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  1. Article ; Online: Current and future options in cholesterol lowering treatments.

    Elis, Avishay

    European journal of internal medicine

    2023  Volume 112, Page(s) 1–5

    Abstract: The relative risk reduction of cardiovascular events is proportional to the absolute reduction in LDL-C levels, the primary target of therapy, no matter the way of reduction. During the last decades, the therapeutic regimens for reducing the LDL-C levels ...

    Abstract The relative risk reduction of cardiovascular events is proportional to the absolute reduction in LDL-C levels, the primary target of therapy, no matter the way of reduction. During the last decades, the therapeutic regimens for reducing the LDL-C levels have been immerged and improved, with favorable effects on the atherosclerotic process and clinical benefits of various cardiovascular outcomes. From a practical view of point, this review is focusing only on the current available lipid lowering agents: statins, ezetimibe, anti PCSK9 monoclonal antibodies, the small interfering RNA (siRNA) agent, Inclisiran, and Bempedoic acid. The recent changes in lipid lowering regimens, including the early combination of lipid lowering agents and "Low LDL-C" levels <30 mg/dL for high/very high cardiovascular risk patients will also be discussed.
    MeSH term(s) Humans ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Cholesterol ; Ezetimibe/therapeutic use ; Drug Therapy, Combination ; Anticholesteremic Agents/therapeutic use ; Anticholesteremic Agents/adverse effects ; Proprotein Convertase 9/genetics
    Chemical Substances Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J) ; Ezetimibe (EOR26LQQ24) ; Anticholesteremic Agents ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2023-02-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HbA1c% level patterns as a marker for malignancy in diabetic patients.

    Rotkopf, Adi / Giladi, Ela / Elis, Avishay

    European journal of internal medicine

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.02.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Welcome to the World of Israeli Internal Medicine.

    Amital, Howard / Elis, Avishay

    The Israel Medical Association journal : IMAJ

    2022  Volume 24, Issue 11, Page(s) 693–694

    MeSH term(s) Humans ; Israel ; Internal Medicine
    Language English
    Publishing date 2022-11-26
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Real-World Use of Alirocumab

    Avishay Elis / Cheli Melzer Cohen / Gabriel Chodick

    Journal of Clinical Medicine, Vol 12, Iss 1084, p

    Experience from a Large Healthcare Provider

    2023  Volume 1084

    Abstract: With the emerging use of anti-PCSK9 monoclonal antibodies for lowering low-density lipoprotein cholesterol (LDL-C) levels, real-world evidence (RWE) is needed to evaluate drug effectiveness. This study aimed to characterize new users of alirocumab and ... ...

    Abstract With the emerging use of anti-PCSK9 monoclonal antibodies for lowering low-density lipoprotein cholesterol (LDL-C) levels, real-world evidence (RWE) is needed to evaluate drug effectiveness. This study aimed to characterize new users of alirocumab and evaluate its effectiveness in achieving LDL-C target levels. Included were patients initiating treatment with alirocumab from 1 August 2016 to 1 May 2020, with blood lipids evaluations during baseline (180 days prior to therapy initiation) and after 120 (±60) days of follow-up. Patients with treatment intensification during the follow-up period were excluded. LDL-C change from baseline and reaching LDL-C target levels, according to 2019 ESC/EAS guidelines, were evaluated. Among 623 included patients, 50.2% were men, the mean age was 65 years (±9 y), 62% were classified as very-high risk, and 76% had statin intolerance. During the follow-up, 65% (n = 407) were treated only with alirocumab. In 90% the initiation dose was 75 mg, and 21% were up-titrated. Alirocumab was associated with a 31.7% reduction in LDL-C, with 20.5% of patients reaching target levels. In this RWE study, alirocumab was used primarily as a single agent for eligible patients. Suboptimal use and adherence to therapy may have led to a lower LDL-C reduction compared to previous RCTs and most reported real-world studies.
    Keywords real-world evidence ; alirocumab ; anti-PCSK9 monoclonal antibodies ; target levels ; LDL-C ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Real-World Use of Alirocumab: Experience from a Large Healthcare Provider.

    Elis, Avishay / Melzer Cohen, Cheli / Chodick, Gabriel

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: With the emerging use of anti-PCSK9 monoclonal antibodies for lowering low-density lipoprotein cholesterol (LDL-C) levels, real-world evidence (RWE) is needed to evaluate drug effectiveness. This study aimed to characterize new users of alirocumab and ... ...

