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Article ; Online: [Radiological manifestation of COVID-19].

Degn, Stine / Delekta, Agnieszka Monika

2020 Volume 182, Issue 25

Abstract: In this case report, a 70-year-old male was admitted to the hospital with respiratory tract symptoms and a fever, and he was isolated, suspected of COVID-19. A chest radiograph showed bilateral consolidations, and subsequent chest CT scan revealed ... ...

Abstract	In this case report, a 70-year-old male was admitted to the hospital with respiratory tract symptoms and a fever, and he was isolated, suspected of COVID-19. A chest radiograph showed bilateral consolidations, and subsequent chest CT scan revealed bilateral and peripheral ground glass opacities, which are the most common radiological manifestations of COVID-19. The characteristic radiological findings can be exploited in the diagnosis of COVID-19, and radiologists should have knowledge of the usual manifestations of COVID-19, as they may play a role in early detection and diagnosis of the disease.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Radiography, Thoracic ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	Danish
Publishing date	2020-06-25
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: Radiologisk manifestation ved COVID-19 ; Radiological manifestation of COVID-19

Degn, Stine / Delekt, Agnieszka Monika

Degn , S & Delekt , A M 2020 , ' Radiologisk manifestation ved COVID-19 ' , Ugeskrift for Laeger , bind 182 , nr. 14 , V04200208 . < https://ugeskriftet.dk/videnskab/radiologisk-manifestation-ved-covid-19 >

2020

Keywords	Aged ; Betacoronavirus ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Male ; Pandemics ; Pneumonia ; Viral/diagnostic imaging ; Radiography ; Thoracic ; Tomography ; X-Ray Computed ; covid19
Language	Danish
Publishing date	2020-06-15
Publishing country	dk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cryoablation: a potential treatment option for renal metastasis from lung cancer?

Degn, Stine / Davidsen, Jesper Rømhild / Graumann, Ole

BMJ case reports

2018 Volume 2018

Abstract: Cryoablation is successfully performed as a treatment for small renal cancers. The occurrence of a solitary renal metastasis from lung cancer is an uncommon finding entailing a limited knowledge on the choice of its optimal treatment. We present two ... ...

Abstract	Cryoablation is successfully performed as a treatment for small renal cancers. The occurrence of a solitary renal metastasis from lung cancer is an uncommon finding entailing a limited knowledge on the choice of its optimal treatment. We present two patients diagnosed with non-small cell lung cancer, who were initially treated with curatively intended chemoradiotherapy. In the follow-up period, a non-symptomatic solitary renal metastasis was found in both patients. Both received CT-guided cryoablation of their renal metastases. One patient was successfully treated with no relapse, whereas the other patient received re-cryoablation due to development of a new renal metastasis. In both patients, no residual tumour was found at the 3 months' follow-up examination. Whether the minimally invasive procedure of cryoablation is a feasible treatment in the management of solitary renal metastases from lung cancer is still undetermined. The recurrence and incomplete treatment are concerns requiring further research.
MeSH term(s)	Aged ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/pathology ; Cryosurgery/methods ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/secondary ; Kidney Neoplasms/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Neoplasm Metastasis ; Treatment Outcome
Language	English
Publishing date	2018-11-01
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2018-225841
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Segmental Testicular Infarction - Is Conservative Management Feasible?

Bak-Ipsen, Camilla Brinkmann / Degn, Stine / Blichert-Refsgaard, Linea Sandfeld / Nielsen, Tommy Kjærgaard / List, Henriette / Graumann, Ole

Ultrasound international open

2020 Volume 6, Issue 2, Page(s) E50–E52

Language	English
Publishing date	2020-11-10
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2838384-9
ISSN	2199-7152 ; 2509-596X
ISSN (online)	2199-7152
ISSN	2509-596X
DOI	10.1055/a-1270-7795
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Article ; Online: Segmental Testicular Infarction – Is Conservative Management Feasible?

Camilla Brinkmann Bak-Ipsen / Stine Degn / Linea Sandfeld Blichert-Refsgaard / Tommy Kjærgaard Nielsen / Henriette List / Ole Graumann

Ultrasound International Open, Vol 06, Iss 02, Pp E50-E

2020 Volume 52

Keywords	Medicine ; R ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Georg Thieme Verlag KG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Segmental Testicular Infarction – Is Conservative Management Feasible?

