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Article: [Pharmacokinetics of mercury after oral administration of cinnabaris and Fufang Niuhuang Xiaoyan capsule in rats].

Song, Xiao-Ni / Lu, Yu-Ting / Yang, Dan-Yi / Wang, Sheng / Hang, Tai-Jun / Song, Min

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2017 Volume 42, Issue 14, Page(s) 2779–2783

Abstract: Fufang Niuhuang Xiaoyan capsule was a classical compound prescription with the efficacy of heat ... Fufang Niuhuang Xiaoyan capsule, in order to explore the effect of combined traditional Chinese medicines ... blood of rats. Fufang Niuhueng Xiaoyan capsule had three dose schemes of oral administration, namely ...

Abstract	Fufang Niuhuang Xiaoyan capsule was a classical compound prescription with the efficacy of heat-clearing, detoxification, sedation and anti-inflammation, with cinnabaris as one of its active ingredients. The study focuses on the pharmacokinetics of mercury in rats after oral administration of cinnabaris and Fufang Niuhuang Xiaoyan capsule, in order to explore the effect of combined traditional Chinese medicines on mercury metabolism. In this study, the method of nitric-perchloric acid digestion system coupled with cold atomic-atomic fluorescence spectroscopy (CV-AFS) was adopted to accurately determine mercury in whole blood of rats. Fufang Niuhueng Xiaoyan capsule had three dose schemes of oral administration, namely equivalent clinical dose, 3 times of equivalent clinical dose and 10 times of equivalent clinical dose; And the doses of oral administration of cinnabaris was calculated according to that of Fufang Niuhuang Xiaoyan capsule. SPF grade healthy SD rats were fasted overnight before the oral administration with cinnabaris suspension (or Fufang Niuhuang Xiaoyan capsule suspension). After oral administration of different doses of cinnabaris, no obvious changes in tmax and MRT were observed, while Cmax/dose, AUC0-48 h/dose and AUC0-∞/dose decreased with the increase in dose, indicating that total mercury absorption in body was declining. As the dose increased, Ke, CL/F decreased, and t1/2 increased, indicating that the elimination slowed down, and mercury metabolism showed non-linear dynamic characteristics within a certain range of dose (22-220 mg•kg⁻¹). The total mercury metabolism in the whole blood of rats after oral administration with different doses of Fufang Niuhuang Xiaoyan capsule also showed non-linear dynamic characteristics. The results were correlated with the low solubility of cinnabaris in the body. Compared with cinnabaris, Fufang Niuhuang Xiaoyan capsule showed no obvious changes in V/F and MRT, while Ke, CL/F, tmax decreased, and t1/2, Cmax/dose, AUC0-48 h/dose, AUC0-∞/dose increased significantly. The results showed that Fufang Niuhuang Xiaoyan capsule accelerated absorption, slowed down elimination and improved the total absorption of mercury in the whole blood, indicating that Fufang Niuhuang Xiaoyan capsule may contain components for promoting absorption and alleviating elimination of mercury. Fufang Niuhuang Xiaoyan capsule had an impact on the pharmacokinetics of cinnabaris, and long-term administration of cinnabaris (Fufang Niuhuang Xiaoyan capsule) was possible to cause accumulation of mercury in the body. This study could explain changes in efficacy of Fufang Niuhuang Xiaoyan capsule, evaluate the rationality of compound medicines containing toxic elements and provide scientific basis for the rational and safe use of Fufang Niuhuang Xiaoyan capsule.
MeSH term(s)	Administration, Oral ; Animals ; Area Under Curve ; Biological Products/administration & dosage ; Drugs, Chinese Herbal/administration & dosage ; Mercury/pharmacokinetics ; Mercury Compounds/administration & dosage ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Biological Products ; Drugs, Chinese Herbal ; Mercury Compounds ; niuhuang (4162LZ0N4O) ; Mercury (FXS1BY2PGL) ; cinnabar (ZI0T668SF1)
Language	Chinese
Publishing date	2017-10-06
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20170524.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3056: Show issues

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Book ; Online: Electromyography (EMG) Techniques for the Assessment and Rehabilitation of Motor Impairment Following Stroke

Klein, Cliff S. / Li, Sheng / Hu, Xiaogang / Li, Xiaoyan

2019

Keywords	Medicine ; Neurology & clinical neurophysiology ; electromyography ; MUSC ; motor ; rehabilitation ; stroke
Size	1 electronic resource (205 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021229838
ISBN	9782889458530 ; 2889458539
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Volatile aroma compounds of passion fruit seed Oils: HS-GC-IMS analysis and interpretation.

Zheng, Lili / Wang, Shenwan / Yang, Yang / Zheng, Xiaoyan / Xiao, Dao / Ai, Binling / Sheng, Zhanwu

Food chemistry: X

2024 Volume 21, Page(s) 101212

Abstract: The physicochemical properties, fatty acid composition and volatile aroma compounds of cold-pressed passion fruit seed oils were analyzed. The oils were rich in linoleic acid, oleic acid and volatile compounds. A total of 108 volatile compounds including ...