    Abstract With the emerging use of anti-PCSK9 monoclonal antibodies for lowering low-density lipoprotein cholesterol (LDL-C) levels, real-world evidence (RWE) is needed to evaluate drug effectiveness. This study aimed to characterize new users of alirocumab and evaluate its effectiveness in achieving LDL-C target levels. Included were patients initiating treatment with alirocumab from 1 August 2016 to 1 May 2020, with blood lipids evaluations during baseline (180 days prior to therapy initiation) and after 120 (±60) days of follow-up. Patients with treatment intensification during the follow-up period were excluded. LDL-C change from baseline and reaching LDL-C target levels, according to 2019 ESC/EAS guidelines, were evaluated. Among 623 included patients, 50.2% were men, the mean age was 65 years (±9 y), 62% were classified as very-high risk, and 76% had statin intolerance. During the follow-up, 65% (n = 407) were treated only with alirocumab. In 90% the initiation dose was 75 mg, and 21% were up-titrated. Alirocumab was associated with a 31.7% reduction in LDL-C, with 20.5% of patients reaching target levels. In this RWE study, alirocumab was used primarily as a single agent for eligible patients. Suboptimal use and adherence to therapy may have led to a lower LDL-C reduction compared to previous RCTs and most reported real-world studies.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031084
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  6. Article: The Treatment of Venous Thromboembolism in the Emergency Department in the DOACs Era.

    Osman, Ibrahim / Atamna, Alaa / Elis, Avishay

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 11, Page(s) 734–740

    Abstract: Background: Low-risk venous thromboembolism (VTE) patients are advised to be discharged from the emergency department (ED) on direct oral anticoagulants (DOACs) treatment. There is no data on whether this recommendation is followed in Israel.: ... ...

    Abstract Background: Low-risk venous thromboembolism (VTE) patients are advised to be discharged from the emergency department (ED) on direct oral anticoagulants (DOACs) treatment. There is no data on whether this recommendation is followed in Israel.
    Objectives: To characterize newly diagnosed VTE patients who were discharged from the ED, their anticoagulation treatment at the ED, the recommended discharge protocol, and patient adherence.
    Methods: We conducted a retrospective cohort study, which included all newly diagnosed VTE patients who were discharged from the ED. Collected data included demographic and clinical background; anticoagulation treatment at the ED, recommended discharge protocol and its subsequent adherence, patient subsequent, recommended hematological evaluation, and adverse events.
    Results: The study group included 443 patients, 89% with deep vein thrombosis (DVT). Approximately three-quarters were treated with anticoagulants in the ED, 98% with enoxaparin. At discharge, anticoagulants were recommended for all; 49% continued enoxaparin, 47% DOACs, and 4% warfarin. After 4 weeks, 67% were treated with DOACs, 22% with enoxaparin, 5% with warfarin. Approximately 6% discontinued all treatment. After 12 weeks, 90% of the patients who were taking DOACs adhered to the protocol, whereas only 70% and 50% among the enoxaparin and warfarin users, respectively, did. Only 56% were referred for hematological evaluation. The 12-week rate of adverse reactions was approximately 2%. The use of DOACs and the recommendation for further hematological evaluation increased over time.
    Conclusions: Clinician training regarding discharge of VTE patients from the ED should continue.
    MeSH term(s) Humans ; Venous Thromboembolism/drug therapy ; Enoxaparin/adverse effects ; Warfarin/adverse effects ; Retrospective Studies ; Emergency Service, Hospital ; Anticoagulants/adverse effects
    Chemical Substances Enoxaparin ; Warfarin (5Q7ZVV76EI) ; Anticoagulants
    Language English
    Publishing date 2023-11-19
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Congestive Heart Failure at the Department of Medicine: Demographic and Clinical Characteristics.

    Elis, Avishay / Giladi, Ella / Raiyan, Ahmad / Atamna, Alaa

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 9, Page(s) 622–626

    Abstract: Background: Congestive heart failure (CHF) with reduced ejection fraction (HFrEF) or with preserved ejection fraction (HFpEF) is a common diagnosis in patients hospitalized in the department of internal medicine. Recently, the therapeutic regimens were ... ...