Bak-Ipsen, Camilla Brinkmann / Degn, Stine / Blichert-Refsgaard, Linea Sandfeld / Nielsen, Tommy Kjærgaard / List, Henriette / Graumann, Ole

Ultrasound International Open

2020 Volume 06, Issue 02, Page(s) E50–E52

Language	English
Publishing date	2020-09-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2838384-9
ISSN	2199-7152 ; 2509-596X
ISSN (online)	2199-7152
ISSN	2509-596X
DOI	10.1055/a-1270-7795
Database	Thieme publisher's database

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Article ; Online: DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis.

Toksvang, Linea N / Grell, Kathrine / Nersting, Jacob / Degn, Matilda / Nielsen, Stine N / Abrahamsson, Jonas / Lund, Bendik / Kanerva, Jukka / Jónsson, Ólafur G / Lepik, Kristi / Vaitkevičienė, Goda / Griškevičius, Laimonas / Quist-Paulsen, Petter / Vora, Ajay / Moorman, Anthony V / Murdy, Daniel / Zimmermann, Martin / Möricke, Anja / Bostrom, Bruce /

Joshi, Jaitri / Hjalgrim, Lisa L / Dalhoff, Kim P / Als-Nielsen, Bodil / Schmiegelow, Kjeld

Leukemia

2021 Volume 36, Issue 1, Page(s) 33–41

Abstract: Methotrexate/6-mercaptopurine maintenance therapy improves acute lymphoblastic leukemia (ALL) outcome. Cytotoxicity is mediated by DNA incorporation of thioguanine nucleotides (DNA-TG). We investigated the association of DNA-TG to relapse risk in 1 910 ... ...

Abstract	Methotrexate/6-mercaptopurine maintenance therapy improves acute lymphoblastic leukemia (ALL) outcome. Cytotoxicity is mediated by DNA incorporation of thioguanine nucleotides (DNA-TG). We investigated the association of DNA-TG to relapse risk in 1 910 children and young adults with non-high risk ALL. In a cohort-stratified Cox regression analysis adjusted for sex, age, and white cell count at diagnosis, the relapse-specific hazard ratio (HRa) per 100 fmol/μg increase in weighted mean DNA-TG (
MeSH term(s)	Adult ; Child ; Clinical Trials as Topic/statistics & numerical data ; Cohort Studies ; DNA, Neoplasm/metabolism ; Female ; Humans ; Male ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Thioguanine/metabolism ; Young Adult
Chemical Substances	DNA, Neoplasm ; Thioguanine (FTK8U1GZNX)
Language	English
Publishing date	2021-06-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-021-01182-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2295: Show issues

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Article ; Online: Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia.

Larsen, Rikke Hebo / Utke Rank, Cecilie / Grell, Kathrine / Nørgaard Møller, Lisbeth / Malthe Overgaard, Ulrik / Kampmann, Peter / Nersting, Jacob / Degn, Matilda / Nygaard Nielsen, Stine / Holst, Helle / Klug Albertsen, Birgitte / Skov Wehner, Peder / Thude Callesen, Michael / Kanerva, Jukka / Leth Frandsen, Thomas / Als-Nielsen, Bodil / Lyngsie Hjalgrim, Lisa / Schmiegelow, Kjeld

Haematologica

2021 Volume 106, Issue 11, Page(s) 2824–2833

Abstract: Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is associated ...

Abstract	Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is associated with increased relapse-free survival. As 6-thioguanine provides 6- fold higher cytosolic levels of thioguanine nucleotides than does 6- mercapto purine, we added low-dose 6-thioguanine to methotrexate/6- mercapto purine maintenance therapy to explore if this combination results in significantly higher DNA-TG. The target population of the "Thiopurine Enhanced ALL Maintenance therapy" (TEAM) study was 30 patients with non-high-risk ALL, aged 1-45 years on methotrexate/6-mercaptopurine maintenance therapy receiving no other systemic chemotherapy. Incremental doses of 6-thioguanine were added to methotrexate/6-mercaptopurine maintenance therapy (starting 6-thioguanine dose: 2.5 mg/m2/day, maximum: 12.5 mg/m2/day). The primary endpoint was DNA-TG increments. Thirty-four patients were included, and 30 patients completed maintenance therapy according to the TEAM strategy. Of these 30 patients, 26 (87%) tolerated 10.0-12.5 mg/m2/day as the maximum 6-thioguanine dose. TEAM resulted in significantly higher DNA-TG levels compared to those in both TEAM patients before their inclusion in TEAM (on average 251 fmol/mg DNA higher [95% confidence interval: 160-341; P<0.0001]), and with historical patients receiving standard methotrexate/6-mercapto - purine maintenance therapy (on average 272 fmol/mg DNA higher [95% confidence interval: 147-398; P<0.0001]). TEAM did not increase myelotoxicity or hepatotoxicity. In conclusion, TEAM is an innovative and feasible approach to improve maintenance therapy and results in higher DNA-TG levels without inducing additional toxicity. It may therefore be an effective strategy to reduce the risk of ALL relapse through increased DNA-TG. This will be tested in a randomized ALLTogether-1 substudy.
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Child ; Child, Preschool ; DNA ; Humans ; Infant ; Mercaptopurine ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Thioguanine/therapeutic use ; Young Adult
Chemical Substances	DNA (9007-49-2) ; Mercaptopurine (E7WED276I5) ; Thioguanine (FTK8U1GZNX)
Language	English
Publishing date	2021-11-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2020.278166
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Article ; Online: Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia.

