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Article: Re: Myths of whiplash. Ferrari R. Surg J R Coll Surg Edinb Irel 2003. 1; 2: 99-103.

Alpar, E K

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2004 Volume 2, Issue 1, Page(s) 58; author reply 58–9

MeSH term(s)	Chronic Disease ; Combined Modality Therapy ; Comorbidity ; Compartment Syndromes/diagnosis ; Compartment Syndromes/epidemiology ; Compartment Syndromes/surgery ; Decompression, Surgical/methods ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Pain/diagnosis ; Pain/epidemiology ; Pain Management ; Pain Measurement ; Physical Therapy Modalities ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Whiplash Injuries/diagnosis ; Whiplash Injuries/epidemiology ; Whiplash Injuries/therapy
Language	English
Publishing date	2004-02
Publishing country	Scotland
Document type	Comment ; Comparative Study ; Letter
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
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Article: The Driverless Triple-Wild-Type (BRAF, RAS, KIT) Cutaneous Melanoma: Whole Genome Sequencing Discoveries.

Pipek, Orsolya / Vizkeleti, Laura / Doma, Viktória / Alpár, Donát / Bödör, Csaba / Kárpáti, Sarolta / Timar, Jozsef

Cancers

2023 Volume 15, Issue 6

Abstract: The genetic makeup of the triple-wild-type melanoma (BRAF, NRAS and NF1) has been known for some time, but those studies grouped together rare histopathological versions with common ones, as well as mucosal and even uveal ones. Here we used whole genome ... ...

Abstract	The genetic makeup of the triple-wild-type melanoma (BRAF, NRAS and NF1) has been known for some time, but those studies grouped together rare histopathological versions with common ones, as well as mucosal and even uveal ones. Here we used whole genome sequencing to genetically characterize the triple-wild-type melanoma (TWM), termed here as BRAF, RAS and KIT wild type (the most frequent oncogenic drivers of skin melanoma), using the most common histological forms and excluding rare ones. All these tumors except one were clearly induced by UV based on the mutational signature. The tumor mutational burden was low in TWM, except in the NF1 mutant forms, and a relatively high frequency of elevated LOH scores suggested frequent homologue recombination deficiency, but this was only confirmed by the mutation signature in one case. Furthermore, all these TWMs were microsatellite-stabile. In this driverless setting, we revealed rare oncogenic drivers known from melanoma or other cancer types and identified rare actionable tyrosine kinase mutations in NTRK1, RET and VEGFR1. Mutations of TWM identified genes involved in antitumor immunity (negative and positive predictors of immunotherapy), Ca
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061712
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Article ; Online: Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn

Patthy, Ágoston / Hanics, János / Zachar, Gergely / Kovács, Gábor G / Harkany, Tibor / Alpár, Alán

Neuropathology and applied neurobiology

2023 Volume 49, Issue 1, Page(s) e12887

Abstract: Aims: The endocannabinoid system with its type 1 cannabinoid receptor (CB: Methods: Foetal brains with normal development or with Down's syndrome were analysed using standard immunohistochemistry, digitalised light microscopy and image analysis ( ... ...

Abstract	Aims: The endocannabinoid system with its type 1 cannabinoid receptor (CB Methods: Foetal brains with normal development or with Down's syndrome were analysed using standard immunohistochemistry, digitalised light microscopy and image analysis (NanoZoomer). CB Results: We detected a meshwork of fine-calibre, often varicose processes between the subventricular and intermediate zones of the cortical plate in the late first trimester, when telencephalic fibre tracts develop. The density of CB Conclusions: We suggest that neuroarchitectural impairments in Down's syndrome brains involve the delayed development and errant functions of the endocannabinoid system, with a particular impact on endocannabinoids modulating axonal wiring.
MeSH term(s)	Animals ; Humans ; Mice ; Brain/metabolism ; Down Syndrome/metabolism ; Endocannabinoids/metabolism ; Mice, Transgenic ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/metabolism
Chemical Substances	Endocannabinoids ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid ; CNR1 protein, human ; CNR1 protein, mouse
Language	English
Publishing date	2023-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	80371-6
ISSN	1365-2990 ; 0305-1846
ISSN (online)	1365-2990
ISSN	0305-1846
DOI	10.1111/nan.12887
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Article ; Online: Professor Jan Gerben Frans Worst.

Alpar, John J

Journal of cataract and refractive surgery

2016 Volume 42, Issue 6, Page(s) 809

Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2016.04.015
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Article ; Online: A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.