Abstract	The physicochemical properties, fatty acid composition and volatile aroma compounds of cold-pressed passion fruit seed oils were analyzed. The oils were rich in linoleic acid, oleic acid and volatile compounds. A total of 108 volatile compounds including 17 aldehydes, 23 alcohols, 21 esters, 19 ketones, 6 acids, 9 alkenes, 5 pyrazines and 8 others were identified using HS-GC-IMS. The significant differences of volatile compounds in the purple and yellow passion fruit seed oils were observed via the GalleryPlot graph and distinguished by principal component analysis. The results showed that acids, alcohols, esters and ketones were major aromatic compounds in purple passion fruit seed oils, which contribute to flavors such as flowery, fruity, creamy, yogurt. Whereas the contents of aldehydes, pyrazines, alkenes were higher in yellow passion fruit seed oils, which contributes to fatty and nutty odors. The findings filled in our understanding of volatilization characteristics in passion fruit seed oils.
Language	English
Publishing date	2024-02-09
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2024.101212
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Article ; Online: Current Perspectives of Immunotherapy for Hepatocellular Carcinoma.

Liu, Xiaoyi / Lei, Xiaoyong / Huang, Sheng / Yang, Xiaoyan

Combinatorial chemistry & high throughput screening

2023

Abstract: Hepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. ... ...

Abstract	Hepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, which can prevent recurrence. So, immunotherapy of hepatocellular carcinoma is increasingly becoming a research hotspot in liver cancer treatment. With the intensive research in recent years, great progress has been made in immunotherapy for hepatocellular carcinoma, including immune checkpoint inhibitors, pericyte therapy, vaccination, and antiviral therapy. In addition, the study found that the therapeutic effect of combination therapy was enhanced compared to monotherapy. This review summarizes the most prominent immunotherapies currently available for the clinical treatment of patients with HCC and the main opportunities and challenges facing HCC research.
Language	English
Publishing date	2023-11-29
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073255266231025111125
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Zs.A 5577: Show issues

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Article ; Online: The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells.

Zhang, Xiaoyan / Zhang, Meng / Sun, Hui / Wang, Xu / Wang, Xin / Sheng, Weiqi / Xu, Midie

Journal of advanced research

2024

Abstract: Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status ... ...

Abstract	Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. Despite a subgroup of CAFs exhibit anti-cancer effects, most of them are reported to exert effects on tumor progression, further indicating their heterogeneous origin. Aim of review: This review aimed to summarize and review the roles of TFs in the reciprocal crosstalk between CAFs and tumor cells, discuss the emerging mechanisms, and their roles in cell-fate decision, cellular reprogramming and advancing our understanding of the gene regulatory networks over the period of cancer initiation and progression. Key scientific concepts of review: This manuscript delves into the key contributory factors of TFs that are involved in activating CAFs and maintaining their unique states. Additionally, it explores how TFs play a pivotal and multifaceted role in the reciprocal crosstalk between CAFs and tumor cells. This includes their involvement in processes such as epithelial-mesenchymal transition (EMT), proliferation, invasion, and metastasis, as well as metabolic reprogramming. TFs also have a role in constructing an immunosuppressive microenvironment, inducing resistance to radiation and chemotherapy, facilitating angiogenesis, and even 'educating' CAFs to support the malignancies of tumor cells. Furthermore, this manuscript delves into the current status of TF-targeted therapy and considers the future directions of TFs in conjunction with anti-CAFs therapies to address the challenges in clinical cancer treatment.
Language	English
Publishing date	2024-02-02
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2024.01.033
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Article ; Online: Dielectric barrier discharge cold plasma modifies the multiscale structure and functional properties of banana starch.

Liang, Yonglun / Zheng, Lili / Yang, Yang / Zheng, Xiaoyan / Xiao, Dao / Ai, Binling / Sheng, Zhanwu

International journal of biological macromolecules

2024 Volume 264, Issue Pt 1, Page(s) 130462

Abstract: Banana starch has attracted significant attention due to its abundant content of resistant starch. This study aims to compare the multiscale structure and functional properties of banana starch obtained from five cultivated varieties and investigate the ... ...

