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  1. Article ; Online: Assaying Interactions Between Neutrophils and Plasmodium falciparum-Infected Red Blood Cells.

    Zelter, Tamir / Granot, Zvi / Dzikowski, Ron

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2470, Page(s) 629–639

    Abstract: Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the ... ...

    Abstract Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the adaptive immune response in the course of malaria. However, in recent years there is mounting evidence for the role of the innate immune response to Plasmodium infections. In this context, very little is known on the protective role of neutrophils against blood-stage parasites and the mechanisms by which they recognize and eliminate infected red blood cells. Here we describe several useful methodologies that enable the study and quantification of the interactions between human neutrophils and P. falciparum-infected red blood cells.
    MeSH term(s) Erythrocytes ; Humans ; Malaria ; Malaria, Falciparum/parasitology ; Neutrophils ; Plasmodium falciparum
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2189-9_47
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Principles in health policy during the SARS-CoV-2 outbreak - major lessons from South East-Asia].

    Zelter, Tamir / Bader, Tarif / Glassberg, Elon / Twig, Gilad

    Harefuah

    2020  Volume 159, Issue 4, Page(s) 229–230

    MeSH term(s) Asia, Southeastern ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Health Policy ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language Hebrew
    Publishing date 2020-08-14
    Publishing country Israel
    Document type News
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 291: Show issues Location:
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  3. Article ; Online: Risk of hospitalization with sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes lacking evidence of chronic kidney disease: Real-world data.

    Schechter, Meir / Melzer Cohen, Cheli / Zelter, Tamir / Yanuv, Ilan / Rozenberg, Aliza / Chodick, Gabriel / Karasik, Avraham / Mosenzon, Ofri

    Diabetes, obesity & metabolism

    2023  Volume 25, Issue 10, Page(s) 3054–3058

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/epidemiology ; Hospitalization ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Glucose ; Sodium
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15172
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    Zs.A 5442: Show issues Location:
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  5. Article ; Online: The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer.

    Yajuk, Olga / Baron, Maya / Toker, Sapir / Zelter, Tamir / Fainsod-Levi, Tanya / Granot, Zvi

    Cells

    2021  Volume 10, Issue 6

    Abstract: The PD-L1/PD-1 axis mediates immune tolerance and promotes tumor growth and progression via the inhibition of anti-tumor immunity. Blocking the interaction between PD-L1 and PD-1 was clinically shown to be beneficial in maintaining the anti-tumor ... ...

    Abstract The PD-L1/PD-1 axis mediates immune tolerance and promotes tumor growth and progression via the inhibition of anti-tumor immunity. Blocking the interaction between PD-L1 and PD-1 was clinically shown to be beneficial in maintaining the anti-tumor functions of the adaptive immune system. Still, the consequences of blocking the PD-L1/PD-1 axis on innate immune responses remain largely unexplored. In this context, neutrophils were shown to consist of distinct subpopulations, which possess either pro- or anti-tumor properties. PD-L1-expressing neutrophils are considered pro-tumor as they are able to suppress cytotoxic T cells and are propagated with disease progression. That said, we found that PD-L1 expression is not limited to tumor promoting neutrophils, but is also evident in anti-tumor neutrophils. We show that neutrophil cytotoxicity is effectively and efficiently blocked by tumor cell-expressed PD-1. Furthermore, the blocking of either neutrophil PD-L1 or tumor cell PD-1 maintains neutrophil cytotoxicity. Importantly, we show that tumor cell PD-1 blocks neutrophil cytotoxicity and promotes tumor growth via a mechanism independent of adaptive immunity. Taken together, these findings highlight the therapeutic potential of enhancing anti-tumor innate immune responses via blocking of the PD-L1/PD-1 axis.
    MeSH term(s) Adaptive Immunity ; Animals ; B7-H1 Antigen/metabolism ; B7-H1 Antigen/physiology ; Cell Line, Tumor ; Female ; Humans ; Immune Tolerance ; Immunity, Innate ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Neoplasms/metabolism ; Neoplasms/pathology ; Neutrophils/metabolism ; Neutrophils/physiology ; Programmed Cell Death 1 Receptor/metabolism ; Programmed Cell Death 1 Receptor/physiology
    Chemical Substances B7-H1 Antigen ; Cd274 protein, mouse ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10061510
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  6. Article ; Online: Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria.

    Zelter, Tamir / Strahilevitz, Jacob / Simantov, Karina / Yajuk, Olga / Adams, Yvonne / Ramstedt Jensen, Anja / Dzikowski, Ron / Granot, Zvi

    EMBO reports

    2022  Volume 23, Issue 6, Page(s) e53641

    Abstract: Plasmodium falciparum, the deadliest form of human malaria, remains one of the major threats to human health in endemic regions. Its virulence is attributed to its ability to modify infected red blood cells (iRBC) to adhere to endothelial receptors by ... ...

    Abstract Plasmodium falciparum, the deadliest form of human malaria, remains one of the major threats to human health in endemic regions. Its virulence is attributed to its ability to modify infected red blood cells (iRBC) to adhere to endothelial receptors by placing variable antigens known as PfEMP1 on the iRBC surface. PfEMP1 expression determines the cytoadhesive properties of the iRBCs and is implicated in severe malaria. To evade antibody-mediated responses, the parasite undergoes continuous switches of expression between different PfEMP1 variants. Recently, it became clear that in addition to antibody-mediated responses, PfEMP1 triggers innate immune responses; however, the role of neutrophils, the most abundant white blood cells in the human circulation, in malaria remains elusive. Here, we show that neutrophils recognize and kill blood-stage P. falciparum isolates. We identify neutrophil ICAM-1 and specific PfEMP1 implicated in cerebral malaria as the key molecules involved in this killing. Our data provide mechanistic insight into the interactions between neutrophils and iRBCs and demonstrate the important influence of PfEMP1 on the selective innate response to cerebral malaria.
    MeSH term(s) Erythrocytes/parasitology ; Humans ; Malaria, Cerebral/genetics ; Malaria, Cerebral/metabolism ; Malaria, Falciparum/genetics ; Neutrophils/metabolism ; Plasmodium falciparum/genetics ; Plasmodium falciparum/physiology ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202153641
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 41: Show issues