Benevento, Marco / Alpár, Alán / Gundacker, Anna / Afjehi, Leila / Balueva, Kira / Hevesi, Zsofia / Hanics, János / Rehman, Sabah / Pollak, Daniela D / Lubec, Gert / Wulff, Peer / Prevot, Vincent / Horvath, Tamas L / Harkany, Tibor

Nature

2024 Volume 628, Issue 8009, Page(s) 826–834

Abstract: Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary ... ...

Abstract	Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary thermoceptive neurons in the pontine parabrachial nucleus becoming well characterized
MeSH term(s)	Animals ; Hypothalamus/metabolism ; Hypothalamus/cytology ; Mice ; Male ; Hot Temperature ; Neurons/metabolism ; Eating ; Vascular Endothelial Growth Factor A/metabolism ; Parabrachial Nucleus/cytology ; Parabrachial Nucleus/metabolism ; Parabrachial Nucleus/physiology ; Ependymoglial Cells/metabolism ; Ependymoglial Cells/cytology ; Dopamine/metabolism ; Brain Stem/cytology ; Brain Stem/metabolism ; Brain Stem/physiology ; Agouti-Related Protein/metabolism ; Female ; Thermosensing/physiology ; Neural Pathways/metabolism ; Arcuate Nucleus of Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus/cytology ; Feeding Behavior/physiology
Chemical Substances	Vascular Endothelial Growth Factor A ; Dopamine (VTD58H1Z2X) ; Agouti-Related Protein
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07232-3
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.

Pintér, Anna / Hevesi, Zsófia / Zahola, Péter / Alpár, Alán / Hanics, János

Cellular signalling

2020 Volume 74, Page(s) 109710

Abstract: Composition of the brain extracellular matrix changes in time as maturation proceeds. Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse ... ...

Abstract	Composition of the brain extracellular matrix changes in time as maturation proceeds. Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming. Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week. Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus. CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets. Electron microscopy and analysis of synaptosomal fraction showed that CSPG-5 accumulates around, and is associated to synapses, respectively. In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites. In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
MeSH term(s)	Animals ; Cell Line ; Cerebellar Cortex/metabolism ; Chondroitin Sulfate Proteoglycans/physiology ; Humans ; Male ; Membrane Proteins/physiology ; Neurites/metabolism ; Proteoglycans/physiology ; Rats ; Rats, Wistar ; Synapses/metabolism
Chemical Substances	Chondroitin Sulfate Proteoglycans ; Cspg5 protein, rat ; Membrane Proteins ; Proteoglycans
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2020.109710
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Zs.A 2579: Show issues

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Article ; Online: Profiling of Copy Number Alterations Using Low-Coverage Whole-Genome Sequencing Informs Differential Diagnosis and Prognosis in Primary Cutaneous Follicle Center Lymphoma.

Bátai, Bence / Kiss, Laura / Varga, Luca / Nagy, Ákos / Househam, Jacob / Baker, Ann-Marie / László, Tamás / Udvari, Anna / Horváth, Róbert / Nagy, Tibor / Csomor, Judit / Szakonyi, József / Schneider, Tamás / Graham, Trevor A / Alpár, Donát / Fitzgibbon, Jude / Szepesi, Ágota / Bödör, Csaba

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2024 Volume 37, Issue 5, Page(s) 100465

Abstract: Primary cutaneous follicle center lymphoma (PCFCL) has an excellent prognosis using local treatment, whereas nodal follicular lymphoma (nFL), occasionally presenting with cutaneous spread, often requires systemic therapy. Distinction of the 2 diseases ... ...

Abstract	Primary cutaneous follicle center lymphoma (PCFCL) has an excellent prognosis using local treatment, whereas nodal follicular lymphoma (nFL), occasionally presenting with cutaneous spread, often requires systemic therapy. Distinction of the 2 diseases based on histopathology alone might be challenging. Copy number alterations (CNAs) have scarcely been explored on a genome-wide scale in PCFCL; however, they might serve as potential biomarkers during differential diagnosis and risk stratification. Low-coverage whole-genome sequencing is a robust, high-throughput method for genome-wide copy number profiling. In this study, we analyzed 28 PCFCL samples from 20 patients and compared the copy number profiles with a cohort of diagnostic samples of 64 nFL patients. Although the copy number profile of PCFCL was similar to that of nFL, PCFCL lacked amplifications of 18q, with the frequency peaking at 18q21.33 in nFL cases involving the BCL2 locus (PCFCL: 5.0% vs nFL: 31.3%, P = .018, Fisher exact test). Development of distant cutaneous spread was significantly associated with higher genomic instability including the proportion of genome altered (0.02 vs 0.13, P = .033) and number of CNAs (2 vs 9 P = .017), as well as the enrichment of 2p22.2-p15 amplification involving REL and XPO1 (6.3% vs 60.0%, P = .005), 3q23-q24 amplification (0.0% vs 50.0%, P = .004), 6q16.1-q23.3 deletion (6.3% vs 50.0%, P = .018), and 9p21.3 deletion covering CDKN2A and CDKN2B loci (0.0% vs 40.0%, P = .014, all Fisher exact test) in PCFCL. Analysis of sequential tumor samples in 2 cases harboring an unfavorable clinical course pointed to the acquisition of 2p amplification in the earliest common progenitor underlining its pivotal role in malignant transformation. By performing genome-wide copy number profiling on the largest patient cohort to date, we identified distinctive CNA alterations conceivably facilitating the differential diagnosis of PCFCL and secondary cutaneous involvement of nFL and potentially aiding the risk stratification of patients with PCFCL in the future.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2024.100465
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Article ; Online: Genomic Landscape of Normal and Breast Cancer Tissues in a Hungarian Pilot Cohort.