Abstract	Banana starch has attracted significant attention due to its abundant content of resistant starch. This study aims to compare the multiscale structure and functional properties of banana starch obtained from five cultivated varieties and investigate the impact of dielectric barrier discharge cold plasma (DBD) treatment on these starch characteristics. All five types of natural banana starch exhibited an elliptical and irregular shape, conforming to the CB crystal structure, with a bimodal distribution of branch chain lengths. The resistant starch content ranged from 88.9 % to 94.1 %. Variations in the amylose content, amylopectin branch chain length distribution, and structural characteristics resulted in differences in properties such as gelatinization behavior and sensitivity to DBD treatment. The DBD treatment inflicted surface damage on starch granules, reduced the amylose content, shortened the amylopectin branch chain length, and changed the relative crystallinity to varying degrees. The DBD treatment significantly increased starch solubility and light transmittance. Simultaneously, it resulted in a noteworthy decrease in peak viscosity and gelatinization enthalpy of starch paste. The in vitro digestibility test showed that 76.2 %-86.5 % of resistant starch was retained after DBD treatment. The DBD treatment renders banana starch with reduced viscosity, increased paste transparency, enhanced solubility, and broadens its potential application.
MeSH term(s)	Starch/chemistry ; Amylopectin/chemistry ; Amylose/chemistry ; Musa/chemistry ; Plasma Gases/chemistry ; Resistant Starch ; Viscosity
Chemical Substances	Starch (9005-25-8) ; Amylopectin (9037-22-3) ; Amylose (9005-82-7) ; Plasma Gases ; Resistant Starch
Language	English
Publishing date	2024-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130462
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Zs.B 2374: Show issues

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Article ; Online: Synthesis of Bis(silylene) Iron Chlorides and Their Catalytic Activity for Dinitrogen Silylation.

Yang, Wenjing / Li, Xiaomiao / Li, Sheng-Yong / Li, Qingshuang / Sun, Hongjian / Li, Xiaoyan

Inorganic chemistry

2023 Volume 62, Issue 51, Page(s) 21014–21024

Abstract: In this study, three tetracoordinated bis(silylene) iron(II) chlorides, namely, [SiCHRSi] ... ...

Abstract	In this study, three tetracoordinated bis(silylene) iron(II) chlorides, namely, [SiCHRSi]FeCl
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c02445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum to: Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke.

Chen, Maoqi / Lu, Zhiyuan / Li, Xiaoyan / Zong, Ya / Xie, Qing / Li, Sheng / Zhou, Ping

Science China. Life sciences

2023 Volume 66, Issue 11, Page(s) 2700

Language	English
Publishing date	2023-08-25
Publishing country	China
Document type	Published Erratum
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-023-2428-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR/Cas9 mutants delineate roles of Populus FT and TFL1/CEN/BFT family members in growth, dormancy release and flowering.

Sheng, Xiaoyan / Mahendra, R Ayeshan / Wang, Chieh-Ting / Brunner, Amy M

Tree physiology

2023 Volume 43, Issue 6, Page(s) 1042–1054

Abstract: Vegetative and reproductive phase change and phenology are economically and ecologically important traits. Trees typically require several years of growth before flowering and, once mature, seasonal control of the transition to flowering and flower ... ...

Abstract	Vegetative and reproductive phase change and phenology are economically and ecologically important traits. Trees typically require several years of growth before flowering and, once mature, seasonal control of the transition to flowering and flower development is necessary to maintain vegetative meristems and for reproductive success. Members of two related gene subfamilies, FLOWERING LOCUST (FT) and TERMINAL FLOWER1 (TFL1)/CENTRORADIALIS (CEN)/BROTHER OF FT AND TFL1 (BFT), have antagonistic roles in flowering in diverse species and roles in vegetative phenology in trees, but many details of their functions in trees have yet to be resolved. Here, we used CRISPR/Cas9 to generate single and double mutants involving the five Populus FT and TFL1/CEN/BFT genes. The ft1 mutants exhibited wild-type-like phenotypes in long days and short days, but after chilling, to release dormancy, they showed delayed bud flush and GA3 could compensate for the ft1 mutation. After rooting and generating some phytomers in tissue culture, both cen1 and cen1ft1 mutants produced terminal as well as axillary flowers, indicating that the cen1 flowering phenotype is independent of FT1. The CEN1 showed distinct circannual expression patterns in vegetative and reproductive tissues and comparison with the expression patterns of FT1 and FT2 suggests that the relative levels of CEN1 compared with FT1 and FT2 regulate multiple phases of vegetative and reproductive seasonal development.
MeSH term(s)	Plant Proteins/metabolism ; Populus/metabolism ; CRISPR-Cas Systems ; Flowers ; Meristem/genetics ; Gene Expression Regulation, Plant
Chemical Substances	Plant Proteins
Language	English
Publishing date	2023-03-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpad027
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Z 4737: Show issues

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Article: Functional Diversification of

Sheng, Xiaoyan / Hsu, Chuan-Yu / Ma, Cathleen / Brunner, Amy M

Frontiers in plant science

2022 Volume 13, Page(s) 805101

Abstract: Both the evolution of tree taxa and whole-genome duplication (WGD) have occurred many times during angiosperm evolution. Transcription factors are preferentially retained following WGD suggesting that functional divergence of duplicates could contribute ... ...

Abstract	Both the evolution of tree taxa and whole-genome duplication (WGD) have occurred many times during angiosperm evolution. Transcription factors are preferentially retained following WGD suggesting that functional divergence of duplicates could contribute to traits distinctive to the tree growth habit. We used gain- and loss-of-function transgenics, photoperiod treatments, and circannual expression studies in adult trees to study the diversification of three
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.805101
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