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  7. Article ; Online: The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer

    Olga Yajuk / Maya Baron / Sapir Toker / Tamir Zelter / Tanya Fainsod-Levi / Zvi Granot

    Cells, Vol 10, Iss 1510, p

    2021  Volume 1510

    Abstract: The PD-L1/PD-1 axis mediates immune tolerance and promotes tumor growth and progression via the inhibition of anti-tumor immunity. Blocking the interaction between PD-L1 and PD-1 was clinically shown to be beneficial in maintaining the anti-tumor ... ...

    Abstract The PD-L1/PD-1 axis mediates immune tolerance and promotes tumor growth and progression via the inhibition of anti-tumor immunity. Blocking the interaction between PD-L1 and PD-1 was clinically shown to be beneficial in maintaining the anti-tumor functions of the adaptive immune system. Still, the consequences of blocking the PD-L1/PD-1 axis on innate immune responses remain largely unexplored. In this context, neutrophils were shown to consist of distinct subpopulations, which possess either pro- or anti-tumor properties. PD-L1-expressing neutrophils are considered pro-tumor as they are able to suppress cytotoxic T cells and are propagated with disease progression. That said, we found that PD-L1 expression is not limited to tumor promoting neutrophils, but is also evident in anti-tumor neutrophils. We show that neutrophil cytotoxicity is effectively and efficiently blocked by tumor cell-expressed PD-1. Furthermore, the blocking of either neutrophil PD-L1 or tumor cell PD-1 maintains neutrophil cytotoxicity. Importantly, we show that tumor cell PD-1 blocks neutrophil cytotoxicity and promotes tumor growth via a mechanism independent of adaptive immunity. Taken together, these findings highlight the therapeutic potential of enhancing anti-tumor innate immune responses via blocking of the PD-L1/PD-1 axis.
    Keywords neutrophils ; cancer ; metastasis ; PD-1 ; PD-L1 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.

    Sionov, Ronit Vogt / Fainsod-Levi, Tanya / Zelter, Tamir / Polyansky, Lola / Pham, Christine T / Granot, Zvi

    Oncoimmunology

    2019  Volume 8, Issue 9, Page(s) e1624129

    Abstract: Neutrophils are a heterogeneous population of myeloid cells which may either promote or hinder tumor growth and progression. Anti-tumor neutrophils have the capacity to kill tumor cells in a contact-dependent manner. However, the molecular mechanisms ... ...

    Abstract Neutrophils are a heterogeneous population of myeloid cells which may either promote or hinder tumor growth and progression. Anti-tumor neutrophils have the capacity to kill tumor cells in a contact-dependent manner. However, the molecular mechanisms underlying tumor cell recognition by neutrophils remained unexplored. Tumor cells were shown to express aberrant glycosylation patterns and neutrophils are equipped with receptors capable of recognizing such glycosylations. Accordingly, we hypothesized that the receptor for advanced glycation end products (RAGE) may facilitate neutrophil recognition of tumor cells. Indeed, RAGE decoy receptors and RAGE-specific blocking antibodies dramatically reduce tumor cell susceptibility to neutrophil cytotoxicity. Unexpectedly, we found that tumor cell RAGE rather than neutrophil RAGE is important for the killing process. We further identified neutrophil Cathepsin G as the neutrophil component interacting with tumor cell RAGE. Cathepsin G-deficient neutrophils show impaired ability to kill tumor cells, suggesting that RAGE-Cathepsin G interaction is required for neutrophil cytotoxicity. These data unravel new aspects of neutrophil anti-tumor activity and identify a novel role for RAGE and Cathepsin G in neutrophil-mediated cytotoxicity.
    Language English
    Publishing date 2019-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2019.1624129
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  9. Article ; Online: TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression.

    Gershkovitz, Maya / Fainsod-Levi, Tanya / Zelter, Tamir / Sionov, Ronit V / Granot, Zvi

    Cancer immunology, immunotherapy : CII

    2018  Volume 68, Issue 1, Page(s) 33–43

    Abstract: In recent years, immune cells were shown to play critical roles in tumor growth and metastatic progression. In this context, neutrophils were shown to possess both pro- and anti-tumor properties. To exert their anti-tumor effect, neutrophils need to ... ...

    Abstract In recent years, immune cells were shown to play critical roles in tumor growth and metastatic progression. In this context, neutrophils were shown to possess both pro- and anti-tumor properties. To exert their anti-tumor effect, neutrophils need to migrate towards, and form physical contact with tumor cells. Neutrophils secrete H
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Movement/immunology ; Chemokine CXCL2/genetics ; Chemokine CXCL2/immunology ; Chemokine CXCL2/metabolism ; Chemotaxis, Leukocyte/immunology ; Coculture Techniques ; Cytotoxicity, Immunologic/immunology ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Mice, Inbred BALB C ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neutrophils/cytology ; Neutrophils/immunology ; RNA Interference/immunology ; TRPM Cation Channels/genetics ; TRPM Cation Channels/immunology ; TRPM Cation Channels/metabolism
    Chemical Substances Chemokine CXCL2 ; Cxcl2 protein, mouse ; TRPM Cation Channels ; TRPM2 protein, mouse
    Language English
    Publishing date 2018-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-018-2249-2
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