Pipek, Orsolya / Alpár, Donát / Rusz, Orsolya / Bödör, Csaba / Udvarnoki, Zoltán / Medgyes-Horváth, Anna / Csabai, István / Szállási, Zoltán / Madaras, Lilla / Kahán, Zsuzsanna / Cserni, Gábor / Kővári, Bence / Kulka, Janina / Tőkés, Anna Mária

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: A limited number of studies have focused on the mutational landscape of breast cancer in different ethnic populations within Europe and compared the data with other ethnic groups and databases. We performed whole-genome sequencing of 63 samples from 29 ... ...

Abstract	A limited number of studies have focused on the mutational landscape of breast cancer in different ethnic populations within Europe and compared the data with other ethnic groups and databases. We performed whole-genome sequencing of 63 samples from 29 Hungarian breast cancer patients. We validated a subset of the identified variants at the DNA level using the Illumina TruSight Oncology (TSO) 500 assay. Canonical breast-cancer-associated genes with pathogenic germline mutations were
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Hungary ; DNA Copy Number Variations ; Genetic Predisposition to Disease ; Mutation ; Germ-Line Mutation ; Genomics
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108553
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Article ; Online: National Traumas – Local Memories Villages Southeast and Southwest from Kolozsvár (Cluj-Napoca) during WW2 – General Research Overview

Nagy Alpár-Csaba

Acta Universitatis Sapientiae: European and Regional Studies, Vol 7, Iss 1, Pp 31-

2015 Volume 39

Abstract: The presentation summarizes the results of two years of oral history research. The aim of the research was to record the recollections of the still living eyewitnesses of the events in the fall of 1944 in Cluj and its surroundings, in settlements that ... ...

Abstract	The presentation summarizes the results of two years of oral history research. The aim of the research was to record the recollections of the still living eyewitnesses of the events in the fall of 1944 in Cluj and its surroundings, in settlements that belonged to the southern part of Transylvania during World War II. Several hours of interviews were made in the villages of the regions of Ţara Călatei (Kalotaszeg) and the Transylvanian Plain (Mezőség), and the lecture presents a synthesis of these interviews. They address issues like deportation, atrocities, fleeing, arm usage, Soviet and Romanian detention camps, adventurous escapes, etc.
Keywords	transylvania ; romanians ; hungarians ; ethnicity ; ww2 ; traumas ; injuries ; requisition ; interning ; forced-labour camps ; Political science ; J
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Book ; Online: State machine inference of QUIC

Rasool, Abdullah / Alpár, Greg / de Ruiter, Joeri

2019

Abstract: QUIC is a recent transport protocol that provides reliable, secure and quick service on top of UDP in the internet. As QUIC is implemented in the application space rather than in the operating system's kernel, it is more efficient to dynamically develop ... ...

Abstract	QUIC is a recent transport protocol that provides reliable, secure and quick service on top of UDP in the internet. As QUIC is implemented in the application space rather than in the operating system's kernel, it is more efficient to dynamically develop and roll out. Currently, there are two parallel specifications, one by Google and one by IETF, and there are a few implementations. In this paper, we show how state machine inference can be applied to automatically extract the state machine corresponding to the protocol from an implementation. In particular, we infer the model of Google's QUIC server. This is done using a black-box technique, making it usable on any implementation of the protocol, regardless of, for example, the programming language the code is written in or the system the QUIC server runs on. This makes it a useful tool for testing and specification purposes, and to make various (future) implementations more easily comparable. Comment: 13 pages, 4 figures
Keywords	Computer Science - Networking and Internet Architecture
Publishing date	2019-03-11
Publishing country	us
Document type	Book ; Online
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