Madsen, Pernille M / Clausen, Bettina H / Degn, Matilda / Thyssen, Stine / Kristensen, Lotte K / Svensson, Martina / Ditzel, Nicholas / Finsen, Bente / Deierborg, Tomas / Brambilla, Roberta / Lambertsen, Kate L

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2015 Volume 36, Issue 9, Page(s) 1553–1569

Abstract: Microglia respond to focal cerebral ischemia by increasing their production of the neuromodulatory cytokine tumor necrosis factor, which exists both as membrane-anchored tumor necrosis factor and as cleaved soluble tumor necrosis factor forms. We ... ...

Abstract	Microglia respond to focal cerebral ischemia by increasing their production of the neuromodulatory cytokine tumor necrosis factor, which exists both as membrane-anchored tumor necrosis factor and as cleaved soluble tumor necrosis factor forms. We previously demonstrated that tumor necrosis factor knockout mice display increased lesion volume after focal cerebral ischemia, suggesting that tumor necrosis factor is neuroprotective in experimental stroke. Here, we extend our studies to show that mice with intact membrane-anchored tumor necrosis factor, but no soluble tumor necrosis factor, display reduced infarct volumes at one and five days after stroke. This was associated with improved functional outcome after experimental stroke. No changes were found in the mRNA levels of tumor necrosis factor and tumor necrosis factor-related genes (TNFR1, TNFR2, TACE), pro-inflammatory cytokines (IL-1β, IL-6) or chemokines (CXCL1, CXCL10, CCL2); however, protein expression of TNF, IL-1β, IL-6 and CXCL1 was reduced in membrane-anchored tumor necrosis factor(Δ/Δ) compared to membrane-anchored tumor necrosis factor(wt/wt) mice one day after experimental stroke. This was paralleled by reduced MHCII expression and a reduction in macrophage infiltration in the ipsilateral cortex of membrane-anchored tumor necrosis factor(Δ/Δ) mice. Collectively, these findings indicate that membrane-anchored tumor necrosis factor mediates the protective effects of tumor necrosis factor signaling in experimental stroke, and therapeutic strategies specifically targeting soluble tumor necrosis factor could be beneficial in clinical stroke therapy.
MeSH term(s)	Animals ; Brain Ischemia/physiopathology ; Cytokines/blood ; Cytokines/genetics ; Membrane Proteins/physiology ; Mice ; Mice, Knockout ; Neuroprotection ; RNA, Messenger/blood ; Solubility ; Stroke/blood ; Stroke/drug therapy ; Time Factors ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Cytokines ; Membrane Proteins ; RNA, Messenger ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2015-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X15610339
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Article: Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt.

Neumann, Anders Bay / Andersen, Stine Degn / Nielsen, Dennis Tønner / Holland-Fischer, Peter / Vilstrup, Hendrik / Grønbæk, Henning

World journal of hepatology

2013 Volume 5, Issue 1, Page(s) 38–42

Abstract: Aim: To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre.: Methods: Twenty-one consecutive patients from 1997-2008 were ... ...

Abstract	Aim: To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre. Methods: Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men, median age 40 years (range 17-66 years)]. Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian hospitals. Management consisted of tests for underlying haematological, endocrinological, or hypercoagulative disorders parallel to initiation of specific treatment of BCS. Results: BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) disorders. Forty-three percents had symptoms for less than one week with ascites as the most prevalent finding. Fourteen (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and diuretics. The median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo), and none required subsequent liver transplantation. Ascites control was achieved in all TIPS patients with a marked reduction in the dose of diuretics. A total of 14 TIPS revisions were needed, mostly of uncovered stents. Two died during follow-up: One non-TIPS patient worsened after 6 mo and died in relation to transplantation, and one TIPS patient died 4 years after the TIPS-procedure, unrelated to BCS. Conclusion: In our BCS cohort TIPS-treated patients have near-complete survival, reduced need for diuretics and compared to historical data a reduced need for liver transplantation.
Language	English
Publishing date	2013-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v5.i1.38
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