Zhang, Jianing / Li, Wanhong / Xiong, Zhen / Zhu, Juanhua / Ren, Xiangrong / Wang, Shasha / Kuang, Haiqing / Lin, Xianchai / Mora, Antonio / Li, Xuri

    Computational and structural biotechnology journal

    2023  Volume 21, Page(s) 2405–2418

    Abstract: Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases ... Yet, it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in the eye ... In this study, using single-cell RNA sequencing (scRNA-seq) and a mouse model of PDGF-D overexpression ...

    Abstract Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet, it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in the eye. In this study, using single-cell RNA sequencing (scRNA-seq) and a mouse model of PDGF-D overexpression in retinal pigment epithelial (RPE) cells, we found that PDGF-D overexpression markedly upregulated the key immunoproteasome genes, leading to increased antigen processing/presentation capacity of RPE cells. Also, more than 6.5-fold ligand-receptor pairs were found in the PDGF-D overexpressing RPE-choroid tissues, suggesting markedly increased cell-cell interactions. Moreover, in the PDGF-D-overexpressing tissues, a unique cell population with a transcriptomic profile of both stromal cells and antigen-presenting RPE cells was detected, suggesting PDGF-D-induced epithelial-mesenchymal transition of RPE cells. Importantly, administration of ONX-0914, an immunoproteasome inhibitor, suppressed choroidal neovascularization (CNV) in a mouse CNV model
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.03.047
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  6. Article ; Online: Collapsed Woman With a D-Shaped Left Ventricle on Echocardiogram.

    Chen, Jie-Ming / Wang, Liang-Han / Chang, Chih-Jung / Huang, Chun-Yen / Sun, Jen-Tang / Chiang, Wen-Chu / Huei-Ming Ma, Matthew / Tsai, Kuang-Chau / Chu, Sheng-En

    Annals of emergency medicine

    2022  Volume 80, Issue 6, Page(s) e95–e96

    MeSH term(s) Humans ; Female ; Heart Ventricles/diagnostic imaging ; Echocardiography ; Thorax
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2022.06.023
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    Zs.A 1344: Show issues Location:
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  7. Article: Reply to JFMA-D-23-00843, comments on "Efficacy of intraoperative thoracoscopic intercostal nerve blocks in nonintubated and intubated video-assisted thoracic surgery".

    Chan, Kuang-Cheng / Cheng, Ya-Jung

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2024  

    Language English
    Publishing date 2024-01-18
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2024.01.006
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    Zs.B 1041: Show issues Location:
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  8. Article ; Online: NK-cell-elicited gasdermin-D-dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitates HBV-related acute-on-chronic liver failure.

    Zhao, Qiang / Chen, Dong-Ping / Chen, Hua-Di / Wang, Ying-Zhe / Shi, Wei / Lu, Yi-Tong / Ren, Yi-Zheng / Wu, Yuan-Kai / Pang, Yi-Hua / Deng, Hong / He, Xiaoshun / Kuang, Dong-Ming / Guo, Zhi-Yong

    Hepatology (Baltimore, Md.)

    2024  

    Abstract: Background aims: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell ... ...

    Abstract Background aims: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF.
    Approach results: We identified that pyroptosis represented the main cell death pattern in the liver of patients with HBV-related ACLF. Deficiency of MHC-I in HBV-reactivated hepatocytes activated cytotoxic NK cells, which in turn operated in a perforin/granzyme-dependent manner to trigger GSDMD/caspase-8-dependent pyroptosis of hepatocytes. Neutrophils selectively accumulated in pyroptotic liver, and HMGB1 derived from pyroptotic liver constituted an important factor triggering generation of pathogenic extracellular traps in neutrophils (NETs). Clinically, elevated plasma levels of MPO-DNA complexes were a promising prognostic biomarker for HBV-related ACLF. More importantly, targeting GSDMD pyroptosis-HMGB1 release in the liver abrogates NETs that intercept the development of HBV-related ACLF.
    Conclusions: Studying the mechanisms that selectively modulate GSDMD-dependent pyroptosis, as well as its immune landscapes, will provide a novel strategy for restoring liver function of HBV-related ACLF patients.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000868
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    Zs.A 1660: Show issues Location:
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  9. Article ; Online: 1,25-Dihydroxyvitamin D

    Lee, Ching-Tien / Wang, Jiz-Yuh / Chou, Kuang-Yi / Hsu, Ming-I

    The Journal of steroid biochemistry and molecular biology

    2018  Volume 185, Page(s) 200–211

    Abstract: ... of BPA on the mitochondria of ovarian granulosa cells is not clear. Further, 1,25-dihydroxyvitamin D ...