    Abstract Background: Congestive heart failure (CHF) with reduced ejection fraction (HFrEF) or with preserved ejection fraction (HFpEF) is a common diagnosis in patients hospitalized in the department of internal medicine. Recently, the therapeutic regimens were updated, as the sodium-glucose cotransporter-2 (SGLT2) inhibitors became an integral part of the therapeutic regimen for either HFrEF or HFpEF.
    Objectives: To define the demographic and clinical characteristics of CHF patients hospitalized in the department of medicine.
    Methods: We conducted a retrospective cohort study that included all patients hospitalized in the departments of medicine at the Rabin Medical Center, Israel, between 2016 and 2019. Demographic and clinical background, in-hospital procedures, discharge regimens, and outcome parameters were evaluated according to HFrEF/HFpEF.
    Results: The cohort included 4458 patients. The majority (97%) presented with a preexisting diagnosis, whereas HF was an active condition in only half of them. The rates of HFrEF/HFpEF were equal. In most cases, the trigger of the exacerbation could not be determined; however, infection was the most common cause. There were basic differences in the demography, clinical aspects, and therapeutic regimens at discharge between HFrEF and HFpEF. Both conditions were associated with high in hospital mortality (8%) and re-admissions rates (30 days [20%], 90 days [35%]) without any difference between them.
    Conclusions: HFrEF/HFpEF patients differed by demographics and co-morbidities. They were equally represented among patients admitted to medical wards and had similar prognosis. For both diagnoses, hospitalization should be considered for updating therapeutic regimens, especially with SGLT2 inhibitors.
    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Retrospective Studies ; Stroke Volume ; Internal Medicine ; Hospital Mortality
    Language English
    Publishing date 2023-08-31
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Diagnosis of Antiphospholid Syndrome Uncovered Co-occurrence of Myelodysplastic Syndrome: A Case Report.

    Giladi, Ela / Rotkopf, Adi / Elis, Avishay

    The Israel Medical Association journal : IMAJ

    2022  Volume 24, Issue 11, Page(s) 785–786

    MeSH term(s) Humans ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnosis
    Language English
    Publishing date 2022-11-23
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: [RESEARCH AND CLINICAL PRACTICE- THE SOUL AND BREATH OF INTERNAL MEDICINE].

    Elis, Avishay / Amital, Howard

    Harefuah

    2021  Volume 160, Issue 8, Page(s) 486–487

    Abstract: Background: We welcome the readers of Harefuah to the following issue that deals with the research and clinical practice that was carried out in this challenging year of the COVID-19 pandemic. Despite the high hospitalization rates throughout the ... ...

    Abstract Background: We welcome the readers of Harefuah to the following issue that deals with the research and clinical practice that was carried out in this challenging year of the COVID-19 pandemic. Despite the high hospitalization rates throughout the country in these times, our clinicians found the spirit to continue and conduct their research activities. The following issue presents the essence of the good clinical practice along with interesting research outcomes.
    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Internal Medicine ; Pandemics ; SARS-CoV-2
    Language Hebrew
    Publishing date 2021-08-16
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 291: Show issues Location:
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  10. Article ; Online: The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage

    Chen Gurevitz / Eitan Auriel / Avishay Elis / Ran Kornowski

    Journal of Clinical Medicine, Vol 11, Iss 536, p

    Cause for Concern?

    2022  Volume 536

    Abstract: Excessive levels of low-density lipoprotein cholesterol (LDL-C) in the blood are a known risk factor for atherosclerosis, and a common target of treatment for primary and secondary prevention of cerebrocardiovascular disease. As lipid lowering agents ... ...

    Abstract Excessive levels of low-density lipoprotein cholesterol (LDL-C) in the blood are a known risk factor for atherosclerosis, and a common target of treatment for primary and secondary prevention of cerebrocardiovascular disease. As lipid lowering agents including statins, ezetimibe and anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have shown good therapeutic results, the guidelines are constantly lowering the “optimal” LDL-C goals. However, old and new data point towards an association between low LDL-C and total cholesterol and intracerebral hemorrhage (ICH). In this review we aimed to shed light on this troubling association and identify the potential risk factors of such a potential adverse reaction. With respect to the data presented, we concluded that in patients with high risk of ICH, a cautious approach and individualized therapy strategy are advised when considering aggressive LDL reduction.
    Keywords low-density lipoprotein cholesterol ; intracerebral hemorrhage ; dyslipidemia ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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