    Abstract Bisphenol A (BPA), an endocrine-disrupting chemical, is capable of producing reproductive toxicity. BPA results in mitochondrial DNA (mtDNA) deletion and mitochondrial dysfunction; however, the effect of BPA on the mitochondria of ovarian granulosa cells is not clear. Further, 1,25-dihydroxyvitamin D
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Calcitriol/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; DNA, Mitochondrial/genetics ; Electron Transport Complex IV/metabolism ; Endocrine Disruptors/toxicity ; Estradiol/metabolism ; Female ; Granulosa Cells/metabolism ; Mitochondria/pathology ; Oxidative Stress/drug effects ; Phenols/toxicity ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Receptors, Calcitriol/metabolism ; Sequence Deletion/drug effects ; Sequence Deletion/genetics ; Superoxide Dismutase/metabolism
    Chemical Substances Benzhydryl Compounds ; DNA, Mitochondrial ; Endocrine Disruptors ; Phenols ; Reactive Oxygen Species ; Receptors, Calcitriol ; Estradiol (4TI98Z838E) ; Superoxide Dismutase (EC 1.15.1.1) ; Electron Transport Complex IV (EC 1.9.3.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Calcitriol (FXC9231JVH) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2018-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2018.09.002
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    Zs.A 708: Show issues Location:
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  10. Article ; Online: Effects of vitamin D and zinc deficiency in acute and long COVID syndrome.

    Chen, Kuang-Yu / Lin, Chin-Kuo / Chen, Ning-Hung

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2023  Volume 80, Page(s) 127278

    Abstract: ... whether detection of zinc concentration or vitamin D concentration could provide treatment benefits for patients ... for detecting zinc and chemiluminescence immunoassay for detecting vitamin D were performed in laboratory tests ... Results: Fifty-five patients were included. Of the participants, 29.1 % and 27.3 % had vitamin D and zinc ...

    Abstract Objectives: Acute inflammatory or neuropsychiatric symptoms, such as headache, fatigue, anosmia, and hyposmia, sometimes persist for more than 30 days or longer than 12 weeks after infection with the Omicron variant of SARS‑CoV‑2 (hereafter referred to as COVID-19). The aim of this study was to determine whether detection of zinc concentration or vitamin D concentration could provide treatment benefits for patients with COVID-19, thus reducing the risk of them experiencing long COVID.
    Methods: The interval between the date of COVID-19 diagnosis and the date of visit to pulmonary department for prolonged symptoms of COVID-19 was recorded for statistical analysis. Inductively coupled plasma mass spectrometry for detecting zinc and chemiluminescence immunoassay for detecting vitamin D were performed in laboratory tests.
    Results: Fifty-five patients were included. Of the participants, 29.1 % and 27.3 % had vitamin D and zinc deficiency, respectively. On average, the patients underwent long COVID treatment for 31.7 ± 17.7 days. A positive statistical correlation was observed between vitamin D and zinc concentrations (Pearson's correlation = 0.378). Compared with sufficient zinc levels, zinc deficiency was associated with a higher fibrinogen level (p < 0.05). Within 30 days, the observed vitamin D deficiency rate was only 21.4 %; after 30 days, the vitamin D deficiency rate rose to 37.0 % (McNemar's chi-square test; p < 0.05).
    Conclusion: Zinc deficiency correlates to acute and persistent inflammation and vitamin D deficiency is associated with delayed recovery in long COVID syndrome.
    MeSH term(s) Humans ; Vitamin D ; Post-Acute COVID-19 Syndrome ; COVID-19 Testing ; SARS-CoV-2 ; COVID-19 ; Vitamins ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/therapy ; Minerals ; Zinc
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins ; Minerals ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-08-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2023.127278
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